Patents Assigned to The Curators of the University of Missouri
  • Publication number: 20200347512
    Abstract: A process for forming an epitaxial film comprising spinning a substrate having an ordered crystal structure; heating the substrate during spinning to a temperature between 70° C. and 150° C.; dripping epitaxial film precursor solution onto the spinning substrate, where the precursor solution comprises inorganic film precursor material in a solvent; and continuing the heating and spinning to remove the solvent and epitaxially grow the epitaxial film on the substrate.
    Type: Application
    Filed: April 30, 2019
    Publication date: November 5, 2020
    Applicant: The Curators of the University of Missouri
    Inventor: Jay A. Switzer
  • Publication number: 20200325659
    Abstract: A water production system including a radiative cooling/heating unit comprising an oscillating heat pipe (OHP) heat spreader, wherein the radiative cooling/heating unit lowers the temperature of the OHP heat spreader to a temperature below the temperature of the ambient environment in which the water production system is disposed. The system additionally including a first OHP heat exchanger thermally connected to the OHP heat spreader such that the first OHP heat exchanger will acquire substantially the same temperature as the OHP heat spreader, and a second OHP heat exchanger thermally connected to the OHP heat spreader such that the second OHP heat exchanger will acquire substantially the same temperature as the OHP heat spreader. The system further includes a rotatable OHP water absorption bed disposed in thermal contact with the radiative cooling/heating unit such that the OHP absorption bed will acquire substantially the same temperature as the OHP heat spreader.
    Type: Application
    Filed: April 10, 2020
    Publication date: October 15, 2020
    Applicant: The Curators of the University of Missouri
    Inventor: Hongbin Ma
  • Publication number: 20200323812
    Abstract: A method for forming crystalline solid dispersions (CSDs) of a pharmaceutical agent with low water solubility is described. The properties of the CSDs are described. Also described is the enhancement of bioavailability of the pharmaceutical agent resulting from formation of the CSD.
    Type: Application
    Filed: April 14, 2020
    Publication date: October 15, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: Albert N. Ngo, Bi Botti Youan
  • Patent number: 10804524
    Abstract: Manufacturing an electrode by forming an electrode structure on a grounded conductive substrate and applying a voltage across the electrode structure to generate an electric field through the electrode structure to arrange the dipolar particles within the electrode structure.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: October 13, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Jonghyun Park, Jie Li
  • Patent number: 10791740
    Abstract: Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with synthetic amphiphiles, including lariat ethers and hydraphiles. Methods and compositions for overcoming antibiotic resistance are also provided.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: October 6, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: George W. Gokel, Michael R. Gokel, Saeedeh Negin, Mohit B. Patel
  • Patent number: 10790405
    Abstract: An electro-optically triggered power switch is disclosed utilizing a wide bandgap, high purity III-nitride semiconductor material such as BN, AlN, GaN, InN and their compounds. The device is electro-optically triggered using a laser diode operating at a wavelength of 10 to 50 nanometers off the material's bandgap, and at a power level of 10 to 100 times less than that required in a conventionally triggered device. The disclosed device may be configured as a high power RF MOSFET, IGBT, FET, or HEMT that can be electro-optically controlled using photons rather than an electrical signal. Electro-optic control lowers the power losses in the semiconductor device, decreases the turn-on time, and simplifies the drive signal requirements. It also allows the power devices to be operated from the millisecond to the sub-picosecond timeframe, thus allowing the power device to be operated at RF frequencies (i.e., kilohertz to terahertz range) and at high temperatures where the bandgap changes with temperature.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: September 29, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Heikki I. Helava, Randy D. Curry
  • Patent number: 10774337
    Abstract: The present invention is directed to a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, the present invention is directed to seeds from said plants with altered ratios of monosaturated and polyunsaturated fats. In particular, the present invention is directed to plants where the plants exhibit elevated levels of oleic acid.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: September 15, 2020
    Assignees: The Curators of the University of Missouri, The United States of America as Represented by the Secretary of Agriculture
    Inventors: Kristin D. Bilyeu, James Grover Shannon, Jeong-Dong Lee, Anh Tung Pham
  • Patent number: 10759774
    Abstract: The present invention provides novel compounds and methods for treating, preventing or inhibiting hepatitis B virus (HBV).
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: September 1, 2020
    Assignees: THE CURATORS OF THE UNIVERSITY OF MISSOURI, REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Stefan G. Sarafianos, Zhengqiang Wang, Andrew D. Huber, Jing Tang
  • Patent number: 10759893
    Abstract: The present invention is directed to a process for preparing a porous material, at least compris-ing the steps of providing a mixture (I) comprising a composition (A) at least comprising at least one polyfunctional isocyanate as component (ai) and at least one mineral acid (aa), and a sol-vent (B), reacting the components in the composition (A) obtaining an organic gel, and drying of the gel obtained. The invention further relates to the porous materials which can be obtained in this way and the use of the porous materials as thermal insulation material and as catalysts.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: September 1, 2020
    Assignees: BASF SE, THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Wibke Loelsberg, Marc Fricke, Dirk Weinrich, Nicholas Leventis, Chariklia Sotiriou-Leventis, Adnan M. Saeed
  • Publication number: 20200270628
    Abstract: A transgenic soybean plant resistant to soybean cyst nematode (SCN), or parts thereof, are provided. Also provided are methods of increasing SCN resistance of a soybean plant and associated DNA constructs.
    Type: Application
    Filed: January 10, 2020
    Publication date: August 27, 2020
    Applicants: Board of Trustees of Southern Illinois University, The Curators of the University of Missouri
    Inventors: Khalid Meksem, Henry Nguyen, Naoufal Lakhssassi, Mariola Klepadlo, Gunvant Patil
  • Patent number: 10706983
    Abstract: A method of producing an integrated circuit-type active radioisotope battery, the method comprising exposing at least a portion of an electronically functional, unactivated integrated circuit-type battery to radiation to convert transmutable material in the unactivated battery to a radioisotope thereby producing an active cell and thus the integrated circuit-type active radioisotope battery.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: July 7, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Jae Wan Kwon, John Michel Gahl, Bradley Ryan Nullmeyer
  • Patent number: 10689260
    Abstract: Methods for disaggregating nanodiamond clusters, for example, by using ultrasound to break apart nanodiamond aggregates in a sodium chloride aqueous slurry. Compositions, such as aqueous nanodiamond dispersions and dry particulate compositions that may be produced using these methods.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: June 23, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Vadym Mochalin, Kostiantyn Turcheniuk, Caleb Trecazzi
  • Patent number: 10675364
    Abstract: The present disclosure encompasses embodiments of a novel near-infrared-emitting molecular fluorophore and probes incorporating said fluorophore advantageous for in vitro and in vivo research studies. The fluorophore is robust, photostable, and possesses functionalities for easy bioorthogonal conjugation (e.g., click chemistry, hydrazone formation, Diels Alder, Staudinger ligation, etc.). It is biocompatible and emits at 711 nm in aqueous conditions. These fluorophores may be used to fluorescently tag biological molecules or structures of interest, or used as optical reporters (i.e., activatable molecular probes, fluorescent dyes) for specific biomarkers/analytes as they can be switched from “off” to “on.” This fluorophore is useful for cellular assays and preclinical small animal imaging as the near-infrared emission is highly penetrating, and the photophysical properties are outstanding. As such, the properties of this class of fluorophores could easily be translated for use in clinical applications.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: June 9, 2020
    Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Kenneth Hettie, Jessica Klockow, Timothy Glass, Frederick T. Chin
  • Patent number: 10669212
    Abstract: The present invention discloses novel methods for producing highly porous ceramic and/or metal aerogel monolithic objects that are hard, sturdy, and resistant to high temperatures. These methods comprise preparing nanoparticulate oxides of metals and/or metalloids via a step of vigorous stirring to prevent gelation, preparing polymer-modified xerogel powder compositions by reacting said nanoparticulate oxides with one or more polyfunctional monomers, compressing said polymer-modified xerogel powder compositions into shaped compacts, and carbothermal conversion of the shaped xerogel compacts via pyrolysis to provide the highly porous ceramic and/or metal aerogel monolithic objects that have the same shapes as to their corresponding xerogel compact precursors. Representative of the highly porous ceramic and/or metal aerogel monolithic objects of the invention are ceramic and/or metal aerogels of Si, Zr, Hf, Ti, Cr, Fe, Co, Ni, Cu, Ru, Au, and the like.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: June 2, 2020
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Nicholas Leventis, Chariklia Sotiriou-Leventis, Malik Adnan Saeed, Parwani Rewatkar, Tahereh Taghvaee
  • Patent number: 10624982
    Abstract: Glass-based particles of a biocompatible material which comprises 40 to about 80 wt % borate (B2O3) intermixed into a carrier which is an ointment, cream, or surgical glue.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: April 21, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Steven B. Jung, Delbert E. Day
  • Publication number: 20200101447
    Abstract: Porous zeolite monolith compositions for the catalytic cracking of alkanes. The compositions may be prepared layer by layer using a 3D printer such that the compositions comprise a plurality of micropores and a plurality of mesopores and may be characterized by macro-meso-microporosity.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 2, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: Ali A. Rownaghi, Xin Li, Fateme Rezaei
  • Publication number: 20200103537
    Abstract: A system for detecting gamma radiation by neutron activation of a material includes a switchable radiation source and at least a first detector. The switchable radiation source includes a primary source assembly having an alpha particle emitter, and a target assembly in which, upon irradiation of the target assembly by alpha particles from the primary source assembly, secondary radiation comprising neutrons is produced. An alignment, proximity or exposure of the primary source assembly relative to the target assembly is adjustable to control irradiation of the target assembly by the primary source assembly and thereby selectively irradiate a material under interrogation with the secondary radiation. The first detector is configured to detect gamma radiation prompted by neutron activation of the material under interrogation.
    Type: Application
    Filed: November 15, 2019
    Publication date: April 2, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: Hyoung K. Lee, Kyle Paaren
  • Publication number: 20200087346
    Abstract: Described herein is the discovery of novel PSMA-specific peptides, which were identified through a novel combinatorial biopanning method. One of the novel PSMA-specific peptides discovered, GTIQPYPFSWGY (or GTI) (SEQ ID NO: 2), exhibits high binding affinity and selectivity to PSMA and PSMA-positive prostate cancer cells. It was found that GTI can mediate internalization of the apoptotic KLA peptide to PSMA-positive LNCaP cells and induce cell death. Moreover, a FAM-labeled GTI peptide shows a high and specific tumor uptake in nude mice bearing human prostate cancer xenografts. It was demonstrated that the GTI peptide can be employed as a PSMA-specific ligand for prostate cancer diagnosis and/or for targeted drug delivery to prostate cancer cells.
    Type: Application
    Filed: August 8, 2019
    Publication date: March 19, 2020
    Applicant: The Curators of the University of Missouri
    Inventors: Kun Cheng, Wei Jin
  • Patent number: 10591418
    Abstract: A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmuting an input light signal and a tip for inserting into a cell or other substance for measuring pH, temperature, and/or antigens. The pH micro-probe and the temperature micro-probe each include a luminescent material positioned on the tip of the micro-probe. The light signal excites the luminescent material so that the luminescent material emits a luminescent light signal. The luminescent light signal has a property value dependent on the pH or temperature being measured and reflects back through the shaft for being measured by a light signal measuring device. The immuno-based micro-probe includes a reflective material that has an effective refractive index dependent on the number of antigen-antibody bonds present on the reflective material.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: March 17, 2020
    Assignees: The Curators of the University of Missouri, Clemson University
    Inventors: Yinfa Ma, Honglan Shi, Qingbo Yang, Hai Xiao
  • Patent number: 10566638
    Abstract: A radiolytic electrochemical system that comprises a cathode, an anode that comprises a semiconductor, an aqueous electrolyte solution disposed between the cathode and anode, and ionizing radiation, wherein the ionizing radiation splits water molecules and forms solvated free radicals that migrate to the anode or cathode, depending upon a radical's charge, and participate in redox reactions at the anode and cathode thereby producing electrical current capable of performing work when the anode and cathode are electrically connected.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: February 18, 2020
    Assignee: The Curators of the University of Missouri
    Inventors: Jae Wan Kwon, Baek Hyun Kim