Abstract: The present disclosure relates to a method of accelerating a flow velocity in a lateral-flow microfluidic chip in which an analysis time is not delayed while sequential reactions are possible in the lateral-flow microfluidic chip by accelerating a flow velocity in at least a section of a channel, it is easy to manufacture the microfluidic chip for applying the method, and it is possible to mass-produce the microfluidic chip, and more particularly, by increasing a vapor pressure around a specific channel, a flow velocity of a fluid in the corresponding channel is accelerated.
Type:
Application
Filed:
December 20, 2018
Publication date:
December 12, 2019
Applicants:
The Industry & Academic Cooperation in Chungnam National University (IAC), ISIN TECHNOLOGY CO., LTD.
Inventors:
Chang Soo LEE, Seong Geun JEONG, Jin Hyeon LEE, Na Mi SONG, Chang Hwan YANG
Abstract: The present invention relates to a novel indene derivative, a preparation method for the same, and a pharmaceutical composition for treating retinal disease comprising the same as an active ingredient. The novel indene derivative of the present invention, the optional isomer of the same, or the pharmaceutically acceptable salts of the same have excellent inhibitory efficiency of receptor-interacting serine-threonine-protein kinase 1 (RIPK1). Therefore, the composition containing the same as an active ingredient can be effectively used as a pharmaceutical composition for treating retinal disease.
Type:
Grant
Filed:
January 27, 2017
Date of Patent:
December 10, 2019
Assignee:
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
Inventors:
Eunhee Kim, Sung-Eun Yoo, Nam Sook Kang, Tae-Sung Koo, Min-Young Park, Young-Hoon Kim, Hyun-Ju Bae, Jin-Woo Kim, Tae-Kyu In, Choun-Ki Joo
Abstract: Provided is an in-situ X-ray analysis apparatus including a potentiostat connected to an in-situ electrochemical cell and configured to adjust voltage, current, and time of the in-situ electrochemical cell or to record information regarding voltage, current, resistance, capacity, and time information of the in-situ electrochemical cell; an X-ray analysis apparatus configured to obtain X-ray diffraction information regarding the in-situ electrochemical cell; and a controller connected to the X-ray analysis apparatus and the potentiostat and configured to provide or receive signals to or from the X-ray analysis apparatus and the potentiostat.
Type:
Application
Filed:
January 31, 2019
Publication date:
August 15, 2019
Applicant:
The Industry & Academic Cooperation In Chungnam National University (IAC)
Inventors:
Yung-Eun SUNG, Jungjin PARK, Chunjoong KIM, Jong Sig LEE, Jae-Hyuk PARK
Abstract: The present invention relates to a method for preparing a free-standing polymer film with micropores in a simple and economical way, and particularly to a method for preparing a free-standing polymer film with micropores that includes: (a) forming a thin film of a water-soluble polymer on a substrate; (b) forming a thin film of a hydrophobic polymer on the water-soluble polymer thin film; (c) treating the substrate having the polymer thin films formed on with a mixed solution of a solvent and a C1-C3 alcohol and drying the substrate; and (d) immersing the dried substrate in water to dissolve the water-soluble polymer thin film and thereby to peel the hydrophobic polymer thin film from the substrate.
Type:
Grant
Filed:
December 4, 2015
Date of Patent:
August 6, 2019
Assignee:
The Industry & Academic Cooperation in Chungnam National University (IAC)
Abstract: Disclosed are a system and method for endpoint discovery based on the Data Distribution Service. The endpoint discovery system includes: a discovery information collecting part that collects first discovery information about a first domain network in which a plurality of endpoints including a first endpoint are interconnected, and that collects second discovery information about the first domain network after a preset period of time after collecting the first discovery information; and an endpoint discovery part that detects a second endpoint that is added to or deleted from the first domain network by comparing the first discovery information and the second discovery information, and that discovers the first endpoint having the same topic information as the second endpoint and transmits information about the second endpoint to the first endpoint.
Type:
Grant
Filed:
January 12, 2017
Date of Patent:
July 23, 2019
Assignee:
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
Abstract: Disclosed is a new compound that inhibits binding between a DX2 protein and a p14/ARF protein, a pharmaceutical composition including the new compound as an effective component for treating or preventing a cancer disease, an anticancer adjuvant for improving an anticancer effect of a drug-resistant anticancer drug, and a composition including an AIMP2-DX2 protein or a fragment thereof for diagnosing lung cancer.
Type:
Grant
Filed:
August 10, 2018
Date of Patent:
May 7, 2019
Assignees:
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION, THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
Inventors:
Bum Joon Park, Gyu Yong Song, Ah-Young Oh, Jee-Hyun Lee, Jin-Hyuk Her
Abstract: A signal processing apparatus includes an input voltage selector configured to select an input voltage from a plurality of input voltages; an input element connected to the input voltage selector; and an input current controller configured to control an inflow of an input current in conjunction with an operation of the input voltage selector.
Type:
Application
Filed:
November 7, 2018
Publication date:
March 7, 2019
Applicants:
Samsung Electronics Co., Ltd., The Industry & Academic Cooperation in Chungnam National University (IAC)
Inventors:
JongPal KIM, TakHyung LEE, Hyoung Ho KO
Abstract: A signal processing apparatus includes an input voltage selector configured to select an input voltage from a plurality of input voltages; an input element connected to the input voltage selector; and an input current controller configured to control an inflow of an input current in conjunction with an operation of the input voltage selector.
Type:
Grant
Filed:
May 19, 2015
Date of Patent:
December 11, 2018
Assignees:
Samsung Electronics Co., Ltd., The Industry & Academic Cooperation In Chungnam National University (IAC)
Inventors:
JongPal Kim, TakHyung Lee, Hyoung Ho Ko
Abstract: Disclosed is a new compound that inhibits binding between a DX2 protein and a p14/ARF protein, a pharmaceutical composition including the new compound as an effective component for treating or preventing a cancer disease, an anticancer adjuvant for improving an anticancer effect of a drug-resistant anticancer drug, and a composition including an AIMP2-DX2 protein or a fragment thereof for diagnosing lung cancer.
Type:
Grant
Filed:
June 30, 2015
Date of Patent:
September 11, 2018
Assignees:
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION, THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
Inventors:
Bum Joon Park, Gyu Yong Song, Ah-Young Oh, Jee-Hyun Lee, Jin-Hyuk Her
Abstract: The present invention relates to a replication retrovirus vector system comprising thymidine kinase (HSV-TK) gene and cytosine deaminase (CD) gene which make gene transfer to cancer cell tissue for the efficient treatment of cancer. Particularly, the HSV-TK/CD combined self-replicating retrovirus vector system of the present invention characteristically contains both HSV-TK and CD genes; has no worries about losing a therapeutic gene because recombination does not occur in this system during virus infection; and has an excellent stability, and also is able to induce cancer cell death by using the prodrug GCV or 5-FC and can apply a therapeutic gene or a prodrug thereof selectively to such cancer that shows resistance against cancer treatment using either TK or CD, so that this system of the invention can be advantageously used as a pharmaceutical composition for the treatment of cancer.
Type:
Grant
Filed:
November 30, 2016
Date of Patent:
August 7, 2018
Assignee:
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
Inventors:
Yeon Soo Kim, Moonkyung Kang, Min Jeong Baek
Abstract: The present invention relates to an repebody capable of binding specifically to interleukin-6 (IL-6) to inhibit the biological activity of IL-6, a polynucleotide encoding the repebody, a vector comprising the polynucleotide, a recombinant microorganism having introduced therein the polynucleotide or the vector, a method of producing the repebody using the recombinant microorganism, a composition for preventing or treating cancer, which comprises the repebody, and a method for preventing or treating cancer, which comprises administering the composition for preventing or treating cancer, which comprises the repebody. The repebody of the present invention significantly reduces the activity of signal transduction and activator of transciption3 (STAT3) and the concentration of interleukin-6, and thus can be widely used as an agent for preventing or treating IL-6-related diseases.
Type:
Grant
Filed:
February 27, 2013
Date of Patent:
July 10, 2018
Assignees:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC), KOREA BASIC SCIENCE INSTITUTE
Inventors:
Hak-Sung Kim, Joong-Jae Lee, Jung Min Choi, Eun-Kyeong Jo, Chul-Su Yang, Hae-Kap Cheong, Hyun Jung Kim
Abstract: The present invention relates to an antimicrobial glass having both electromagnetic shielding and antimicrobial characteristics while maintaining the transparency of glass, and more particularly to an optically transmissive antimicrobial glass with an electromagnetic shielding effect that includes an AZO/Ag/AZO multilayer thin film deposited on a glass substrate.
Type:
Grant
Filed:
September 15, 2015
Date of Patent:
June 26, 2018
Assignee:
The Industry & Academic Cooperation in Chungnam National University (IAC)
Abstract: A pharmaceutical composition comprises a Quisaqualis indica extract as an active ingredient, for preventing or treating prostatic hyperplasia, and may also be used in a food composition. The Quisaqualis indica extract may be used to treat and prevent prostatic hyperplasia by exhibiting effects of a reduction in prostate weight, a reduction in DHT as a prostatic hyperplasia inducing factor, and a reduction in prostate epithelial cell hyperplasia.
Type:
Application
Filed:
May 3, 2016
Publication date:
June 7, 2018
Applicant:
The Industry & Academic Cooperation in Chungnam National University (IAC)
Abstract: The present invention relates to a replication retrovirus vector system comprising thymidine kinase (HSV-TK) gene and cytosine deaminase (CD) gene which make gene transfer to cancer cell tissue for the efficient treatment of cancer. Particularly, the HSV-TK/CD combined self-replicating retrovirus vector system of the present invention characteristically contains both HSV-TK and CD genes; has no worries about losing a therapeutic gene because recombination does not occur in this system during virus infection; and has an excellent stability, and also is able to induce cancer cell death by using the prodrug GCV or 5-FC and can apply a therapeutic gene or a prodrug thereof selectively to such cancer that shows resistance against cancer treatment using either TK or CD, so that this system of the invention can be advantageously used as a pharmaceutical composition for the treatment of cancer.
Type:
Application
Filed:
November 30, 2016
Publication date:
May 31, 2018
Applicant:
The Industry & Academic Cooperation in Chungnam National University (IAC)
Inventors:
Yeon Soo KIM, Moonkyung KANG, Min Jeong BAEK
Abstract: Disclosed is a method for reducing contact resistance, including depositing a GST layer on an InGaAs substrate, generating an InGaAs/GST/Ni stacked structure by depositing a Ni layer on the GST layer, and thermally treating the stacked structure to rearrange components of the GST layer and to generate a Ni—InGaAs alloy.
Type:
Grant
Filed:
February 13, 2017
Date of Patent:
October 10, 2017
Assignee:
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
Inventors:
Hi Deok Lee, Meng Li, Geon Ho Shin, Jeongchan Lee
Abstract: A bio impedance measurement apparatus includes a current applicator configured to provide, to terminals contacting a body, a current based on a first control signal, and a modulator configured to modulate a voltage generated as the current flows through the body, based on a second control signal. The apparatus further includes an amplifier configured to amplify the modulated voltage, and a demodulator configured to demodulate the amplified voltage based on a third control signal.
Type:
Grant
Filed:
January 20, 2015
Date of Patent:
September 19, 2017
Assignees:
Samsung Electronics Co., Ltd., THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
Inventors:
Hyoung Ho Ko, Jong Pal Kim, Tak Hyung Lee
Abstract: An apparatus of processing a signal or a biosignal, and a method of processing a signal or a biosignal are provided. The method of processing signal involves receiving a first reference signal having a frequency component of a measurement signal to be applied to a subject, receiving a second reference signal having a frequency component within a frequency bandwidth of an amplifier, and converting a first signal measured from the subject to a second signal within the frequency bandwidth of the amplifier, based on the first reference signal and the second reference signal.
Type:
Grant
Filed:
February 4, 2015
Date of Patent:
September 12, 2017
Assignees:
Samsung Electronics Co., Ltd., THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
Inventors:
Jong Pal Kim, Hyoung Ho Ko, Tak Hyung Lee
Abstract: Disclosed is a new compound that inhibits binding between a DX2 protein and a p14/ARF protein, a pharmaceutical composition including the new compound as an effective component for treating or preventing a cancer disease, an anticancer adjuvant for improving an anticancer effect of a drug-resistant anticancer drug, and a composition including an AIMP2-DX2 protein or a fragment thereof for diagnosing lung cancer.
Type:
Application
Filed:
June 30, 2015
Publication date:
May 11, 2017
Applicants:
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION, THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC)
Inventors:
Bum Joon PARK, Gyu Yong SONG, Ah-Young OH, Jee-Hyun LEE, Jin-Hyuk HER
Abstract: A biosignal apparatus is described including an amplifier and a sampler. The amplifier is configured to alternate between an operating state and a low power state based on a periodically changing control signal. The sampler is configured to sample a signal output from the amplifier in response to the amplifier being in the operating state and maintain the sampled signal in response to the amplifier being in the low power state.
Type:
Grant
Filed:
January 12, 2015
Date of Patent:
March 28, 2017
Assignees:
Samsung Electronics Co., Ltd., The Industry & Academic Cooperation in Chungnam National University (IAC)
Inventors:
Hyoung Ho Ko, Jong Pal Kim, Tak Hyung Lee
Abstract: The present invention relates to a transfer-free method for forming a graphene layer, in which a high-quality graphene layer having excellent crystallinity can be easily formed over a large area at low temperature by a transfer-free process so that it can be applied directly to a base substrate, which is used in a transparent electrode, a semiconductor device or the like, without requiring a separate transfer process, and to an electrical device comprising a graphene layer formed by the method. More specifically, the transfer-free method for forming a graphene layer comprises the steps of: depositing a Ti layer having a thickness of 3-20 m on a base substrate by sputtering; and growing graphene on the deposited Ti layer by chemical vapor deposition.
Type:
Application
Filed:
September 22, 2016
Publication date:
March 23, 2017
Applicant:
The Industry & Academic Cooperation in Chungnam National University (IAC)