Patents Assigned to The Massachusetts Institute Technology
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Patent number: 10276735Abstract: A semiconductor nanocrystal include a first I-III-VI semiconductor material and have a luminescence quantum yield of at least 10%, at least 20%, or at least 30%. The nanocrystal can be substantially free of toxic elements. Populations of the nanocrystals can have an emission FWHM of no greater than 0.35 eV.Type: GrantFiled: July 26, 2017Date of Patent: April 30, 2019Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Peter Matthew Allen, Moungi G. Bawendi
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Patent number: 10273170Abstract: A method reuses produced water resulting from a fossil fuel extraction operation. The method includes providing the produced water as an input to an electrodialysis system. The method also includes running the electrodialysis system to produce a diluate and a concentrate. The diluate is contaminated so as to have a conductivity of no less than 0.1 Siemens/meter. The method also includes reformulating the diluate to produce fossil fuel extraction fluid. The method also includes using the produced fossil fuel extraction fluid in the fossil fuel extraction operation. An electrodialysis system includes first and second stacks. The electrodialysis system also includes first and second voltage sources, coupled to the first and second stacks, so as to apply a first voltage to the first stack lower by at least about 10% than a second voltage to the second stack.Type: GrantFiled: April 23, 2015Date of Patent: April 30, 2019Assignees: Massachusetts Institute of Technology, King Fahd University of Petroleum and MineralsInventors: John H. Lienhard, Ronan Killian McGovern, Lige Sun, Adam Michael Weiner, Syed M. Zubair
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Patent number: 10275718Abstract: Described herein are structures and techniques for highly-connected qubit interaction using a “paramagnetic tree coupling” scheme. In one embodiment, a structure for providing highly-connected qubit interaction includes a plurality of qubits and, for each of the plurality of qubits, a paramagnetic medium connecting the qubit to each other one of the plurality of qubits, where the paramagnetic medium includes a series of inductive couplers.Type: GrantFiled: November 17, 2016Date of Patent: April 30, 2019Assignee: Massachusetts Institute of TechnologyInventor: Andrew J. Kerman
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Patent number: 10273405Abstract: Colloidal perovskite nanoplatelets can provide a material platform, with tunability extending from the deep UV, across the visible, into the near-IR. The high degree of spectral tunability can be achieved through variation of the cation, metal, and halide composition as well as nanoplatelet thickness.Type: GrantFiled: May 3, 2017Date of Patent: April 30, 2019Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Mark Clayton Weidman, Michael Seitz, William Alfred Tisdale
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Publication number: 20190119667Abstract: A method for directed exaptation includes dividing an original microorganism monoculture into subcultures that are subjected to different exaptation agents to obtain diversified substrains. At least one of the exaptation agents is selected to favor survival of sub strains exhibiting desired traits. The steps of dividing and subjecting may be iterated using at least some of the diversified substrains. Performance of diversified substrains is assessed and those that meet performance criteria for at least one desired trait are selected. Exaptation agents may include mutagenesis agents, training, horizontal gene transfer opportunities, and stressors. Substrains may be co-incubated with other living or dead microorganisms known to be preferentially adapted to have the desired trait. Diversified substrains may be combined into a multiculture microorganism population, to which microorganisms from the original monoculture may be added.Type: ApplicationFiled: September 17, 2018Publication date: April 25, 2019Applicant: Massachusetts Institute of TechnologyInventors: Andreas Mershin, Shannon Leigh Johnson
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Publication number: 20190120818Abstract: An RFID-based anemia detection sensor that integrates a paper-based diagnostic device with a passive Ultra High Frequency (UHF) RFID tag. Differences in red blood cell (RBC) count in a patient's blood manifests itself as a controlled time-dependent change in the tag's signal response. In one embodiment, the sensor is capable of reliably differentiating between blood having 20, 30, 40 and 50 percent RBC concentration by volume, which is indicative of anemic vs. healthy blood. In another embodiment, the sensor is read using standard RFID equipment allowing for large-scale automated screening of blood specimens.Type: ApplicationFiled: April 14, 2017Publication date: April 25, 2019Applicants: Massachusetts Institute of Technology, Diagnostics for All, Inc.Inventors: Sanjay E. Sarma, Rahul Bhattacharyya, Christina D. Swanson
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Publication number: 20190118232Abstract: Presented herein are articles and methods relating to manufactured superhydrophobic, superoleophobic, and/or supermetallophobic surfaces with macro-scale features (macro features) configured to induce controlled asymmetry in a liquid film produced by impinging phase (e.g., impinging droplet(s)) onto the surface, thereby further reducing the contact time between an impinging liquid and the surface.Type: ApplicationFiled: May 15, 2018Publication date: April 25, 2019Applicant: Massachusetts Institute of TechnologyInventors: Rajeev Dhiman, James C. Bird, Hyukmin Kwon, Kripa K. Varanasi
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Patent number: 10265497Abstract: The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-? (A?) peptide, C-terminal fragment-? (?-CTF), ?-secretase (BACE1), ?-secretase, neuroinflammation, and/or dementia (e.g., Alzheimer's disease or age-related decline) in a subject by inducing synchronized gamma oscillations in the brain of the subject using, for example, a stimulus-emitting device to emit a stimulus (e.g., light, sound, and/or haptic) at a frequency (e.g., about 40 Hz) that synchronously activates in vivo a specific cell type (e.g., fast-spiking-parvalbumin (FS-PV) immunoreactive interneurons) and/or brain region (e.g., a sensory cortex and/or hippocampus) of the subject.Type: GrantFiled: November 23, 2016Date of Patent: April 23, 2019Assignee: Massachusetts Institute of TechnologyInventors: Li-Huei Tsai, Emery Brown, Hannah Iaccarino, Anthony James Martorell, Chinnakkaruppan Adaikkan
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Patent number: 10265683Abstract: The present invention provides methods for uniform growth of nanostructures such as nanotubes (e.g., carbon nanotubes) on the surface of a substrate, wherein the long axes of the nanostructures may be substantially aligned. The nanostructures may be further processed for use in various applications, such as composite materials. For example, a set of aligned nanostructures may be formed and transferred, either in bulk or to another surface, to another material to enhance the properties of the material. In some cases, the nanostructures may enhance the mechanical properties of a material, for example, providing mechanical reinforcement at an interface between two materials or plies. In some cases, the nanostructures may enhance thermal and/or electronic properties of a material. The present invention also provides systems and methods for growth of nanostructures, including batch processes and continuous processes.Type: GrantFiled: June 14, 2016Date of Patent: April 23, 2019Assignee: Massachusetts Institute of TechnologyInventors: Anastasios John Hart, Brian L. Wardle, Enrique J. Garcia, Alexander H. Slocum
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Patent number: 10268232Abstract: An optical neural network is constructed based on photonic integrated circuits to perform neuromorphic computing. In the optical neural network, matrix multiplication is implemented using one or more optical interference units, which can apply an arbitrary weighting matrix multiplication to an array of input optical signals. Nonlinear activation is realized by an optical nonlinearity unit, which can be based on nonlinear optical effects, such as saturable absorption. These calculations are implemented optically, thereby resulting in high calculation speeds and low power consumption in the optical neural network.Type: GrantFiled: June 2, 2017Date of Patent: April 23, 2019Assignee: Massachusetts Institute of TechnologyInventors: Nicholas Christopher Harris, Jacques Johannes Carolan, Mihika Prabhu, Dirk Robert Englund, Scott A. Skirlo, Yichen Shen, Marin Soljacic
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Patent number: 10264999Abstract: Systems, apparatus, and methods for collecting, interpreting, and utilizing noise exposure data may include sensors to obtain an analog signal representative of impulse noise sound pressure and an analog signal representative of continuous noise sound pressure. At least one ADC may generate digital signals by sampling the analog signals at rates equal to or greater than twice the reciprocal of a minimum impulse noise rise time. Accelerometers may obtain data in close proximity to and remote from the sensors. At least one processor may include a first combining node to combine the digital signals to represent both the continuous noise and the impulse noise, a shock-artifact detection filter to identify a time frame including a shock artifact based on the accelerometry data, a frequency filter to generate a background-removed audio signal, an adaptive filter to estimate the shock artifact, and a second combining node to produce a shock-artifact-free audio signal.Type: GrantFiled: January 5, 2018Date of Patent: April 23, 2019Assignee: Massachusetts Institute of TechnologyInventors: Joseph J. Lacirignola, Trina Rae Vian, Christopher J. Smalt, David F. Aubin, Jr., David C. Maurer, Mary Katherine Byrd, Christine M. Weston, Kerry A. Johnson, Shakti Davis, Olha Townsend, Paul T. Calamia, Edward H. Chen, Paula P. Collins
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Patent number: 10266442Abstract: In illustrative implementations of this invention, a crucible kiln heats glass such that the glass becomes or remains molten. A nozzle extrudes the molten glass while one or more actuators actuate movements of the nozzle, a build platform or both. A computer controls these movements such that the extruded molten glass is selectively deposited to form a 3D glass object. The selective deposition of molten glass occurs inside an annealing kiln. The annealing kiln anneals the glass after it is extruded. In some cases, the actuators actuate the crucible kiln and nozzle to move in horizontal x, y directions and actuate the build platform to move in a z-direction. In some cases, fluid flows through a cavity or tubes adjacent to the nozzle tip, in order to cool the nozzle tip and thereby reduce the amount of glass that sticks to the nozzle tip.Type: GrantFiled: January 23, 2018Date of Patent: April 23, 2019Assignee: Massachusetts Institute of TechnologyInventors: John Klein, Giorgia Franchin, Michael Stern, Markus Kayser, Chikara Inamura, Shreya Dave, Neri Oxman, Peter Houk
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Patent number: 10266887Abstract: The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.Type: GrantFiled: March 9, 2018Date of Patent: April 23, 2019Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Omar Abudayyeh, James Joseph Collins, Jonathan Gootenberg, Feng Zhang, Eric S. Lander
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Patent number: 10265698Abstract: Microfluidic structures featuring substantially circular channels may be fabricated by embossing polymer sheets.Type: GrantFiled: November 6, 2015Date of Patent: April 23, 2019Assignees: The Charles Stark Draper Laboratory, Inc., The Brigham and Women's Hospital, Inc., The Massachusetts Institute of TechnologyInventors: Jeffrey T. Borenstein, Eli J. Weinberg, James C. Hsiao, Ahmad S. Khalil, Malinda M. Tupper, Guillermo Garcia-Cardena, Peter Mack, Sarah L. Tao
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Patent number: 10268601Abstract: In a system executing a program, a method comprises detecting one or more input/output calls associated with the program and re-randomizing memory associated with the program in response to the one or more input/output calls. A related system is also described.Type: GrantFiled: June 17, 2016Date of Patent: April 23, 2019Assignee: Massachusetts Institute of TechnologyInventors: Hamed Okhravi, Thomas R. Hobson, David O. Bigelow, Robert Rudd, David M. Perry, Kristin S. Dahl, William W. Streilein
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Publication number: 20190112600Abstract: Disclosed herein are protein translation switches and conditional gene expression systems that are compatible with retroviral and lentiviral gene delivery. The linking of a protein translation switch to a 3? gene of interest suppresses translation of the gene of interest, and the alteration of the protein translation switch by DNA recombinase-mediated DNA recombination relieves the suppressed translation of the 3? gene of interest. Also disclosed herein are methods of mimicking clinical pharmacology in a pre-clinical setting.Type: ApplicationFiled: October 11, 2018Publication date: April 18, 2019Applicant: Massachusetts Institute of TechnologyInventor: Patrick J. Stern
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Publication number: 20190111393Abstract: A spiral-wound electrodialysis module includes an inner electrode positioned about a central axis and an outer electrode surrounding the inner electrode. Ion exchange membranes are arranged in a stack, and each membrane extends in a spiral outward from an inner position proximate the inner electrode to an outer position proximate the outer electrode. The spirals expand outward at a greater-than-linear rate as a function of angle along a length of the spiral from the inner positions to the outer positions.Type: ApplicationFiled: October 16, 2018Publication date: April 18, 2019Applicant: Massachusetts Institute of TechnologyInventors: Amos G. Winter, Natasha Catherine Wright
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Publication number: 20190113512Abstract: The present disclosure relates to proteins comprising a target-binding domain for detection of a target of interest, methods, compositions and kits thereof.Type: ApplicationFiled: October 12, 2018Publication date: April 18, 2019Applicant: Massachusetts Institute of TechnologyInventors: Hadley Sikes Johnson, Eric Alexander Miller, Ki-Joo Sung
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Patent number: 10261297Abstract: A remote imaging apparatus, and corresponding method, includes a hyperbolic primary mirror that receives light from a remote object to be imaged. The primary mirror has a continuous surface that reflects, at least twice, the light from the remote object. The apparatus also includes a hyperbolic secondary mirror having a continuous surface that reflects, at least twice, the light from the remote object. The secondary mirror delivers the light to a field corrector via a port of the hyperbolic primary mirror, and the field corrector is configured to correct for an optical aberration of one or both of the hyperbolic primary and secondary mirrors. Embodiments can provide low distortion, small aspect ratios, and small form factors and moments of inertia for fleets satellite-based and other imaging systems.Type: GrantFiled: June 27, 2017Date of Patent: April 16, 2019Assignee: Massachusetts Institute of TechnologyInventor: Gregory G. Cappiello
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Patent number: 10261389Abstract: An integrated optical beam steering device includes a planar dielectric lens that collimates beams from different inputs in different directions within the lens plane. It also includes an output coupler, such as a grating or photonic crystal, that guides the collimated beams in different directions out of the lens plane. A switch matrix controls which input port is illuminated and hence the in-plane propagation direction of the collimated beam. And a tunable light source changes the wavelength to control the angle at which the collimated beam leaves the plane of the substrate. The device is very efficient, in part because the input port (and thus in-plane propagation direction) can be changed by actuating only log2 N of the N switches in the switch matrix. It can also be much simpler, smaller, and cheaper because it needs fewer control lines than a conventional optical phased array with the same resolution.Type: GrantFiled: June 22, 2017Date of Patent: April 16, 2019Assignee: Massachusetts Institute of TechnologyInventors: Scott Skirlo, Cheryl Marie Sorace-Agaskar, Marin Soljacic, Simon Verghese, Jeffrey S. Herd, Paul William Juodawlkis, Yi Yang, Dirk Robert Englund, Mihika Prabhu