Abstract: A widely tunable vertical-cavity surface-emitting laser (VCSEL) having a semiconductor cavity followed by an air-gap over which is a movable reflector. Lasing wavelength is controlled by a combination of the resonance of the semiconductor cavity, which is fixed, and the resonance of the air cavity, which can be changed by moving the reflector. Tuning range and slope of the VCSEL are increased by configuring the semiconductor cavity to be antiresonant at the center of the tuning range, which forces electromagnetic energy to be confined more strongly in the air gap than in the semiconductor, thus making emission wavelength more sensitive to the displacement of the tuning mirror.

Abstract: In certain aspects, the disclosure relates to compositions and methods relating to mutant bacteriophage that target Propionibacterium acnes. In certain aspects, compositions and methods described herein are useful for the treatment of acne.

Abstract: Described are devices, systems and methods for thermographic imaging of conditions of the ear, nose, and throat (ENT). An example device for thermographic ENT imaging includes an endoscope and a thermal imaging camera that can be either integrated or added as an attachment to the endoscope. The device may also include a mirror configured to direct thermal radiation emitted by a target area to the thermal imaging camera.

Abstract: Disclosed herein are methods of electrochemically enhanced amine-based CO2 capture and systems for performing the methods of amine-based CO2 capture. The present methods and systems advantageously may be carried out at ambient temperatures and allow for reusing the amine through multiple cycles.

Abstract: Source identification for unknown molecules using mass spectral matching. In an embodiment, a representation of a query mass spectrum is received in a spectrum query. A repository is searched for the query mass spectrum by, for each of a plurality of reference mass spectra, generating a similarity score between the representation of the query mass spectrum and the representation of the reference mass spectrum, when the similarity score exceeds a predetermined threshold value, without utilizing a molecular identity of a molecule represented by the reference mass spectrum, retrieving metadata associated with the reference mass spectrum, and derive context information from the retrieved metadata, and adding the context information to consensus metadata associated with the query mass spectrum, wherein the context information indicates a source of the reference mass spectrum. The consensus metadata is then returned in response to the spectrum query.

Abstract: Systems, methods, and techniques for optofluidic analyte detection and analysis using multi-mode interference (MMI) waveguides are disclosed herein. In some embodiments, spatially and spectrally multiplexed optical detection of particles is implemented on an optofluidic platform comprising multiple analyte channels intersecting a single MMI waveguide. In some embodiments, multi-stage photonic structures including a first stage MMI waveguide for demultiplexing optical signals by spatially separating different wavelengths of light from one another may be implemented. In some embodiments, a second stage may use single-mode waveguides and/or MMI waveguides to create multi-spot patterns using the demultiplexed, spatially separated light output from the first stage.

Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for reducing the expression of genes in plants.

Abstract: A system and method described herein is effective for generating automated visual analytics and player statistics for videos of sporting events. A dataset of videos is collected that comprises multiple teams. Training the networks on RGB and grayscale images affects the generalization ability of the network learned and augmenting more images using generative adversarial networks to the dataset helps further improves the performance.

Abstract: In alternative embodiments, provided are compositions, medical devices or products of manufacture, systems, diagnostic tools, and methods, including computer implemented methods, for predicting the response of patients with dyssynchronous heart failure (DHF) to cardiac resynchronization therapy (CRT), comprising: measuring or determining the fraction of the LV/septum performing negative work (MNW); and measuring or determining the coefficient of variation of external work density (COVW), wherein the MNW fraction performing negative work and coefficient of variation COVW (sd/mean) correlated strongly with observed reduction in end-systolic volume after CRT.

Abstract: A device includes: (1) a boron arsenide substrate; and (2) an integrated circuit disposed in or over the boron arsenide substrate.

Abstract: Systems and methods for a dual-input double-tuned transmitter (Tx) configured to wirelessly power and control a plurality of implantable stimulators using radio frequency (RF) signals in accordance with embodiments of the invention are illustrated. One embodiment includes a transmitter, where the transmitter includes a matching network configured to isolate two input signals of different frequencies, wherein the matching network includes a lumped element frequency trap comprising at least one inductor and a plurality of capacitors. The transmitter further includes a Tx coil, wherein the Tx coil is configured to transmit two RF signals at the frequencies of the input signals with a difference in frequency by a factor of 10% or more.

Abstract: Methods and systems for treating brackish desalination brine for the recovery of fresh water are disclosed. The method includes treating a source of brackish desalination brine with an ultraviolet-driven persulfate photolysis oxidation pre-treatment; treating the source of brackish desalination brine treated with the ultraviolet-driven persulfate photolysis oxidation pre-treatment to a chemical demineralization process; treating the source of brackish desalination brine treated with the ultraviolet-driven persulfate photolysis oxidation pre-treatment and with the chemical demineralization process to a microfiltration process; and treating the source of brackish desalination brine treated to the ultraviolet-driven persulfate photolysis oxidation pre-treatment, the chemical demineralization process, and the microfiltration process to a reverse osmosis treatment.

Abstract: This disclosure provides a wearable device implemented as a headset such as a virtual reality (VR) headset comprising at least a screen, a gaze tracker, and either one or both the anterior segment or retinal optical coherence tomography and fundus imaging modalities. In some embodiments, the disclosed headset can display a movie on the screen to catch/hold the attention of a patient, and meanwhile capture ocular images of the patient using the ophthalmic imaging modalities in a fully-automated manner. While capturing ophthalmic images, the movie on the screen can cause the patient's gaze to move in various directions in a controllable manner. The gaze tracker can track the movements of the pupils of the patient. The tracked pupil positions can be used to reposition the ophthalmic imaging modalities to refocus and capture images of different regions of the fundus/retina, which allows a widefield-of-view image of the fundus/retina to be reconstructed.

Abstract: A multimodal biometric device is disclosed. An apparatus may include a non-contact imaging system. The non-contact imaging system may include imaging optics, optical illumination optically coupled to the imaging optics, and a configurable body part support to support different body parts at corresponding focal lengths to capture different portions of the different body parts. An apparatus may also include a housing coupled to the imaging optics, the optical illumination, and the configurable body part support.

Abstract: Dual nucleic acid and protein isoform measurements are performed on low starting cell numbers (e.g. equivalent to the number of blastomeres composing early embryonic development stages (morula and blastocysts)), comprising integrating fractionation polyacrylamide gel electrophoresis (fPAGE) of 10-100 cells with off-chip analysis of nucleic acids in the nuclei.

Abstract: A microfluidic device uses hydrodynamic shear forces on a sample to improve the speed and efficiency of tissue digestion is disclosed. The microfluidic channels are designed to apply hydrodynamic shear forces at discrete locations on tissue specimens up to 1 cm in length and 1 mm in diameter, thereby accelerating digestion through hydrodynamic shear forces and improved enzyme-tissue contact. The microfluidic digestion device can eliminate or reduce the need to mince tissue samples with a scalpel, while reducing sample processing time and preserving cell viability. Another advantage is that downstream microfluidic operations could be integrated to enable advanced cell processing and analysis capabilities. The device may be used in research and clinical settings to promote single cell-based analysis technologies, as well as to isolate primary, progenitor, and stem cells for use in the fields of tissue engineering and regenerative medicine.

Abstract: Disclosed are systems, devices and methods for estimating blood glucose parameters, including blood glucose concentration glucose sensor signals.

Abstract: The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and/or RNA during and following a clinical treatment regime. The methods may also be used to evaluate protein and/or metabolite levels that correlate with such clinical conditions. The methods are also of use to ascertain the probability outcome for a patient's particular prognosis.

Abstract: The present invention provides for a genetically modified plant or plant cell comprising a nucleic acid encoding one or more heterologous enzymes operatively linked a promoter, wherein one or more heterologous enzymes synthesizes muconic acid (MA).

Abstract: Provided herein are novel proteins and protein domains from newly discovered anaerobic fungal species. The anaerobic fungal species have unique enzymatic capabilities, including the ability to digest diverse lignocellulosic biomass feedstocks and to synthesize secondary metabolites. The scope of the invention encompasses novel engineered proteins comprising glycoside hydrolase enzymes, dockerin domains, carbohydrate binding domains, and polyketide synthase enzymes. The invention further encompasses artificial cellulosomes comprising novel proteins and domains of the invention. The scope of the invention further includes novel nucleic acid sequences coding for the engineered proteins of the invention, and methods of using such engineered organisms to degrade lignocellulosic biomass and to create polyketides.