Abstract: Systems and methods in accordance with embodiments of the invention implement electronic frequency-comb detector systems. One embodiment includes an electronic frequency-comb detector, where the electronic frequency-comb detector includes: a frequency-comb generator configured to generate a frequency comb reference signal, and a heterodyne mixer. In addition, the heterodyne mixer is configured to use the frequency comb reference signal to downconvert received millimeter wave (mm-wave) and terahertz (THZ) frequency tones into an intermediate frequency (IF) signal. In a further embodiment, the electronic frequency-comb detector includes an IF amplifier, where the IF amplifier is configured to feed a spectrum analyzer configured to detect a signature of a material under test (MUT).

Abstract: The present disclosure provides recombinant adeno-associated virus (AAV) virions comprising: a) a variant capsid protein; and b) a heterologous nucleic acid comprising one or more nucleotide sequences encoding one or more heterologous gene products. The rAAV virions are useful for delivery of gene products to a retinal cell. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.

Abstract: The present disclosure provides novel anti-inflammatory therapeutics, and method of use thereof. The disclosed anti-inflammatory therapeutics comprise soluble, membrane-anchored, and/or extracellular vesicle (EV)-associated PrPC, and/or analogues thereof, that interacts with NMDA-R/LRP1 receptor complext to regulate innate immunity and provide anti-inflammatory activity in diseases in which innate immunity plays an important role.

Abstract: In a Byzantine computing environment in which a database is sharded or partitioned among multiple clusters of computing nodes, consensus for and execution of data transactions (e.g., transactions that require and/or affect data of one or more shards) are achieved in a resilient manner Within some clusters, multiple primary replicas concurrently propose transactions for processing in parallel by all replicas. For some multi-shard transactions, shards involved in the transactions may be logically ring-ordered; each shard in turn achieves consensus among its nodes to commit the transactions, and then executes its portion of the operation after consensus is obtained among all shards. For some other multi-shard transactions, involved shards first determine whether local data constraints are satisfied, after which data modifications are made in parallel.

Abstract: Provided herein is a method of producing an oxide-dispersion strengthened (ODS) alloy that includes providing a master alloy powder comprising a metal or metal alloy and particles of a metal oxide; adding the master alloy powder to a molten diluent alloy to form an oxide-dispersion strengthened (ODS) alloy; and allowing the ODS to solidify. The molten diluent alloy includes a molten metal or metal alloy, and a wetting-enhancing metal is added to the molten diluent alloy either prior to, during, or after adding of the master alloy to the molten diluent alloy. The wetting-enhancing alloy reduces an interfacial energy and vdW attraction between the particles of the metal oxide and the molten alloy diluent to achieve a stable nanoparticulate ODS solid.

Abstract: The present invention provides peptide conjugates that target an integrin such as ?v?6 integrin. In particular embodiments, the peptide conjugates comprise a moiety such as a PEG moiety, an imaging agent, or a therapeutic agent. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue. Compositions and kits containing the peptide conjugates of the present invention are also provided herein.

Abstract: The invention provides an apparatus for the generation and administration of a micro-nanobubble solution to a tissue, a method for the treatment of a tissue with a solution of micro-nanobubbles, and a kit for the treatment of tissue with micro-nanobubbles.

Abstract: Methods of bonding and structures with such bonding are disclosed. One such method includes providing a first substrate with a first electrical contact; providing a second substrate with a second electrical contact above the first electrical contact, wherein an upper surface of the first electrical contact is spaced apart from a lower surface of the second electrical contact by a gap; and depositing a layer of selective metal on the lower surface of the second electrical contact and on the upper surface of the first electrical contact by a thermal Atomic Layer Deposition (ALD) process until the gap is filled to create a bond between the first electrical contact and the second electrical contact.

Abstract: An imaging device includes an alignment platform configured to hold a cell culture plate having a plurality of wells and an imaging assembly including a plurality of imaging units, each of which is configured to image one well of the plurality of wells.

Abstract: Closed cell chitin foam is provided. The closed-cell chitin foam composition does not absorb water, is biodegradable, and is mechanically characterized by a density range of 16 to 800 kg/m3, closed-cell pore sizes ranging from 50 microns to 1 mm, an elastic modulus of 3 to 175 MPa, and a tensile strength of 0.15 to 6.5 MPa. The chitin is at least 70% acetylated. In one aspect, the foam is enclosed in a shell e.g. in the form of a surfboard. Chitin foam according to this invention is fully biodegradable. The chitin foam overcomes the current problems with foams that contain polyurethane and polystyrene, and which are manufactured from petroleum-based sources. Petroleum based foams are not renewable, have an adverse impact on our environment, and pose significant health hazards to those who manufacture them. The chitin foam with its water-based manufacturing process and naturally sourced chitin, solves these problems.

Abstract: Methods and compositions for rapid and efficient assembly of substrates (e.g., fibers) coated with lamellar vesicles are provided, wherein the vesicles are more strongly attached to the substrate than those made using other methods.

Abstract: A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode.

Abstract: A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation method includes providing a neuromodulation system including a processor, a signal generator communicatively coupled to the processor, and at least one transcutaneous electrode communicatively coupled to the signal generator. The method also includes causing the at least one transcutaneous electrode to be applied a human patient having at least one dysfunctional spinal circuit. The method further includes facilitating transcutaneous electrical stimulation of the patient's spinal cord via the processor in cooperation with the signal generator causing activation of at least one spinal network (“SN”) to enable or improve voluntary movements of the patient's arms, trunk, and legs, or autonomic control of at least one of sexual activity, vasomotor activity, speech, swallowing, chewing, cardiovascular function, respiratory activity, body temperature, metabolic processes, or cognitive function.

Abstract: A method of detecting and/or discriminating mismatched or complementary nucleic acids using a field-effect transistor (FET). The FET comprises source and drain electrodes formed on substrate and separated by a channel that includes a thin semiconducting film. One or more nucleic acid molecules are immobilized to thin semiconducting film. The FET includes a gate electrode in contact with solution containing the sample (or located on the surface of the device). Samples possibly containing target nucleic acid are exposed to the FET of the biosensor device and current response is measured after samples containing target nucleic acid have been exposed to the FET of the biosensor device. Measured current response in the FET is used to detect and/or discriminate whether target nucleic acid is present as well as complementary or mismatched. Measured current response may also be used to differentiate among different mismatches.

Abstract: The invention provides compositions and methods for treatment of glioblastoma and other conditions. In particular, the invention provides a recombinant adeno-associated virus (AAV) vector comprising a transgene encoding one or more interferon polypeptides and a CAG promoter which directs the expression of the transgene. The compositions are particularly suitable for intratumoral administration in gene therapy applications.

Abstract: ‘UC Monarch’ is a ‘short-day’ cultivar strawberry plant that has an unusual long-truss plant architecture, provides high yields of firm flavorful, long shelf-life fruit, and has resistance to various soil-borne pathogens.

Abstract: ‘UC Eclipse’ is a summer-plant cultivar strawberry plant that is Fusarium wilt-resistant and produces large, firm fruit throughout the growing season.

Abstract: ‘UC Keystone’ is a ‘day-neutral’ flowering cultivar of a strawberry plant that produces exceptionally high yields of firm, long shelf-life fruit and is resistant to Fusarium wilt, Verticillium wilt, and Phytophthora crown rot.

Abstract: ‘UC Golden Gate’ is a Fusarium wilt-resistant day-neutral cultivar of a strawberry plant that produces flavorful, long shelf-life fruit.

Abstract: Chemical additives are disclosed to increase solubility of salts in liquefied gas electrolytes.