Abstract: A computational cytometer operates using magnetically modulated lensless speckle imaging, which introduces oscillatory motion to magnetic bead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three-dimensions (3D). Detection specificity is further enhanced through a deep learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network (P3D CNN), which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic force. This compact, cost-effective and high-throughput computational cytometer can be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications.

Abstract: The present disclosure relates to layered 2D MoS2 nanostructures wherein light-matter interactions are enhanced by intercalation with transition metal atoms and/or post-transition metal atoms, specifically Cu and/or Sn. Photodetectors comprising Cu and/or Sn intercalated 2D MoS2 nanostructures amplify the response in the near-infrared for devices based on 2D MoS2.

Abstract: Provided herein are methods and systems for screening a candidate agent to determine whether the candidate agent modulates an activity of cultured cells. Compositions for screening a candidate agent are also provided herein.

Abstract: In vivo positionable filtration devices are provided that filter one or more therapeutic agents in blood flowing in a blood vessel. The filtration devices include an elongated member and a filtering component coupled to the elongated member. The elongated member and the filtering component are dimensioned for positioning within the blood vessel. Further, the filtering component includes a filtration material to filter the one or more therapeutic agents from the blood. Methods of in vivo filtration of the one or more therapeutic agents are also provided. The methods include positioning a filtration device of the filtration devices in the blood vessel, and administering a therapeutic agent of the one or more therapeutic agents upstream from a target tissue site to direct flow of the therapeutic agent to the target tissue site and then to the filtration device. The filtration device is positioned downstream from the target tissue site.

Abstract: A method for operating an electric vehicle charging station that comprises a first number of fixed chargers and a second number of mobile devices. Each of the mobile devices moves in the charging station to plug and unplug an electric vehicle. The method includes, at a time step, obtaining, upon receiving a charging request from an electric vehicle arriving at a beginning of the time step, a first charging demand; deriving, upon receiving charging dynamics of an electric vehicle having been staying at the charging station before the time step, a second charging demand; generating, with respect to an optimization horizon including the time step and a plurality of subsequent time steps, a charging demand forecast; and solving, with respect to the optimization horizon, an optimal operation solution, based on the first charging demand, the second charging demand, and the charging demand forecast.

Abstract: A method for performing single gating in a positron emission tomography (PET) system includes: receiving list-mode data acquired by scanning an imaging object using the PET system, the list-mode data being affected by quasi-periodic motion of the imaging object; producing a plurality of vectors based on the received list-mode data; generating a reference vector based on the produced plurality of vectors; selecting, from the produced plurality of vectors, a set of vectors corresponding to a single gate, based on respective differences compared with the generated reference vector; and generating an image of the imaging object based on the selected set of vectors.

Abstract: A method for signal separation includes obtaining list mode data representing radiation detected during an imaging scan, the list mode data being affected by quasi-periodic motion of an imaging object; dividing the list mode data into first non-overlapping frames of a first frame length, and process the first frames to determine a cardiac cycle length; determining a second frame length, longer than the first frame length, based on the determined cardiac cycle length; re-binning the list mode data into overlapping frames having the second frame length, based on the non-overlapping frames having the first frame length; applying a principal component analysis (PCA) process on the re-binned list mode data having the second frame length to determine a respiratory waveform; determining a cardiac waveform using the determined respiratory waveform; and reconstructing an image based on the list mode data using the determined respiratory waveform and the determined cardiac waveform.

Abstract: Methods are described for preventing or treating skeletal diseases such as period paralysis by administering to a subject a Kv7 channel opener.

Abstract: Oncology faces a digital chasm in its quest for personalized treatments. Despite the adoption of electronic health records (EHR), most hospitals are ill-equipped for data science research. Embodiments herein describe a continuously learning infrastructure through which multimodal health data are systematically organized and data quality is assessed with the goal of applying artificial intelligence to address unmet clinical needs. Embodiments describe systems and methods for improved cancer prognostics, including by obtaining electronic medical records and performing natural language processing thereon. Additional embodiments apply term frequency inverse document frequency to identify terms that are predictive for cancer survival. Additional embodiments are capable of performing in silico clinical trials based on information comprised in a collection of health records.

Abstract: Systems and methods for shaping temporal and amplitude profiles of optical pulses in accordance with embodiments of the invention are illustrated. One embodiment includes at least two laser emitters where each emitter configured to generate at least two input optical pulses, a pulse-shaping device configured to apply dispersions of different orders on each of the at least two input pulses, and a nonlinear crystal where the at least two input pulses applied with dispersions combine to emit an output optical pulse having an angular frequency that is the sum of the angular frequencies of the at least two input pulses.

Abstract: Provided herein are compositions for inducing anesthesia in a subject, where the compositions include at least one compound that is either a terpenoid or a salicylate. The provided compositions are particularly useful for applications where the subject is a livestock animal used for meat or milk production, as the anesthetic agents have no toxic effects on food byproducts. The compositions provide further advantages for applications where the subject is a human undergoing a medical procedure. Also provided are methods for using the disclosed compositions and compounds.

Abstract: This disclosure relates to an apparatus and method of transforming gaseous hydrocarbons such as methane into hydrogen and carbon. In some embodiments, the method includes flowing gaseous hydrocarbon onto a porous substrate in a reaction zone; and exposing the porous substrate to a concentrated solar irradiation in the reaction zone such that the porous substrate and gases surrounding the porous substrate absorb the concentrated solar irradiation producing heat, wherein the heat decomposes the gaseous hydrocarbon into hydrogen gas and carbon. The carbon may deposit onto the porous substrate as high quality graphitic carbon.

Abstract: Systems and methods for implementation of a disposable miniaturized implant for treatment of Post-Operative Ileums (POI), a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.

Abstract: The present disclosure provides a composition comprising extracellular vesicles (EVs) derived from induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs). The present EVs possess immunoregulatory functions that are distinct from those of EVs derived from mesenchymal stem cells. The present EVs can be used to treat or modulate immune responses in diseases such as cancer or autoimmune diseases.

Abstract: A cabin air filtration system and method for regenerating a cabin air filtration system are disclosed. The filtration system includes a frame, and a renewable sorption layer within the frame, the renewable sorption layer configured to clean air from one or more of outside of an automobile and inside an automobile. The cabin air filtration system for an automobile can include a first layer, the first layer configured to particulates, and a second layer, the second layer configured to remove volatile compounds and gases. The method includes placing a renewable sorption layer within a frame in an oven, the renewable sorption layer configured to filter air from one or more of outside of the automobile and inside the automobile; creating a vacuum within the oven; and heating a source of water within the oven to perform a steam regeneration treatment on the renewable sorption layer.

Abstract: Many embodiments implement quantum confined nanoplatelets (NPLs) that can be induced to emit bright and tunable infrared emission from attached quantum dot (QD). Some embodiments provide mesoscale NPLs with a largest dimension of greater than 1 micron. Certain embodiments provide methods for growing mesoscale NPLs and QD on mesoscale NPLs heterostructures. Several embodiments provide near unity energy transfer from NPLs to QDs, which can quench NPL emission and emit with high quantum yield through the shortwave infrared. The QD defect emission can be kinetically tunable, enabling controlled mid-gap emission from NPLs.

Abstract: The invention provides compositions and methods for treating asthma in a subject in need thereof comprising administering chemically synthesized secoisolaricirecinol diglucoside (SDG), and in particular, a racemic mixture of the SDG (LGM2605), stereoisomers thereof, metabolites thereof, and analogs thereof. Also provided are methods for treating or preventing ozone-induced damage in a subject in need thereof.

Abstract: A mobile device and user association system can include wireless routers to execute software for capturing data including received signal strength (RSS) values and media access controller (MAC) addresses for a number of mobile devices (MDs) from existing wireless fidelity (WiFi) traffic. The system can also include a server to receive the RSS values and MAC addresses of the MDs to estimate a location of each MD and generate historical location data of each MD, identify and filter out temporary MDs, classify each non-temporary MDs as either a static device (SD) or a mobile phone (MP), and associate a user with each SD and MP.

Abstract: An exoskeleton includes two torque generators, thigh links, and a supporting trunk rotatably coupled to the thigh links. When a wearer bends forward in the sagittal plane such that the supporting trunk extends beyond a predetermined angle A with respect to vertical, at least one of the torque generators imposes a resisting torque between the supporting trunk and a corresponding thigh link, thus imposing a force onto a wearer's trunk and thighs to aid in supporting the wearer in a bent position. The torque generators may be active or passive torque generators. When the supporting trunk does not extend beyond the predetermined angle A, the torque generators do not impose resisting torques between the supporting trunk and thigh links during the entire range of motion of the thigh links, thus enabling a wearer to walk, run, and sit without constraint while in a substantially upright position.

Abstract: Provided are methods and yeast cultures for producing polyol lipids and polyol lipid compositions.