Abstract: A subcutaneous continuous blood pressure monitor system based on piezoelectric micromachined ultrasonic transducers (PMUTs) provides remote, silent and continuous monitoring solutions for the BP management.

Abstract: A device may at least one laser with a first optical frequency the at least one laser stabilized to a at least one frequency reference, wherein the at least one laser is locked to the at least one frequency reference. A device may at least one photodiode and at least one laser current servo for locking the at least one laser to the at least one frequency reference. A device may at least one modulator configured to modulate a resonator, wherein the at least one frequency reference is a resonator, the resonator comprising a waveguide core and a tuner, wherein the tuner is laterally offset from the waveguide core.

Abstract: The present disclosure relates to methods for preparing car cartilage for eyelid reconstruction, including upper eyelid reconstruction, after trauma, disease, or tumor excision. The present disclosure also relates to compositions, uses, and methods for reconstructing an eyelid. The present disclosure also relates to kits for preparing ear cartilage for eyelid reconstruction. The disclosed compositions, uses, kits, and methods may also be used for autograft, allograft, isograft, and xenograft transplantation, for stored or banked grafts, and for other therapeutic uses.

Abstract: Disclosed herein is methods for fabricating ultra-low loss waveguides. One particular method may include: preparing a substrate including a lower cladding layer in a deposition chamber; flowing precursors including deuterated silane and nitrogen onto the lower cladding layer in the deposition chamber; subjecting the precursors to an inductively coupled plasma-plasma enhanced chemical vapor deposition (ICP-PECVD) process which disassociates the deuterated silane and nitrogen and deposits waveguide material of silicon nitride or silicon oxynitride onto the lower cladding layer; patterning the waveguide material into a patterned waveguide material; and depositing a top cladding layer on the patterned waveguide material, wherein the ICP-PECVD process occurs at a temperature less than or equal to 250° C. Advantageously, the ICP-PECVD process allows for deposition of low hydrogenated deposition of material layers which may allow for low temperature fabrication of ultra-low loss waveguides.

Abstract: Food compositions that mimic flavors and texture of animal meats are made from an edible filamentous fungus genetically engineered to overexpress heme biosynthesis genes to elevate heme levels.

Abstract: A pressure sore prevention mattress is provided alternating pressure points on the body of an occupant that is easily transformable between two stable configurations. The four-layer mattress construction has a top foam pad, a webbing layer, a dynamic layer of deformable panels trapezoid-shaped four-bar mechanisms that deform to produce an undulating pattern of peaks, and a base. Panel geometry can determine peak height. The mattress has a spatially hollow geometry that allows natural air convection through the breathable top foam pad to enable drying of moisture as well as the use of forced air convective drying or cooling. The mattress can be transformed from one configuration to the other while the occupant is on the mattress.

Abstract: A multicomponent carbide has at least five transition metals, and a valence electron concentration (VEC) is greater 8.80 electrons. Preferred off-equiatomic multicomponent carbides have five transition metals and a VEC of more than 8.80. Preferred equiatomic multicomponent carbides have five transition metals and a VEC of 9.00 or greater. The valence electron configuration is important for its relationship to the mechanical properties of carbides. Since carbon forms four bonds, when there are more than four valence electrons available from the metals, there are excess electrons in the system. This increases metallic character of bonding and therefore allows for more ductility and higher toughness.

Abstract: Methods are described for treating systemic fungal and mycobacterial infections by treatment to enhances a Th1 response, reduces a Th2 response, or the combination thereof. Agents that antagonize the IL-4, the IL-13 receptor, or the combination thereof achieve the desired results.

Abstract: A switched-capacitor (SC) network in an SC converter is controlled to operate at varying resonant modes to achieve high conversion ratio efficiency, at a low circuit component count. These power converters are suited to numerous application areas including improving energy efficiency of data centers. A family of resonant switched capacitor (SC) converters with multiple operating phases are presented “Multi-Resonant SC Converters”. Described in detail are an 8-to-1 Multi-Resonant-Doubler (MRD) converter and a 6-to-1 Cascaded Series-Parallel (CaSP). The topology of these converters make them amenable to combining like units in parallel toward reaching higher power levels.

Abstract: Articles of manufacture, including an apparatus for acoustic wave based atomization, are provided. The apparatus may include a monocrystalline piezoelectric substrate. The monocrystalline piezoelectric substrate may include a surface patterned with at least one wetting region. The monocrystalline piezoelectric substrate may be configured to respond to an electric signal by at least generating acoustic waves including, for example, surface acoustic waves, Bluestein-Gulayev waves, Lamb waves, Love waves, flexural waves, thickness mode vibrations, mixed-mode waves, longitudinal waves, shear mode vibrations, and/or bulk wave vibrations. The acoustic waves may atomizing at least a portion of a material collected within the at least one wetting region to form a mist of the material. Methods for acoustic wave based atomization are also provided.

Abstract: In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for treating or ameliorating a cancer by inhibiting expression or activity of Mouse Double Minute 2 homolog (MDM2), an APOBEC3G (A3G) protein, message (mRNA) or gene, and/or an ADAR1p150 protein, message (mRNA) or gene, e.g., by increasing the presence of in a cell or adding to a cell a molecule inhibitory to MDM2, APOBEC3G and/or ADAR1p150 expression, such as an miRNA that binds to MDM2, APOBEC3G and/or ADAR1p150 transcripts, or any molecule that can inhibit or destabilize the transcripts, resulting in decreased MDM2, APOBEC3G and/or ADAR1p150 expression, to treat a cancer such as leukemia, e.g., by inhibiting the propagation of a cancer cell, a leukemia cell, a leukemia stem cell (LSC) or a pre-leukemia cell stem cell (pre-LSC).

Abstract: The system includes: a sample holder configured to hold a stained tissue sample; an objective positioned to gather and focus light from the stained tissue sample; and a white light source that produces unpolarized white light and a polarizing beam splitter that allows one polarization direction of the white light to pass through to form an illumination beam having a first polarization direction, which is directed through the objective and onto the stained tissue sample causing the stained tissue sample to remit light that passes back through the objective and into the polarizing beam splitter. The polarizing beam splitter divides the remitted light into two orthogonally polarized remitted light beams, wherein one of the beams provides an imaging beam, which has a second polarization direction that is substantially orthogonal to the first polarization direction. Finally, the system includes an imaging device, which captures the imaging beam.

Abstract: Embodiments provide a modular phantom that enables quantitative assessment of imaging performance (e.g., spatial resolution, image uniformity, image noise, contrast to noise ratio, cone-beam artifact) and dosimetry in cone-beam computed tomography (CT). The modular phantom includes one or more modules for various imaging performance tests that may be rearranged in the phantom to accommodate the design of various cone-beam CT imaging systems. The modular phantom includes one or more of a cone-beam module, an angled edge module, or a line spread module. The phantom may be inserted into a larger sleeve and be used to assess imaging performance and dosimetry in whole body CT imaging systems.

Abstract: The present disclosure provides devices, methods and systems for analyte detection and/or monitoring, e.g., the continuous and/or semi-continuous monitoring of in-vivo analyte concentrations in real time. Generally, the devices, methods and systems of the present disclosure make use of signaling probes; methods or devices for reducing interferent-based fouling of the signaling probes, non-specific binding to the signaling probes and/or occlusion of a sensor surface; and methods and/or devices for providing an adjusted signal based on a detected signal from the signaling probes. Compositions including conformation switching signaling probes are also provided.

Abstract: This disclosure provides systems, methods, and apparatus related to Li-ion batteries. In one aspect an electrolyte structure for use in a battery comprises an electrolyte and an interconnected boron nitride structure disposed in the electrolyte.

Abstract: Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously.

Abstract: A trained deep neural network transforms an image of a sample obtained with a holographic microscope to an image that substantially resembles a microscopy image obtained with a microscope having a different microscopy image modality. Examples of different imaging modalities include bright-field, fluorescence, and dark-field. For bright-field applications, deep learning brings bright-field microscopy contrast to holographic images of a sample, bridging the volumetric imaging capability of holography with the speckle-free and artifact-free image contrast of bright-field microscopy.

Abstract: A docking system for intraocular surgery that is configured to simultaneously: (1) physically stabilize a position and an orientation of an eye during intraocular surgical procedures; (2) preserve an unobstructed path for optical instruments; (3) provide access to the eye that allows for tool movement; (4) maintain eyeball hydration and improve the scan quality of an imaging system, such as an OCT system or a surgical microscope and may maintain or control an intraocular pressure of the eye to a stable, desired level during surgical procedures.

Abstract: Described in this disclosure are CRISPRi systems and methods, along with the related compositions and kits, that combine modularity, stable genomic integration, and ease of transfer to diverse bacteria by conjugation. CRISPRi compositions, methods, systems and kits described herein allow for genetic dissection of bacteria, facilitating analyses of microbiome function, antibiotic resistances and sensitivities, as well as comprehensive screening for host-microbe interactions. Embodiments of the invention comprise compositions, methods, systems, and kits for CRISPRi-based repression of gene expression in bacteria.

Abstract: Provided herein are, inter alia, methods and kits for detecting epoxide hydrolase genes. In embodiments, methods and kits for detecting the risk of developing atopy or asthma are included. Also included are methods for preventing or treating atopy or asthma.