Patents Assigned to The Regents of the University of Colorado
  • Anti-cancer compounds targeting Ral GTPases and methods of using the same
    Patent number: 11472812
    Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: October 18, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Chao Yan, Phillip Reigan
  • Method for differentiating cannabis plant cultivars based on cannabinoid synthase paralogs
    Patent number: 11473096
    Abstract: Compositions and methods for providing desired cannabinoid content in cannabis plants. More particularly, the invention relates to compositions and methods for using cannabinoid synthase paralogs as guidance for breeding cannabis plants with a desired cannabinoid content, including but not limited to cultivars, varieties, lines and methods of breeding the same for commercial use.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: October 18, 2022
    Assignees: The Regents of the University of Colorado, A Body Corporate, Steve DeAngelo & Associates, LLC
    Inventors: Christopher Pauli, Kayia Clancy, Daniela Vergara, Nolan Coburn Kane, Reginald Gaudino, Robert Givens, Anthony C. Torres, Christian Cizek
  • Toll-like receptor 8 (TLR8) specific antagonists and methods of making and uses thereof
    Patent number: 11466010
    Abstract: Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: October 11, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Hang Hubert Yin, Shuting Zhang, Zhenyi Hu
  • Hydraulically Amplified Self-Healing Electrostatic (HASEL) Pumps
    Publication number: 20220316466
    Abstract: A pumping system includes a conduit with an inlet region and an outlet region and a first pump coupled with the conduit between the inlet region and the outlet region. The first pump includes a first actuator chamber configured to house at least a first actuator, a first pump chamber aligned along a longitudinal axis of the conduit, wherein the first pump chamber is in fluid communication with the inlet region and the outlet region, and a first flexible diaphragm separating the first actuator chamber from the first pump chamber. Methods for operating the pumping system are also disclosed.
    Type: Application
    Filed: August 14, 2020
    Publication date: October 6, 2022
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Shane Karl Mitchell, Eric Lucas Acome, Christoph Matthias Keplinger
  • METHODS FOR THE TREATMENT OF INFLAMMATORY JOINT DISEASE
    Publication number: 20220313785
    Abstract: This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.
    Type: Application
    Filed: June 21, 2022
    Publication date: October 6, 2022
    Applicants: Xalud Therapeutics, Inc., The Regents of the University of Colorado, a Body Corporate
    Inventors: Raymond A. Chavez, Linda May Rothblum Watkins, Robert Landry
  • Methods and compositions for reprogramming cells
    Patent number: 11459560
    Abstract: The present disclosure relates to methods and compositions for reprogramming cells to a pluripotent state. In particular, it relates to an integration- and feeder cell-free method for reprogramming primary human fibroblast cells to induced pluripotent stem cells (iPSCs).
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: October 4, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Igor Kogut, Dennis R. Roop, Ganna Bilousova
  • Quantum plasmon fluctuation devices
    Patent number: 11463026
    Abstract: Described herein are devices incorporating plasmon Casimir cavities, which modify the distribution of allowable plasmon modes within the cavities. The plasmon Casimir cavities can drive charge carriers from or to an electronic device adjoining the plasmon Casimir cavity by modifying the distribution of zero-point energy-driven plasmons on one side of the electronic device to be different from the distribution of zero-point energy-driven plasmons on the other side of the electronic device. The electronic device can exhibit a structure that permits transport or capture of carriers in very short time intervals, such as in 1 picosecond or less.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: October 4, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventor: Garret Moddel
  • SYSTEMS FOR DRIVING THE GENERATION OF PRODUCTS USING QUANTUM VACUUM FLUCTUATIONS
    Publication number: 20220311360
    Abstract: Described herein are systems incorporating a Casimir cavity, such as an optical Casimir cavity or a plasmon Casimir cavity. The Casimir cavity modifies the zero-point energy density therein as compared to outside of the Casimir cavity. The Casimir cavities are paired in the disclosed systems with product generating devices and the difference in zero-point energy densities is used to directly drive the generation of products, such as chemical reaction products or emitted light.
    Type: Application
    Filed: January 31, 2022
    Publication date: September 29, 2022
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventor: Garret Moddel
  • Compositions and methods for preventing and treating radiation-induced bystander effects caused by radiation or radiotherapy
    Patent number: 11452709
    Abstract: The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: September 27, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, TSINGHUA UNIVERSITY, CHANG GUNG UNIVERSITY
    Inventors: Ding Xue, Yu Peng, Man Zhang, Lingjun Zheng, Qian Liang, Hanzeng Li, Jau-Song Yu, Jeng-Ting Chen
  • System and method for fastening of two or more interacting elements
    Patent number: 11452554
    Abstract: A method for securing a first interacting element to a second interacting element is provided. The first interacting element includes a lateral surface established by a first surface and a second surface and at least a portion of the lateral surface includes a thread receipt. The second interacting element includes a distal end and a proximal end that establishes a body therebetween. The body has a thread that is configured to at least partially engage with the thread receipt of the first interacting element. The second interacting element is then inserted at least partially through the surface of an object. The thread receipt of the first interacting element is then abutted adjacent to the thread of the second interacting element. Upon rotation of the second interacting element the thread of the second interacting element at least partially engaged with the thread receipt of the fist interacting element.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: September 27, 2022
    Assignee: The Regents of the University of Colorado
    Inventors: Vikas Patel, Jay Nanninga
  • Optically pumped magnetometers for communication reception
    Patent number: 11454682
    Abstract: Various embodiments of the present technology use low-frequency magnetic signals for communication and location applications. Compared to the case of traditionally used radio-frequency electromagnetic signals, their advantage in the presence of strong signal attenuation is in the extended spatial range. Some embodiments use an optically pumped atomic magnetometer operated as a sensor to achieve high detection sensitivity. The spatial range can be extended to hundreds of meters when noise is suppressed by the use of the available sensor sensitivity. In some embodiments, a one-channel spread-spectrum signal processing technique can be used to eliminate the systematic fluctuations coming from power grid (or another source) harmonics and reduce the ambient noise by averaging uncorrelated fluctuations from the environment.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: September 27, 2022
    Assignees: The Regents of the University of Colorado, a body corporate, Government of the United States of America, as represented by the Secretary of Commerce
    Inventors: Vladislav Gerginov, Fabio da Silva
  • METHODS AND COMPOSITIONS FOR INHIBITING FREEZE-THAW DAMAGE IN CONCRETE AND CEMENT PASTE
    Publication number: 20220298075
    Abstract: Cement paste compositions, concrete compositions, and methods of forming the cement paste compositions and concrete compositions are disclosed. Exemplary cement paste compositions and concrete compositions include a water-soluble additive that is dissolved and is configured to perform one or more of ice recrystallization inhibition and dynamic ice shaping when the cement composition is exposed to temperatures less than or equal to a freezing temperature of water.
    Type: Application
    Filed: June 17, 2020
    Publication date: September 22, 2022
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Wilfred V. Srubar, III, Shane Frazier, Elizabeth A. Delesky, Jaqueline D. Wallat-Pullara
  • Modular intraocular lens designs, tools and methods
    Patent number: 11446138
    Abstract: Modular IOL removal systems and methods that cut an optic portion of an intraocular in a single motion such to facilitate removal of the optic portion from an eye through an incision, for example a corneal incision, without increasing the size of the corneal incision. Various cutting tools having one or more blades may be utilized. The cut intraocular lens may have one continuous cut or be cut into multiple smaller pieces. The single cutting step may apply balanced forces and torque to avoid damaging the surrounding eye anatomy, reducing the risk of trauma.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: September 20, 2022
    Assignees: Alcon Inc., The Regents of the University of Colorado
    Inventors: Malik Y. Kahook, Glenn Sussman, Paul McLean, Andrew Thomas Schieber
  • Eyeglass Frames For Treatment Of Dry Eye Syndrome And Corresponding 3D Printing Systems And Methods
    Publication number: 20220291527
    Abstract: Various embodiments of the present technology generally relate to treatment for dry eyes. More specifically, some embodiments of the present technology relate to eyeglass frames for treatment of dry eye syndrome and corresponding three-dimensional printing systems and methods. In some embodiments an eyewear apparatus includes a frame with a seal configured to engage with the skin of the wearer around a majority of the perimeter of an interior portion of the front of the frame sufficient to keep the humidity around the eye high enough to provide relief from symptoms of dry eye syndrome.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 15, 2022
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Stephen Petty, Cristos Ifantides, Jahmel Jordon, Jonathan Petty, Jeffrey SooHoo
  • Biomarkers for head and neck cancer and methods of their use
    Patent number: 11441193
    Abstract: Disclosed is a diagnostic panel of methylated genomic loci encoding microRNA (mgmiR) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell carcinoma (HNSCC). These results represent the first use of quantitative MS-PCR for the detection of mgmiRs. In addition, this panel demonstrates the ability to detect hypermethylation in the adjacent mucosa of cancer patients, suggesting its utility in early detection. This panel is also capable of detecting cancer by using saliva, blood and FNA tissue samples.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: September 13, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Shi-long Lu, John Song
  • High concentration medicant solutions for treating neurological disorders
    Patent number: 11433038
    Abstract: Highly concentrated solutions are disclosed along with methods of inhibiting and/or ameliorating functional neurological disorders of the brain. The method may include administering directly to a brain of a subject a medicament multiple times over a time period of at least two days. The medicament may include a half-life of less than 2 hour in the cerebrospinal fluid. The method may include inhibiting and/or ameliorating a functional neurological disorder of the brain using the medicant.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: September 6, 2022
    Assignees: Cerebral Therapeutics, Inc., The Regents of the University of Colorado
    Inventors: Daniel J. Abrams, Thomas Joseph Anchordoquy
  • Methods for treatment of vascular endothelial dysfunction using nicotinamide mononucleotide
    Patent number: 11433088
    Abstract: Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: September 6, 2022
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Douglas R. Seals, Lindsey Gano, Natalie Poliektor
  • Protection from stress, anxiety, neuroinflammation, and cognitive dysfunction
    Patent number: 11433126
    Abstract: Methods of treating or preventing stress, anxiety, or postoperative cognitive dysfunction. Also provided are methods of improving resilience in a subject by administering a therapeutically effective amount of isolated Mycobacterium.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: September 6, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Christopher A. Lowry, Matthew G. Frank, Laura Fonken, Steven F. Maier
  • Catalyst, structures, reactors, and methods of forming same
    Patent number: 11426717
    Abstract: Structures, catalysts, and reactors suitable for use for a variety of applications, including gas-to-liquid and coal-to-liquid processes and methods of forming the structures, catalysts, and reactors are disclosed. The catalyst material can be deposited onto an inner wall of a microtubular reactor and/or onto porous support structures using atomic layer deposition techniques.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: August 30, 2022
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Staci A. Moulton, Alan W. Weimer
  • Photocatalyst-free, light-induced carbon-sulfur cross-coupling methods
    Patent number: 11427536
    Abstract: In one aspect, the invention provides a method of promoting a carbon-sulfur bond forming reaction. In certain embodiments, the reaction comprises cross-coupling of a(n) (hetero)aryl halide with a thiol to form the carbon-sulfur bond, wherein the method is promoted by light irradiation in the absence of a photocatalyst. In other embodiments, the cross-coupling reaction can be promoted through visible light irradiation, including sunlight.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: August 30, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Garret Miyake, Bin Liu, Chern-Hooi Lim