Abstract: Described herein are devices incorporating Casimir cavities, which modify the quantum vacuum mode distribution within the cavities. The Casimir cavities can create energy differences within layers or device to drive energy from or to a portion of a layer disposed adjacent to or contiguous with the Casimir cavity by modifying the quantum vacuum mode distribution incident on one portion of the layer to be different from the quantum vacuum mode distribution incident on another portion of the layer. Additionally, Casimir cavities in which the cavity layer comprises a conductor that can be used to carry a flow of electrical power induced by the presence of the Casimir cavity.

Abstract: Methods for inducing the regeneration of non-cancerous tissues in a cancer patient undergoing radiotherapy and/or chemotherapy using continuous administration of tyrosine kinase inhibitors for at least 90 days following a cancer treatment in the patient.

Abstract: The present disclosure provides a high-power-density power converter topology with a common neutral between its input and output AC ports while having a single DC bus. The topology may also be embodied as an online uninterruptible power supply (UPS). The presently-disclosed topology enables high power density by utilizing half-bridge switch structures suitable for MHz-frequency operation.

Abstract: Methods of treating or preventing microbial infection in a subject in need of treatment by administering a therapeutically effective amount of ergothioneine, or functional analog, or prodrug, or salt thereof. Ergothioneine may be advantageously administered in conjunction with lactoferrin.

Abstract: Embodiments of the present disclosure provide novel compositions, methods of use and methods for single composition, multi-dose, thermostable vaccine formulations. In certain embodiments, the present disclosure provides compositions and methods for dehydrating immunogenic agents in the presence of glass-forming agents, and coating the particles formed by the glass-forming agents. In other embodiments, the present disclosure provides for generating compositions for administering an immunogenic composition to a subject multiple times using a single immunogenic composition capable of time-release administration. In other embodiments, single-dose immunogenic agent-containing particles can be directed to two or more pathogens.

Abstract: An implantable anastomotic assembly, which is configured to be attached to cardiovascular tissue, includes a connection interface, a plurality of outer plates, and a plurality of connectors configured to extend between and interconnect the connection interface and the plurality of outer plates, respectively, according to various embodiments. The connection interface is separate from and non-contiguous with the plurality of outer plates, according to various embodiments.

Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The invention relates to a multi-blade device for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

Abstract: An electric field mill (EFM) incorporates a novel rotor and shaft grounding mechanism providing a low-impedance path to ground via a bearing packed with electrically conductive grease. A removable bearing washer allows for servicing. The EFM includes a data processing scheme built around a peak detection algorithm and moving much of the signal processing to digital processing. A GPS disciplined sampling clock and cellular connectivity allow for use and maintenance of arrays of widely scattered EFMs.

Abstract: A low-cost, magnetically-driven device that enables visualization and quantification of dynamic changes in cell behavior during mechanical stretch. Using this device, it was observed that nuclei of mouse embryonic skin fibroblasts underwent rapid but divergent responses to strain magnitude, showing nuclear area increase and chromatin decompaction during 5% (low) strain, but nuclear area decrease and chromatin condensation during 20% (high) strain. Only responses to low strain were dependent on calcium, while actin inhibition abrogated any nuclear response and increased stretch-induced DNA damage. Stretch-activation revealed a shift in actin filaments away from (low strain) or towards (high strain) the nuclear periphery. The findings suggest that different pathways control strain level-dependent cell behavior and that mechanical confinement of nuclei through actin may be a protective mechanism during high strain loads.

Abstract: Described herein are synthetic oligonucleotides for editing a cell. The oligonucleotides described herein comprise the following covalently-linked components: (i) a nucleic acid encoding a guide RNA (gRNA) sequence targeting a target region in a cell; (ii) a region homologous to the target region comprising a change in sequence relative to the target region; and (iii) a site conferring immunity to nuclease-mediated editing.

Abstract: The invention provides novel compounds and methods that are useful in promoting reactions that proceed through an oxidative quenching pathway. In certain embodiments, the reactions comprise atom transfer radical polymerization.

Abstract: Systems and method herein provide for energy buffering. In one embodiment, a system includes an energy buffer comprising at least two energy storage elements. Each energy storage element is operable to buffer electrical energy. The system also includes a switch module operable to charge a first of the at least two energy storage elements while discharging a second of the at least two energy storage elements, and to discharge the first energy storage element while charging the second energy storage element after charging the first energy storage element. The switched charging of the energy storage elements compensates voltage variations between the energy storage elements to increase available electrical energy from the energy buffer.

Abstract: An intraocular antioxidant generation device is configured to be implanted within an eye. The intraocular antioxidant generation device comprises a scaffold and a generation medium coupled to the scaffold, according to various embodiments. The generation medium is configured to at least one of generate, regenerate, recycle, and produce antioxidants, according to various embodiments.

Abstract: High-order balanced bandpass filters that are continuously tunable in terms of frequency and bandwidth (BW) and can be intrinsically switched-off. The filters include multiple resonant sections cascaded between a differential RF input and a differential RF output. The resonant sections comprise at least one multi-resonant cell and at least one transmission pole cell. The multi-resonant cell includes four frequency tunable resonators, and is configured to create a frequency tunable pole at the center frequency of the filter, and two frequency tunable transmission zeroes at resonating frequencies of the resonators of the multi-resonant cell. The transmission pole cells each include two resistively-terminated frequency-tunable resonators configured to resonate at the center frequency of the filter.

Abstract: An enhanced optical design for imaging of live human tissue as a supplemental attachment to wireless mobile devices such as smartphones. The improved imaging system includes a series of optical ball lenses coupled to a medical-grade light source to allow universal compatibility to mobile device (e.g., smartphone) cameras. The releasable optical attachment comprises optical enhancement elements allowing universal compatibility without the need of an application or special program to re-orient the image therein permitting less loss of picture acuity and blanket usability to HIPAA-verified smartphone applications used in hospitals and patient's electronic health records. The addition of an external light source and light-redirecting elements negates the need for a smartphone light source or smartphone re-programming to illuminate target.

Abstract: A hydraulically amplified self-healing electrostatic (HASEL) transducer includes a composite, multi-layered structure. In an example, a HASEL transducer includes a dielectric layer including at least one fluid dielectric layer. The dielectric layer includes a first side and a second side opposing the first side. The HASEL transducer further includes a first electrode disposed at the first side of the dielectric layer, a second electrode disposed at the second side of the dielectric layer, a first outer layer disposed at the first electrode opposite the dielectric layer, and a second outer layer disposed at the second electrode opposite the dielectric layer. The first outer layer and second outer layer exhibit different mechanical and electrical properties from the dielectric layer.

Abstract: A millimeter-wave frequency synthesizer generates a millimeter wave by photomixing two Kerr-soliton microcombs. A single-frequency laser beam is modulated to create first and second pump components having first and second pump frequencies. The first pump component excites a first microresonator to create a first microcomb while the second pump component excites a second microresonator to generate a second microcomb. A pair of comb lines from the two microcombs is detected to generate a low-frequency beat note that is phase-locked by identically tuning the pump frequencies. Another pair of comb lines is detected with a high-speed photodiode to generate the millimeter wave. The frequency of the millimeter wave is based on (i) the difference between the pump frequencies, (ii) the difference between the repetition rates, and (iii) the index of the comb lines that are photomixed to generate the millimeter wave.

Abstract: Disclosed are biopolymeric and biologically active mortars suitable for use in providing building materials having enhanced physical properties. Further disclosed are methods for making and using the disclosed materials.

Abstract: Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.

Abstract: The present invention provides a method of PEGylating a human truncated cystathionine ?-synthase protein containing a mutation of a cysteine to a serine at amino acid position 15 (htCBS C15S). The htCBS C15S was PEGylated with one of 5 kDa, 10 kDa, or 20 kDa NHS ester PEG molecules. In-process monitoring of the PEGylation process was used in the method to reduce levels of unPEGylated htCBS C15S and htCBS C15S with insufficient PEGylation. Administration of the PEGylated htCBS C15S had efficacy throughout the course of treatment for homocystinuria.