Patents Assigned to The Trustees of Princeton University
  • Patent number: 10927152
    Abstract: Provided are astexin-1, astexin-2 and astexin-3 lasso peptides, which are based on sequences identified in Asticcacaulis excentricus, and methods of making and using same. Astexin-1 is highly polar, in contrast to many lasso peptides that are primarily hydrophobic, and has modest antimicrobial activity against Caulobacter crescentus, a bacterium related to Asticcacaulis excentricus. The solution structure of astexin-1 was determined, revealing a unique topology that is stabilized by hydrogen bonding between segments of the peptide. Astexins-2 and -3 are intracellular lasso peptides.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: February 23, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: A James Link, Mikhail O. Maksimov
  • Publication number: 20210047659
    Abstract: Disclosed is a system and method for the controlled clustering of gene regulatory proteins at the specific target genomic loci. The technology enables formation of liquid-like droplets closely interfaced with genome organization. This technology can be utilized for perturbing endogenous nuclear structures as well as nucleating synthetic membrane-less assemblies. The technology can also be utilized for inducing or detecting mechanical stresses within the genome.
    Type: Application
    Filed: January 23, 2019
    Publication date: February 18, 2021
    Applicant: The Trustees of Princeton University
    Inventors: Cliff BRANGWYNNE, Yongdae SHIN, Dan BRACHA
  • Publication number: 20210047699
    Abstract: Disclosed herein is early genetic screening to aid in the selection of dogs for assistance training programs. Disclosed methods include a method for predicting the probability of canine success in a training program, involving genotyping a biological sample from a canine; determining at least one mobile element insertion copy number within the Williams-Beuren Syndrome (WBS) locus on canine chromosome 6; and predicting the probability of the canine's success in a training program based on the at least one mobile element insertion copy number. Another disclosed method is a method of producing dogs that are more likely to exhibit a sociable behavior, involving providing a male and female dog for breeding; determining at least one mobile element insertion copy number within the Williams-Beuren Syndrome (WBS) locus on canine chromosome 6 for each of the provided dogs; and mating the dogs of step (a) to produce offspring.
    Type: Application
    Filed: August 11, 2020
    Publication date: February 18, 2021
    Applicants: The Trustees of Princeton University, Oregon State University
    Inventors: Bridgett vonHoldt, Monique Udell
  • Patent number: 10920334
    Abstract: A method for the electrohydrodynamic deposition of carbonaceous materials utilizing an electrohydrodynamic cell comprising two electrodes comprised of a conductive material, by first combining a solid phase comprising a carbonaceous material and a suspension medium, placing the suspension between the electrodes, applying an electric field in a first direction, varying the intensity of the electric field sufficiently to drive lateral movement, increasing the electrical field to stop the lateral transport and fix the layers in place, then removing the applied field and removing the electrodes. Among the many different possibilities contemplated, the method may advantageously utilize: varying the spacing between the electrodes; removing the buildup from one or both electrodes; placing the electrodes into different suspensions; adjusting the concentration, pH, or temperature of the suspension(s); and varying the direction, intensity or duration of the electric fields.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: February 16, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Ilhan A. Aksay, Valerie Alain-Rizzo, Michael Bozlar, David J. Bozym, Daniel M. Dabbs, Nicholas Szamreta, Cem B. Ustundag
  • Patent number: 10923236
    Abstract: According to some embodiments, a system for widening and densifying a scrape-off layer (SOL) in a field reversed configuration (FRC) fusion reactor is disclosed. The system includes a gas box at one end of the reactor including a gas inlet system and walls of suitable heat bearing materials. The system further includes an exit orifice adjoining the gas box, wherein the exit orifice has a controllable radius and length to allow plasma to flow out from the gas box to populate the SOL with the plasma. The system may also include fusion products, which decrease in speed in the plasma in the SOL, allowing energy to be extracted and converted into thrust or electrical power and further allowing ash to be extracted to reduce neutron emissions and maintain high, steady-state fusion power.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: February 16, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Samuel A. Cohen, Matthew K. Chu-Chueong
  • Publication number: 20210041452
    Abstract: Microorganisms are prolific producers of natural products, a group of molecules that make up the majority of drugs approved by the FDA in the past 35 years. After decades of mining, the low-hanging fruit has been picked and so discovery of drug-like molecules from microorganisms has come to a near-halt. The reason for this lack of productivity is that most biosynthetic pathways that give rise to natural products are not active under typical laboratory growth conditions. These so-called ‘cryptic’ or ‘silent’ pathways are a major source of new bioactive molecules and methods that reliably activate them could have a profound impact on drug discovery. Disclosed herein is a rapid genetics-free method for eliciting and detecting cryptic metabolites using an imaging mass spectrometry-based approach. An organism of choice is challenged with elicitors from a small molecule library. The molecules elicited are then imaged by mass spec, which allows for rapid identification of cryptic metabolites.
    Type: Application
    Filed: July 30, 2018
    Publication date: February 11, 2021
    Applicant: The Trustees of Princeton University
    Inventors: Mohammad R. SEYEDSAYAMDOST, Fei XU, Yihan WU, Leah BUSHIN, Katherine Davis
  • Patent number: 10914729
    Abstract: The present application provides a method of analyzing protein binding sequence, a method of making sequencing library, and compositions for performing such methods, which employs a transposome complex.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: February 9, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Kai Chen, Michael Levine
  • Patent number: 10905775
    Abstract: Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: February 2, 2021
    Assignees: Celator Pharmaceuticals, Inc., The Trustees of Princeton University
    Inventors: Lawrence D. Mayer, Robert K. Prud'homme, Christine J. Allen, Walid S. Saad
  • Publication number: 20210027855
    Abstract: Processes to determine the effect of genetic sequence on gene expression levels are described. Generally, models are used to determine spatial chromatin profile from genetic sequence, which can be used in several downstream applications. The effect of the spatial chromatin profile on gene expression is also determined in some instances. Various methods further develop research tools, perform diagnostics, and treat individuals based on sequence effects on gene expression levels.
    Type: Application
    Filed: March 26, 2019
    Publication date: January 28, 2021
    Applicants: The Trustees of Princeton University, The Simons Foundation, Inc.
    Inventors: Jian Zhou, Chandra Theesfeld, Olga G. Troyanskaya
  • Patent number: 10903439
    Abstract: In one aspect, solid-state organic intermediate-band photovoltaic devices are provided. A solid-state organic intermediate-band photovoltaic device, in some embodiments, comprises an organic electron donor and an organic electron acceptor, wherein the organic electron donor comprises a singlet energy level separated from a triplet energy level by an energy gap. The device also comprises a triplet sensitizer comprising singlet and triplet energy levels falling within the singlet-triplet energy gap of the electron donor.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: January 26, 2021
    Assignee: The Trustees of Princeton University
    Inventors: Barry P. Rand, YunHui L. Lin
  • Patent number: 10882938
    Abstract: This invention relates generally to the field of quasicrystalline structures. In preferred embodiments, the stopgap structure is more spherically symmetric than periodic structures facilitating the formation of stopgaps in nearly all directions because of higher rotational symmetries. More particularly, the invention relates to the use of quasicrystalline structures for optical, mechanical, electrical and magnetic purposes. In some embodiments, the invention relates to manipulating, controlling, modulating and directing waves including electromagnetic, sound, spin, and surface waves, for pre-selected range of wavelengths propagating in multiple directions.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: January 5, 2021
    Assignee: The Trustees of Princeton University
    Inventors: Paul Joseph Steinhardt, Paul Michael Chaikin, Weining Man
  • Patent number: 10883980
    Abstract: The present invention provides a method of inhibiting hepatitis E virus (HEV) release from a cell that is infected with an HEV, and a method of treating a HEV infection in a subject in need thereof. The present invention also provides a method of identifying agent that inhibits HEV infectivity using a transcomplementation system.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: January 5, 2021
    Assignee: The Trustees of Princeton University
    Inventors: Alexander Ploss, Qiang Ding
  • Patent number: 10886963
    Abstract: Embodiments generally disclosed herein relate to a sub-wavelength multi-port codesign approach between the unit transceiver element and the integrated EM interface to enable a generalized broadband MIMO array with individually programmable element patterns. The co-design approach allows processing of radiated signals at the antenna level distinct from classical arrays. The transmitter and receiver architectures with the integrated EM interface are implemented in 65-nm CMOS and have a bandwidth of 37-73 GHz. Wireless links with data rates up to 12 Gb/s are demonstrated across the spectrum with a wide range of reconfigurability of the active EM interface. The multifunctional EM interface and the broadband transceivers can enable future efficient and compact MIMO arrays for reliable links exploiting frequency, spatial, pattern and polarization diversities.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: January 5, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Kaushik Sengupta, Xue Wu, Chandrakanth Chappidi, Xuyang Lu
  • Patent number: 10879702
    Abstract: A system and method for performing novel wind forecasting that is particularly accurate for forecasting over short-term time periods, e.g., over the next 1-5 hours. Such wind forecasting is particularly advantageous in wind energy applications. The disclosed method is anchored in a robust physical model of the wind variability in the atmospheric boundary layer (ABL). The disclosed method approach leverages a physical framework based on the unsteady dynamics of earth's atmosphere, and drives forecasting as a function of previously-observed atmospheric condition data observed at the same location for which a wind forecast is desired.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: December 29, 2020
    Assignee: Trustees of Princeton University
    Inventors: Elie Bou-Zeid, Mostafa Momen
  • Publication number: 20200402677
    Abstract: According to some embodiments, a system for widening and densifying a scrape-off layer (SOL) in a field reversed configuration (FRC) fusion reactor is disclosed. The system includes a gas box at one end of the reactor including a gas inlet system and walls of suitable heat bearing materials. The system further includes an exit orifice adjoining the gas box, wherein the exit orifice has a controllable radius and length to allow plasma to flow out from the gas box to populate the SOL with the plasma. The system may also include fusion products, which decrease in speed in the plasma in the SOL, allowing energy to be extracted and converted into thrust or electrical power and further allowing ash to be extracted to reduce neutron emissions and maintain high, steady-state fusion power.
    Type: Application
    Filed: September 3, 2020
    Publication date: December 24, 2020
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: SAMUEL A. COHEN, MATTHEW CHU-CHUEONG
  • Publication number: 20200393148
    Abstract: Using thermal radiation to supply occupant comfort has long existed in the heating domain, and to a lesser scale in the cooling domain. Cooling power of radiant cooling systems is limited by the risk of condensation on the panel itself, as well as adjacent surfaces. Similarly, convective system losses to the ambient air prevent maintaining a large temperature difference from the surface and the surroundings. The disclosed approach combats these common pitfalls of radiant cooling systems in the building domain, increasing the power and therefore applicability of radiant cooling.
    Type: Application
    Filed: November 16, 2018
    Publication date: December 17, 2020
    Applicant: The Trustees of Princeton University
    Inventors: Eric TEITELBAUM, Forrest MEGGERS, Adam RYSANEK
  • Patent number: 10864266
    Abstract: The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: December 15, 2020
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Thomas J. Silhavy, Marcin Grabowicz, Daniel Kahne, Matthew Lebar, Dorothee Andres
  • Patent number: 10862073
    Abstract: Methods for forming a coating over a surface are disclosed. A method includes directing a first source of barrier film material toward a substrate in a first direction at an angle ? relative to the substrate, wherein ? is greater than about 0° and less than about 85°. Additionally, a method of depositing a barrier film over a substrate includes directing a plurality of N sources of barrier film material toward a substrate, each source being directed at an angle ?N relative to the substrate, wherein for each ?N, ? is greater than about 0° and less than about 180°. For at least a first of the ?N, ?N is greater than about 0° and less than about 85°, and for at least a second of the ?N, ?N is greater than about 95° and less than about 180°.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: December 8, 2020
    Assignees: The Trustees of Princeton University, Universal Display Corporation
    Inventors: Prashant Mandlik, Ruiqing Ma, Sigurd Wagner, Bhadrinarayana Lalgudi Visweswaran
  • Patent number: 10852220
    Abstract: Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: December 1, 2020
    Assignees: The Trustees of Princeton University, University of Maryland, Baltimore
    Inventors: Joseph D'Silva, Robert H. Austin, Curt Civin, James C. Sturm
  • Patent number: 10852371
    Abstract: Disclosed is a method and apparatus relating generally to scalar atomic magnetometers. The disclosed methods and apparatus utilize a pressurized sample chamber and a high frequency pulsed pump laser to increase spin polarization and significantly suppress heading errors. These methods and apparatus may also include alternating polarization of the pump light between pulses.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: December 1, 2020
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Michael Romalis, Haifeng Dong, Andrei Baranga