Patents Assigned to The Trustees of the University of Pennsylvania
  • Patent number: 11234896
    Abstract: Devices and methods for blood flow enhancement and hemodynamic power monitoring are provided. A blood flow enhancement device includes a pump system configured to be coupled to a central vasculature of a subject during cardiopulmonary resuscitation (CPR). The pump system includes a pumping mechanism configured to increase forward blood flow generated during the CPR while substantially limiting backward blood flow generated during the CPR. The pumping mechanism being operated concurrently with the CPR. The hemodynamic power monitor is configured to control a chest compression device and an active valve.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: February 1, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Joshua Lampe, Lance Becker
  • Patent number: 11236074
    Abstract: The present invention includes compounds, compositions comprising the same, and methods using the compounds and/or compositions therein, for modulating skin pigmentation in a mammalian subject. In certain embodiments, the compounds of the invention treat or prevent skin disorders or diseases associated with hyperpigmentation in the subject. In other embodiments, the compounds of the invention act as antagonist to the non-canonical sex steroid hormone receptor GPRE1 and do not bind to a canonical nuclear estrogen receptor (ER). In yet other embodiments, the compounds of the invention comprise acts as agonists to the non-canonical sex steroid hormone receptor PAQR7 and do not bind to a canonical nuclear progesterone receptor (PR).
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: February 1, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Todd Ridky, Christopher Natale
  • Patent number: 11235040
    Abstract: In one embodiment a vaccine composition comprises two or three AChR subunit constructs and an adjuvant. In some embodiments the AChR subunit construct is an AChR ?1 subunit construct, an AChR ?1 subunit construct, an AChR ? subunit construct, an AChR ? subunit construct, or an AChR ? subunit construct. In another embodiment, the invention provides a method of treating myasthenia gravis in a patient in need thereof, comprising administering a vaccine composition comprising one or more acetylcholine receptor subunit constructs selected from the group consisting of AChR ?1 subunit, AChR ?1 subunit, AChR ? subunit, AChR ? subunit, AChR ? subunit, a fragment thereof, and a combination thereof, and an adjuvant.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: February 1, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Jon Lindstrom, Jie Luo
  • Patent number: 11232208
    Abstract: Methods, systems, and computer readable media for using variable metadata tags. A method occurs at a metadata processing system for enforcing security policies in a processor architecture. The method comprises: receiving, at the metadata processing system, a tag associated with a word in memory, wherein the tag indicates a memory location containing metadata associated with the word and wherein the tag length is at least in part determined using tag usage frequency; obtaining the metadata from the memory location, and determining, using the metadata, whether the word or a related instruction violates a security policy.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: January 25, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andre DeHon, Udit Dhawan, Nicholas Edward Roessler
  • Patent number: 11232319
    Abstract: A computerized method of providing automatic anatomy recognition (AAR) includes gathering image data from patient image sets, formulating precise definitions of each body region and organ and delineating them following the definitions, building hierarchical fuzzy anatomy models of organs for each body region, recognizing and locating organs in given images by employing the hierarchical models, and delineating the organs following the hierarchy. The method may be applied, for example, to body regions including the thorax, abdomen and neck regions to identify organs.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: January 25, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jayaram K. Udupa, Dewey Odhner, Drew A. Torigian, Yubing Tong
  • Patent number: 11224372
    Abstract: An implantable electrode for use in the body of a subject has a metal layer and a graphene passivation layer formed on at least a portion of the metal layer. The graphene passivation layer may be a single monolayer of graphene. A process for passivating an implantable electrode is also disclosed.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: January 18, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Duygu Kuzum, Ertugrul Cubukcu, Brian Litt
  • Publication number: 20220010357
    Abstract: This invention provides compounds that inhibit p38 mitogen-activated protein kinase. Moreover, the invention provides methods for testing a candidate compound for a p38 mitogen-activated protein kinase modifying activity by calculating the level of relocalization of an SMN complex component from the cytoplasm to the nucleus of a cell. Additionally, the invention provides a kit and a system for calculating the same.
    Type: Application
    Filed: August 10, 2020
    Publication date: January 13, 2022
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Gideon DREYFUSS, Mumtaz KASIM
  • Publication number: 20220010255
    Abstract: The presently disclosed subject matter provides systems and methods for producing a three-dimensional model of a human cervix. A microdevice is provided for culturing human cervical cells. The microdevice can include an upper microchannel including live ectocervical epithelial cells. The microdevice can include a lower microchannel including a first parallel lane and a second parallel lane including stromal media. The first and the second parallel lanes can be lined with live vascular endothelial cells. The lower microchannel can include a third parallel lane including uterine fibroblasts and live smooth muscle cells embedded in hydrogel. The first, second, and third lanes of the lower microchannel can be separated by protrusion structures. The third parallel lane can be positioned in the lower microchannel in between the first and the second parallel lanes. The microdevice can further include a porous membrane positioned in between the upper microchannel and the lower microchannel.
    Type: Application
    Filed: June 18, 2021
    Publication date: January 13, 2022
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Dongeun Huh, Jeongyun Seo
  • Patent number: 11220597
    Abstract: A method of making a bijel includes dispersing surface-active nanoparticles in a ternary liquid mixture. The ternary liquid mixture includes a hydrophilic liquid, a hydrophobic liquid, and a solvent. The ternary liquid mixture is contacted with water. A bijel includes a stable mixture of two immiscible liquids separated by an interfacial layer of colloidal particles. The bijel has temperature-independent stability, and the domain sizes are below one micrometer.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: January 11, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Martin F. Haase, Daeyeon Lee, Kathleen J. Stebe
  • Patent number: 11220538
    Abstract: The present disclosure provides monoclonal antibodies that bind ?-Synuclein. In certain aspects, the antibodies preferentially bind to ?-Synuclein fibrils over ?-Synuclein monomer. In other aspects, the invention comprises a method of treating ?-Synucleopathic disease in a subject, comprising administering any of the antibodies of the invention to the subject. In yet other aspects, the invention comprises methods of detecting ?-Synuclein fibrils using any of the antibodies of the invention.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: January 11, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Kelvin C. Luk, Virginia M. Y. Lee, John Q. Trojanowski, Kurt R. Brunden, Dustin Covell
  • Publication number: 20220000119
    Abstract: Systems and methods for eradicating biofilms by killing bacteria within a biofilm, degrading the matrix and removing biofilm debris are disclosed herein. The disclosed subject matter provides techniques for administering a suspension of H2O2 and iron oxide nanoparticles to substantially eradicate bacteria within a biofilm matrix and degrade the bio film matrix, actuating the iron oxide nanoparticles for assembly into biohybrid robots suitable for removal of biofilm debris, and moving the biohybrid robots to remove the bio film debris from accessible or enclosed surfaces. In some embodiments, the disclosed subject matter can include embedding iron oxide nanoparticles in a hydrogel to form a soft robotic structure, administering the soft robotic structure to a biofilm-covered location, and magnetizing the soft robot structure to substantially eradicate bacteria within a biofilm matrix, degrade the biofilm matrix, and remove biofilm debris from enclosed surfaces.
    Type: Application
    Filed: November 25, 2019
    Publication date: January 6, 2022
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Hyun Koo, Kathleen Stebe, Vijay Kumar, Elizabeth Hunter, Edward Steager, Evan Brink
  • Patent number: 11213699
    Abstract: Methods and systems are described for determining particle treatment information. An example method may comprise determining a segment-averaged dose-averaged restricted linear energy transfer. The linear energy transfer may be determined by accounting for variations in segment length of paths of particles in a site.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: January 4, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alejandro Carabe-Fernandez, Alejandro Bertolet Reina, Miguel Antonio Cortes-Giraldo
  • Patent number: 11213747
    Abstract: A system of stacking interlocking blocks can be configured into a series of states in order to capture and display both physical and virtual events or content. In some examples, the system includes the stacking interlocking blocks, a grid base having the stacking interlocking blocks stacked on top of the grid base in a physical configuration, and a user system. Each stacking interlocking block includes a block circuit. The grid base includes an embedded computing system configured, by virtue of communicating with each of the block circuits, to determine a position of each stacking interlocking block with respect to the grid base and in some cases both the grid base and the other blocks which have been detected by the grid base.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: January 4, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Rahul Mangharam, Matthew Edward O'Kelly, Vincent Scott Pacelli, Matthew Anthony Brady
  • Patent number: 11213378
    Abstract: Techniques for mesh augmentation and prevention of incisional hernia, including systems and methods for affixing mesh to a fascial incision. A mesh strip can be integrated with one or more uni-directional fasteners. Each fastener can include an anchoring mechanism adapted for affixation to anterior abdominal wall fascia and a mating interface. An applicator can include tension arms adapted to interface with the mating interfaces of the fasteners to maintain a vertical tension of the mesh strip and a handle coupled with the tension arms adapted to spread the tension arms and thereby control a horizontal tension of the mesh strip. The mesh strip can be configured to be aligned over a fascial incision using the applicator and affixed under tension to anterior abdominal wall fascia by tissue penetration of the anchoring mechanisms of the one or more fasteners.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: January 4, 2022
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: John Patrick Fischer
  • Patent number: 11208661
    Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin and FAS further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: December 28, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Jiangtao Ren, Xiaojun Liu, Carl H. June
  • Patent number: 11208470
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: December 28, 2021
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • Patent number: 11203758
    Abstract: The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR ? chain, TCR ? chain, beta-2 microglobulin and FAS further comprising a nucleic acid encoding a modified T cell receptor (TCR) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (CAR). Also included are methods and pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as an autoimmune disease.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: December 21, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Yangbing Zhao, Jiangtao Ren, Xiaojun Liu, Carl H. June
  • Patent number: 11202602
    Abstract: Methods, systems, and computer readable media for non-invasively predicting patient-specific mechanical competence at an anatomical site. In some examples, a method includes receiving images from the anatomical site of a patient; using computational analysis of the images to simulate mechanical loading at the anatomical site; and generating, based on the analysis, an indication of stiffness, strength, resilience or toughness under the mechanical loading conditions.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: December 21, 2021
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, NEW YORK UNIVERSITY
    Inventors: Chamith Sudesh Rajapakse, Gregory Chang
  • Publication number: 20210386853
    Abstract: The present invention provides compositions for the prevention and treatment of genital herpes, comprising nucleoside modified mRNAs that encode herpes simplex virus (HSV) glycoproteins, including those involved in virus entry and immune evasion, and methods of use thereof.
    Type: Application
    Filed: June 17, 2021
    Publication date: December 16, 2021
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Harvey FRIEDMAN, Drew WEISSMAN, Sita AWASTHI, Gary Cohen
  • Patent number: 11198938
    Abstract: A nanoscale plate structure includes base plates and rib plates with nanoscale thickness and macroscopic lateral dimensions. The base plate resides in the first plane, the ribs can reside out-of-plane and form at least one strengthening rib, and additional base plates can reside in planes parallel to the first plane. The strengthening rib can be patterned such that there is no straight line path extending through a lateral dimension of the plate structure that does not intersect the at least one base plate and the at least one strengthening rib. The plates and ribs used in the structure have a thickness between about 1 nm and about 100 nm. The plate structures can be fabricated using a conformal deposition method including atomic layer deposition.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: December 14, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Igor Bargatin, Keivan Davami