Patents Assigned to The Trustees of the University of Pennsylvania
  • Patent number: 11197937
    Abstract: A recombinant adeno-associated virus (rAAV) having an AAV8 capsid which is suitable for intra-retinal injection is provided herein. The rAAV comprises a vector genome packaged within the capsid which contains, operably linked to regulatory elements which direct expression of anti-human vascular endothelial growth factor (VEGF) antigen binding antibody fragment (aVEGF), a coding sequence for aVEGF, wherein the coding sequence is operably linked to regulatory elements which direct expression of the anti-VEGF Fab in the eye. Also provided herein are liquid suspensions containing these rAAV8.aVEGF and methods of using same for treatment of wet AMD and other ocular conditions.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: December 14, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Anna P. Tretiakova, James M. Wilson
  • Patent number: 11197936
    Abstract: Codon optimized nucleic acid sequences for RDH12 are provided, as well as recombinant viral vectors, such as AAV, expression cassettes, proviral plasmids or other plasmids containing the codon optimized sequence for functional RDH12. Recombinant vectors are provided that express the codon optimized, functional RDH12. Compositions containing these codon optimized sequences are useful in methods for treating, retarding or halting certain blinding diseases resulting from the absence, deficiency or inappropriate expression of RDH12. Other compositions and methods are providing for correcting a non-functional, defective or inadequately expressed native RDH12.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: December 14, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jean Bennett, Junwei Sun, Vidyullatha Vasireddy
  • Patent number: 11191847
    Abstract: Compositions for the treatment of hemophilia B are provided. In certain embodiments, the composition is a recombinant adeno-associated virus (rAAV) comprising an AAVrh10 capsid and a vector genome packaged therein, wherein the vector genome comprises an AAV 5? inverted terminal repeat (ITR), a coding sequence for a human Factor IX (F9) having coagulation function operably linked to regulatory elements which direct expression of the human Factor IX in liver cells, and an AAV 3? ITR.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: December 7, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Lili Wang, James M. Wilson
  • Patent number: 11191784
    Abstract: The present invention provides compositions and methods for transducing cells (e.g. T cells or immune cells). Also provided herein are methods of treating a disease in a subject in need thereof.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: December 7, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Saar Gill
  • Patent number: 11185294
    Abstract: A super-resolution digital tomosynthesis system for imaging an object including a source configured to emit penetrating particles toward an object; a detector configured to acquire a series of projection images of the object in response to the penetrating particles from the source; positioning apparatus configured to position the source and the detector; and an imaging system coupled to the source, the detector, and the positioning apparatus. The imaging system is configured to control the positioning apparatus to position the source in relation to the detector along a scan path and to change a distance between the source and the detector, control the source and the detector to acquire the series of projection images along the scan path with the distance change between the source and detector, and construct a tomographic volume exhibiting super-resolution from data representing the acquired series of projection images.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: November 30, 2021
    Assignees: The Trustees of the University of Pennsylvania, Real Time Tomography, LLC
    Inventors: Andrew D. A. Maidment, Raymond J. Acciavatti, Susan Ng, Peter A. Ringer, Johnny Kuo
  • Patent number: 11187536
    Abstract: A method for simultaneous location and mapping (SLAM) includes receiving, by at least one processor, a set of sensor measurements from a movement sensor of a mobile robot and a set of images captured by a camera on the mobile robot as the mobile robot traverses an environment. The method includes, for each image of at least a subset of the set of images, extracting, by the at least one processor, a plurality of detected objects from the image. The method includes estimating, by the at least one processor, a trajectory of the mobile robot and a respective semantic label and position of each detected object within the environment using the sensor measurements and an expectation maximization (EM) algorithm.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: November 30, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Konstantinos Daniilidis, George J. Pappas, Sean Laurence Bowman, Nikolay Asenov Atanasov
  • Patent number: 11179385
    Abstract: Compositions and methods for treatment of viral skin disease, precancerous and cancerous skin disease, and other neoplasms are disclosed.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: November 23, 2021
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Xiaowei Xu, Shujing Liu, Alain Rook, Pankaj Karande
  • Patent number: 11179458
    Abstract: Provided herein is a vaccine comprising a Porcine Epidemic Diarrhea Virus (PEDV) antigen. The antigen can be a consensus antigen. Also disclosed herein is a method of treating a porcine in need thereof, by administering the vaccine to the porcine.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: November 23, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David Weiner, Emma L. Reuschel, Karuppiah Muthumani
  • Patent number: 11180550
    Abstract: The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having ?-folate receptor (FR?) binding domain and 4-1BB (CD137) costimulatory domain to treat ovarian cancer.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: November 23, 2021
    Assignees: The Trustees of the University of Pennsylvania, Fondazione IRCCS Istituto Nazionale dei Tumori
    Inventors: Daniel J. Powell, George Coukos, Mariangela Figini, Silvana Canevari
  • Patent number: 11179379
    Abstract: Methods and compositions for producing fetal hemoglobin and treating a hemoglobinopathy or thalassemia are disclosed.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: November 23, 2021
    Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, COLD SPRING HARBOR LABORATORY
    Inventors: Gerd Blobel, Jeremy Grevet, Junwei Shi, Christopher Vakoc
  • Publication number: 20210355420
    Abstract: Described herein is a beads-free bioprocessor as an automated and cost-effective T cell processing and manufacturing platform. T cells are a core component in CAR T cell therapies for cancer treatment, but are difficult to manufacture to scale in clinically relevant quantities. The 3D bioprocessor provides an alternative device that is scalable, beads-free, easy-to-use, and cost-effective for using CAR T cell therapy in cancer immunotherapy. Besides CAR T cell application, this platform technology has potential for many other applications such as cancer cell isolation.
    Type: Application
    Filed: May 12, 2020
    Publication date: November 18, 2021
    Applicants: Southwest Research Institute, The Trustees of the University of Pennsylvania
    Inventors: Jian Ling, Kreg A. Zimmern, Michael C. Milone
  • Publication number: 20210347845
    Abstract: The present invention includes compositions and methods comprising sortase immune receptors and sortase chimeric antigen receptors (CARs).
    Type: Application
    Filed: October 12, 2019
    Publication date: November 11, 2021
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Mauro Castellarin, June Carl
  • Publication number: 20210348095
    Abstract: The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spacial geometry and microarchitecture of 3D collagen hydrogels. For example, the disclosed subject matter provides for compositions, methods, and systems employing N-sulfosuccinimidyl-6-(4?-azido-2?-nitro-phenylamino)hexanoate (“sulfo-SANPAH”), to prevent detachment of the hydrogel from the anchoring substrate due to cell-mediated contraction.
    Type: Application
    Filed: April 16, 2021
    Publication date: November 11, 2021
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Dongeun Huh, Mark Mondrinos, Cassidy Blundell, Jeongyun Seo
  • Patent number: 11170984
    Abstract: A small-gap device system, preferably including two or more electrodes and one or more spacers maintaining a gap between two or more of the electrodes. A spacer for a small-gap device system, preferably including a plurality of legs defining a mesh structure. A method of spacer and/or small-gap device fabrication, preferably including: defining lateral features, depositing spacer material, selectively removing spacer material, separating the spacer from a fabrication substrate, and/or assembling the small-gap device.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: November 9, 2021
    Assignees: Spark Thermionics, Inc., The Trustees of the University of Pennsylvania
    Inventors: Jared William Schwede, Igor Bargatin, Samuel M. Nicaise, Chen Lin, John Provine
  • Publication number: 20210340479
    Abstract: The present disclosure is directed to portable bioreactors that allow the custom production of microbial cultures, and in some embodiments, the production of custom microbial biofilms. Also disclosed are portable bioreactor systems that are networked and capable of cooperative work in parallel.
    Type: Application
    Filed: October 9, 2019
    Publication date: November 4, 2021
    Applicants: The Trustees of the University of Pennsylvania, Biorealize, Inc.
    Inventors: Orkan TELHAN, Karen HOGAN
  • Publication number: 20210340183
    Abstract: De novo artificial protein based reporters that may be expressed in eukaryotic (e.g., mammalian) cells and methods of using the same are provided herein.
    Type: Application
    Filed: June 29, 2021
    Publication date: November 4, 2021
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Goutham KODALI, Molly Marie SHEEHAN, Joshua MANCINI, Bohdana Marie DISCHER, Michael MAGARACI, Nathan M. ENNIST, Brian CHOW, Peter Leslie DUTTON, Christopher MOSER
  • Publication number: 20210338887
    Abstract: The present disclosure relates to modified polymers, compositions comprising the same, and methods for repairing damaged tissue in a subject, including cartilage tissue. The modified polymers, compositions comprising the same, and methods described comprise one or more tunable characteristics such that the modified polymers, compositions comprising the same, and methods form an integrated microenvironment comprising one or more of viable cells, a fibrous barrier, or a bioseal at a site of damaged tissue in a subject.
    Type: Application
    Filed: July 12, 2019
    Publication date: November 4, 2021
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Jay Milan Patel, Claudia Loebel, Anthony R. Martin, Robert Leon Mauck, Jason A. Burdick
  • Publication number: 20210341462
    Abstract: The presently disclosed subject matter provides a microfluidic device that can simulate the cross section of the large and small human airways, including the air-exposed epithelial layer, the adjacent surrounding stromal layer, and the blood-facing endothelial layer of near-by vessels in the circulatory system. The microfluidic device can reconstitute the air-liquid interface in the lung and molecular transport characteristics of bronchi and bronchioles in the human pulmonary airways, and provide a more realistic alternative to current in vitro models of airway structures. Additionally, the model can reconstitute the native response of airway tissues to infection by bacterial and viral agents, and also the extravasation of immune cells from the bloodstream and into the stromal and epithelial compartments of the lung in response to an infection.
    Type: Application
    Filed: October 7, 2019
    Publication date: November 4, 2021
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Dongeun Huh, Andrei Georgescu
  • Patent number: 11161865
    Abstract: The present disclosure relates to compounds of Formula I and II, wherein R1-R20 and FL are defined herein. Also provided are methods of targeting alpha-radiation to poly(ADP-ribose)polymerase 1 (PARP-1) enzyme expression, reducing proliferation of cancer cells, reducing proliferation of cancer cells, detecting intact and enzymatically active poly(ADP-ribose)polymerase 1 (PARP-1) enzyme expression, detecting PARP-1 enzyme expression in a subjects tissue sample, monitoring cancer treatment in a subject, or detecting a PARP-1 receptive cancer in a subject.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: November 2, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Robert H. Mach, Sean Reilly, Mehran Makvandi, Kuiying Xu, Daniel A. Pryma, Roger A. Greenberg
  • Patent number: 11161907
    Abstract: The invention provides compositions and methods for treating cancer by using immune effector cells (e.g., T cells, NK cells) engineered to conditionally express an agent which enhances the immune effector response of an immune effector cell that expresses a Chimeric Antigen Receptor (CAR). The conditional agents described herein include agents that target a cancer associated antigen, e.g., a CAR, agents that inhibit one or more checkpoint inhibitors of the immune response, and a cytokine.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: November 2, 2021
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Carl H. June, Daniel J. Powell, Jr.