Abstract: A novel family of cycloalkanes compounds having one or more allylidene functionalities which can be used to create cross-linked thermosets and thermoplastics having thermal stability. An example heptacyclo [6.6.0.02,6.03,13.04,11.05,9.010,14] tetradecane (HCTD) complex with terminal allylidene groups at the 7- and 12-positions (HCTD-7,12-diallylidene) was generated from norbornadiene via an efficient six-step synthesis. Thermal polymerization at temperatures ranging from 160 to 240° C. yielded a robust cross-linked material with thermal stability up to 485° C. in air, a glass transition temperature of 377° C., and a char yield (600° C.) of 56% in air. Applications include heat resistant composites utilized in the aerospace, electronic, automotive and textile industries.

Abstract: An instrumented wind tunnel. The wind tunnel receives a test subject which can be a model of an object to be tested with dynamic airflow. The test subject is fitted with at least one sensor to deliver data to a chassis, which in turn uses a network having at least 10 Gb/s capability to deliver the data to a RAM cache. The RAM cache can push the data to multiple viewers for real time monitoring of wind tunnel tests. The operator can then make live adjustments of the test conditions.

Abstract: The present disclosure is directed to a missile having a main body and an articulating nosecone connected to the main body. An actuation system is operable for moving the nosecone relative to the main body via one or more electric motors and associated components. A central aperture is formed through electric motors and the associated components between the main body and the nosecone. One or more cables for transmitting electrical power, sensor data, control signals and the like extend through the central aperture between the main body and the nosecone to provide means for controlling the actuation system.

Abstract: Provided herein are shaped charges for focusing a fluid mass and related methods of using the shaped charges for disruption of an explosive target with a spherical projectile. The shaped charge comprises a plastic shell having a special geometric shape configured to support a shape-conforming explosive. A cylindrical plastic body has an interior volume for containing a fluid and the plastic shell. The plastic body closed distal end has a geometric shape that is substantially matched to the shape of the plastic shell. Metal spherical projectiles having an outer layer of metal selected to have an effective density matched to the fluid provide advantageous target disruption capabilities.

Abstract: The present disclosure defines a morphing airfoil having a dynamic flexible skin system that is capable of carrying high level aerodynamic (or fluid) pressure loads over a structural surface. The structural surface can morph and deflect in response to control inputs to change a lift force without separate movable control surfaces. The anisotropic skin is attached to underlying structure that is both actively controlled and passively supported. A control system causes the underlying support structure to move to a desired location which in turn causes the skin to bend and/or flex without exceeding a stress threshold and thus vary the lift profile along a span of the airfoil.

Abstract: Provided is an interchangeable modular chamber system for a firearm. The system includes a firearm receiver, a barrel comprising lands and grooves, a chamber insert sleeve comprising lands and grooves, an index pin, a locking collar, and a recoil lug. The barrel is threaded into the receiver with the chamber insert sleeve positioned within the barrel. The chamber insert sleeve is indexed to align the lands and grooves of the chamber insert sleeve with those of the barrel. The locking collar and recoil lug are threaded onto the external threads of the barrel and are adjustable to optimize the headspace for different cartridges of the same caliber and to allow for the sacrificial replacement of the throat area of a barrel.

Abstract: A device and method for remote-controlled explosive ordnance disposal using an explosive ordnance disposal device that includes a carriage adjustably attached to a device frame having a rotatable bar. The rotatable bar including at least a laser face, an x-ray face, and a disarm device face; the rotatable bar rotated by a servo motor, the servomotor being remotely operable. The laser face having a laser capable of a laser beam visible to a remote viewing device. The remote viewing device co-mounted to the laser face and remotely viewable. The x-ray face having an x-ray device attached to it. The disarm device face having a bomb disarming device attached; wherein the carriage and the rotatable bar may be remotely adjusted such that upon remote rotation the laser, x-ray and bomb disarming device share an aligned orientation and placement for operation.

Abstract: The present Disclosure is directed to methods for inhibiting or suppressing metastasis of a tumor in a mammalian subject using a cysteamine product, e.g., cysteamine or cystamine or a derivative thereof. Also described herein is a method for treating pancreatic cancer in a mammalian subject by administering a cysteamine product described herein.

Abstract: Disclosed is a method of irradiating a composition having water and hydrogen-terminated nanodiamonds with light that generates water-solvated electrons from the nanodiamonds. The method can be used to degrade fluoroalkyl compounds such as perfluorooctane sulfonate.

Abstract: Examples are directed toward systems and methods relating to security screening. For example, a screening system includes a sensor array to sense a gravitational field caused by an item, and a conveyor to convey the item through sensing positions for scanning by the sensor array. A controller acquires weight measurement information from sensor elements, and gravitational measurement information from the sensor array. The conveyor incrementally advances the item through additional sensing positions to acquire weight measurement information and gravitational measurement information. The controller performs tomographic reconstruction to generate a tomographic image of the item, using a generated weight map as a static weight input vector and using a generated mass map as a static mass input vector for the tomographic reconstruction.

Abstract: The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.

Abstract: A test fixture is provided for dropping an article from a height to a floor, with the article oriented in relation to the floor at a select angle. The fixture includes a column frame, an overhead beam, a carriage, first and second guy wires, first and second spools, and first and second chains. The frame supports first and second guide arms on opposing sides. The overhead beam has a distance span substantially parallel to the floor. The carriage is disposed substantially parallel to the floor and has first and second opposing guides separated by the span. The guy wires attach to the beam separated the span and pass through the guide arms. The first and second spools to receive the corresponding guy wires. The first and second chains suspend the article from the carriage above the floor. Upon release of the guy wires, the carriage falls until contact with the guide arms while the article contacts the floor.

Abstract: The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.

Abstract: A mounting platform is provided for securing munitions. The platform includes a flat plate, a front block and a rear block. The plate includes a plurality of cutout holes. The front block has a first saddle disposed between first flanking ends and at least one extension at one of the flanking ends for inserting into a first opening of the cutouts. The rear block has a second saddle disposed between second flanking ends at least one extension for inserting into a second opening of the cutouts. The munitions are disposable atop the first and second saddles of the front and rear blocks. The munitions are restrained axially against a rear stop block and laterally by the saddles and straps.

Abstract: The present disclosure is directed to antibodies binding to Glypican 2 and methods of using such antibodies to treat cancers that express or overexpress the Glypican 2 antigen.

Abstract: The invention relates to cyanate ester resin blends containing resveratrol-based cyanate esters. At room temperature, the cyanate ester resin blend offers improved processability by remaining a liquid or forming a solid that melts at less than 70° C. The cyanate ester resin blend includes a resveratrol-based cyanate ester and a flexible cyanate ester having a configuration different than that of the resveratrol-based cyanate ester, where the resveratrol-based cyanate ester is no more than 80% of the total mass of the cyanate esters in the cyanate ester resin blend. A composite product can include the cyanate ester resin blend and a support material. When making the composite product, the support material is combined with the cyanate resin blend and cured at temperatures ranging from about 100° C. to about 300° C.

Abstract: Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. A protective device can be placed between the annuloplasty device and an underlying coronary artery to inhibit compression of the underlying coronary artery by the annuloplasty device in the coronary sinus. In addition, the protective device can inhibit compression of the coronary artery from inside the heart, such as from a prosthetic mitral valve that exerts radially outward pressure toward the coronary artery. The annuloplasty device can also create an artificial inner ridge or retaining feature projecting into the native mitral valve region to help secure a prosthetic mitral valve.

Abstract: Embodiments are directed to direct impingement cook-off mitigation systems. As assembled, a munition fuzewell is torqued into the aft end of a munition. During a cook-off event, the expanding gases from the booster energetic will burn instead of detonating. The hot expanding booster gases are vented to the munition's main fill energetic causing the main fill energetic to burn concurrently with the booster energetic. The combined expanding gases from both the booster and main fill energetics are then vented through longitudinal vents.

Abstract: A non-linear charge pump for phased lock loops. Furthermore, an auxiliary charge pump apparatus, comprising a positive switch electrically connected to a current source configured to supplement power to a charge pump, a negative switch electrically connected to a current sink configured to discharge power from the charge pump, a windowing comparator, further comprising an input signal received from a phase-locked loop, a first comparator configured to compare the input signal against a high voltage threshold, a second comparator configured to compare the input signal against a low voltage threshold, an AND logic gate configured to provide a window signal and an activation circuit electrically connected to the positive switch and negative switch. Additionally, a non-linear charge pump system and method for reacquiring frequency lock of a phase lock loop.

Abstract: Shape-programmable liquid crystal elastomers. The shape-programmable liquid crystal elastomers being synthesized by filling an alignment cell with liquid crystal monomers. The liquid crystal monomers align to a surface of the alignment cell and then are polymerized with a dithiol chain transfer agent. The alignment cell is configured to impose a director orientation on a portion of the shape-programmable liquid crystal elastomer. For some embodiments, liquid crystal elastomer laminates are prepared by arranging a plurality of liquid crystal elastomers such that a director orientation of each liquid crystal elastomer of the plurality is in registered alignment with an adjacent liquid crystal elastomer of the plurality. The arrangement is secured and the plurality of liquid crystal elastomers cured.