Patents Assigned to The United States of America, As Represented By
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Patent number: 11939356Abstract: Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.Type: GrantFiled: March 15, 2021Date of Patent: March 26, 2024Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Peter Kwong, Ivelin Georgiev, Michael Gordon Joyce, Masaru Kanekiyo, Aliaksandr Druz, Ulrich Baxa, Joseph Van Galen, Cheng Cheng, John Mascola, Yaroslav Tsybovsky, Yongping Yang, Barney Graham, Syed Mohammad Moin, Jeffrey Boyington
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Patent number: 11938177Abstract: Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen.Type: GrantFiled: November 2, 2021Date of Patent: March 26, 2024Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Robert Seder, Geoffrey Lynn
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Patent number: 11939365Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.Type: GrantFiled: September 17, 2018Date of Patent: March 26, 2024Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Drew C. Deniger, Steven A. Rosenberg, Anna Pasetto, Rami Yoseph, Winifred M. Lo, Yong-Chen Lu, Maria R. Parkhurst, Paul F. Robbins, Parisa Malekzadeh
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Patent number: 11938221Abstract: Novel, nanoparticle-based vaccines are provided that elicit an immune response to a broad range of infectious agents, such as influenza viruses. The nanoparticles comprise a heterogeneous population of fusion proteins, each comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to one or more immunogenic portions of a protein from an infectious agent, such as influenza virus. The fusion proteins self-assemble to form nanoparticles that display a heterogeneous population of immunogenic portions on their surface. When administered to an individual, such nanoparticles elicit an immune response to different strains, types, subtypes and species with in the same taxonomic family. Thus, such nanoparticles can be used to vaccinate an individual against infection by different Types, subtypes and/or strains of infectious agents.Type: GrantFiled: November 4, 2021Date of Patent: March 26, 2024Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Barney S. Graham, Masaru Kanekiyo, Hadi M. Yassine
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Patent number: 11940714Abstract: A quantum EIT-based optical switch includes a first waveguide, linear or nonlinear, a separate nonlinear waveguide evanescently coupled to the first waveguide, and a pump coupled to the nonlinear waveguide. A quantum STIRAP-based optical transduction device, which includes an auxiliary, intermediate spectral state for the quantum signal that aids efficient transduction of the quantum signal from the input spectral state to the output spectral state in a single device.Type: GrantFiled: December 8, 2021Date of Patent: March 26, 2024Assignees: University of Maryland, College Park, Government of the United States of America, as Represented by the Secretary of CommerceInventors: Ivan A. Burenkov, Sergey V. Polyakov
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Patent number: 11944011Abstract: Thermoelectric (TE) nanocomposite material that includes at least one component consisting of nanocrystals. A TE nanocomposite material in accordance with the present invention can include, but is not limited to, multiple nanocrystalline structures, nanocrystal networks or partial networks, or multi-component materials, with some components forming connected interpenetrating networks including nanocrystalline networks. The TE nanocomposite material can be in the form of a bulk solid having semiconductor nanocrystallites that form an electrically conductive network within the material.Type: GrantFiled: December 2, 2022Date of Patent: March 26, 2024Assignee: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Boris N. Feigelson, Kevin P. Anderson, Benjamin L. Greenberg, James A. Wollmershauser, Alan G. Jacobs
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Publication number: 20240098503Abstract: In an example, a provider system receives from a client device a request for client access. The provider system sends to the client device a request for identification information of the client. The provider system receives client information associated with a mobile identification credential (MIC) which the client device received from an authorizing party system (APS), the client having consented to release the client information to the provider system, and the client information having been verified by the APS. The provider system uses the verified client information associated with the MIC to verify or not verify the identity of the client. The provider system verifies the identity of the client before granting the client the request for client access.Type: ApplicationFiled: November 22, 2023Publication date: March 21, 2024Applicant: The Government of the United States of America, as represented by the Secretary of Homeland SecurityInventors: Jason Lim, Daniel Boyd, Chang Ellison, William Washington
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Publication number: 20240094425Abstract: A detector for detecting optically undetectable sub-cm orbital debris. A ring detector comprising a current pulse transformer (CPT) in which a conducting wire coil is wrapped around a loop of high permeability material having a magnetic nanoparticle (MNP) core. Debris objects in low earth orbit become charged as they pass through local plasma. As each charged debris object passes through the coil-wrapped loop, its current generates an induced voltage pulse, which can be used to detect the presence of the debris object. By fielding such a detector on a satellite, a long duration survey of the debris distribution in the LEO region can be made as the satellite's altitude is systematically varied.Type: ApplicationFiled: March 3, 2023Publication date: March 21, 2024Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: William E. Amatucci, Gurudas I. Ganguli, Abhijit Sen, Christopher Crabtree
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Publication number: 20240092767Abstract: Benzoxazine compounds, methods of making them, polymers made therefrom and methods of polymerizing the benzoxazines. These renewable benzoxazine monomers and polymers that utilize the variety of building blocks found in renewable plant biomass, demonstrate excellent processability and large temperature windows for processing of resin systems.Type: ApplicationFiled: March 24, 2023Publication date: March 21, 2024Applicants: DREXEL UNIVERSITY, The Government of the United States of America, as represented by The Secretary of the ArmyInventors: Giuseppe R. Palmese, Santosh K. Yadav, John J. LaScala
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Publication number: 20240091264Abstract: Provided are chimeric antigen receptors (CARs) having antigen specificity for B-cell Maturation Antigen (BCMA). Also provided are related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs. Methods of treating or preventing cancer in a mammal are also provided.Type: ApplicationFiled: November 30, 2023Publication date: March 21, 2024Applicants: The United States of America, as represented by the Secretary, Dept. of Health and Human Services, TeneoBio, Inc.Inventors: James N. Kochenderfer, Norris Lam, Nathan Trinklein, Katherine E. Harris, Shelley Force Aldred, Wim Van Schooten
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Patent number: 11933580Abstract: Provided herein are shaped charges for focusing a fluid mass and related methods of using the shaped charges for disruption of an explosive target with a spherical projectile. The shaped charge comprises a plastic shell having a special geometric shape configured to support a shape-conforming explosive. A cylindrical plastic body has an interior volume for containing a fluid and the plastic shell. The plastic body closed distal end has a geometric shape that is substantially matched to the shape of the plastic shell. Metal spherical projectiles having an outer layer of metal selected to have an effective density matched to the fluid provide advantageous target disruption capabilities.Type: GrantFiled: February 8, 2021Date of Patent: March 19, 2024Assignee: The United States of America as Represented by the Federal Bureau of Investigation, Department of JusticeInventors: Ian B. Vabnick, Lee R. Foltz, Daniel E. McCarthy, Marc J. La Belle, Michael S. Shattuck
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Patent number: 11933568Abstract: Provided is an interchangeable modular chamber system for a firearm. The system includes a firearm receiver, a barrel comprising lands and grooves, a chamber insert sleeve comprising lands and grooves, an index pin, a locking collar, and a recoil lug. The barrel is threaded into the receiver with the chamber insert sleeve positioned within the barrel. The chamber insert sleeve is indexed to align the lands and grooves of the chamber insert sleeve with those of the barrel. The locking collar and recoil lug are threaded onto the external threads of the barrel and are adjustable to optimize the headspace for different cartridges of the same caliber and to allow for the sacrificial replacement of the throat area of a barrel.Type: GrantFiled: April 6, 2022Date of Patent: March 19, 2024Assignee: The United States of America, as Represented by the Secretary of the NavyInventors: Rand W. Hammel, Alex J. Toon, Donald Richardville
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Patent number: 11933694Abstract: An instrumented wind tunnel. The wind tunnel receives a test subject which can be a model of an object to be tested with dynamic airflow. The test subject is fitted with at least one sensor to deliver data to a chassis, which in turn uses a network having at least 10 Gb/s capability to deliver the data to a RAM cache. The RAM cache can push the data to multiple viewers for real time monitoring of wind tunnel tests. The operator can then make live adjustments of the test conditions.Type: GrantFiled: August 18, 2021Date of Patent: March 19, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Paul Smith, Tina Reynolds
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Patent number: 11933596Abstract: A device and method for remote-controlled explosive ordnance disposal using an explosive ordnance disposal device that includes a carriage adjustably attached to a device frame having a rotatable bar. The rotatable bar including at least a laser face, an x-ray face, and a disarm device face; the rotatable bar rotated by a servo motor, the servomotor being remotely operable. The laser face having a laser capable of a laser beam visible to a remote viewing device. The remote viewing device co-mounted to the laser face and remotely viewable. The x-ray face having an x-ray device attached to it. The disarm device face having a bomb disarming device attached; wherein the carriage and the rotatable bar may be remotely adjusted such that upon remote rotation the laser, x-ray and bomb disarming device share an aligned orientation and placement for operation.Type: GrantFiled: September 29, 2021Date of Patent: March 19, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventors: John Bales, Alexander Orsi, James Okeefe, Kyle Schory, Stuart Baker
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Patent number: 11933587Abstract: The present disclosure is directed to a missile having a main body and an articulating nosecone connected to the main body. An actuation system is operable for moving the nosecone relative to the main body via one or more electric motors and associated components. A central aperture is formed through electric motors and the associated components between the main body and the nosecone. One or more cables for transmitting electrical power, sensor data, control signals and the like extend through the central aperture between the main body and the nosecone to provide means for controlling the actuation system.Type: GrantFiled: November 3, 2022Date of Patent: March 19, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Richard Beblo, Tizoc Cruz-Gonzalez, Mackenzie Tidball, Gregory Reich, Benjamin Dickinson
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Patent number: 11932724Abstract: A novel family of cycloalkanes compounds having one or more allylidene functionalities which can be used to create cross-linked thermosets and thermoplastics having thermal stability. An example heptacyclo [6.6.0.02,6.03,13.04,11.05,9.010,14] tetradecane (HCTD) complex with terminal allylidene groups at the 7- and 12-positions (HCTD-7,12-diallylidene) was generated from norbornadiene via an efficient six-step synthesis. Thermal polymerization at temperatures ranging from 160 to 240° C. yielded a robust cross-linked material with thermal stability up to 485° C. in air, a glass transition temperature of 377° C., and a char yield (600° C.) of 56% in air. Applications include heat resistant composites utilized in the aerospace, electronic, automotive and textile industries.Type: GrantFiled: April 1, 2021Date of Patent: March 19, 2024Assignee: The United States of America, as represented by the Secretary of the NavyInventors: Benjamin G. Harvey, Kyle E. Rosenkoetter
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Patent number: 11931881Abstract: A tool box with vertically stacked monolithic trays. Each tray has pockets specifically shaped to receive complementary tools. The trays have upstanding cantilevered posts, which can space apart the superjacent tray. Alternatively, the posts can be received in complementary sockets of superjacent trays to prevent undue lateral movement while in the tool box. The post and socket geometry can be constructed to index the order in which trays are stacked and index how individual trays are oriented for optimal and sequenced access to the tools.Type: GrantFiled: September 30, 2021Date of Patent: March 19, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventor: Courtney O'Brien
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Patent number: 11937361Abstract: A cathode emitter assembly includes a cathode tube having a gas feed portion and a plasma outflow portion; an outer annular cathode insert in the plasma outflow portion of the cathode tube; an inner cathode insert in the plasma outflow section of the cathode tube; and an annular plasma emission portion defined between an inner surface of the outer annular cathode insert and an outer surface of the inner cathode insert.Type: GrantFiled: February 9, 2022Date of Patent: March 19, 2024Assignee: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Michael McDonald, Marcel Georgin
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Patent number: 11932389Abstract: The present disclosure defines a morphing airfoil having a dynamic flexible skin system that is capable of carrying high level aerodynamic (or fluid) pressure loads over a structural surface. The structural surface can morph and deflect in response to control inputs to change a lift force without separate movable control surfaces. The anisotropic skin is attached to underlying structure that is both actively controlled and passively supported. A control system causes the underlying support structure to move to a desired location which in turn causes the skin to bend and/or flex without exceeding a stress threshold and thus vary the lift profile along a span of the airfoil.Type: GrantFiled: December 22, 2020Date of Patent: March 19, 2024Assignee: United States of America as represented by the Secretary of the Air ForceInventors: Jared Neely, James Joo
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Patent number: 11931046Abstract: A junctional tourniquet apparatus and related methods of use. An exemplary tourniquet has an inverted cone shape, wherein a narrower end has a mushroom shaped base that is pressed against a compression target and a broader end has a plurality of pass-through slots for straps. Another exemplary tourniquet has a broad plate component and a handle component. The handle component has a mushroom shaped base on a first end and a handle on a second end. The handle component passes through the center of the plate component with threads that allow the handle component to compress a target by twisting the handle.Type: GrantFiled: January 13, 2023Date of Patent: March 19, 2024Assignee: The United States of America, as Represented by the Secretary of the NavyInventors: Joseph Thomas Burkart, Danielle E. Cafasso, Robert Henry Hayford, Huckelberry A. Finne, Jose Ramirez Vargas, Michael P. Abbott
