Patents Assigned to The United States of America, As Represented By
  • Patent number: 11944951
    Abstract: Calcium silicate hydrate nanoparticles are combined with ammonia control materials (e.g. alum, aluminum chloride, ferric chloride, ferric sulfate, and/or sodium bisulfate) to create a phosphorus-binding composition. In the preferred embodiment, the composition is applied to poultry litter, poultry bedding or other non-aqueous substrates that are at least partially comprised of animal manure. The composition binds with phosphorus to at least reduce the amount of phosphorus in runoff water or in leachate from fields fertilized with treated manure. The combining of the calcium silicate hydrate nanoparticles with the ammonia control products has a surprising and unexpected result. The calcium silicate hydrate-ammonia control material mix reduces soluble phosphorus more than either component of the mix alone.
    Type: Grant
    Filed: February 9, 2021
    Date of Patent: April 2, 2024
    Assignee: The United States of America, as represented by the Secretary of Agriculture
    Inventor: Philip A. Moore, Jr.
  • Patent number: 11946058
    Abstract: Herein is disclosed synthetic oligonucleotides comprising 2?F-ANA nucleosides that can be utilized to control plant-chewing and phloem-feeding insects, bacteria present in such insects, and bacteria present in plants. The novel approaches and materials provided herein allow for reduction of pesticide and antibiotic use without the need to create genetically modified plants.
    Type: Grant
    Filed: January 5, 2022
    Date of Patent: April 2, 2024
    Assignees: The United States of America, as represented by the Secretary of Agriculture, AUM LifeTech, Inc.
    Inventors: Wayne B. Hunter, Veenu Aishwarya
  • Patent number: 11946832
    Abstract: A portable tracer fluid injection system. The system has a vapor cloud generator which vaporizes a vapor cloud generating liquid. The vapor cloud generator is uses a sub-ohm resistive heater to vaporize small volumes of the vapor cloud generating liquid, allowing for a relatively small tracer fluid injection system. This system has the benefit of being able to target specific regions of a test object within a wind tunnel and being usable for different positions within the test section of a wind tunnel.
    Type: Grant
    Filed: April 10, 2023
    Date of Patent: April 2, 2024
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventor: Natalia Posada
  • Patent number: 11946110
    Abstract: A metal structure includes an alloy material containing structural deformation twins embedded during a manufacturing process of the alloy material along defined directions, a defined deformation sequence, and defined strain levels. The embedded structural deformation twins mitigate failure and fracture in the alloy material.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: April 2, 2024
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Jeffrey T. Lloyd, Phillip A. Jannotti, Daniel J. Magagnosc
  • Patent number: 11944090
    Abstract: Disclosed herein are compositions for attracting fire ants wherein the compositions contain at least one fire ant food source, and at least one of 10-oxo-dodecanoic acid, 11-oxo-dodecanoic acid, or a mixture thereof, and optionally a carrier. Disclosed are also methods for attracting fire ants, the methods involving treating an object or area with a fire ant-attracting effective amount of a composition of the invention.
    Type: Grant
    Filed: August 3, 2022
    Date of Patent: April 2, 2024
    Assignee: The United States of America, as Represented by the Secretary of Agriculture
    Inventor: Jian Chen
  • Patent number: 11946392
    Abstract: A flow control device for constraining fluid flow between axial flow turbomachines in series has a flow constrainer which constrains the fluid flow downstream of the first turbomachine in the series to the blades region of the second turbomachine, preventing fluid flow from impacting the hub or nosecone of the second turbomachine and providing more uniform fluid flow to the second turbomachine. The flow control device includes connective elements for positioning between the downstream region of the first turbomachine and the upstream region of the second turbomachine. The device may be equipped with stator vanes having a variety of optional configurations to further improve the uniformity of the fluid flow load on the second turbomachine.
    Type: Grant
    Filed: January 18, 2023
    Date of Patent: April 2, 2024
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Michael E. Slipper, Tristan M. Wolfe, Kyle J. Verrinder
  • Publication number: 20240101685
    Abstract: Provided herein are methods of treating a subject with cancer using a therapeutically effective amount of one or more one or more tumor-specific antibody-IR700 molecules. The methods can further include administering to the subject a therapeutically effective amount of (a) one or more CTLA4 antibody-IR700 molecules, one or more PD-L1 antibody-IR700 molecules, or combinations thereof, (b) one or more reducing agents, (c) one or more immunoactivators, or combinations of a, b, and c, for example, either simultaneously or substantially simultaneously with the tumor-specific antibody-IR700 molecules, or sequentially (for example, within about 0 to 24 hours). The method also includes irradiating the subject or cancer cells in the subject (for example, a tumor or cancer cells in the blood) at a wavelength of 660 to 740 nm at a dose of at least 1 J/cm2. The use of one or more reducing agents can reduce edema resulting from treatment.
    Type: Application
    Filed: January 28, 2022
    Publication date: March 28, 2024
    Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human
    Inventors: Hisataka Kobayashi, Peter Choyke
  • Publication number: 20240102027
    Abstract: The inventive subject matter includes an antimicrobial peptide vectored composition made of a bacterial protein expression vehicle expressing one or more recombinant antimicrobial peptide effector molecules. More specifically these novel recombinant antimicrobial peptide effector molecules exhibit preferential antimicrobial activity. In some embodiments, the antimicrobial activity is facilitated via interaction with the lipid bilayer of the parasitic cell form, leading to membrane pore formation and resulting in cell lysis. The utility of the current inventive subject matter has demonstrated a reduced viability of Eimeira acervulina sporozoites was shown in vitro using a sporozoite killing assay.
    Type: Application
    Filed: October 4, 2023
    Publication date: March 28, 2024
    Applicants: US BIOLOGIC, INC, The United States of America as represented by the Secretary of Agriculture
    Inventors: Jolieke G. Van Oosterwijk, Luciana Meirelles Richer, Douglas Steven Zetechka, JR., Hyun Soon Lillehoj, Woohyun Kim, Cyril Gay, Christopher Anthony Przybyszewski
  • Publication number: 20240102805
    Abstract: A single body multi-mode mechanical resonator includes two or more spring-mass devices, one or more anchor springs, a phase 1 parallel plate electrode and a phase 2 parallel plate electrode, a plurality of interdigitated shaped combs, a plurality of interdigitated drive combs, and a plurality of interdigitated sense combs. The spring-mass devices further include two or more lumped masses and one or more anchor springs. The coupling springs couple the motion of the two or more lumped masses. The parallel plate electrodes apply forces to the in-phase mode that yield equal in magnitude but opposite in sign frequency shifts of the anti-phase mode. The shaped combs compensate for a frequency drift of the anti-phase mode and cancels first-order displacement effects. The drive combs are aligned to the anti-phase mode, with a frequency selective excitation. The sense combs are aligned to the anti-phase mode and capable of cancelling common-mode noise effects.
    Type: Application
    Filed: September 22, 2022
    Publication date: March 28, 2024
    Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY
    Inventor: Andrew B. Sabater
  • Publication number: 20240101609
    Abstract: Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
    Type: Application
    Filed: December 12, 2023
    Publication date: March 28, 2024
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servi, Institute for Research in Biomedicine
    Inventors: Baoshan Zhang, Guillaume Stewart-Jones, Tongqing Zhou, John Mascola, Kai Xu, Yongping Yang, Paul Thomas, Gwo-Yu Chuang, Li Ou, Peter Kwong, Yaroslav Tsybovsky, Wing-Pui Kong, Aliaksandr Druz, Davide Corti, Antonio Lanzavecchia
  • Patent number: 11939151
    Abstract: A dunnage assembly has a plurality of dunnage sections removably attached to each other and includes a forwardmost dunnage section and an aftmost dunnage section. The forwardmost dunnage section has the longest length and the aftmost dunnage section has the shortest length. Each dunnage section has a plurality of tubes and a plurality of tube collars that support the tubes such that the tubes are substantially parallel to each other. Each tube of each dunnage section has an interior region sized to receive a longitudinally extending item and is substantially coaxially aligned with a tube of an adjacent dunnage section. Each tube collar has a plurality of thru-holes therein where each thru-hole is sized to receive a portion of a tube. Each dunnage section includes a tube collar removably attached to a tube collar of an adjacent dunnage section.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: March 26, 2024
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Timothy D. Underwood, Andrew S. Coombs
  • Patent number: 11939787
    Abstract: A rapidly deployable structure that includes a first and second hub, a plurality of legs and a rod connected to the first hub. The first hub includes first recesses. The second hub includes second recesses and an alignment guide. Each leg is connected to the first hub and the second hub. The rod connected is to the first hub and includes pins that are movable between an extended state, where pins protrude from the rod, and a retracted state where the pins are retracted within the rod. The first hub is movable relative to the second hub between a first state in which the rod is disposed above the alignment guide in an axial direction defined by an opening in the alignment guide and a second state in which a portion of the rod comprising the pins is below the alignment guide in the axial direction.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: March 26, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Edward Michaelchuck, Scott Ramsey, Christopher Strem
  • Patent number: 11939345
    Abstract: A physiologically stable fluorophore includes a terminal moiety including a terminal reactive site that reacts with a reactive group of a substrate; a stability linker covalently bonded to the terminal moiety; and a bridge moiety covalently bonded to the stability linker such that the stability linker is interposed through chemical bonds between the bridge moiety and the terminal moiety; and a fluorescent moiety covalently bonded to the bridge moiety of the redox moiety and including: an electron bandgap mediator that is covalently bonded to the bridge moiety; a coordinate center covalently bonded to the electron bandgap mediator and that forms a Zwitterionic member with an atom in the electron bandgap mediator; and a steric hinder bonded to the electron bandgap mediator to provide steric hindrance for protection of the coordinate center.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: March 26, 2024
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: Jeremiah Wallace Woodcock, Jeffrey William Gilman, Douglas Matthew Fox
  • Patent number: 11939377
    Abstract: An affinity matured anti-CD22 human monoclonal antibody exhibiting significantly higher affinity (less than 50 pM) compared to the parental antibody (affinity of about 2 nM) is described. The anti-CD22 variant antibody or a fragment thereof, such as a single-chain variable fragment (scFv), can be used as the antigen-binding portion of chimeric antigen receptors (CARs), antibody-drug conjugates (ADCs), immunotoxins or multi-specific antibodies for the treatment of B-cell malignancies.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: March 26, 2024
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Dimiter S. Dimitrov, Zhongyu Zhu, Sneha Ramakrishna, Terry J. Fry
  • Patent number: 11939276
    Abstract: A nanoparticle of a decomposition product of a transition metal aluminum hydride compound, a transition metal borohydride compound, or a transition metal gallium hydride compound. A process of: reacting a transition metal salt with an aluminum hydride compound, a borohydride compound, or a gallium hydride compound to produce one or more of the nanoparticles. The reaction occurs in solution while being sonicated at a temperature at which the metal hydride compound decomposes. A process of: reacting a nanoparticle with a compound containing at least two hydroxyl groups to form a coating having multi-dentate metal-alkoxides.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: March 26, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Albert Epshteyn, Zachary J. Huba
  • Patent number: 11940276
    Abstract: An inertial point-source matter-wave atom interferometer gyroscope includes an analyzer that receives fringe images of gyroscope atoms and includes: a first fringe image that includes a first fringe phase, a second fringe image that includes a second fringe phase; and a third fringe image that includes a third fringe phase, wherein the first fringe phase, the second fringe phase, and the third fringe phase are different; a phase mapper of the analyzer that produces a interferometric phase map for the gyroscope atoms from the fringe images of the gyroscope atoms; and a fitter of the analyzer in communication with the phase mapper and that receives the interferometric phase map from the analyzer and determines inertial parameters of the gyroscope atoms from the interferometric phase map, the inertial parameters including an acceleration and a rotation rate of the inertial point-source matter-wave atom interferometer gyroscope relative to the gyroscope atoms.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: March 26, 2024
    Assignee: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
    Inventors: John Edward Kitching, Elizabeth Ann Donley, Azure Lynn Hansen, Yun-Jhih Chen
  • Patent number: 11939297
    Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, comprising (i) a CB1 receptor mediating scaffold conjugated to (ii) a second therapeutic scaffold.
    Type: Grant
    Filed: February 10, 2023
    Date of Patent: March 26, 2024
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: George Kunos, Malliga Iyer, Resat Cinar, Kenner C. Rice
  • Patent number: 11940558
    Abstract: Described herein are examples of evaluating electromagnetic energy reflection data of security scans. In embodiments, a method to evaluate electromagnetic energy reflection data determines whether electronic information of a security scan contains an anomaly, and identifies an anomaly location in the electronic information corresponding to the anomaly. The method determines a subset of the electronic information corresponding to the anomaly location, determines anomaly attributes using the subset of the electronic information, and evaluates the anomaly attributes using a database of reference items by comparing anomaly attributes to respective reference characteristics of reference items or identity information. When a comparison meets the respective match criterion for the given reference item, the method assigns to the anomaly the respective identifier as an anomaly identifier.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: March 26, 2024
    Assignee: The Government of the United States of America, represented by the Secretary of Homeland Security
    Inventors: Melissa Conley, John Fortune, Michael Chandarlis, William Garrett, Brian Lewis
  • Patent number: 11940365
    Abstract: The present invention is directed to a passive outdoor air sampler device with various screen types and materials for efficient collection of air particles. Screens are used as a collection surface for aerosolized particles. The air sampler is suitable for long-term use in different outdoor settings with no power requirements.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: March 26, 2024
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventors: Jana S Kesavan, Jerold R Bottiger
  • Patent number: 11941100
    Abstract: An apparatus verifies hosted information associated with a user. The apparatus establishes, by the online host serving as a relying party system (RPS), a secure connection between the RPS and a user mobile-identification-credential device (UMD). The RPS sends a mobile identification credential (MIC) user information request to the UMD, via the secure connection, seeking release of MIC user information (official information). The RPS obtains from authorizing party system (APS) verification of the MIC user information received in response to the MIC user information request. The RPS stores the MIC user information as hosted information pertaining to the user. The RPS designates the hosted information as base truth information representing the user.
    Type: Grant
    Filed: May 4, 2023
    Date of Patent: March 26, 2024
    Assignee: The Government of the United States of America, represented by the Secretary of Homeland Security
    Inventors: Daniel A. Boyd, Kelli L Biegger, Chang Ellison, Brandon P. Gutierrez, Jason Lim, William Washington