Patents Assigned to The University Hospital
  • Publication number: 20250046213
    Abstract: A bronchoscopy simulator includes: a main body part which is formed to be similar to the bronchial tree of the human body; and a bleeding producing part which is provided on the main body part to create a situation where bleeding occurs bronchial tree inside the main body part, thereby enabling practice of a response process for bleeding situations occurring during bronchoscopy. A control method for the bronchoscope simulator, includes: a bleeding occurrence step in which bleeding occurs inside a main body part by a bleeding simulation part; and a bleeding stop step, after hemostasis responding to the bleeding is performed, in which the bleeding is stopped by the bleeding simulation part.
    Type: Application
    Filed: January 11, 2024
    Publication date: February 6, 2025
    Applicants: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION, PUSAN NATIONAL UNIVERSITY HOSPITAL
    Inventors: Hee Yun SEOL, Seo rin KIM, Seok Young AHN, Hwan Yi JOO, Joon Ho MOON, Jae Young KIM, Moon Chae KIM
  • Publication number: 20250046214
    Abstract: A manufacturing method of a bronchoscopy simulator, includes: a base part printing step in which a base part is printed by a 3D printer; a plastic dipping step in which plastic dipping is applied to the outside of the base part; a through-hole forming step in which a through-hole is formed in the base part; and a liquid passing step in which liquid passes through the through-hole to melt away only the base part while leaving the plastic dipping intact.
    Type: Application
    Filed: January 11, 2024
    Publication date: February 6, 2025
    Applicants: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION, PUSAN NATIONAL UNIVERSITY HOSPITAL
    Inventors: Hee Yun SEOL, Seo rin Kim, Seok Young Ahn, Hwan Yi Joo, Joon Ho Moon, Jae Young Kim, Moon Chae Kim
  • Patent number: 12217384
    Abstract: A method for spatial resolution enhanced imaging is provided. The method includes determining a target region of a subject being imaged; estimating an achievable spatial resolution; selecting an increased spatial resolution that is greater than a predetermined spatial resolution and equal to or less than the achievable spatial resolution; and acquiring image data of the target region with the increased spatial resolution. A method for enhancing the contrast between the region of interest and other tissue region in the image data acquired with the increased spatial resolution and other tissue region in image data acquired with the predetermined spatial resolution due to the intrinsic partial volume effect is also provided.
    Type: Grant
    Filed: January 26, 2021
    Date of Patent: February 4, 2025
    Assignees: University of Cincinnati, Children's Hospital Medical Center
    Inventors: Jinghua Wang, Lili He
  • Publication number: 20250032015
    Abstract: A blood physiological parameter sensing device includes a housing, a flow channel structure, a control unit and a sensing unit. The flow channel structure is disposed in the housing and forms a channel for a liquid to be measured to pass. The control unit is disposed in the housing. The sensing unit is disposed in the housing, is electrically connected to the control unit, and has a sensing end. The sensing end passes through the flow channel structure, is configured in the channel, and has an electrochemical sensing material. The electrochemical sensing material is used to exchange electrons with the blood physiological parameter in the liquid to be measured to produce redox reactions to generate current or voltage change parameters. The sensing unit transmits the current or voltage change parameters to the control unit, which obtains a blood physiological parameter concentration value to achieve instantaneous and continuous monitor the patients.
    Type: Application
    Filed: July 22, 2024
    Publication date: January 30, 2025
    Applicants: National Taiwan University, National Taiwan University Hospital Hsin-Chu Branch, National Yang Ming Chiao Tung University
    Inventors: Yih-Sharng CHEN, Hsiao-En TSAI, Yu-Ting CHENG
  • Patent number: 12207939
    Abstract: A method or system for assessing a patient response to a cancer treatment is provided. The method or system includes acquiring at least one base-line radiological image related to a patient immediately before a treatment, acquiring at least one follow-up radiological image during or after the treatment at a predetermined time interval, estimating a first number of specific tumor cells in a region of interest of the patient based on image features of the base-line radiological image using an algorithm or a model, estimating a second number of specific tumor cells in the region of interest of the patient based on image features of the follow-up radiological image using the algorithm or the model, obtaining a difference between the first number of specific tumor cells and the second number of specific tumor cells, and classifying a treatment response to a cancer based on the difference.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: January 28, 2025
    Assignees: University of Cincinnati, Children's Hospital Medical Center
    Inventors: Jinghua Wang, Lili He
  • Patent number: 12202202
    Abstract: A personalized naturally designed mitral valve prosthesis and a method for manufacturing the such to precisely fit a specific patient for which the valve prosthesis is made for, is provided. The method includes measuring size and shape of a mitral valve of the specific patient by using imaging means, building a 3D model of the personalized mitral valve prosthesis, optimizing the 3D model using FEM method and fabricating the personalized mitral valve prosthesis by cutting and connecting the annular ring, leaflets and chords to form a personalized prosthesis mitral valve.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: January 21, 2025
    Assignees: NATIONAL UNIVERSITY OF SINGAPORE, NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD
    Inventor: Theodoros Kofidis
  • Patent number: 12193741
    Abstract: An example method includes establishing a wireless link between a mobile device and an optical coherence tomography (OCT) test system, which includes a wireless interface. The method also includes executing an application on the mobile device to present a graphical user interface on a display of the mobile device. The method also includes sending instructions from the mobile device through the wireless link to activate the OCT test system to record OCT measurements for an OCT scan of at least one eye. The method also includes receiving OCT test data at the mobile device from the OCT test system through the wireless link. The OCT test data can represent the OCT measurements recorded by the OCT test system for the OCT scan of the at least one eye.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: January 14, 2025
    Assignees: CASE WESTERN RESERVE UNIVERSITY, UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS
    Inventors: Warren M. Sobol, Alan Dogan, Ellis Saupe
  • Patent number: 12186240
    Abstract: The present invention provides an inpatient unit of modular design, built of recycled materials and environmentally friendly materials, allowing reconfiguration, redeployment and quick assembly, preventing indoor air from leaking, applicable to epidemic prevention and treating special patients, with high structural strength, lower cost and good environmental benefit.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: January 7, 2025
    Assignee: FU JEN CATHOLIC UNIVERSITY HOSPITAL, FU JEN CATHOLIC UNIVERSITY
    Inventors: Han-Sun Chiang, Ching-Chuan Jiang, Heng-Tai Chao, Wei-Lun Liu, Yi-Jen Jiang, Shiau-Jiun Lai, Heng-Lang Lin, Po-Jui Yu, Chin-Yu Hsieh, Chia-Jung Tsai, Yu-Hsuan Wu
  • Patent number: 12181386
    Abstract: The present disclosure relates to an optical clearing method called lipid-preserving index matching for prolonged imaging depth (LIMPID). The optical clearing method can include simply immersing a sample in an optical clearing solution before imaging (e.g., with microscopy or optical coherence tomography). The optical clearing solution can include water; an iodine-containing non-ionic radiocontrast agent; and urea.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: December 31, 2024
    Assignees: CASE WESTERN RESERVE UNIVERSITY, UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER, VANDERBILT UNIVERSITY
    Inventors: Michael W. Jenkins, Yehe Liu
  • Patent number: 12168005
    Abstract: The invention provides methods of treating cancer characterized by the presence of one or both of wild type isocitrate dehydrogenase 1 (IDH1) gene and wild type IDH1 enzyme, by administering compounds that inhibit mutant IDH1 enzyme, such as Ivosidenib (AG-120, IVOSIDENIB®). The invention also provides cell-based methods for determining anti-cancer activity of test compounds under in vitro conditions of low concentrations of magnesium ion and/or glucose.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: December 17, 2024
    Assignee: UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER
    Inventor: Jordan M. Winter
  • Publication number: 20240389952
    Abstract: A continuous arterial blood pressure monitoring system includes a data receiving unit that receives a photoplethysmography measurement value and a non-invasive blood pressure measurement value, a photoplethysmography analysis unit that acquires a primary arterial blood pressure waveform from the photoplethysmography measurement value using a first learning model, a derived variable extraction unit that extracts a derived variable using the non-invasive blood pressure measurement value, a non-invasive blood pressure analysis unit that inputs the derived variable and the non-invasive blood pressure measurement value to a second learning model and extracts a second feature value, a blood pressure waveform prediction unit that inputs the primary arterial blood pressure waveform and the second feature values to a third learning model, and predicts the continuous arterial blood pressure waveform, and a blood pressure state prediction unit that predicts the blood pressure state of a patient using the continuous arte
    Type: Application
    Filed: May 20, 2024
    Publication date: November 28, 2024
    Applicant: SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventors: Hyung-Chul LEE, Hyeonhoon LEE
  • Patent number: 12152011
    Abstract: The present invention relates to a novel Usnic acid derivative exhibiting an inhibitory effect on TSLP secretion or pharmaceutically acceptable salts thereof, and a use thereof.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: November 26, 2024
    Assignee: SEOUL NATIONAL UNIVERSITY HOSPITAL
    Inventors: Chan Yeong Heo, So Min Kang, Da Som Jeon
  • Publication number: 20240374726
    Abstract: A BAG6 specific chimeric antigen receptor, a nucleic acid, a BAG6 specific chimeric antigen receptor expression plasmid, a BAG6 specific chimeric antigen receptor expressing cell, a pharmaceutical composition for treating cancer, and use of the BAG6 specific chimeric antigen receptor expressing cell are provided. The BAG6 specific chimeric antigen receptor specifically binds to BCL2 associated athanogene 6 (BAG6). The nucleic acid encodes the BAG6 specific chimeric antigen receptor. The BAG6 specific chimeric antigen receptor expression plasmid expresses the BAG6 specific chimeric antigen receptor. The BAG6 specific chimeric antigen receptor expressing cell is obtained by transducing the BAG6 specific chimeric antigen receptor into an immune cell. The pharmaceutical composition for treating cancer includes the BAG6 specific chimeric antigen receptor expressing cell and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: May 3, 2024
    Publication date: November 14, 2024
    Applicant: China Medical University Hospital
    Inventors: Der-Yang Cho, Shao-Chih Chiu, Chia-Ing Jan, Chih-Ming Pan, Shi-Wei Huang
  • Patent number: 12133802
    Abstract: Disclosed is a method for forming an orthopaedic implant. The method comprises determining one or more parameters of a bone, of a subject, to which the implant is to be attached, and calculating specifications based on parameters. That calculation includes calculating a mechanical property relating to elasticity of the implant, a length of the implant, and positions of two or more fixation locations by which to fix the implant to the bone. The method further comprises forming the implant based on the specifications, wherein each fixation location comprises a longitudinal axis through the implant, and calculating specifications comprises calculating a trajectory for the longitudinal axis of the respective fixation location.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: November 5, 2024
    Assignees: National University of Singapore, National University Hospital (Singapore) Pte Ltd
    Inventors: Gavin Kane O'Neill, Lina Yan
  • Publication number: 20240362242
    Abstract: Provided are a method and apparatus for proposing a solution, based on a survey. The method includes storing indicators in a data format in a database, wherein each of the indicators is transformed from a pattern of responses of respondents related to an issue, transforming a response of a user to the survey to a patterned response, the patterned response in the data format, selecting an indicator to be compared with the patterned response among the indicators, the indicators and the patterned response are being in the same data format, determining one or more issues, based on a comparison of the patterned response and the selected indicator, determining a proposal solution set, based on the one or more issues, and displaying the one or more issues and the proposal solution set on a device of the user.
    Type: Application
    Filed: April 25, 2024
    Publication date: October 31, 2024
    Applicants: SEOUL NATIONAL UNIVERSITY HOSPITAL, INVITES BIOCORE CO., LTD.
    Inventor: Ju Won LIM
  • Publication number: 20240352530
    Abstract: Disclosed herein is a method for determining whether a subject is suffering from, or is at risk of developing breast cancer, wherein the method comprises detecting differential expression levels of at least two or more miRNA markers from a biological sample. Also disclosed herein is a method of determining whether a subject is suffering from, or is at risk of developing, breast cancer based on miRNA expression.
    Type: Application
    Filed: August 2, 2022
    Publication date: October 24, 2024
    Applicants: National University of Singapore, Singapore Health Services Pte. Ltd., MiRXES Lab Pte. Ltd., National University Hospital (Singapore) Pte. Ltd.
    Inventors: Mikael Hartman BO ANDERS, Heng-Phon TOO, Siew Gek Ann LEE-LIM, Ruiyang ZOU, Lihan ZHOU, He CHENG
  • Publication number: 20240350008
    Abstract: A system and method for measuring intraocular pressure (IOP) of the eye. The method 5 comprises the steps of touching the eyelid with a pressure sensor array; obtaining a spatiotemporal representation of pressure sensor stimulation of the pressure sensor array while touching the eyelid with the pressure sensor array; and applying a machine learning model to classify the spatiotemporal representation into an IOP value.
    Type: Application
    Filed: August 22, 2022
    Publication date: October 24, 2024
    Applicants: NATIONAL UNIVERSITY OF SINGAPORE, NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD
    Inventors: Chee Keong TEE, Kelu YU, Si LI, Victor KOH, Kwok Hung LEE
  • Patent number: 12121740
    Abstract: A system for inducing synthesis of Vitamin D in a body includes a wearable illumination device formed in a structure that is wearable on the body, and including a plurality of light sources configured to radiate an ultraviolet light to a skin of a worn part; and a control device connected to the plurality of light sources and configured to drive the plurality of light sources to radiate the ultraviolet light, wherein the wearable illumination device includes a light diffusion panel configured to equalize an irradiance of the ultraviolet light reaching the skin by causing diffusion of the ultraviolet light radiated from the plurality of light sources.
    Type: Grant
    Filed: January 28, 2022
    Date of Patent: October 22, 2024
    Assignees: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, SEOUL NATIONAL UNIVERSITY HOSPITAL, GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Seunghyup Yoo, Jaehyeok Park, Hanul Moon, Sunhyoung Koo, Changhun Seok, Dongho Choi, Hyuk Joo Lee, In-Young Yoon, Jun Seok Ahn, Ji Su Choi, Jung Kyung Hong, Tae Kim, Jiseung Kang, Jieun Jung
  • Publication number: 20240341708
    Abstract: Provided is a method for providing the information for diagnosing nonalcoholic steatohepatitis.
    Type: Application
    Filed: March 25, 2024
    Publication date: October 17, 2024
    Applicant: CHUNGNAM NATIONAL UNIVERSITY HOSPITAL
    Inventors: Hyuk Soo EUN, Hong Jae JEON, Ha Neul KIM
  • Patent number: 12115312
    Abstract: A securement device for a protruding oral or nasal device includes a continuous strip extending along a longitudinal axis between a first end and a second end. The continuous strip has a first anchor portion at the first end, a second anchor portion at the second end, a first bridge portion, a second bridge portion, and an adhesive for affixing the strip to a patient. The first bridge portion is disposed between the first anchor portion and the second bridge portion, the second bridge portion is disposed between the first bridge portion and the second anchor portion, the second bridge portion extends at an angle relative to the longitudinal axis. The first anchor portion and the second anchor portion are offset from one another relative to the longitudinal axis.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: October 15, 2024
    Assignee: LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST
    Inventors: Matthew John Cullinane, Robert Brothwood