Abstract: The present disclosure relates to an optical clearing method called lipid-preserving index matching for prolonged imaging depth (LIMPID). The optical clearing method can include simply immersing a sample in an optical clearing solution before imaging (e.g., with microscopy or optical coherence tomography). The optical clearing solution can include water; an iodine-containing non-ionic radiocontrast agent; and urea.

Abstract: The invention provides methods of treating cancer characterized by the presence of one or both of wild type isocitrate dehydrogenase 1 (IDH1) gene and wild type IDH1 enzyme, by administering compounds that inhibit mutant IDH1 enzyme, such as Ivosidenib (AG-120, IVOSIDENIB®). The invention also provides cell-based methods for determining anti-cancer activity of test compounds under in vitro conditions of low concentrations of magnesium ion and/or glucose.

Abstract: A continuous arterial blood pressure monitoring system includes a data receiving unit that receives a photoplethysmography measurement value and a non-invasive blood pressure measurement value, a photoplethysmography analysis unit that acquires a primary arterial blood pressure waveform from the photoplethysmography measurement value using a first learning model, a derived variable extraction unit that extracts a derived variable using the non-invasive blood pressure measurement value, a non-invasive blood pressure analysis unit that inputs the derived variable and the non-invasive blood pressure measurement value to a second learning model and extracts a second feature value, a blood pressure waveform prediction unit that inputs the primary arterial blood pressure waveform and the second feature values to a third learning model, and predicts the continuous arterial blood pressure waveform, and a blood pressure state prediction unit that predicts the blood pressure state of a patient using the continuous arte

Abstract: The present invention relates to a novel Usnic acid derivative exhibiting an inhibitory effect on TSLP secretion or pharmaceutically acceptable salts thereof, and a use thereof.

Abstract: A BAG6 specific chimeric antigen receptor, a nucleic acid, a BAG6 specific chimeric antigen receptor expression plasmid, a BAG6 specific chimeric antigen receptor expressing cell, a pharmaceutical composition for treating cancer, and use of the BAG6 specific chimeric antigen receptor expressing cell are provided. The BAG6 specific chimeric antigen receptor specifically binds to BCL2 associated athanogene 6 (BAG6). The nucleic acid encodes the BAG6 specific chimeric antigen receptor. The BAG6 specific chimeric antigen receptor expression plasmid expresses the BAG6 specific chimeric antigen receptor. The BAG6 specific chimeric antigen receptor expressing cell is obtained by transducing the BAG6 specific chimeric antigen receptor into an immune cell. The pharmaceutical composition for treating cancer includes the BAG6 specific chimeric antigen receptor expressing cell and a pharmaceutically acceptable carrier.

Abstract: Disclosed is a method for forming an orthopaedic implant. The method comprises determining one or more parameters of a bone, of a subject, to which the implant is to be attached, and calculating specifications based on parameters. That calculation includes calculating a mechanical property relating to elasticity of the implant, a length of the implant, and positions of two or more fixation locations by which to fix the implant to the bone. The method further comprises forming the implant based on the specifications, wherein each fixation location comprises a longitudinal axis through the implant, and calculating specifications comprises calculating a trajectory for the longitudinal axis of the respective fixation location.

Abstract: Provided are a method and apparatus for proposing a solution, based on a survey. The method includes storing indicators in a data format in a database, wherein each of the indicators is transformed from a pattern of responses of respondents related to an issue, transforming a response of a user to the survey to a patterned response, the patterned response in the data format, selecting an indicator to be compared with the patterned response among the indicators, the indicators and the patterned response are being in the same data format, determining one or more issues, based on a comparison of the patterned response and the selected indicator, determining a proposal solution set, based on the one or more issues, and displaying the one or more issues and the proposal solution set on a device of the user.

Abstract: Disclosed herein is a method for determining whether a subject is suffering from, or is at risk of developing breast cancer, wherein the method comprises detecting differential expression levels of at least two or more miRNA markers from a biological sample. Also disclosed herein is a method of determining whether a subject is suffering from, or is at risk of developing, breast cancer based on miRNA expression.

Abstract: A system and method for measuring intraocular pressure (IOP) of the eye. The method 5 comprises the steps of touching the eyelid with a pressure sensor array; obtaining a spatiotemporal representation of pressure sensor stimulation of the pressure sensor array while touching the eyelid with the pressure sensor array; and applying a machine learning model to classify the spatiotemporal representation into an IOP value.

Abstract: A system for inducing synthesis of Vitamin D in a body includes a wearable illumination device formed in a structure that is wearable on the body, and including a plurality of light sources configured to radiate an ultraviolet light to a skin of a worn part; and a control device connected to the plurality of light sources and configured to drive the plurality of light sources to radiate the ultraviolet light, wherein the wearable illumination device includes a light diffusion panel configured to equalize an irradiance of the ultraviolet light reaching the skin by causing diffusion of the ultraviolet light radiated from the plurality of light sources.

Abstract: Provided is a method for providing the information for diagnosing nonalcoholic steatohepatitis.

Abstract: A securement device for a protruding oral or nasal device includes a continuous strip extending along a longitudinal axis between a first end and a second end. The continuous strip has a first anchor portion at the first end, a second anchor portion at the second end, a first bridge portion, a second bridge portion, and an adhesive for affixing the strip to a patient. The first bridge portion is disposed between the first anchor portion and the second bridge portion, the second bridge portion is disposed between the first bridge portion and the second anchor portion, the second bridge portion extends at an angle relative to the longitudinal axis. The first anchor portion and the second anchor portion are offset from one another relative to the longitudinal axis.

Abstract: Embodiments relate to a system and method for electrocardiogram image-based patient evaluation, wherein: a source electrocardiogram image of a target patient is acquired by a user terminal; a server is requested by the user terminal to evaluate the target patient, the request including the source electrocardiogram image; electrocardiogram image-based evaluation information of the patient is generated by the server, the evaluation information of the target patient is transmitted to the user terminal; and reported feedback based on the evaluation information of the target patient is provided by the user terminal.

Abstract: An intervertebral fusion cage is disclosed. An intervertebral fusion cage according to an embodiment of the present invention comprises: a body including a receiving part of which upper and lower portions are open, an upper guide part, and a lower guide part; a moving member disposed in the receiving part; a screw which is screw-coupled to the body and moves forwards or backwards relative to the body integrally with the moving member when rotating; an upper plate which has a guided part guided by the upper guide part and is disposed above the body while being engaged with the moving member; and a lower plate which has a guided part guided by the lower guide part and is disposed under the body while being engaged with the moving member.

Abstract: Systems and methods are provided for assessing microvascular dysfunction of a patient. A series of images is acquired of a region of interest within the body of the patient. An imaging-derived index of microcirculatory resistance is determined from the series of images. A clinical parameter representing microvascular dysfunction is assigned to the patient via a predictive model according to at least the imaging-derived index of microcirculatory resistance.

Abstract: A surgical cutting tool for keyhole surgery comprises: a handle 2 at a proximal end of the tool; an elongate member 4 extending from the handle to a distal end of the tool; and a saw 6 at the distal end of the tool, the saw being supported by the elongate member 4. The elongate member 4 has a length allowing for insertion of the saw 6 into the body by a distance of at least 150 mm. The tool is arranged for insertion of the saw 6 into the body during keyhole surgery; and the saw 6 is able to cut bone when pressed against the bone.

Abstract: The present invention relates to isolated and engineered human antibodies that specifically bind to at least one conformational (non-linear) epitope of HBsAg and neutralize hepatitis B virus infection, methods for producing the same, and uses thereof in treating human HBV infection.

Abstract: The disclosure provides an eye state assessment method and an electronic device. The method includes: obtaining an optic disc image area from a first fundus photography and generating multiple optic cup-to-disc ratio assessment results by multiple first models based on the optic disc image area; obtaining a first assessment result of an eye based on the optic cup-to-disc ratio assessment results; performing multiple data augmentation operations on the first fundus photography to generate multiple second fundus photographies; generating multiple retinal nerve fiber layer (RNFL) defect assessment results by multiple second models based on the second fundus photographies; obtaining a second assessment result of the eye based on the RNFL defect assessment results; and obtaining an optic nerve assessment result of the eye based on the first assessment result and the second assessment result.

Abstract: An anti-fibrosis pharmaceutical composition and application thereof. The anti-fibrosis pharmaceutical composition specifically comprises: (a) an NRP1 inhibitor and/or an HIF2? inhibitor; and (b) an EPCR pathway activator that promotes the activity of an EPCR pathway. The anti-fibrosis pharmaceutical composition helps reduce organ fibrosis to a certain extent and promotes corresponding organ repair and regeneration.

Abstract: A method of treating and/or preventing Dravet Syndrome in a patient such as a patient previously diagnosed with Dravet Syndrome, by administering an effective dose of fenfluramine or its pharmaceutically acceptable salt to that patient. Dravet Syndrome patients are typically children under the age of 18 and are treated at a preferred dose of less than about 0.5 to about 0.01 mg/kg/day.