Abstract: Methods and apparatus for the in vitro modelling of changes that occur on administration of a drug formulation are described, in particular for studying the changes that take place on administration of protein or peptide drug formulations by subcutaneous injection.

Abstract: The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.

Abstract: The invention provides orvinol and thevinol compounds useful for the treatment of drug and alcohol abuse, the compounds being particularly useful for the prevention of relapse in recovering addicts.

Abstract: The invention provides vesicles that may be used in diagnosing infection, especially with infection by bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. The vesicles can be used in wound dressings.

Abstract: The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes, domain specific modulators, pharmaceutical compositions and uses of the N-domain crystal and the structure co-ordinates thereof.

Abstract: The invention relates to compositions having RGS (regulator of G-protein Signaling) inhibiting activity, and methods of use thereof. In some embodiments, RGS-inhibiting compositions find use in research on or treatment of disease states (e.g., diabetes, epilepsy, neuropathic pain, depression and other diseases).

Abstract: The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes, domain specific modulators, pharmaceutical compositions and uses of the N-domain crystal and the structure co-ordinates thereof.

Abstract: A hollow fibre containing one or more layers having a mean pore size in one or more of said layers of less than 100?m. The invention also extends to a method for preparing porous hollow fibres and to the apparatus for preparing said fibres.

Abstract: The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of the ACE crystal and the structure co-ordinates thereof.

Abstract: There is provided a compound having Formula I wherein each of R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from (a) H, (b) R13, —OC(R13)3, —OCH(R13)2, —OCH2R13, C(R13)3, —CH(R13)2, or —CH2R13 wherein R13 is a halogen; (c) —CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (l) aryloxy; (m) —SO2-alkyl; and (n) —N(R14)C(O)R15, wherein R14 and R15 are independently selected from H and hydrocarbyl, wherein the optional substituents of (d) (e) (f) (h) and (i) are selected from the group consisting of: C1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, C1-6 alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; wherein n and p are independently selected from 0 and 1; X is an optional group selected from O, S, S=0

Abstract: This invention relates to a method for modifying cell proliferation in a plant which comprises the step of transforming a plant, or plant propagating material, with a nucleic acid molecule comprising at least one regulatory sequence capable of directing expression within the integuments and/or seed coat and at least one nucleic acid sequence whose expression or transcription product is capable of directly or indirectly modulating cell proliferation, whereby on expression of that nucleic acid sequence cell proliferation is modified. The invention also relates to a plant which includes a nucleic acid molecule comprising at least one regulatory sequence capable of directing expression within integuments and/or seed coat an at least one nucleic acid sequence whose expression or transcription product is capable of directly or indirectly modulated cell proliferation, whereby on expression of that nucleic acid sequence cell proliferation is modified.

Abstract: A biocompatible electrode formed from an integrated circuit, the electrode comprising: a semiconductor substrate; and an electrode layer at least partially comprising porous valve metal oxide.

Abstract: A method of fabricating a bone substitute material comprises the steps of providing a foam material (3) having an open cell structure, distorting the shape of the foam material (3) and holding the material in a distorted shape, coating the walls of the cells of the foam material with a ceramic slip (5), removing the foam material, and sintering the ceramic slip to form a bone substitute material that is approximately a positive image of the distorted foam material (3). In another method, a granular bone material is formed from a multiplicity of pieces of foam that are not distorted.

Abstract: An optical assembly includes a gas cell and an optical fiber portion in which the gas cell is contiguously attached to the optical fiber portion. The gas cell can be made, for example from hollow-core photonic crystal fiber (HC-PCF).

Abstract: An optical fibre is provided having a fibre cladding around a longitudinally extending optical propagation core. The cladding has a reflection region of a varying refractive index in the longitudinal direction.

Abstract: A joint part (1) has a porous portion (2) that is defined by a multiplicity of solid regions where material is present and a remaining multiplicity of pore regions where material is absent, the locations of at least most of the multiplicity of solid regions being defined by one or more mathematical functions. The nature of the porous portion can be varied systematically by changing one or more constants in the mathematical functions and the part is made by a process of solid freeform fabrication.

Abstract: An optical assembly includes a gas cell and an optical fibre portion in which the gas cell is contiguously attached to the optical fibre portion. The gas cell can be made, for example from hollow-core photonic crystal fibre (HC-PCF).

Abstract: The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of ACE crystal and the structure coordinates thereof.

Abstract: A hollow core photonic crystal fibre (HCPCF) having a wavelength of operation, the HCPCF comprising: a core region having a first refractive index; a cladding region surrounding the core region and comprising a plurality of microcapillaries arranged in a transverse structure having a pitch, the pitch of the structure being at least five times larger than the wavelength of operation, the cladding region having a second refractive index higher than the first refractive index.

Abstract: A method for controlling endosperm size and development in plants. The method employs nucleic acid constructs encoding proteins involved in genomic imprinting, in the production of transgenic plants. The nucleic acid constructs can be used in the production of transgenic plants to affect interspecific hybridisation.