Abstract: Systems and methods for distracted driving detection are described. A method includes receiving proximate vehicle data about a proximate vehicle proximate to the host vehicle. The method also includes estimating one or more baselines for a predetermined future time for the proximate vehicle from the proximate vehicle data. The method further includes comparing current kinematic data of the proximate vehicle data for the predetermined future time to the one or more baselines. The method includes generating distraction flags associated with the proximate vehicle based on the comparison. The method also includes controlling one or more vehicle systems of the host vehicle based on the generated distraction flags.

Abstract: An in-memory computing system for computing vector-matrix multiplications includes an array of resistive memory devices arranged in columns and rows, such that resistive memory devices in each row of the array are interconnected by a respective word line and resistive memory devices in each column of the array are interconnected by a respective bitline. The in-memory computing system also includes an interface circuit electrically coupled to each bitline of the array of resistive memory devices and computes the vector-matrix multiplication between an input vector applied to a given set of word lines and data values stored in the array. For each bitline, the interface circuit receives an output in response to the input being applied to the given wordline, compares the output to a threshold, and increments a count maintained for each bitline when the output exceeds the threshold. The count for a given bitline represents a dot-product.

Abstract: The present disclosure provides compounds of Formula (I-A) for inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compounds are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.

Abstract: Provided herein are methods and systems for the analysis of biomarkers, and methods of providing diagnoses and/or prognoses therewith. In particular, methods and systems for performing biomarker ratio imaging microscopy (BRIM) are provided, as well as methods of using BRIM for the analysis of biomarker pairs (e.g., CD44/CD24, N-cadherin/E-cadherin, CD74/CD59, etc.) diagnosis and/or prognosis of cancer (e.g., ductal carcinoma in situ).

Abstract: A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.

Abstract: A computing system architecture is presented for decoupling execution of workload by crossbar arrays and similar memory modules. The computing system includes: a data bus; a core controller connected to the data bus; and a plurality of local tiles connected to the data bus. Each local tile in the plurality of local tiles includes a local controller and at least one memory module, where the memory module performs computation using the data stored in memory without reading the data out of the memory.

Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free 3-dimensional engineered tendon constructs.

Abstract: Gyroscopes are sensors that measure angular rate and angular orientation. A three-dimensional fused silica micro shell rate-integrating gyroscope is presented. One aspect of the gyroscope includes the use of optical sensors to detect motion of the resonator. The proposed gyroscope is attractive because it achieves several magnitudes higher accuracy as well as high vibration and shock insensitivity from a novel resonator design as well as other unique manufacturing processes.

Abstract: A reference electrode includes a metal body, a lead disposed within the metal body, an insulator disposed between the lead and the metal body, the insulator including a ceramic material, and a porous metal chamber coupled to the metal body, the lead extending into the porous metal chamber. The porous metal chamber is configured to maintain an electrolyte solution within the porous metal chamber to establish a redox couple with the lead.

Abstract: The present disclosure provides fused 1,4-oxazepines and related analogs represented by Formula (I) and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, R4, R5, A, and Y are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a condition or disorder responsive to inhibition of BET bromodomains such as cancer.

Abstract: An organic vapor deposition device comprises a print head, comprising a source channel, in fluid communication with a flow of carrier gas and a quantity of organic source material configured to mix with the carrier gas, a nozzle having a deposition outlet, in fluid communication with the source channel, and a shutter configured at least to open and close the deposition outlet, wherein the print heat is configured to allow the flow of carrier gas and the organic source material exit the deposition outlet when the shutter is in an open position, and to prevent the flow of carrier gas and the organic source material from exiting the deposition outlet when the shutter is in a closed position. A method of manufacturing a device comprising an organic feature on a substrate is also described.

Abstract: A printer is configured to provide a jet of extraction gas that extracts a printing fluid from a printing nozzle in the presence of an electric field that accelerates the extracted printing fluid toward a printing substrate. The printer is also configured to selectively turn the electric field and the jet of extraction gas off and on to enable printing in gas-extraction mode, an e-assisted gas-extraction mode, or an e-jet mode. The jet of gas can be provided by a second nozzle concentric with the printing nozzle. A third nozzle can discharge a focusing gas around the extracted printing fluid.

Abstract: An apparatus for light detection includes a light, or photon, detector assembly and a dielectric resonator layer coupled to the detector assembly. The dielectric resonator layer is configured to receive transmission of incident light that is directed into the detector assembly by the dielectric resonator layer. The dielectric resonator layer resonates with a range of wavelengths of the incident light.

Abstract: The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compositions and methods of use are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.

Abstract: Provided is a bioink comprising a mixture comprising a collagen and a polysaccharide, and a polyhedral oligomeric silsesquioxane (POSS), a hydrogel matrix formed from a bioink comprising a mixture comprising a collagen and a polysaccharide, and a polyhedral oligomeric silsesquioxane (POSS), a 3D biomaterial scaffold comprising a hydrogel matrix of the disclosure as a first hydrogel layer and a hydrogel matrix of the disclosure as a second hydrogel layer, optionally having an intervening layer between the first hydrogel layer and the second hydrogel layer, and methods of forming and using same.

Abstract: Encapsulation packages for stent-deployable monitoring devices formed of resonator sensors and allowing for magnetic biasing elements that exhibit a targeted impact on the mechanical characteristics of a stent are provided. Encapsulation packages are formed of different types and include a longitudinal shield and curved end on profile for aligning the shield within the deployable stent, the shield having perforations such that a resonator can be positioned adjacent the perforations for allowing particulate within the stent to collect and be measured by the resonator during deployment.

Abstract: A method of predicting a mood state of a user may include recording an audio sample via a microphone of a mobile computing device of the user based on the occurrence of an event, extracting a set of acoustic features from the audio sample, generating one or more emotion values by analyzing the set of acoustic features using a trained machine learning model, and determining the mood state of the user, based on the one or more emotion values. In some embodiments, the audio sample may be ambient audio recorded periodically, and/or call data of the user recorded during clinical calls or personal calls.

Abstract: A gas chromatography device for peak focusing of one or more target analytes is provided that include a chromatographic column with an inlet and an outlet. A stationary phase is deposited inside the chromatographic column and has a positive thickness gradient. The stationary phase extends from the inlet to the outlet and has a first thickness at the inlet of the chromatographic column and a second thickness at the outlet of the chromatographic column. The second thickness is at least about 10% greater than the first thickness. Methods of peak focusing in a gas chromatography device, method of verifying peak focusing in a gas chromatography device and creating a gas chromatography device having a chromatographic column with a positive thickness gradient are also provided.

Abstract: A number of new solutions for enhancing the extraction of waveguided mode and suppressing surface plasmon polariton mode in OLEDs are disclosed.

Abstract: The present disclosure relates to compound parabolic concentrators. In one implementation, a compound parabolic concentrator may include a parabolic array having a base, a side wall, and an aperture for receiving light and a dielectric layer having a refractive index. In another implementation, a stacked compound parabolic concentrator may include a parabolic array having a base, a side wall, and an aperture for receiving light and multiple dielectric layers within the array. Each dielectric layer may have a refractive index, and the refractive index may decrease with each dielectric layer moving from the base of the parabolic array to the light receiving aperture.