Abstract: Aspects of the subject disclosure may include, for example, obtaining and decoding a video file to obtain raw frames, providing the raw frames to the virtual camera that generates video content from the raw frames, providing the video content to a broadcasting application on a first communication device that provides output frames, and providing network conditions that are applied to the output frames resulting in conditioned output frames. The conditioned output frames are provided to a video content server from the first communication device, the video content server provides ABR tracks to a second communication device, the ABR tracks are associated with the conditioned output frames in response to receiving requests for the ABR tracks. Also, embodiments include obtaining and analyzing the conditioned output frames, the ABR tracks, and the requests, and generating metrics associated with the broadcasting application based on the analysis. Other embodiments are disclosed.

Abstract: A number of new solutions for enhancing the extraction of waveguided mode and suppressing surface plasmon polariton mode in OLEDs are disclosed. For example, an OLED is disclosed that includes: a substrate having a first side and a second side; a reflective layer disposed over the first side of the substrate; a grid layer consisting of two optically transparent materials with different refractive indices disposed on the reflective layer; a transparent first electrode provided over the grid layer; an organic emissive layer provided over the transparent first electrode; and a transparent second electrode provided over the organic emissive layer, where the grid layer scatters trapped waveguided modes from the organic emissive layer.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)—calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selectively inhibiting SE-CRT interactions and/or signal transduction pathways commonly overactive or dysregulated in arthritic and/or other diseases or conditions.

Abstract: An inflatable structure includes a top end cap, a bottom end cap, a bladder, a nozzle, a loop, and a first tether. The bladder is attached to the top and bottom end caps and is configured to hold pressurized fluid therebetween. The nozzle is configured to allow fluid to enter and exit the bladder. The loop is attached to one of the top and bottom end caps. A tether is disposed within the bladder, coupled to the other one of the top and bottom end caps, and extends through the at least one loop. The top end cap assumes a first position when the bladder is inflated. When the top end cap is adjusted from the first position to a second position, the first tether is configured to maintain the top end cap in the second position.

Abstract: A system for automatically analyzing a video recording of a colonoscopy includes a processor and memory storing instructions, which when executed by the processor, cause the processor to receive the video recording of the colonoscopy performed on the colon and detect informative frames in the video recording. A frame is informative if the clarity of the frame is above a threshold or if the frame includes clinically relevant information about the colon. The instructions cause the processor to generate scores indicating severity levels of a disease for a plurality of the informative frames, estimate locations of the plurality of the informative frames in the colon, and generate an output indicating a distribution of the scores over one or more segments of the colon by combining the scores generated for the plurality of the informative frames and the estimated locations of the plurality of the informative frames in the colon.

Abstract: A drug delivery system comprises a porous, self-healing biodegradable polymer matrix having a ionic, charged, biopolymer and a pH modifying species disposed within the pores. An ionic macromolecule having the opposite charge binds the biopolymer and forms a nonsoluble polyelectrolyte complex. The molecular weight of the biopolymer, the self healing polymer matrix, the concentration of pore forming agent and the concentration of the pH modifying species are selected for optimal binding and release of the macromolecule.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or a quinoline structure which function as dual inhibitors of EGFR proteins and PI3K proteins, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract: Organic photovoltaic cells (OPVs) and their compositions are described herein. In one or more embodiments, the acceptor with an active layer of an OPV includes is a non-fullerene acceptor. Such non-fullerene acceptors may provide improved OPV performance characteristics such as improved power conversion efficiency, open circuit voltage, fill factor, short circuit current, and/or external quantum efficiency. One example of a non-fullerene acceptor is (4,4,10,10-tetrakis(4-hexylphenyl)-5,11-(2-ethylhexyloxy)-4,10-dihydro-dithienyl[1,2-b:4,5b?] benzodi-thiophene-2,8-diyl) bis(2-(3-oxo-2,3-dihydroinden-5,6-dichloro-1-ylidene) malononitrile.

Abstract: Traditional speaker verification systems are vulnerable to voice spoofing attacks, such as voice-replay attack, voice-cloning attack, and cloned-replay attack. To overcome these vulnerabilities, a secure automatic speaker verification system based on a novel sign modified acoustic local ternary pattern (sm-ALTP) features and asymmetric bagging-based classifier-ensemble with enhanced attack vector is presented. The proposed audio representation approach clusters the high and low frequency components in audio frames by normally distributing them against a convex function. Afterwards, the neighborhood statistics are applied to capture the user specific vocal tract information.

Abstract: A method of treating a T-cell mediated disease in a subject by administering to the subject a therapeutically effective amount of an antibody or fragment thereof that specifically binds to CD6 is described. Humanized antibodies useful for the method are also described.

Abstract: Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.

Abstract: An imaging system for cell-based therapies is provided. The imagining system includes one or more optical tags configured for insertion into a cell or biological tissue, an excitation light source configured to illuminate the one or more optical tags; a detector configured to measure optical emission of the one or more optical tags; an imaging subsystem configured to determine a three-dimensional location of each of the one or more optical tags in the cell or biological tissue; and a controller in electrical communication with the excitation light source, the detector, and the imaging subsystem. Each of the one or more optical tags has a contrasting feature and includes a fluorescent material. The contrasting feature may be defined by at least one of a refractive index, shape, color, and laser emission of each optical tag of the one or more optical tags.

Abstract: The disclosure relates to bioreactors, for example for biological treatment and, more specifically to bioreactor insert apparatus including biofilms and related methods. The bioreactor insert apparatus provides a means for circulation of reaction medium within the bioreactor, a biofilm support, and biological treatment of an inlet feed to the reactor/insert apparatus. The bioreactor insert apparatus has a high relative surface area for biofilm attachment and is capable of generating complex flow patterns and increasing treatment efficiency/biological conversion activity in a biologically-active reactor. The high surface area structure incorporates multiple biofilm support structures such as meshes at inlet and outlet portions of the structure. The biofilm support structures and biofilms thereon can increase overall reaction rate of the bioreactor and/or perform some solid/liquid separation in the treatment of the wastewater or other influent.

Abstract: A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems.

Abstract: A vehicle power system includes a coil that, in a first operational mode, receives power wirelessly from an external source, a first battery connected to the coil to receive power transferred from the coil while the coil is in the first operational mode, a second battery that receives power from the first battery, and a switch that switches the coil between the first operational mode and a second operational mode in which the coil receives power from the second battery and wirelessly transfers power from the second battery to an electrical load in the vehicle.

Abstract: Organic photovoltaic cells (OPVs) and their compositions are described herein. one or more embodiments, the acceptor with an active layer of an OPV includes is a non-fullerene acceptor. Such non-fullerene acceptors may provide improved OPV performance characteristics such as improved power conversion efficiency, open circuit voltage, fill factor, short circuit current, and/or external quantum efficiency.

Abstract: A method is presented for mapping weights for kernels of a neural network onto a crossbar array. In one example, the crossbar array is comprised of an array of non-volatile memory cells arranged in columns and rows, such that memory cells in each row of the array is interconnected by a respective drive line and each column of the array is interconnected by a respective bit line; and wherein each memory cell is configured to receive an input signal indicative of a multiplier and operates to output a product of the multiplier and a weight of the given memory cell onto the corresponding bit line of the given memory cell, where the value of the multiplier is encoded in the input signal and the weight of the given memory cell is stored by the given memory cell.

Abstract: A method is presented for measuring motion of a moving body using an atom interferometer. The method includes: positioning at least one atom in a cavity of the atom interferometer, where the atom interferometer is attached to the moving body; splitting the at least one atom into a pair of wave-function components; guiding the pair of wave-function components along respective paths in the cavity such that the pair of wave-function components are confined spatially along the respective paths in all degrees of freedom and without interruption; coherently recombining the pair of wave-function components into the at least one atom; and measuring a property of the at least one atom after the pair of wave-function components have been recombined into the at least one atom, where the property of the at least one atom is indicative of motion of the moving body.

Abstract: A method of predicting patient deterioration includes receiving an electronic health record data set of the patient, determining a risk score corresponding to the patient by analyzing the electronic health record data set of the patient using a trained machine learning model, determining a threshold value using an online/reinforcement learning model, comparing the risk score to the threshold value, and when the risk score exceeds the threshold value, generating an alarm. A non-transitory computer readable medium includes program instructions that when executed, cause the computer to receive a list of patients, display selectable patient information corresponding to each of the list of patients according to an ordering established by a feature importance algorithm, receive a selection, retrieve vital sign information corresponding to the selection, and display the vital sign information.

Abstract: An automated microfluidic bioreactor device and methods to rapidly detect drugs of abuse from human sweat are provided. The bioreactor can perform either single-plexed measurements (detecting only one target analyte at a time) or multiplexed measurement (detecting multiple analytes simultaneously). The bioreactor device has a cartridge comprising a capillary array that employs competitive enzyme-linked immunosorbent assay (ELISA) to detect the presence of various drugs or metabolite compounds. For example, four common drugs, methadone, methamphetamine, amphetamine, and tetrahydrocannabinol, were detected rapidly and quantitatively in about 16 minutes with a low sweat sample volume (about 4 ?L per analyte) and a large dynamic range (methadone: 0.0016 ng/mL-1 ng/mL; METH: 0.016 ng/mL-25 ng/mL; amphetamine: 0.005 ng/mL-10 ng/mL; THC: 0.02 ng/mL-1000 ng/mL).