Abstract: Provided herein is technology relating to engineered tissues and particularly, but not exclusively, to methods, compositions, and systems for engineering a biosynthetic vascular network.

Abstract: An integrated vascular delivery system having a frame configured to receive a catheter insertable in a patient to deliver fluid at an insertion site. The frame includes a first hub, a second hub, and a pair of flexible lateral members extending between the hubs and including a tubular lateral member. The system also includes a fluidic channel that fluidically communicates with the catheter, wherein the fluidic channel passes through the tubular lateral member and at least one of the hubs, and includes a fixed turnabout portion in which fluid flows in a direction different from that within the catheter. The first and second hubs provide anchoring points on the patient distributed around the insertion site and on opposite ends of the catheter, thereby anchoring the frame to the patient and stabilizing the catheter. A method is provided for using an integrated vascular delivery system.

Abstract: A colored visibly opaque, highly efficient NIR-transmitting optical filter displaying angle insensitivity is based on one-dimensional photonic crystals. The filter comprises a photonic crystal stack comprising at least one high refractive index layer and two low refractive index layers respectively disposed along a first side and a second side of the high refractive index layer. The photonic crystal stack may have 10 or fewer layers. The filter transmits a first portion of an electromagnetic spectrum having a first range of predetermined wavelengths in an infrared light range or near infrared light range, while reflecting a second portion of the electromagnetic spectrum having a second range of predetermined wavelengths in a visible light range to generate a reflected output. In certain aspects, a refractive index contrast between the at least one high refractive index layer and at least one of the two low refractive index layers is ? about 40%.

Abstract: A subsurface imaging technique using distributed sensors is introduced. Instead of monostatic transceivers employed in conventional ground penetrating radars, the proposed technique utilizes bi-static transceivers to sample the reflected signals from the ground at different positions and create a large two-dimensional aperture for high resolution subsurface imaging. The coherent processing of the samples in the proposed imaging method eliminates the need for large antenna arrays for obtaining high lateral resolution images. In addition, it eliminates the need for sampling on a grid which is a time-consuming task in imaging using ground penetration radar. Imaging results show that the method can provide high-resolution images of the buried targets using only samples of the reflected signals on a circle with the center at the transmitter location.

Abstract: A system for generating a concentrated product from a feedstock includes a feedstock chamber to which the feedstock is provided, a heat exchanger assembly in thermal communication with the feedstock chamber, the heat exchanger assembly being configured to freeze the feedstock in the feedstock chamber, an output flow arrangement configured to carry liquid from the feedstock chamber as the feedstock thaws, the output flow arrangement comprising a flow controller, a sensor disposed along the output flow arrangement or the heat exchanger assembly, the sensor being configured to measure a characteristic of the liquid, the characteristic being indicative of a solute concentration level of the liquid or the heat exchanger assembly, and a processor responsive to the characteristic and configured to control the flow controller to, based on the solute concentration level, direct the liquid passing through the output flow arrangement to define a plurality of products at different concentration levels, the plurality of p

Abstract: A method for simulating interactions between a propagating field and occluding bodies in a volume is provided. The method includes using a processor to construct a three-dimensional grid structure having a plurality of cells, the volume containing a plurality of two-dimensional triangles that intersect or reside in one or more of the cells; to iterate through a plurality of rays and trace each ray of the plurality to approximate the propagating field; to determine and account for all interactions between each ray of the plurality and the occluding bodies, where the determining includes performing ray-triangle intersection for all triangles of the plurality of triangles intersecting or residing in cells occupied by the occluding bodies, and the accounting includes adding additional rays of the plurality of rays as reflections, transmissions, and diffractions of the approximated propagating field.

Abstract: A gas delivery device includes a nitric oxide generating system. The system has a medium including a source of nitrite ions. A working electrode is in contact with the medium. A Cu(II)-ligand complex is in contact with the working electrode. A reference/counter electrode is, or a reference electrode and a counter electrode are in contact with the medium and separated from the working electrode. An inlet conduit is to deliver nitrogen gas to the medium, and an outlet conduit is to transport a stream of nitrogen gas and nitric oxide from the medium. An inspiratory gas conduit is operatively connected to the outlet conduit to introduce an oxygen-containing gas and form an output gas stream of the gas delivery device.

Abstract: In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed.

Abstract: Thermophotovoltaic (TPV) systems and devices with improved efficiencies are disclosed herein. In one example, a thermophotovoltaic (TPV) cell includes an active layer; a back-surface reflective (BSR) layer; and a spacer layer positioned between the active layer and back-surface reflective layer.

Abstract: Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.

Abstract: A system and method for determining a predicted trajectory of a human-driven host vehicle as the human-driven host vehicle approaches a traffic signal. The method includes: obtaining a host vehicle-traffic light distance dx and a longitudinal host vehicle speed vx that are each taken when the human-driven host vehicle approaches the traffic signal; obtaining a traffic light signal phase Pt and an traffic light signal timing Tt; obtaining a time of day TOD; providing the host vehicle-traffic light distance dx, the longitudinal host vehicle speed vx, the traffic light signal phase Pt, the traffic light signal timing Tt, and the time of day TOD as input into an artificial intelligence (AI) vehicle trajectory prediction application, wherein the AI vehicle trajectory prediction application implements an AI vehicle trajectory prediction model; and determining the predicted trajectory of the human-driven host vehicle using the AI vehicle trajectory prediction application.

Abstract: A multiple-point basket-type or crown-shaped catheter device provides simultaneously mapping over a three-dimensional (3D) region of a subject, such as, one or more chambers of a subject's heart. The catheter device may include a series of splines each having a wave-like profile formed of a periodic series of peaks and troughs, with electrodes located at the peaks and troughs for mapping purposes.

Abstract: Systems and methods for distracted driving detection are described. A method includes receiving proximate vehicle data about a proximate vehicle proximate to the host vehicle. The method also includes estimating one or more baselines for a predetermined future time for the proximate vehicle from the proximate vehicle data. The method further includes comparing current kinematic data of the proximate vehicle data for the predetermined future time to the one or more baselines. The method includes generating distraction flags associated with the proximate vehicle based on the comparison. The method also includes controlling one or more vehicle systems of the host vehicle based on the generated distraction flags.

Abstract: An in-memory computing system for computing vector-matrix multiplications includes an array of resistive memory devices arranged in columns and rows, such that resistive memory devices in each row of the array are interconnected by a respective word line and resistive memory devices in each column of the array are interconnected by a respective bitline. The in-memory computing system also includes an interface circuit electrically coupled to each bitline of the array of resistive memory devices and computes the vector-matrix multiplication between an input vector applied to a given set of word lines and data values stored in the array. For each bitline, the interface circuit receives an output in response to the input being applied to the given wordline, compares the output to a threshold, and increments a count maintained for each bitline when the output exceeds the threshold. The count for a given bitline represents a dot-product.

Abstract: The present disclosure provides compounds of Formula (I-A) for inhibiting the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compounds are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.

Abstract: Provided herein are methods and systems for the analysis of biomarkers, and methods of providing diagnoses and/or prognoses therewith. In particular, methods and systems for performing biomarker ratio imaging microscopy (BRIM) are provided, as well as methods of using BRIM for the analysis of biomarker pairs (e.g., CD44/CD24, N-cadherin/E-cadherin, CD74/CD59, etc.) diagnosis and/or prognosis of cancer (e.g., ductal carcinoma in situ).

Abstract: A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.

Abstract: A computing system architecture is presented for decoupling execution of workload by crossbar arrays and similar memory modules. The computing system includes: a data bus; a core controller connected to the data bus; and a plurality of local tiles connected to the data bus. Each local tile in the plurality of local tiles includes a local controller and at least one memory module, where the memory module performs computation using the data stored in memory without reading the data out of the memory.

Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free 3-dimensional engineered tendon constructs.

Abstract: Gyroscopes are sensors that measure angular rate and angular orientation. A three-dimensional fused silica micro shell rate-integrating gyroscope is presented. One aspect of the gyroscope includes the use of optical sensors to detect motion of the resonator. The proposed gyroscope is attractive because it achieves several magnitudes higher accuracy as well as high vibration and shock insensitivity from a novel resonator design as well as other unique manufacturing processes.