Abstract: A resistive device that enables adjustable resistance in at least one direction using an attachment system and associated eddy current braking system. The resistive device can be bench-mounted, in some embodiments, used for physical therapy caused by neuromuscular diseases, such as stroke and cerebral palsy, orthopedic disorders, general disuse, or even for overall fitness.

Abstract: An energy harvesting imaging sensor includes an array of pixel structures each formed from a semiconductor having a photodiode overlying a photovoltaic diode. The photodiode and photovoltaic diode are implemented as a vertically stacked P+/NWELL/PSUB junction. This structure enables simultaneous imaging and energy harvesting by generating charge in the photodiode that is indicative of light impinging on the photodiode and simultaneously generating charge from the light in the photovoltaic diode located underneath the photodiode.

Abstract: Laser emission based microscope devices and methods of using such devices for detecting laser emissions from a tissue sample are provided. The scanning microscope has first and second reflection surfaces and a scanning cavity holding a stationary tissue sample with at least one fluorophore/lasing energy responsive species. At least a portion of the scanning cavity corresponds to a high quality factor (Q) Fabry-Pérot resonator cavity. A lasing pump source directs energy at the scanning cavity while a detector receives and detects emissions generated by the fluorophore(s) or lasing energy responsive species. The second reflection surface and/or the lasing pump source are translatable with respect to the stationary tissue sample for generating a two-dimensional scan of the tissue sample. Methods for detecting multiplexed emissions or quantifying one or more biomarkers in a histological tissue sample, for example for detection and diagnosis of cancer, or other disorders/diseases are provided.

Abstract: A method is presented for analyzing interactions in a human genome. The method includes: receiving a biological sample of a cell from a subject; extracting read data from the biological sample, where the read data includes a set of reads; and constructing, by a computer processor, a hypergraph from the read data, where each node in the hypergraph represents a locus and hyperedges in the hypergraph represent interactions between two or more loci. The hypergraphs may be used for different applications including determining entropy, comparing different biological samples and reporting multi-way contacts in a set of transcription clusters.

Abstract: A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.

Abstract: The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.

Abstract: Techniques for measuring metabolic tissue state and oxygenation in human or animal models, through optical techniques capable of simultaneous measurement at single region of interest. Simultaneously measuring CCO, oxygenated hemoglobin (HbO), and deoxygenated (HbR) hemoglobin is performed and metabolic activity of the tissue is determined. The methods employ a super-continuum light source and a probe to deliver light to the individual, and reflected light from the individual is analyzed to determine the metabolic function of the individual.

Abstract: Computational algorithms integrate and analyze data to consider multiple interdependent, heterogeneous sources and forms of patient data, and using a classification model, provide new learning paradigms, including privileged learning and learning with uncertain clinical data, to determine patient status for conditions such as acute respiratory distress syndrome (ARDS) or non-ARDS.

Abstract: Protein-based nanoparticles and methods of forming such protein-based nanoparticles via electrohydrodynamic jetting methods are provided. The nanoparticle may comprise a water-soluble protein having an average molecular weight of ? about 8 kDa and < about 700 kDa. In certain variations, the water-soluble protein is cross-linked (e.g., with an optional crosslinking agent) and defines a mesh structure having an average linear mesh size of ? about 1 nm to ? about 4 nm. Methods of making such nanoparticles may include jetting a liquid comprising the water-soluble protein through a nozzle, followed by exposing the liquid to an electric field sufficient to solidify the liquid and form the protein-based nanoparticles described above.

Abstract: A method of forming a structural color filter includes: depositing a first metal layer on a surface of a substrate by applying an electric potential to the substrate; depositing a first dielectric layer on the first metal layer by contacting the first metal layer with a second electrolyte; and depositing a second metal layer on the first dielectric layer. The surface of the substrate is in contact with a first electrolyte; the first electrolyte comprises a first precursor, an electrochemical reaction of the first precursor at the surface of the substrate is driven by the electric potential; the depositing the first metal layer on the surface of the substrate is performed at a temperature of less than or equal to 50° C. The second electrolyte comprises a second precursor of a first dielectric material of the first dielectric layer.

Abstract: A pneumatic textile system capable of transforming from a two-dimensional structure to a three-dimensional structure under pneumatic pressure is provided. The pneumatic textile system includes a seamless knit fabric having a grid configuration defining a plurality of grid areas—a first of the plurality of grid areas having a tensile strength that is different from a second of the plurality of grid areas. A pneumatic bladder member is disposed along at least a portion of a boundary between adjacent ones of the plurality of grid areas and is inflatable to exert a force on the seamless knit fabric, wherein upon inflation of the pneumatic bladder member the force is exerted on the seamless knit fabric such that the first of the plurality of grid area assumes a shape different than the second of the plurality of grid areas resulting in a three-dimensional structure transformation.

Abstract: In one embodiment, example systems and methods related to a manner of unifying heterogeneous datasets are provided. Multiple heterogeneous datasets containing traffic or driving data are collected. The records of the datasets are combined, and the records in the combined dataset are ordered into a plurality of time series based on timestamps associated with each record. A Bayesian learning method, such as hidden Markov models, is used to identify traffic primitives in the datasets. Each traffic primitive may include several consecutive records in the combined dataset and may correspond to particular driving actions such as turning left or right, stopping, accelerating, etc. The traffic primitives are used to create a traffic primitive index that can be queried by users or researchers for specific records. These records can be used to train or test one or more learning-based algorithms.

Abstract: An integrated flow source is a limiting factor in numerous microfluidic applications. In addition to precise gradients and controlling molecular transports, a built-in source of stable and accurate flow can enable novel shear stress modulations for long-term cell culturing studies. The Tesla turbine, when used as a pump on the microfluidic regime, produces stable and accurate fluid gradients by utilizing laminar flow between its rotating discs Utilizing a stereolithography based 3D printer, a tesla pump (Ø10 cm) and associated housing capable of driving a microfluidic gradient is provided having a printed rotor surface topology of the pump in order to enhance pumping of biological fluids like blood at elevated viscosities. The surface topology is tuned via 3D pixilation, and this modulation completely recovered the pressure loss between pumping water at 1 cP versus glycerol solution at 3 cP. As a result, increased fluid viscosities, and even Non-Newtonian viscosities, can be used.

Abstract: Provided herein are compositions and methods for quantifying polyphosphates. In particular, provided herein are solution and substrate based assays for quantifying polyphosphates in complex samples.

Abstract: A linear time varying model predictive control (LTV-MPC) framework is developed for degradation-conscious control of automotive polymer electrolyte membrane (PEM) fuel cell systems. A reduced-order nonlinear model of the entire system is derived first. This nonlinear model is then successively linearized about the current operating point to obtain a linear model. The linear model is utilized to formulate the control problem using a rate-based MPC formulation. The controller objective is to ensure offset-free tracking of the power demand, while maximizing the overall system efficiency and enhancing its durability. To this end, the fuel consumption and the power loss due to auxiliary equipment are minimized. Moreover, the internal states of the fuel cell stack are constrained to avoid harmful conditions that are known stressors of the fuel cell components.

Abstract: An electrode of a chemical cell includes a substrate having a surface, an array of conductive projections supported by the substrate and extending outward from the surface of the substrate, each conductive projection of the array of conductive projections having a semiconductor composition for reduction of carbon dioxide (CO2) in the chemical cell, and a catalyst arrangement disposed along each conductive projection of the array of conductive projections, the catalyst arrangement including a copper-based catalyst and an iron-based catalyst for the reduction of carbon dioxide (CO2) in the chemical cell.

Abstract: Disclosed are electrochemical devices, such as sodium ion conducting solid state electrolytes, sodium battery electrodes, and solid-state sodium metal batteries including these electrodes and solid state electrolytes. One example method for preparing a sodium/sodium-??-alumina interface with low interfacial resistance and capable of achieving high current density in an electrochemical cell includes the steps of: (a) providing a precursor electrolyte having a resistive surface region, wherein the precursor electrolyte comprises sodium-??-alumina; (b) removing at least a portion of the resistive surface region; (c) heating the precursor electrolyte thereby forming a solid state electrolyte, and (d) placing a side of the solid state electrolyte in contact with a sodium anode.

Abstract: The present invention provides compositions comprising tolerizing immune modified particles (TIMPs) and methods for using and making said TIMPs. In particular, carrier polymer is covalently conjugated with antigenic peptide before particle formation, which allows for exquisite control of particle size and antigen encapsulation (e.g., for use in eliciting induction of immunological tolerance).

Abstract: Provided herein are compositions and methods for production of organic acids. In particular, provided herein are consolidated bioprocessing compositions and methods for single reactor production of organic acids.

Abstract: The instant invention describes pharmaceutical compositions and dosing regimens comprising radiation therapy and seviteronel with or without dexamethasone, and methods of treating diseases, disorders or symptoms thereof.