Abstract: Methods and systems for training a model labeling two or more organic structures in an image. One method includes receiving a set of training images including a first plurality of images and a second plurality of images. Each of the first plurality of images including a label for a first subset of the two or more organic structures and each of the second plurality of images including a label for a second subset of the two or more organic structures, the second subset being different than the first subset. The method also includes training the model using the first plurality of images, the second plurality of images, and a label merging function mapping a label included in the first plurality of images to a label included in the second plurality of images.

Abstract: The present invention provides a novel design for sheaths intended for medical procedures. The sheath includes structures that anchor the sheath in a cavity or space when deployed but are at the same time retractable such that the sheath can be removed without tearing the tissue defining the space.

Abstract: With increasing demand for distributed intelligent physical systems performing big data analytics on the field and in real-time, processing-in-memory (PIM) architectures integrating 3D-stacked memory and logic layers could provide higher performance and energy efficiency. Towards this end, the PIM design requires principled and rigorous optimization strategies to identify interactions and manage data movement across different vaults.

Abstract: A sensor for measuring electrochemical impedance includes a primary circuit that includes a primary electrically conducting coil and a secondary circuit that includes a secondary electrically conducting coil. The primary electrically conducting coil is inductively coupled to the secondary circuit. During operation, the secondary electrically conductive couple has contact electrodes that contact a medium for which the impedance is to be measured. An alternating current source energizes the primary electrically conducting coil during impedance measurements.

Abstract: Novel peptide analogs of a ?-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These novel ?-defensin analogs are protective at concentrations where naturally occurring ?-defensins have no apparent effect, and include a core set of structural and sequence features not found in native ?-defensins.

Abstract: Methods and systems of monitoring and controlling thermal therapy treatments. One method includes determining, with an electronic processor, a propagation constant for a plurality of waveports. The method also includes modeling an object within an imaging cavity using a sparse mesh model. The method also includes determining a simulated impedance of the object based on the model of the object. The method also includes calibrating the simulated impedance with a theoretical impedance numerically calculated for the object. The method also includes determining a distribution of an electric field and a distribution of a magnetic field for a mode in a conformal modeled waveport based on the calibrated impedance and the model of the object. The method also includes exciting the plurality of waveports to generate the determined distribution of the electric field and the distribution of the magnetic field.

Abstract: The disclosure provides compounds and method useful for modulating gp130 biological activity. The disclosure also provides methods and compositions for treating disease and disorders associated with gp130 activity, particularly those associated with inflammation.

Abstract: Aspects of the present disclosure relate to methods and compositions related to the preparation of immune cells, including engineered immune cells. Certain embodiments of the disclosure include compositions, cells, and methods related to engineered invariant natural killer T (iNKT) cells for off-the-shelf use for clinical therapy. The iNKT cells may be produced from hematopoietic stem progenitor cells and may be suitable for allogeneic cellular therapy because they are HLA negative. In some aspects, the cells have imaging and suicide targeting capabilities.

Abstract: Tracer kinetic models are utilized as temporal constraints for highly under-sampled reconstruction of DCE-MRI data. The method is flexible in handling any TK model, does not rely on tuning of regularization parameters, and in comparison to existing compressed sensing approaches, provides robust mapping of TK parameters at high under-sampling rates. In summary, the method greatly improves the robustness and ease-of-use while providing better quality of TK parameter maps than existing methods. In another embodiment, TK parameter maps are directly reconstructed from highly under-sampled DCE-MRI data. This method provides more accurate TK parameter values and higher under-sampling rates. It does not require tuning parameters and there are not additional intermediate steps. The proposed method greatly improves the robustness and ease-of-use while providing better quality of TK parameter maps than conventional indirect methods.

Abstract: A method for alleviating a symptom of multiple sclerosis or other autoimmune or inflammatory disease includes a step of identifying a subject having multiple sclerosis or other autoimmune diseases. A fasting mimicking diet is administered to the subject for a first predetermined time period, the fasting mimicking diet providing less than 50% of the subject's normal caloric intake. A non-fasting diet is administered to the subject for a second time period following the first time period. The non-fasting diet provides the subject greater than 60 percent of the subject's normal caloric intake but a calorie intake necessary for the subject to return to a normal healthy weight.

Abstract: A lithium-sulfur battery cell includes a cathode that includes sulfur, an anode that includes lithium metal; and a bilayer membrane interposed between the cathode and the anode. The bilayer membrane includes a mixed conduction membrane layer and a lithium ion-conducting polymer electrolyte layer where the lithium ion-conducting layer is interposed between the mixed conduction membrane layer and the anode.

Abstract: Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.

Abstract: Methods are provided of identifying a male fertility condition in a subject. Methods of performing a fertility treatment and an in vitro fertilization procedure are also provided. The methods may comprise determining the DNA methylation pattern of DNA extracted from a semen sample of a subject.

Abstract: Time-efficient identification of a brain network input-output (IO) dynamics model for brain stimulation includes generating an input stochastic-switched noise-modulated waveform characterized by at least one parameter modulated according to a stochastic-switched noise sequence, inputting the input stochastic-switched noise-modulated waveform to a clinical brain-response system, recording one or more time-correlated outputs of the clinical brain-response system responsive to the input stochastic-switched noise-modulated waveform, and identifying a brain network IO dynamics model that optimally correlates the input stochastic-switched noise-modulated waveform to the one or more time-delimited outputs of the clinical brain-response system. A desired brain response to an input electrical signal may be obtained using the model, such as by modulating the input electrical signal using a closed-loop control algorithm based on the brain network IO dynamics model.

Abstract: Volumetric imaging with selective volume illumination (SVI) using light field detection is provided using various systems and techniques. A volumetric imaging apparatus includes a light source configured to emit an illumination light that propagates via an illumination light path to illuminate a three-dimensional (3D) sample; and an optical system arranged with respect to the light source to receive a light field, which comes from the illuminated 3D sample. The light field propagates via a detection light path, and the light source, the optical system, or both, are configurable to perform SVI, which selects a volume of a 3D-confined illumination of the 3D sample based on the 3D sample to be illuminated and a light field detection (LFD) process to be applied. Further, the volume of the 3D-confined illumination is a selected 3D volume of the 3D sample to be particularly excited by the 3D-confined illumination for imaging.

Abstract: Various embodiments of a computer-implemented framework for predicting exploitation of software vulnerabilities are disclosed.

Abstract: The present invention provides for organometallic and organic dopants suitable for use in organic carrier transporting materials. Also provided are organic light emitting devices containing doped organic carrier transporting materials.

Abstract: Described herein are methods for selecting lymphocytes for adoptive cell therapy based on P-glycoprotein expression and compositions comprising same.

Abstract: Described herein are optical phased array receivers. In various embodiments, an optical phased array receiver includes a set of antennas, each antenna configured to receive an optical signal; a local oscillator configured to generate one or more optical carrier signals; one or more optical signal combiners coupled to the set of antennas and the local oscillator, the one or more optical signal combiners configured to combine (i) the optical signals received by the antennas and (ii) the optical carrier signal; and one or more photodetectors configured to extract information carried by one or more of the received optical signals into an electrical signal, wherein the extracted information is indicative of a phase and an amplitude of the one or more of the received optical signals.

Abstract: The present disclosure describes, among other things, a thereto-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.