Abstract: Systems and methods for reducing latency in use of mobile applications include creating a list of potential internet requests from a mobile application based on an analysis of the mobile application. The systems and methods include creating a trigger map that maps each of a plurality of trigger points of the mobile application with a corresponding target internet request to be prefetched from the list of potential internet requests. The systems and methods include creating a URL map that maps each of a plurality of the potential internet requests with corresponding URL values. The systems and methods include identifying that a current app function matches a trigger point of the plurality of trigger points. The systems and methods include performing the potential internet request in response to identifying that the current app function matches the trigger point prior to the target request being received in order to reduce latency.

Abstract: An open coiled pacemaker lead is provided that has improved structural stability and functional life in vivo. The open coiled lead includes an electrically conductive material that is coated or covered by a thin layer of electrically insulative material. The coated coiled lead has adequate spacing between adjacent coils, and has a lumen of sufficient diameter, to allow for infiltration of biological connective tissue onto the surface of the coated coil when maintained in vivo for a sufficient amount of time. Infiltration of the connective tissue essentially uniformly along the entire coiled lead strengthens and lengthens the functional life of the coated coil lead.

Abstract: A swallow exerciser device that exercises and thereby strengthens the muscles involved in swallowing includes a rigid shell, an adjustable fastener, and an inflatable pad. The rigid shell has a longitudinal dimension such that the shell extends above and below the larynx of the subject when the swallow exerciser device is positioned over the larynx of the subject. The adjustable fastener is dimensioned to secure the shell around a neck of the subject with the shell positioned over the larynx of the subject. The inflatable pad is connected to a proximal surface of the shell. The inflatable pad is dimensioned to apply resistance to force of at least one swallowing muscle of the subject when the shell positioned over the larynx of the subject and when the inflatable pad is in an inflated position. The swallow exerciser device can be used in a method for improving swallowing function in a subject.

Abstract: A system for exhaust gas remediation includes an engine, a plasma reactor, and a pulse source. The engine emits exhaust gas that includes NO molecules and NOx molecules. The plasma reactor includes an internal chamber that is fluidly connected to the engine such that the exhaust gas flows into the internal chamber. An electrode is disposed within the internal chamber of the plasma reactor. The electrode is electrically coupled to an electrical pulse source. The electrical pulse source delivers electrical pulse to the electrode to form a plasma from the exhaust gas, which removes at least a portion of the NO molecules and at least a portion of the NOx molecules.

Abstract: Disclosed are methods and systems for determining the three-dimensional structure of chromatin in eukaryotic cells. More specifically, disclosed are methods and systems for obtaining chromatin structural information by surface immobilization that includes tethering crosslinked protein:DNA complexes and/or ligated DNA complexes to media such as beads, gels, and or matrices during the conformation capture assay.

Abstract: Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90? and methods of using the same to treat HIF-1a-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP in Hsp90? or VKHFSVEGQ in Hsp90?.

Abstract: Histologic classification of pathology specimens through machine learning is a nascent field which offers tremendous potential to improve cancer medicine. Its utility has been limited, in part because of differences in tissue preparation and the relative paucity of well-annotated images. We introduce tissue recognition, an unsupervised learning problem analogous to human face recognition, in which the goal is to identify individual tumors using a learned set of histologic features. This feature set is the “tissue fingerprint.” Because only specimen identities are matched to fingerprints, constructing an algorithm for producing them is a self-learning task that does not need image metadata annotations. Here, we provide an algorithm for self-learning tissue fingerprints, that, in conjunction with color normalization, can match hematoxylin and eosin stained tissues to one of 104 patients with 93% accuracy.

Abstract: The disclosure presents methods and apparatus for adaptive control of one or more traffic signals. A method may include determining an offset value based on a function of a traffic flow performance metric. The method may further include determining a green time split value based on a distributed algorithm. The method may further include adaptive control of the one or more traffic signals based on the green time split value and the offset value.

Abstract: This invention relates to methods and systems for reducing the concentration of SOx and/or NOx in gas streams.

Abstract: This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

Abstract: A method for monitoring and understanding interpersonal relationships includes a step of monitoring interpersonal relations of a couple or group of interpersonally connected users with a plurality of smart devices by collecting data streams from the smart devices. Representations of interpersonal relationships are formed for increasing knowledge about relationship functioning and detecting interpersonally-relevant mood states and events. Feedback and/or goals are provided to one or more users to increase awareness about relationship functioning.

Abstract: Described herein is a method to create dendritic biocompatible polymers from pairs of complementary dendritic nucleic acid monomers in a controlled manner, using polymerization triggers. The dendritic monomers are constituted of nucleic acids and an organic polymer capable of self-assembly. A variety of additional improvements are described herein, including processes not requiring snap cooling, “wobble clamp” designs to confer a transitory measure of hairpin stability prior to branch migration, and multiple assemblies of amplifying systems. Depending on the context this technology could be used to reveal the presence of a large variety of analytes such as specific nucleic acid molecules, small molecules, proteins, and peptides.

Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.

Abstract: A vehicle is described, and includes an on-board controller, an extra-vehicle communication system, a GPS sensor, a spatial monitoring system, and a navigation system that employs an on-vehicle navigation map. Operation includes capturing a 3D sensor representation of a field of view and an associated GPS location, executing a feature extraction routine, executing a semantic segmentation of the extracted features, executing a simultaneous location and mapping (SLAM) of the extracted features, executing a context extraction from the simultaneous location and mapping of the extracted features, and updating the on-vehicle navigation map based thereon. A parsimonious map representation is generated based upon the updated on-vehicle navigation map, and is communicated to a second, off-board controller. The second controller executes a sparse map stitching to update a base navigation map based upon the parsimonious map representation. The on-vehicle navigation map is updated based upon the off-board navigation map.

Abstract: An optimally stopped heuristic optimizer includes a processor. The processor heuristically generates a sequence of proposed solutions for solving a discrete optimization problem associated with an objective function, and for each additional proposed solution of the sequence, derives an estimate of a quality distribution that is based on the sequence including the additional proposed solution. The quality distribution assigns a probability to each of the proposed solutions according to quality of the proposed solution. The processor further, responsive to a most recent additional proposed solution of the sequence having quality better than a quality threshold that is defined by the estimate corresponding to the sequence including the most recent additional proposed solution, commands a stop such that further proposed solutions to the discrete optimization problem are no longer generated, and identifies and outputs a selected one of the sequence having best quality.

Abstract: Described herein are methods for assessing cytotoxicity of an agent. The methods include providing a target cell that has been engineered to express intracellularly a reporter that is not expressed endogenously by the target cell, exposing the target cell to an agent capable of modulating cytotoxicity and assaying the activity of the reporter, wherein a change in reporter activity relative to a reference value is indicative of the agent being able to modulate cytotoxicity of the target cell.

Abstract: An SFQ circuit system includes at least one SFQ block having a plurality of SFQ logic gates. Characteristically, at least a portion of the SFQ logic gates are arranged in series. The SFQ circuit system includes a timing system configured to provide a first set of inputs and collect a first set of outputs of the at least one SFQ block at a rate defined by a slow clock frequency while the SFQ logic gates are clocked at a fast clock frequency. Advantageously, the rate is sufficiently slow to allow the first set of inputs to propagate through all levels of the SFQ logic gates to produce the first set of outputs of the at least one SFQ block without colliding with a second set of inputs to the at least one SFQ block.

Abstract: In various embodiments of the present disclosure, an oxygen-generating bioelectrical reactor comprises two chambers, a first oxidative chamber configured for the abiotic oxidation of water to generate molecular oxygen, and a second reductive chamber configured for the biotic reduction of an insoluble metal(loid) oxide or hydroxide. In various embodiments, the biotic reduction comprises microbially-catalyzed metal(loid) ion reduction of the insoluble metal(loid) oxide or hydroxide, wherein a dissimilatory metal(loid) reducing microorganism transfers electrons obtained from the oxidation of the water extracellularly to the metal(loid) ions.

Abstract: A fasting mimicking diet package providing daily meal portions for a predetermined number of days is provided. The fasting mimicking diet package includes a kale cracker composition, a first vegetable broth composition, a mushroom soup composition, a tomato soup composition, a quinoa-containing minestrone soup composition, a bean-containing minestrone soup composition, and a pumpkin soup composition. Characteristically, the daily meal portions are packaged into meal servings or into a total daily serving to be divided into meals.

Abstract: Novel antibody-drug conjugates (ADCs) and methods of using such ADCs to treat proliferative disorders are described herein. The ADCs may comprise a PARP protein automodified with a plurality of poly-ADP-ribose polymers functionalized with novel NAD+ analogues. The automodified PARP with functionalized poly-ADP-ribose polymers provide a novel type of drug carrier, which allows facile conjugation of monoclonal antibodies and cytotoxic drug in high ratios.