Patents Assigned to The University of Southern California
  • Instruments and Methods for the Implantation of Cell-Seeded Ultra-thin Substrates
    Publication number: 20230017116
    Abstract: A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.
    Type: Application
    Filed: September 28, 2022
    Publication date: January 19, 2023
    Applicant: University of Southern California
    Inventor: Mark S. Humayun
  • Wearable respiratory monitoring system based on resonant microphone array
    Patent number: 11547381
    Abstract: A method for continuous acoustic signature recognition and classification includes a step of obtaining an audio input signal from a resonant microphone array positioned proximate to a target, the audio input signal having a plurality of channels. The target produces characterizing audio signals depending on a state or condition of the target. A plurality of features is extracted from the audio input signal with a signal processor. The plurality of features is classified to determine the state of the target. An acoustic monitoring system implementing the method is also provided.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: January 10, 2023
    Assignee: University of Southern California
    Inventors: Eun Sok Kim, Anton Andreevich Shkel
  • Fasting mimicking diet (FMD) as an immunoregulatory treatment for gastrointestinal autoimmune/inflammatory diseases
    Patent number: 11540550
    Abstract: A method for treating autoimmune and/or inflammatory diseases includes a step of identifying a subject having a gastrointestinal autoimmune/inflammatory disease. A fasting mimicking diet (FMD) is administered to the subject for a first time period.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: January 3, 2023
    Assignee: University of Southern California
    Inventors: Valter D. Longo, In Young Choi
  • Real-time 3D microwave monitoring of thermal therapy
    Patent number: 11540724
    Abstract: A method for determining a change of temperature of an object. The method may include heating an object and measuring scattering parameters (S-parameters) of scattered microwave electric fields from the object. A distorted Born iterative method may be used to determine a change of a dielectric property of the object based on the measured S-parameters. A change of temperature of the object may be determined based on the change of the dielectric property of the object.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: January 3, 2023
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Guanbo Chen, Mahta Moghaddam, John Stang, Mark Haynes
  • Method of cryopreservation of stem cell-derived retinal pigment epithelial cells on polymeric substrate
    Patent number: 11533908
    Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: December 27, 2022
    Assignee: University of Southern California
    Inventors: Danhong Zhu, David R. Hinton, Ashish Ahuja, Mark S. Humayun
  • Optimized gene editing utilizing a recombinant endonuclease system
    Patent number: 11535871
    Abstract: Described herein are methods and compositions for genomic editing. Endonucleases for genomic editing involve inducing breaks in double stranded DNA, for which knock-ins are notoriously inefficient for relying on random integration of homologous DNA sequences into the break site by repair proteins. To address these issues, described herein are novel recombinant fusion proteins that actively recruit linear DNA inserts in closer proximity to the genomic cleavage site, increasing integration efficiency of large DNA fragments into the genome. Such improvements to genomic editing technology allow one to use lower linear DNA concentrations without sacrificing efficiency and can be further combined with other features, such as fluorescent protein reporting systems.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: December 27, 2022
    Assignee: University of Southern California
    Inventors: Jason Junge, Timothy Hunt, Scott E. Fraser
  • Inexpensive metal-free organic redox flow battery (ORBAT) for grid-scale storage
    Patent number: 11532830
    Abstract: A flow battery includes a positive electrode, a positive electrode electrolyte, a negative electrode, a negative electrode electrolyte, and a polymer electrolyte membrane interposed between the positive electrode and the negative electrode. The positive electrode electrolyte includes water and a first redox couple. The first redox couple includes a first organic compound which includes a first moiety in conjugation with a second moiety. The first organic compound is reduced during discharge while during charging the reduction product of the first organic compound is oxidized to the first organic compound. The negative electrode electrolyte includes water and a second redox couple. The second couple includes a second organic compound including a first moiety in conjugation with a second moiety. The reduction product of the second organic compound is oxidized to the second organic compound during discharge.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: December 20, 2022
    Assignee: University of Southern California
    Inventors: Sri Narayan, Surya G. K. Prakash, Bo Yang, Lena Hoober-Burkhardt, Sankarganesh Krishnamoorthy
  • Model training using fully and partially-annotated images
    Patent number: 11526694
    Abstract: Methods and systems for training a model labeling two or more organic structures within an image. One method includes receiving a set of training images. The set of training images including a first plurality of images and a second plurality of images. Each of the first plurality of images including a label for each of the two or more organic structures and each of the second plurality of images including a label for only a subset of the two or more organic structures. The method further includes training the model using the first plurality of images, the second plurality of images, and a label merging function mapping a label from the first plurality of images to a label included in the second plurality of images.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: December 13, 2022
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Hongzhi Wang, Tanveer Fathima Syeda-Mahmood, John Paul Francis
  • Miniature fixed and adjustable flow restrictor for the body
    Patent number: 11523939
    Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: December 13, 2022
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Aubrey M. Shapero, Nicholas E. Scianmarello, Mark S. Humayun
  • MODIFIED HERBAL COMPOSITIONS FOR NEUROMODULATION
    Publication number: 20220387379
    Abstract: Herbal compositions comprising dihydromyricetin (DHM) and methods of use. The herbal compositions include DHM in combination with other ingredients to form compositions that can significantly improve the quality and duration of sleep, reduce the time for onset of improved sleep quality and duration, and treat or alleviate the symptoms of sleep-related disorders and neurological conditions. The composition is a therapeutic alternative to drugs to alleviate sleep disorders and related symptoms and ailments.
    Type: Application
    Filed: April 25, 2022
    Publication date: December 8, 2022
    Applicant: University of Southern California
    Inventor: Jing LIANG
  • Systems and methods for a text mining approach for predicting exploitation of vulnerabilities
    Patent number: 11520900
    Abstract: Various embodiments of a computer-implemented framework for predicting exploitation of software vulnerabilities are disclosed.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: December 6, 2022
    Assignees: Arizona Board of Regents on Behalf of Arizona State University, University of Southern California
    Inventors: Nazgol Tavabi, Palash Goyal, Kristina Lerman, Mohammed Almukaynizi, Paulo Shakarian
  • Orthodontic appliance with snap fitted, non-sliding archwire
    Patent number: 11517405
    Abstract: An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: December 6, 2022
    Assignee: University of Southern California
    Inventors: Behrokh Khoshnevis, Hongsheng Tong, Yong Chen, Philong John Pham, Robert Lee
  • Orthodontic appliance with snap fitted, non-sliding archwire
    Patent number: 11510757
    Abstract: An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: November 29, 2022
    Assignee: University of Southern California
    Inventors: Behrokh Khoshnevis, Hongsheng Tong, Yong Chen, Philong John Pham, Robert Lee
  • System and method for predicting survival time
    Patent number: 11515039
    Abstract: Methods, systems, and apparatus for a method that predicts an individual survival survival time of a patient. The method includes obtaining clinical data associated with health factors of the patient. The method includes obtaining liquid biopsy data associated with one or more attributes of diseased cells within the patient. The method includes predicting or determining a survival time of the patient using a deep learning model based on the clinical data and the liquid biopsy data. The method includes providing or outputting the survival time.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: November 29, 2022
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Anand Kolatkar, Peter Kuhn, Yan Liu, Paymaneh Malihi, Sanjay Purushotham
  • Orthodontic appliance with snap fitted, non-sliding archwire
    Patent number: 11510758
    Abstract: An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: November 29, 2022
    Assignee: University of Southern California
    Inventors: Behrokh Khoshnevis, Hongsheng Tong, Yong Chen, Philong John Pham, Robert Lee
  • Automated model building and updating environment
    Patent number: 11507069
    Abstract: Methods and systems for building and maintaining model(s) of a physical process are disclosed. One method includes receiving training data associated with a plurality of different data sources, and performing a clustering process to form one or more clusters. For each of the one or more clusters, the method includes building a data model based on the training data associated with the data sources in the cluster, automatically performing a data cleansing process on operational data based on the data model, and automatically updating the data model based on updated training data that is received as operational data. For data sources excluded from the clusters, automatic building, data cleansing, and updating of models can also be applied.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: November 22, 2022
    Assignees: Chevron U.S.A. Inc., University of Southern California
    Inventors: Yining Dong, Alisha Deshpande, Yingying Zheng, Lisa Ann Brenskelle, Si-Zhao Qin
  • Fasting-mimicking diet (FMD) but not water-only fasting promotes reversal of inflammation and IBD pathology
    Patent number: 11504408
    Abstract: A method for treating autoimmune and/or inflammatory disease includes a step of identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease administering a fasting mimicking diet. A probiotic composition for gastrointestinal autoimmune and/or inflammatory disease Bacteroides acidifaciens, Bifidobacterium choerinum, and combinations thereof is also provided.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: November 22, 2022
    Assignee: University of Southern California
    Inventors: Valter D. Longo, Min Wei, Priya Rangan
  • RECOVERY AND REUSE OF ACID DIGESTED AMINE/EPOXY-BASED COMPOSITE MATRICES
    Publication number: 20220363863
    Abstract: A method for recycling matrix residues includes steps of degrading a target epoxy to form matrix residues, collecting the matrix residues, and adding the matrix residues into a polymer-forming formulation. Characteristically, the polymer-forming formulation includes multifunctional anhydride monomers and polyfunctional co-reactant monomers.
    Type: Application
    Filed: September 18, 2020
    Publication date: November 17, 2022
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Travis J. WILLIAMS, Steven NUTT, Yijia MA, Carlos NAVARRO
  • Functionalized poly-ADP-ribose polymers for drug delivery
    Patent number: 11497787
    Abstract: Novel antibody-drug conjugates (ADCs) and methods of using such ADCs to treat proliferative disorders are described herein. The ADCs may comprise a PARP protein automodified with a plurality of poly-ADP-ribose polymers functionalized with novel NAD+ analogues. The automodified PARP with functionalized poly-ADP-ribose polymers provide a novel type of drug carrier, which allows facile conjugation of monoclonal antibodies and cytotoxic drug in high ratios.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: November 15, 2022
    Assignee: University of Southern California
    Inventor: Yong Zhang
  • Cell-free DNA methylation patterns for disease and condition analysis
    Patent number: 11499196
    Abstract: Disclosed herein are methods and systems of utilizing sequencing reads for detecting and quantifying the presence of a tissue type or a disease type in cell-free DNA prepared from blood samples.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: November 15, 2022
    Assignees: The Regents of the University of California, University of Southern California
    Inventors: Xianghong Jasmine Zhou, Shuli Kang, Steven Dubinett, Wenyuan Li, Qingjiao Li