Abstract: A method for recycling matrix residues includes steps of degrading a target epoxy to form matrix residues, collecting the matrix residues, and adding the matrix residues into a polymer-forming formulation. Characteristically, the polymer-forming formulation includes multifunctional anhydride monomers and polyfunctional co-reactant monomers.

Abstract: Novel antibody-drug conjugates (ADCs) and methods of using such ADCs to treat proliferative disorders are described herein. The ADCs may comprise a PARP protein automodified with a plurality of poly-ADP-ribose polymers functionalized with novel NAD+ analogues. The automodified PARP with functionalized poly-ADP-ribose polymers provide a novel type of drug carrier, which allows facile conjugation of monoclonal antibodies and cytotoxic drug in high ratios.

Abstract: Disclosed herein are methods and systems of utilizing sequencing reads for detecting and quantifying the presence of a tissue type or a disease type in cell-free DNA prepared from blood samples.

Abstract: The present invention provides a method for encoding a video signal on the basis of a graph-based separable transform (GBST), the method comprising the steps of: generating an incidence matrix representing a line graph; training a sample covariance matrix for rows and columns from the rows and columns of a residual signal; calculating a graph Laplacian matrix for rows and columns on the basis of the incidence matrix and the sample covariance matrix for rows and columns; and obtaining a GBST by performing eigen decomposition of the graph Laplacian matrix for rows and columns.

Abstract: A method of making an ink for use in additive manufacturing of a self-healable and shape-memorizable product includes mixing a diol with isophorone diisocyanate, dimethylacetamide, and dibutyltin dilaurate to form a first solution. The method further includes mixing the first solution with 2-Hydroxyethyl disulfide to form a second solution. The method further includes mixing the second solution with 2-Hydroxyethyl methacrylate to form a third solution. The method further includes mixing the third solution with a tributylphosphine, a photoinitiator, and a photoabsorber to facilitate additive manufacturing of the ink.

Abstract: A learning computer system may estimate unknown parameters and states of a stochastic or uncertain system having a probability structure. The system may include a data processing system that may include a hardware processor that has a configuration that: receives data; generates random, chaotic, fuzzy, or other numerical perturbations of the data, one or more of the states, or the probability structure; estimates observed and hidden states of the stochastic or uncertain system using the data, the generated perturbations, previous states of the stochastic or uncertain system, or estimated states of the stochastic or uncertain system; and causes perturbations or independent noise to be injected into the data, the states, or the stochastic or uncertain system so as to speed up training or learning of the probability structure and of the system parameters or the states.

Abstract: A rechargeable battery includes an iron electrode comprising carbonyl iron composition dispersed over a fibrous electrically conductive substrate. The carbonyl iron composition includes carbonyl iron and at least one additive. A counter-electrode is spaced from the iron electrode. An electrolyte is in contact with the iron electrode and the counter-electrode such that during discharge. Iron in the iron electrode is oxidized with reduction occurring at the counter-electrode such that an electric potential develops. During charging, iron oxides and hydroxides in the iron electrode are reduced with oxidation occurring at the counter-electrode (i.e., a nickel electrode or an air electrode).

Abstract: A method of treating post-surgical edema includes a step of administering an effective amount of a pharmaceutical composition to a subject identified a risk of post-surgical edema. The pharmaceutic composition include a retinoic acid component selected from the group consisting of 9-cis retinoic acid, geometric isomers of 9-cis retinoic acid, metabolites of 9-cis retinoic acid, substituted derivatives thereof, and combinations thereof. An implantable pellet including the retinoic acid component is also provided.

Abstract: Methods and systems for additively manufacturing an object having an overhang feature. The system includes an array of platform segments forming a deposition surface. The system includes a plurality of elongated beams each connected to a platform segment. The system includes a moving platform configured to attach to a portion of the plurality of elongated beams and elevate the attached elongated beams. The system includes an additive manufacturing device configured to deposit material onto the deposition surface. The system includes an actuator configured to move the moving platform vertically. The system includes a controller configured to cause the additive manufacturing device to deposit the material onto the deposition surface and cause the actuator to move the moving platform upward to cause the elongated beams and their respective connected platform segments to form a support structure for the overhang when the overhang is fabricated by the additive manufacturing device.

Abstract: This invention relates to a bone regeneration product comprising at least one stem cell, at least one scaffold, and at least one stem cell. The stem cells suitable for this invention may comprise stem cells suitable for a dense bone regeneration, stem cells suitable for a spongy bone regeneration, or a combination thereof. The bone regeneration product may further comprise a growth factor. This invention also relates to a bone regeneration method and treatment of any bone that has a critical size defect. This invention also relates to a scaffold. This invention further relates to a 3D printed scaffold comprising hydroxyapatite (HA) and tricalcium phosphate (TCP). This invention also relates to a scaffold comprising a polymer. The polymer of this invention may be prepared by using photocurable polymers and/or monomers. The scaffold of this invention may comprise a growth factor and a small molecule. The small molecule N may be a Smurf1 inhibitor.

Abstract: A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.

Abstract: A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material. A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material.

Abstract: Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

Abstract: The invention relates to methods for multiplex tissue imaging by methods such as imaging mass cytometry (IMC) and methods for analysis of imaging mass cytometry data. In various embodiments, methods are provided of cell-of-origin analysis and mutational analysis, coupled with spatial parameters derived from tumor clusters in the tumor microenvironment; which reveals signature marker profiles and therapeutic targets for treating cancers including diffuse large B cell lymphoma.

Abstract: A method for promoting interpersonal interactions includes a step of receiving data streams from a plurality of mobile smart devices from a plurality of users, the data streams recording information about users' daily lives. Intervention signals are sent to a user in response to data acquired from two or more individuals and interpreted with respect to user internal states, moods, emotions, predetermined behaviors, and interactions with other users.

Abstract: The molecular mechanism of the function of TBC1D15 in NOTCH activation and stabilization is associated with maintenance and expansion of tumor-initiating stem-like cells (TICs). We herein demonstrate that TBC1D15 preferentially binds an NUMB isoform and NOTCH1-PEST domain and stabilizes NOTCH1 protein. This interaction enhances phosphorylation of NUMB, taking it away from NUMB-mediated ubiquitin degradation of NOTCH. Thus, TBC1D15 acts as a switch to augment NOTCH signaling in TICs. We also have identified inhibitors of TBC1D15 such as latanoprost acid and a salt thereof, which blocks the NOTCH-TBC1D15 interaction and selectively kills CD133-positive TICs, resulting in a reduction in the tumor size in a patient-derived, hepatocellular carcinoma xenograft model.

Abstract: Presented herein are compositions and devices comprising otopetrin polypeptides and uses thereof for identifying modulators of proton translocation activity through an otopetrin polypeptide, or functional portion thereof.

Abstract: This disclosure provides a novel compositions and methods to deliver cyclosporine A using genetically engineered protein polymers.

Abstract: A method for estimating output neuron spikes based on input-output spike data that includes input spike data and corresponding output spike data includes formulating, using a controller, a weight value that characterizes plastic properties of a neuron based on the input-output spike data. The method further includes receiving, by the controller, an input spike train. The method further includes estimating, using the controller, an output spike train that corresponds to the input spike train by applying the weight value to a feedforward kernel that estimates the output spike train based on the input spike train and the weight value.

Abstract: Methods for treating systemic lupus erythematosus (SLE) are disclosed, based on administering to a subject with SLE an amount effective to treat the subject of a polypeptide including antiogensin 1-7 (A(1-7)), Nle3A 1-7, or a compound according to general formula.