Patents Assigned to The University of Sydney
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Patent number: 11951127Abstract: The present disclosure relates to compositions comprising isolated T cells, with activity against a fungal antigen, a viral antigen or a tumour antigen, wherein the composition comprises a defined number or defined ratio of T cells. Described herein are compositions comprising at least two populations of T cells, the compositions being suitable for treating various diseases and disorders.Type: GrantFiled: June 22, 2018Date of Patent: April 9, 2024Assignees: THE WESTMEAD INSTITUTE FOR MEDICAL RESEARCH, THE UNIVERSITY OF SYDNEY, WESTERN SYDNEY LOCAL HEALTH DISTRICT, NEW SOUTH WALES HEALTH PATHOLOGYInventors: Emily Blyth, Leighton Clancy, David Gottlieb, Kenneth Micklethwaite
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Patent number: 11939296Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).Type: GrantFiled: August 30, 2022Date of Patent: March 26, 2024Assignee: The University of SydneyInventors: Michael Kassiou, William Jorgensen, Lenka Munoz
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Patent number: 11923927Abstract: A method for detecting transmitted data in a multiple-input multiple-output (MIMO) receiver, the method comprising: iteratively calculating symbol estimates by: obtaining input symbol estimates and input symbol variances; calculating error values for the input symbol estimates; refining the input symbol estimates to obtain refined symbol estimates, based on the error values, wherein the refined symbol estimates are used as input symbol estimates for the subsequent iteration of the above calculation, and wherein the refined symbol estimates are used as final symbol estimates when the difference between refined symbol estimates from one iteration to the next is below a threshold change.Type: GrantFiled: October 26, 2020Date of Patent: March 5, 2024Assignee: THE UNIVERSITY OF SYDNEYInventors: Alva Kosasih, Wibowo Hardjawana, Branka Vucetic
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Publication number: 20240019450Abstract: The present invention relates to a compound of formula (I): or a salt or solvate thereof, combinations comprising same, uses and methods thereof, and kits comprising same.Type: ApplicationFiled: November 12, 2021Publication date: January 18, 2024Applicant: THE UNIVERSITY OF SYDNEYInventors: Elizabeth NEW, Linda MITCHELL, Clara SHEN
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Publication number: 20230416341Abstract: The invention relates to the treatment of thromboembolic conditions, to fibrin clot formation and related thrombin activity, and to preparation of compounds, in particular, peptides and polypeptides for inhibiting, or for modifying the cleavage of fibrinogen by thrombin.Type: ApplicationFiled: June 19, 2020Publication date: December 28, 2023Applicants: THE UNIVERSITY OF SYDNEY, THE HEART RESEARCH INSTITUTE LTDInventors: Richard J PAYNE, Emma WATSON, Shaun Phillip JACKSON
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Publication number: 20230383309Abstract: The present invention relates to materials and methods for creating and maintaining a cereal plant line for the production of a hybrid cereal plant, that include for example, and not limitation, using the BLue Aleurone (BLA) system.Type: ApplicationFiled: May 19, 2023Publication date: November 30, 2023Applicants: KWS SAAT SE & Co., KGaA, The University of Sydney, Global Crop Innovations Pty. Ltd.Inventors: Norman DARVEY, Peng Zhang, Richard Trethowan, Chong Mei Dong, Jacob Lage, Nicholas Bird, Christopher Tapsell, Aaron Hummel
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Patent number: 11670401Abstract: One aspect of the present disclosure relates to a method of quantifying soil carbon in a unit of land. The method generally comprises the steps of (i) obtaining an estimated spatial distribution of carbon content in the unit of land, (ii) stratifying the unit of land into a plurality of strata based at least partly on the spatial distribution of carbon content, (iii) selecting one or more locations from each of one or more of the plurality of strata, the one or more locations being selected with randomness, (iv) determining sample carbon content associated with the one or more first locations and (v) determining total carbon content in the unit of land based at least partly on the sample carbon content. In another aspect, this method may be used to quantify soil carbon sequestered in a unit of land by repeating steps (iv) and (v) at a second time and thereafter determining the amount of carbon sequestered.Type: GrantFiled: June 8, 2021Date of Patent: June 6, 2023Assignee: THE UNIVERSITY OF SYDNEYInventors: Alex McBratney, Budiman Minasny, Jaap De Gruijter, Philip James Mulvey
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Patent number: 11657903Abstract: One aspect of the present disclosure relates to a method of quantifying soil carbon in a unit of land. The method generally comprises the steps of (i) obtaining an estimated spatial distribution of carbon content in the unit of land, (ii) stratifying the unit of land into a plurality of strata based at least partly on the spatial distribution of carbon content, (iii) selecting one or more locations from each of one or more of the plurality of strata, the one or more locations being selected with randomness, (iv) determining sample carbon content associated with the one or more first locations and (v) determining total carbon content in the unit of land based at least partly on the sample carbon content. In another aspect, this method may be used to quantify soil carbon sequestered in a unit of land by repeating steps (iv) and (v) at a second time and thereafter determining the amount of carbon sequestered.Type: GrantFiled: June 6, 2011Date of Patent: May 23, 2023Assignee: THE UNIVERSITY OF SYDNEYInventors: Alex McBratney, Budiman Minasny, Jaap De Gruijter, Philip James Mulvey
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Publication number: 20230133885Abstract: The disclosure relates to the synthesis of amide containing compounds inflow. In particular, the disclosure relates to the synthesis of polypeptides via native chemical ligation inflow. The disclosure also relates to selective desulfurization or deselenization of amide containing compounds comprising a thiol, disulfide, selenol or diselenide functional group respectively, particularly polypeptides.Type: ApplicationFiled: May 22, 2019Publication date: May 4, 2023Applicant: The University of SydneyInventors: Richard J. PAYNE, Tim CHISHOLM
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Publication number: 20230119441Abstract: Composite coatings that passively cool when exposed to the sky are provided. The composite coatings are suitable for increasing atmospheric condensation on a surface of a substrate. In particular, the composite coatings may be suitable for capturing atmospheric water. Also provided are methods for producing the composites coatings, methods for coating the surface of substrates with the composite coatings, methods for condensing and collecting atmospheric water, and systems for collecting condensed atmospheric water.Type: ApplicationFiled: March 12, 2021Publication date: April 20, 2023Applicant: THE UNIVERSITY OF SYDNEYInventors: CHIARA NETO, MARTIJN DE STERKE, MING CHIU
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Publication number: 20230115680Abstract: A method of fabricating a casting, the method including applying a substrate to a sacrificial mold, the sacrificial mold including a shaped non-planar receiving surface to receive the substrate and provide a casting of the substrate having a shaped structure corresponding to the receiving surface; and subjecting the sacrificial mold and casting to freeze drying conditions and sublimating the sacrificial mold from the casting to form a cast article including the shaped non-planar structure.Type: ApplicationFiled: October 17, 2022Publication date: April 13, 2023Applicant: THE UNIVERSITY OF SYDNEYInventors: Anthony Steven WEISS, Richard WANG
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Publication number: 20230028660Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).Type: ApplicationFiled: August 30, 2022Publication date: January 26, 2023Applicant: The University of SydneyInventors: Michael KASSIOU, William JORGENSEN, Lenka MUNOZ
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Patent number: 11518069Abstract: A method of fabricating a casting, the method including applying a substrate to a sacrificial mold, the sacrificial mold including a shaped non-planar receiving surface to receive the substrate and provide a casting of the substrate having a shaped structure corresponding to the receiving surface; and subjecting the sacrificial mold and casting to freeze drying conditions and sublimating the sacrificial mold from the casting to form a cast article including the shaped non-planar structure.Type: GrantFiled: May 21, 2019Date of Patent: December 6, 2022Assignee: THE UNIVERSITY OF SYDNEYInventors: Anthony Steven Weiss, Richard Wang
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Patent number: 11510960Abstract: A biofilm disrupting composition for use on chronic wounds comprising (i) at least one biologically acceptable thiol based antioxidant (ii) at least one biofilm disruptor and (iii) at least one biocide. Also disclosed is a process of preparing the composition. Also disclosed is the use of the composition for the manufacture of a medicament for the treatment of a chronic wound, and a method of treating a chronic wound in a patient comprising administering the biofilm disrupting composition.Type: GrantFiled: December 21, 2017Date of Patent: November 29, 2022Assignees: Whiteley Corporation PTY LTD, The University of SydneyInventors: Theerthankar Das Ashish Kumar, Jim Manos, Gregory Stuart Whiteley, Trevor Owen Glasbey
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Patent number: 11472774Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer). In some embodiments, the present invention relates to compounds of formula (I): or pharmaceutically acceptable salts or prodrugs thereof.Type: GrantFiled: February 1, 2019Date of Patent: October 18, 2022Assignee: THE UNIVERSITY OF SYDNEYInventors: Michael Kassiou, William Jorgensen, Lenka Munoz
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Patent number: 11440889Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.Type: GrantFiled: September 1, 2020Date of Patent: September 13, 2022Assignees: The Salk Institute for Biological Studies, The University of SydneyInventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F. W. Keana, Christopher Liddle
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Patent number: 11433375Abstract: Provided herein are photocatalytic carbon filters for the removal impurities such as microorganisms, organic compounds, algal toxins, and their degradation by-products from water and wastewater. The photolytic carbon filters comprise a porous titanium substrate comprising TiO2 nanotube arrays and multi-wall carbon nanotubes disposed on the TiO2 nanotube arrays. Also provided herein are methods of manufacture and methods of use of the disclosed photocatalytic carbon filters.Type: GrantFiled: December 19, 2017Date of Patent: September 6, 2022Assignees: UNIVERSITY OF CINCINNATI, UNIVERSITY OF SYDNEYInventors: Soryong Chae, Tahereh Noeiaghaei, Yoontaek Oh
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Patent number: 11332720Abstract: The present disclosure relates to a novel murine parvovirus, sequences encoded thereby, and applications therefor. In one embodiment the disclosure provides a method for detecting the presence of a parvovirus in a sample, comprising detecting one or more nucleic acids or polypeptides derived from the parvovirus, or antibodies against the parvovirus, in the sample. Also provided are vectors and host cells comprising sequences encoded by the parvovirus and related sequences. Also provided are animal models of kidney disease associated with infection by the parvovirus.Type: GrantFiled: May 25, 2018Date of Patent: May 17, 2022Assignees: Centenary Institute of Cancer Medicine and Cell Biology, University of SydneyInventors: Ben Roediger, Wolfgang Weninger, Shweta Tikoo
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Publication number: 20220117930Abstract: The present disclosure is drawn to methods of treating diseases or disorders, and uses of preparing medicaments. The methods of administering and/or preparation of medicaments can include the use of a compound of Formula (I) disclosed herein, or a geometric isomer, stereoisomer, and/or pharmaceutically acceptable salt or solvate thereof.Type: ApplicationFiled: December 16, 2020Publication date: April 21, 2022Applicant: The University of SydneyInventors: Colin Charles DUKE, Rujee Kyokajee DUKE, Van Hoan TRAN
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Publication number: 20220101948Abstract: The present invention relates to identification of an abnormal splice site. Provided are methods of identifying an abnormal splice site. Methods of classifying the risk of abnormal splicing of a splice site are also provided. Databases for use in the methods provided herein are also disclosed.Type: ApplicationFiled: May 13, 2021Publication date: March 31, 2022Applicants: The University of Sydney, The Sydney Children's Hospitals Network (Randwick and Westmead)Inventors: Sandra Cooper, Himanshu Joshi