Patents Assigned to The University of Sydney
  • Patent number: 10772253
    Abstract: An automated apparatus, method and system for projecting a control agent toward a recognised target for the purposes of agricultural cultivation or environmental management or various other applications; a source of the control agent adapted for use in connection with an environmental control function, an outlet incorporating at least one outlet orifice to direct the control agent emanating from the outlet orifice toward a target. An activation means is movable between an operative mode and an inoperative mode in which the outlet is effectively closed. A targeting mechanism movable on at least one independent control axis provided for selectively orienting the outlet orifice and thereby orienting the control agent in the operative mode. A first sensing system, a classification system, a control system in accordance with a predetermined control logic adapted to deliver doses of the control agent to the identified targets for the purposes of the environmental control function.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: September 15, 2020
    Assignee: The University of Sydney
    Inventors: Mark Calleija, Salah Sukkarieh
  • Patent number: 10745355
    Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: August 18, 2020
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Lenka Munoz, Fadi Maged Shokry Gurgis, Mia Akerfeldt, Michael Kassiou
  • Publication number: 20200255856
    Abstract: The present invention relates to materials and methods for creating and maintaining a cereal plant line for the production of a hybrid cereal plant, that include for example, and not limitation, using the BLue Aleurone (BLA) system.
    Type: Application
    Filed: August 29, 2018
    Publication date: August 13, 2020
    Applicants: KWS SAAT SE & Co. KGaA, THE UNIVERSITY OF SYDNEY, GLOBAL CROP INNOVATIONS PTY. LTD.
    Inventors: Norman DARVEY, Peng ZHANG, Richard TRETHOWAN, Chong Mei DONG, Jacob LAGE, Nicholas BIRD, Christopher TAPSELL, Aaron HUMMEL
  • Patent number: 10722178
    Abstract: A method for the reduction of motion artifacts in CT imaging, the method including the steps of: (a) reconstructing from the raw CT data an initial estimate of the object of interest; (b) estimating the pose of the object at each projection angle; (c) undertaking a motion-corrected reconstruction from the measured projections, accounting for the pose changes estimated in (b) by employing a modified source/detector orbit that accounts for the object motion; (d) iterating steps (b)-(c) until a predetermined convergence criterion is met; and (e) making a final reconstruction of the required image size using the pose estimates obtained in the previous steps.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: July 28, 2020
    Assignees: Western Sydney Local Health District, The University of Sydney, Katholieke Universiteit Leuven KU Leuven R&D
    Inventors: Roger Fulton, Johan Nuyts, Tao Sun, Jung-Ha Kim
  • Patent number: 10709726
    Abstract: The present disclosure generally relates to methods for treating, preventing, inhibiting the progression of or reducing the likelihood of occurrence of a myocardial infarction-related complication, a cardiac disorder characterised by abnormal conduction and other cardiac conditions. The present disclosure also generally relates to one or more inhibitors of Connexin 45.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: July 14, 2020
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Eddy Kizana, Peter Fahmy
  • Patent number: 10701852
    Abstract: An apparatus for controlling weeds, which includes a tine formation adapted to remove or disrupt targeted weeds, and a tine support assembly adapted to support the tine for movement about a first control axis in a generally vertical direction between an engaged position wherein the tine formation in use contacts a ground surface for removal or disruption of targeted weeds and a disengaged position wherein the tine formation is substantially retracted from the ground surface. The tine support assembly is further adapted to support the tine for movement about a second control axis in a generally horizontal direction. The tine support assembly further includes a first actuation mechanism adapted to effect movement of the tine about the first control axis, and a second actuation mechanism adapted to effect movement of the tine about the second control axis.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: July 7, 2020
    Assignee: The University of Sydney
    Inventors: Mark Calleija, Salah Sukkarieh
  • Patent number: 10696615
    Abstract: A method for treating cancer can include administering a therapeutically effective amount of a compound of formula (Ia): or pharmaceutically acceptable salts or solvates thereof, wherein R1a, R1b, R1c, R1d, R2, and R3 are as defined, and A----B is selected from CH?CH, CH?CH(CH2)pCH2, or CH2—CH2(CH2)pCH2, and where p is 1 or 2.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: June 30, 2020
    Assignee: The University of Sydney
    Inventors: Colin Charles Duke, Van Hoan Tran, Rujee Kyokajee Duke
  • Publication number: 20200123113
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Application
    Filed: September 10, 2019
    Publication date: April 23, 2020
    Applicants: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F.W. Keana, Christopher Liddle
  • Publication number: 20200085919
    Abstract: A biofilm disrupting composition for use on chronic wounds comprising (i) at least one biologically acceptable thiol based antioxidant(ii) at least one biofilm disruptor and (iii) at least one biocide. Also disclosed is a process of preparing the composition. Also disclosed is the use of the composition for the manufacture of a medicament for the treatment of a chronic wound, and a method of treating a chronic wound in a patient comprising administering the biofilm disrupting composition.
    Type: Application
    Filed: December 21, 2017
    Publication date: March 19, 2020
    Applicant: The University of Sydney
    Inventors: Theerthankar Das Ashish Kumar, Jim Manos, Gregory Stuart Whiteley, Trevor Owen Glasbey
  • Publication number: 20190367583
    Abstract: The invention relates to the treatment of stroke and related diseases, to fibrin clot formation and related thrombin activity, and to preparation of compounds, in particular, peptides and polypeptides for inhibiting, or for modifying the cleavage of fibrinogen by thrombin.
    Type: Application
    Filed: December 15, 2017
    Publication date: December 5, 2019
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Richard J. PAYNE, Shaun Phillip JACKSON, Pedro Jose BARBOSA PEREIRA
  • Patent number: 10450277
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: October 22, 2019
    Assignees: The Salk Institute for Biological Studies, University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F. W. Keana, Christopher Liddle
  • Publication number: 20190282514
    Abstract: The invention relates to terpenes and uses thereof.
    Type: Application
    Filed: September 7, 2017
    Publication date: September 19, 2019
    Applicant: The University of Sydney
    Inventors: Colin Charles DUKE, Rujee Kyokajee DUKE, Van Hoan TRAN
  • Patent number: 10376589
    Abstract: The present invention relates generally to a method of treating a neoplastic condition and to agents useful for same. More particularly, the present invention is directed to a method of facilitating the treatment of a solid tumor in a localized manner via the co-administration of particulate material and a cellular toxin. The method of the present invention is useful in a range of therapeutic treatments including the treatment of primary and metastatic tumors.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: August 13, 2019
    Assignee: The University of Sydney
    Inventors: Brian Stanley Hawkett, Trevor William Hambley, Nicole Sarah Bryce, Thi Thuy Binh Pham, Nirmesh Jain
  • Patent number: 10369156
    Abstract: Provided herein are pharmaceutical compositions that are useful for the treatment of hypertension comprising an angiotensin II receptor blocker, a diuretic, a calcium channel blocker, and a beta-blocker, wherein the dose of each component is below the lowest dose approved for the treatment of hypertension for the component.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: August 6, 2019
    Assignees: THE GEORGE INSTITUTE FOR GLOBAL HEALTH, THE UNIVERSITY OF SYDNEY
    Inventors: Anthony Rodgers, Clara Chow
  • Publication number: 20190194105
    Abstract: A method for treating cancer can include administering a therapeutically effective amount of a compound of formula (Ia): or pharmaceutically acceptable salts or solvates thereof, wherein R1a, R1b, R1c, R1d, R2, and R3 are as defined, and A----B is selected from CH?CH, CH?CH(CH2)pCH2, or CH2—CH2(CH2)pCH2, and where p is 1 or 2.
    Type: Application
    Filed: December 17, 2018
    Publication date: June 27, 2019
    Applicant: The University of Sydney
    Inventors: Colin Charles Duke, Van Hoan Tran, Rujee Kyokajee Duke
  • Patent number: 10300783
    Abstract: The invention relates to a vehicle including a chassis and a pair of wheels supported in spaced apart relationship by the chassis for rotation about a common axis. A pair of drive modules is associated with the respective wheels. The drive modules and the chassis are connected for rotation as a sub-assembly relative to the wheels about the common axis with the centre of mass of the sub-assembly below the common axis in a static equilibrium position. Each of the drive modules is housed substantially within the respective wheel.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: May 28, 2019
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Mark Calleija, Salah Sukkarieh
  • Patent number: 10301268
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: May 28, 2019
    Assignees: The Salk Institute for Biological Studies, University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F. W. Keana, Christopher Liddle
  • Patent number: 10238667
    Abstract: The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: March 26, 2019
    Assignees: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ning Ding, Michael Downes, Christopher Liddle, Ronald M. Evans, Nanthakumar Subramaniam
  • Publication number: 20190084939
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Application
    Filed: November 27, 2018
    Publication date: March 21, 2019
    Applicants: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F.W. Keana, Christopher Liddle
  • Publication number: 20190070220
    Abstract: The present disclosure provides a composition comprising isolated T cells, wherein the T cells have specificity against a range of clinical fungal pathogens.
    Type: Application
    Filed: July 7, 2016
    Publication date: March 7, 2019
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: David Gottlieb, Leighton Clancy