Patents Assigned to The University of Sydney
  • Patent number: 11126925
    Abstract: This disclosure relates to quantum electronic devices for storing qubits. In particular, this disclosure relates to a quantum electronic device comprising a carbon nanosphere adapted to store a qubit represented by an electron spin and a control and readout device to set the qubit and read the qubit stored on the carbon nanosphere. Qubits stored on carbon nanospheres have a long electron spin lifetime at room temperature. This disclosure further relates to a method for quantum computing. The method comprises storing a qubit represented by an electron spin on a carbon nanosphere, performing a quantum operation on the qubit to generate a resulting qubit and reading the resulting qubit from the nanosphere. There is further provided a spintronic device comprising multiple carbon nanospheres adapted to provide a qubit represented by an electron spin in that carbon nanosphere and a control device to facilitate interaction between the qubits to perform a quantum operation.
    Type: Grant
    Filed: December 3, 2016
    Date of Patent: September 21, 2021
    Assignee: The University of Sydney
    Inventors: Balint Nafradi, Mohammad Choucair
  • Patent number: 11091535
    Abstract: The treatment of stroke related diseases are described herein. In addition, fibrin clot formation and related activity is proposed for the disclosed compounds, in particular, peptides for inhibiting or modifying the cleavages of fibrinogen by thrombin. Methods for producing such compounds are also disclosed.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: August 17, 2021
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Richard J. Payne, Shaun Phillip Jackson, Pedro Jose Barbosa Pereira
  • Publication number: 20210220459
    Abstract: The present invention is directed to novel vaccine compositions and methods for immunising subjects against Mycobacterium avium subspecies paratuberculosis. The invention involves the use of mineral oil adjuvants, or white mineral oil adjuvants, more specifically those having CAS 8042-47-5, CAS 1335203-18-3, CAS 1174522-45-2, CAS 1335203-17-2 (or EC equivalents 232-455-8, 932-078-5, 934-954-2 and 934-956-3, respectively) to reduce lesions or adverse reactions.
    Type: Application
    Filed: November 5, 2018
    Publication date: July 22, 2021
    Applicants: The University of Sydney, Meat & Livestock Australia Limited
    Inventors: Richard WHITTINGTON, Auriol PURDIE, Kumudika DE SILVA, Karren PLAIN, Douglas BEGG, Om DHUNGYEL
  • Publication number: 20210212982
    Abstract: The present disclosure is drawn to methods of treating diseases or disorders, and uses of preparing medicaments. The methods of administering and/or preparation of medicaments can include the use of a compound of Formula (I) disclosed herein, or a geometric isomer, stereoisomer, and/or pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: December 16, 2020
    Publication date: July 15, 2021
    Applicant: The University of Sydney
    Inventors: Colin Charles DUKE, Rujee Kyokajee DUKE, Van Hoan TRAN
  • Publication number: 20210196378
    Abstract: The invention relates to a catheter ablation device for delivery of energy to a selected region of tissue, the device having an antenna portion including a radiating antenna electrically connectable via an electrical feedline to a source of energy, the antenna configured to generate an electromagnetic field able to ablate tissue in said selected region of tissue, the device including a thermocouple having a hot junction formed by electrical connection between a thermocouple conductor and a conducting part of the electrical feedline. This avoids the need for a dedicated thermocouple conductor pair, as the second conductor of the thermocouple is provided by the feedline used to supply the ablation energy to the device antenna.
    Type: Application
    Filed: February 9, 2021
    Publication date: July 1, 2021
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Publication number: 20210186608
    Abstract: The invention relates to an ablation device for delivery of microwave energy to a selected region of tissue, in particular for producing deep endocardial or epicardial ventricular lesions, such as for the treatment or prevention of arrhythmias.
    Type: Application
    Filed: January 6, 2021
    Publication date: June 24, 2021
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Publication number: 20210186609
    Abstract: The invention relates to a catheter ablation device for delivery of energy (such as microwave energy) via a radiating antenna to a selected region of tissue, the device having an elongated catheter with an outer sheath, configured to allow flow of fluid along the catheter to exit through one or more orifices adjacent to the antenna. The device includes an impedance monitoring system having two electrodes arranged respectively inside and outside said catheter sheath, the impedance monitoring system including an electric circuit incorporating an ionic conductivity path through said fluid. The device is introduced into a blood vessel and the invention allows monitoring of changes in the size of the blood vessel during an ablation procedure, as it can be used to measure the impedance of an electrical circuit including a blood path in the blood vessel in the region of the ablation, the measured impedance providing a measure of vascular calibre.
    Type: Application
    Filed: February 9, 2021
    Publication date: June 24, 2021
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Patent number: 11039884
    Abstract: A microwave ablation device (10) comprises a feed line (22), a microwave radiator and a device outer sheath (46) in which at least part of the feed line (22) is contained. The sheath (46) in use, allows an irrigation liquid to flow therethrough, wherein the feed line has a junction (38) with the radiator (22) has an outer conducting shield (28) terminating and insulated at the junction (38). The feed line (22) has a conductive core (32) that extends to the radiator (24). The conductive core forms a radiating element (34) electrically insulated from its surrounding environment. The radiator (24) is unbalanced.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 22, 2021
    Assignees: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Publication number: 20210147365
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Application
    Filed: September 1, 2020
    Publication date: May 20, 2021
    Applicants: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F.W. Keana, Christopher Liddle
  • Publication number: 20210122092
    Abstract: A method of fabricating a casting, the method including applying a substrate to a sacrificial mold, the sacrificial mold including a shaped non-planar receiving surface to receive the substrate and provide a casting of the substrate having a shaped structure corresponding to the receiving surface; and subjecting the sacrificial mold and casting to freeze drying conditions and sublimating the sacrificial mold from the casting to form a cast article including the shaped non-planar structure.
    Type: Application
    Filed: May 21, 2019
    Publication date: April 29, 2021
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Anthony Steven WEISS, Richard WANG
  • Publication number: 20210095048
    Abstract: The specification relates generally to the post-genomic identification of therapeutic targets and agents. In particular the specification relates to PSMD9 inhibitors and methods for preventing or treating metabolic disorders such as fatty liver disease that are associated with dysregulation of lipid homeostasis.
    Type: Application
    Filed: January 21, 2019
    Publication date: April 1, 2021
    Applicants: Baker Heart and Diabetes Institute, The Regents of the University of California, The University of Sydney
    Inventors: Anna Christine DREW, Brian Gary DREW, Thomas de Aguiar VALLIM, David JAMES
  • Publication number: 20210094915
    Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).
    Type: Application
    Filed: February 1, 2019
    Publication date: April 1, 2021
    Applicant: The University of Sydney
    Inventors: Michael KASSIOU, Wiiliam UORGENSEN, Lenka MUNOZ
  • Patent number: 10939868
    Abstract: This invention relates to molecular diagnostics and, more specifically DNA-based tests for the prognosis and/or monitoring of fibrotic disease progression in humans, and processes for stratifying patients based on their likely rates of fibrotic disease progression. The invention also relates to the field of therapy for fibrotic disease, based on such prognoses, monitoring and stratification results, such as in monitoring and/or stratifying and/or treating patients having a higher likelihood of rapid fibrotic disease progression.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: March 9, 2021
    Assignees: WESTERN SYDNEY LOCAL HEALTH DISTRICT, THE UNIVERSITY OF SYDNEY
    Inventors: David Booth, Jacob George, Mohammed Eslam, Golo Ahlenstiel, Kate O'Connor
  • Patent number: 10940165
    Abstract: The present disclosure provides a composition comprising isolated T cells, wherein the T cells have specificity against a range of clinical fungal pathogens.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: March 9, 2021
    Assignees: The University of Sydney, Western Sydney Local Health District, Westmead Institute for Medical Research, NSW Health Pathology
    Inventors: David Gottlieb, Leighton Clancy, Emily Blyth, Kenneth Paul Micklethwaite, Shivashni Deo
  • Patent number: 10921356
    Abstract: This disclosure relates to optical RF spectrum analysers and methods for analysing an input RF signal. An optical modulator modulates an input RF signal onto a carrier frequency and an optical spectral weight with a spectral weight function modifies the modulated optical signal. The spectral weight defines a frequency relationship between the spectral weight function and the carrier frequency. A frequency control module modifies the frequency relationship between the spectral weight function and the carrier frequency over time. An optical sensor senses the modified optical signal over time and to generates an RF signal over time. A signal recovery module calculates the RF spectrum based on the RF signal over time. Shifting the spectral weight against the carrier frequency over time results in a high spectral resolution even if the spectral weight is relatively broad band. The result is an increased spectral resolution at a reduced price/complexity and increased robustness.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: February 16, 2021
    Assignee: The University of Sydney
    Inventors: Shijie Song, Xiaoke Yi
  • Patent number: 10912742
    Abstract: The invention relates to terpenes and uses thereof.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: February 9, 2021
    Assignee: The University of Sydney
    Inventors: Colin Charles Duke, Rujee Kyokajee Duke, Van Hoan Tran
  • Publication number: 20200375658
    Abstract: The invention concerns a method for intra-operative monitoring of the effectiveness of transcatheter renal denervation in a patient, to assist in guiding the procedure and in particular for identifying a physiological procedural endpoint. Through aorticorenal ganglia pace-capture, renal sympathetic nerve function can be assessed. In accordance with the invention, sustained reduction or abolition of renal vasoconstriction induced by the pacing is used as an indicator of successful renal denervation.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 3, 2020
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Patent number: 10815203
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: October 27, 2020
    Assignees: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F. W. Keana, Christopher Liddle
  • Publication number: 20200331833
    Abstract: A compound, composition, or method for treating cancer is disclosed. The compound (that can be used in the composition and/or method) can include or pharmaceutically acceptable salts or solvates thereof. R1a-R1d, R2-R3 (and R4 where applicable), and A---B can be as defined herein.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 22, 2020
    Applicant: The University of Sydney
    Inventors: Colin Charles Duke, Van Hoan TRAN, Rujee Kyokajee DUKE
  • Patent number: 10807931
    Abstract: Method for decarboxylating a carboxylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: Formula I Formula II wherein: R1 is selected from the group consisting of: substituted or unsubstituted C1-C5 alkyl; R2 is selected from the group consisting of: OH or O, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C2-C8 alkene, or a substituted or unsubstituted C2-C8 dialkene; or R2 is O, and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes heating a reaction mixture comprising the carboxylated phytocannabinoid compound and a polar aprotic solvent in the presence of a LiCl for a time sufficient to decarboxylate at least a portion of the carboxylated phytocannabinoid compounds and form the phytocannabinoid compound.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: October 20, 2020
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Tristan Reekie, Michael Scott, Michael Kassiou