Patents Assigned to The University of Sydney
  • Patent number: 11510960
    Abstract: A biofilm disrupting composition for use on chronic wounds comprising (i) at least one biologically acceptable thiol based antioxidant (ii) at least one biofilm disruptor and (iii) at least one biocide. Also disclosed is a process of preparing the composition. Also disclosed is the use of the composition for the manufacture of a medicament for the treatment of a chronic wound, and a method of treating a chronic wound in a patient comprising administering the biofilm disrupting composition.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: November 29, 2022
    Assignees: Whiteley Corporation PTY LTD, The University of Sydney
    Inventors: Theerthankar Das Ashish Kumar, Jim Manos, Gregory Stuart Whiteley, Trevor Owen Glasbey
  • Patent number: 11472774
    Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer). In some embodiments, the present invention relates to compounds of formula (I): or pharmaceutically acceptable salts or prodrugs thereof.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: October 18, 2022
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Michael Kassiou, William Jorgensen, Lenka Munoz
  • Patent number: 11440889
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: September 13, 2022
    Assignees: The Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F. W. Keana, Christopher Liddle
  • Patent number: 11433375
    Abstract: Provided herein are photocatalytic carbon filters for the removal impurities such as microorganisms, organic compounds, algal toxins, and their degradation by-products from water and wastewater. The photolytic carbon filters comprise a porous titanium substrate comprising TiO2 nanotube arrays and multi-wall carbon nanotubes disposed on the TiO2 nanotube arrays. Also provided herein are methods of manufacture and methods of use of the disclosed photocatalytic carbon filters.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: September 6, 2022
    Assignees: UNIVERSITY OF CINCINNATI, UNIVERSITY OF SYDNEY
    Inventors: Soryong Chae, Tahereh Noeiaghaei, Yoontaek Oh
  • Patent number: 11332720
    Abstract: The present disclosure relates to a novel murine parvovirus, sequences encoded thereby, and applications therefor. In one embodiment the disclosure provides a method for detecting the presence of a parvovirus in a sample, comprising detecting one or more nucleic acids or polypeptides derived from the parvovirus, or antibodies against the parvovirus, in the sample. Also provided are vectors and host cells comprising sequences encoded by the parvovirus and related sequences. Also provided are animal models of kidney disease associated with infection by the parvovirus.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: May 17, 2022
    Assignees: Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney
    Inventors: Ben Roediger, Wolfgang Weninger, Shweta Tikoo
  • Publication number: 20220117930
    Abstract: The present disclosure is drawn to methods of treating diseases or disorders, and uses of preparing medicaments. The methods of administering and/or preparation of medicaments can include the use of a compound of Formula (I) disclosed herein, or a geometric isomer, stereoisomer, and/or pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: December 16, 2020
    Publication date: April 21, 2022
    Applicant: The University of Sydney
    Inventors: Colin Charles DUKE, Rujee Kyokajee DUKE, Van Hoan TRAN
  • Publication number: 20220101948
    Abstract: The present invention relates to identification of an abnormal splice site. Provided are methods of identifying an abnormal splice site. Methods of classifying the risk of abnormal splicing of a splice site are also provided. Databases for use in the methods provided herein are also disclosed.
    Type: Application
    Filed: May 13, 2021
    Publication date: March 31, 2022
    Applicants: The University of Sydney, The Sydney Children's Hospitals Network (Randwick and Westmead)
    Inventors: Sandra Cooper, Himanshu Joshi
  • Publication number: 20210401495
    Abstract: A system for monitoring tissue lesion development during a medical ablation process applied to a patient, the system comprising a catheter ablation device having at least one catheter electrode, the device connectable via an electrical feedline to a source of electrical energy and configured to apply ablation energy to ablate tissue in a target region, a plurality of external electrodes for application to the body of the patient, measurement circuitry for determining an electrical characteristic of a current path between the at least one catheter electrode and the external electrodes in the absence of said application of ablation energy, and an electrical controller.
    Type: Application
    Filed: September 7, 2021
    Publication date: December 30, 2021
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry, Alistair McEwan, Duc Minh Nguyen
  • Publication number: 20210388375
    Abstract: An isolated nucleic acid encoding a nucleotide-binding and leucine-rich repeat (NLR) polypeptide including a zinc-finger BED domain, wherein expression of the NLR polypeptide in a plant confers or enhances resistance of the plant to a fungus.
    Type: Application
    Filed: April 9, 2019
    Publication date: December 16, 2021
    Applicants: JOHN INNES CENTRE, COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION, THE UNIVERSITY OF SYDNEY
    Inventors: Cristobal UAUY, Clemence MARCHAL, Evans LAGUDAH, Robert MCINTOSH, Jianping ZHANG, Peng ZHANG
  • Patent number: 11185476
    Abstract: The present application describes fib-reinforced dental composites (FRCs), processes for producing and uses of, the fibre-reinforced dental composites. More particularly, the fibre-reinforced dental 5 composites described herein comprise a polymerisable resin and from about 0.5% to about 25% w/w of fibres having a diameter of from about 3 ?m to about 9 ?m and a length of from about 60 ?m to about 2 mm.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 30, 2021
    Assignees: Newsouth Innovations Pty Limited, The University of Sydney
    Inventors: Bellasanty Gangadhara Prusty, Ginu Rajan, Paul Shouha, Ayman Ellakwa
  • Publication number: 20210348439
    Abstract: A pump-out tube for evacuating a space between two sheets of glass, the pump out tube being receivable in a hole formed in at least one of the sheets of glass, the pump out tube formed as a separate element comprising a tubular member and a seal formed around the tube.
    Type: Application
    Filed: July 21, 2021
    Publication date: November 11, 2021
    Applicant: The University of Sydney
    Inventors: Cenk Kocer, Tom Vu, Clara Thao Hoang Tran
  • Patent number: 11126925
    Abstract: This disclosure relates to quantum electronic devices for storing qubits. In particular, this disclosure relates to a quantum electronic device comprising a carbon nanosphere adapted to store a qubit represented by an electron spin and a control and readout device to set the qubit and read the qubit stored on the carbon nanosphere. Qubits stored on carbon nanospheres have a long electron spin lifetime at room temperature. This disclosure further relates to a method for quantum computing. The method comprises storing a qubit represented by an electron spin on a carbon nanosphere, performing a quantum operation on the qubit to generate a resulting qubit and reading the resulting qubit from the nanosphere. There is further provided a spintronic device comprising multiple carbon nanospheres adapted to provide a qubit represented by an electron spin in that carbon nanosphere and a control device to facilitate interaction between the qubits to perform a quantum operation.
    Type: Grant
    Filed: December 3, 2016
    Date of Patent: September 21, 2021
    Assignee: The University of Sydney
    Inventors: Balint Nafradi, Mohammad Choucair
  • Patent number: 11091535
    Abstract: The treatment of stroke related diseases are described herein. In addition, fibrin clot formation and related activity is proposed for the disclosed compounds, in particular, peptides for inhibiting or modifying the cleavages of fibrinogen by thrombin. Methods for producing such compounds are also disclosed.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: August 17, 2021
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Richard J. Payne, Shaun Phillip Jackson, Pedro Jose Barbosa Pereira
  • Publication number: 20210220459
    Abstract: The present invention is directed to novel vaccine compositions and methods for immunising subjects against Mycobacterium avium subspecies paratuberculosis. The invention involves the use of mineral oil adjuvants, or white mineral oil adjuvants, more specifically those having CAS 8042-47-5, CAS 1335203-18-3, CAS 1174522-45-2, CAS 1335203-17-2 (or EC equivalents 232-455-8, 932-078-5, 934-954-2 and 934-956-3, respectively) to reduce lesions or adverse reactions.
    Type: Application
    Filed: November 5, 2018
    Publication date: July 22, 2021
    Applicants: The University of Sydney, Meat & Livestock Australia Limited
    Inventors: Richard WHITTINGTON, Auriol PURDIE, Kumudika DE SILVA, Karren PLAIN, Douglas BEGG, Om DHUNGYEL
  • Publication number: 20210212982
    Abstract: The present disclosure is drawn to methods of treating diseases or disorders, and uses of preparing medicaments. The methods of administering and/or preparation of medicaments can include the use of a compound of Formula (I) disclosed herein, or a geometric isomer, stereoisomer, and/or pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: December 16, 2020
    Publication date: July 15, 2021
    Applicant: The University of Sydney
    Inventors: Colin Charles DUKE, Rujee Kyokajee DUKE, Van Hoan TRAN
  • Publication number: 20210196378
    Abstract: The invention relates to a catheter ablation device for delivery of energy to a selected region of tissue, the device having an antenna portion including a radiating antenna electrically connectable via an electrical feedline to a source of energy, the antenna configured to generate an electromagnetic field able to ablate tissue in said selected region of tissue, the device including a thermocouple having a hot junction formed by electrical connection between a thermocouple conductor and a conducting part of the electrical feedline. This avoids the need for a dedicated thermocouple conductor pair, as the second conductor of the thermocouple is provided by the feedline used to supply the ablation energy to the device antenna.
    Type: Application
    Filed: February 9, 2021
    Publication date: July 1, 2021
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Publication number: 20210186608
    Abstract: The invention relates to an ablation device for delivery of microwave energy to a selected region of tissue, in particular for producing deep endocardial or epicardial ventricular lesions, such as for the treatment or prevention of arrhythmias.
    Type: Application
    Filed: January 6, 2021
    Publication date: June 24, 2021
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Publication number: 20210186609
    Abstract: The invention relates to a catheter ablation device for delivery of energy (such as microwave energy) via a radiating antenna to a selected region of tissue, the device having an elongated catheter with an outer sheath, configured to allow flow of fluid along the catheter to exit through one or more orifices adjacent to the antenna. The device includes an impedance monitoring system having two electrodes arranged respectively inside and outside said catheter sheath, the impedance monitoring system including an electric circuit incorporating an ionic conductivity path through said fluid. The device is introduced into a blood vessel and the invention allows monitoring of changes in the size of the blood vessel during an ablation procedure, as it can be used to measure the impedance of an electrical circuit including a blood path in the blood vessel in the region of the ablation, the measured impedance providing a measure of vascular calibre.
    Type: Application
    Filed: February 9, 2021
    Publication date: June 24, 2021
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Patent number: 11039884
    Abstract: A microwave ablation device (10) comprises a feed line (22), a microwave radiator and a device outer sheath (46) in which at least part of the feed line (22) is contained. The sheath (46) in use, allows an irrigation liquid to flow therethrough, wherein the feed line has a junction (38) with the radiator (22) has an outer conducting shield (28) terminating and insulated at the junction (38). The feed line (22) has a conductive core (32) that extends to the radiator (24). The conductive core forms a radiating element (34) electrically insulated from its surrounding environment. The radiator (24) is unbalanced.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 22, 2021
    Assignees: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry
  • Publication number: 20210147365
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Application
    Filed: September 1, 2020
    Publication date: May 20, 2021
    Applicants: Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F.W. Keana, Christopher Liddle