Patents Assigned to The University of Sydney
  • Publication number: 20240019450
    Abstract: The present invention relates to a compound of formula (I): or a salt or solvate thereof, combinations comprising same, uses and methods thereof, and kits comprising same.
    Type: Application
    Filed: November 12, 2021
    Publication date: January 18, 2024
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Elizabeth NEW, Linda MITCHELL, Clara SHEN
  • Publication number: 20230416341
    Abstract: The invention relates to the treatment of thromboembolic conditions, to fibrin clot formation and related thrombin activity, and to preparation of compounds, in particular, peptides and polypeptides for inhibiting, or for modifying the cleavage of fibrinogen by thrombin.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 28, 2023
    Applicants: THE UNIVERSITY OF SYDNEY, THE HEART RESEARCH INSTITUTE LTD
    Inventors: Richard J PAYNE, Emma WATSON, Shaun Phillip JACKSON
  • Publication number: 20230383309
    Abstract: The present invention relates to materials and methods for creating and maintaining a cereal plant line for the production of a hybrid cereal plant, that include for example, and not limitation, using the BLue Aleurone (BLA) system.
    Type: Application
    Filed: May 19, 2023
    Publication date: November 30, 2023
    Applicants: KWS SAAT SE & Co., KGaA, The University of Sydney, Global Crop Innovations Pty. Ltd.
    Inventors: Norman DARVEY, Peng Zhang, Richard Trethowan, Chong Mei Dong, Jacob Lage, Nicholas Bird, Christopher Tapsell, Aaron Hummel
  • Patent number: 11670401
    Abstract: One aspect of the present disclosure relates to a method of quantifying soil carbon in a unit of land. The method generally comprises the steps of (i) obtaining an estimated spatial distribution of carbon content in the unit of land, (ii) stratifying the unit of land into a plurality of strata based at least partly on the spatial distribution of carbon content, (iii) selecting one or more locations from each of one or more of the plurality of strata, the one or more locations being selected with randomness, (iv) determining sample carbon content associated with the one or more first locations and (v) determining total carbon content in the unit of land based at least partly on the sample carbon content. In another aspect, this method may be used to quantify soil carbon sequestered in a unit of land by repeating steps (iv) and (v) at a second time and thereafter determining the amount of carbon sequestered.
    Type: Grant
    Filed: June 8, 2021
    Date of Patent: June 6, 2023
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Alex McBratney, Budiman Minasny, Jaap De Gruijter, Philip James Mulvey
  • Patent number: 11657903
    Abstract: One aspect of the present disclosure relates to a method of quantifying soil carbon in a unit of land. The method generally comprises the steps of (i) obtaining an estimated spatial distribution of carbon content in the unit of land, (ii) stratifying the unit of land into a plurality of strata based at least partly on the spatial distribution of carbon content, (iii) selecting one or more locations from each of one or more of the plurality of strata, the one or more locations being selected with randomness, (iv) determining sample carbon content associated with the one or more first locations and (v) determining total carbon content in the unit of land based at least partly on the sample carbon content. In another aspect, this method may be used to quantify soil carbon sequestered in a unit of land by repeating steps (iv) and (v) at a second time and thereafter determining the amount of carbon sequestered.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: May 23, 2023
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Alex McBratney, Budiman Minasny, Jaap De Gruijter, Philip James Mulvey
  • Publication number: 20230133885
    Abstract: The disclosure relates to the synthesis of amide containing compounds inflow. In particular, the disclosure relates to the synthesis of polypeptides via native chemical ligation inflow. The disclosure also relates to selective desulfurization or deselenization of amide containing compounds comprising a thiol, disulfide, selenol or diselenide functional group respectively, particularly polypeptides.
    Type: Application
    Filed: May 22, 2019
    Publication date: May 4, 2023
    Applicant: The University of Sydney
    Inventors: Richard J. PAYNE, Tim CHISHOLM
  • Publication number: 20230119441
    Abstract: Composite coatings that passively cool when exposed to the sky are provided. The composite coatings are suitable for increasing atmospheric condensation on a surface of a substrate. In particular, the composite coatings may be suitable for capturing atmospheric water. Also provided are methods for producing the composites coatings, methods for coating the surface of substrates with the composite coatings, methods for condensing and collecting atmospheric water, and systems for collecting condensed atmospheric water.
    Type: Application
    Filed: March 12, 2021
    Publication date: April 20, 2023
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: CHIARA NETO, MARTIJN DE STERKE, MING CHIU
  • Publication number: 20230115680
    Abstract: A method of fabricating a casting, the method including applying a substrate to a sacrificial mold, the sacrificial mold including a shaped non-planar receiving surface to receive the substrate and provide a casting of the substrate having a shaped structure corresponding to the receiving surface; and subjecting the sacrificial mold and casting to freeze drying conditions and sublimating the sacrificial mold from the casting to form a cast article including the shaped non-planar structure.
    Type: Application
    Filed: October 17, 2022
    Publication date: April 13, 2023
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Anthony Steven WEISS, Richard WANG
  • Publication number: 20230028660
    Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).
    Type: Application
    Filed: August 30, 2022
    Publication date: January 26, 2023
    Applicant: The University of Sydney
    Inventors: Michael KASSIOU, William JORGENSEN, Lenka MUNOZ
  • Patent number: 11518069
    Abstract: A method of fabricating a casting, the method including applying a substrate to a sacrificial mold, the sacrificial mold including a shaped non-planar receiving surface to receive the substrate and provide a casting of the substrate having a shaped structure corresponding to the receiving surface; and subjecting the sacrificial mold and casting to freeze drying conditions and sublimating the sacrificial mold from the casting to form a cast article including the shaped non-planar structure.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: December 6, 2022
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Anthony Steven Weiss, Richard Wang
  • Patent number: 11510960
    Abstract: A biofilm disrupting composition for use on chronic wounds comprising (i) at least one biologically acceptable thiol based antioxidant (ii) at least one biofilm disruptor and (iii) at least one biocide. Also disclosed is a process of preparing the composition. Also disclosed is the use of the composition for the manufacture of a medicament for the treatment of a chronic wound, and a method of treating a chronic wound in a patient comprising administering the biofilm disrupting composition.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: November 29, 2022
    Assignees: Whiteley Corporation PTY LTD, The University of Sydney
    Inventors: Theerthankar Das Ashish Kumar, Jim Manos, Gregory Stuart Whiteley, Trevor Owen Glasbey
  • Patent number: 11472774
    Abstract: The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer). In some embodiments, the present invention relates to compounds of formula (I): or pharmaceutically acceptable salts or prodrugs thereof.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: October 18, 2022
    Assignee: THE UNIVERSITY OF SYDNEY
    Inventors: Michael Kassiou, William Jorgensen, Lenka Munoz
  • Patent number: 11440889
    Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: September 13, 2022
    Assignees: The Salk Institute for Biological Studies, The University of Sydney
    Inventors: Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F. W. Keana, Christopher Liddle
  • Patent number: 11433375
    Abstract: Provided herein are photocatalytic carbon filters for the removal impurities such as microorganisms, organic compounds, algal toxins, and their degradation by-products from water and wastewater. The photolytic carbon filters comprise a porous titanium substrate comprising TiO2 nanotube arrays and multi-wall carbon nanotubes disposed on the TiO2 nanotube arrays. Also provided herein are methods of manufacture and methods of use of the disclosed photocatalytic carbon filters.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: September 6, 2022
    Assignees: UNIVERSITY OF CINCINNATI, UNIVERSITY OF SYDNEY
    Inventors: Soryong Chae, Tahereh Noeiaghaei, Yoontaek Oh
  • Patent number: 11332720
    Abstract: The present disclosure relates to a novel murine parvovirus, sequences encoded thereby, and applications therefor. In one embodiment the disclosure provides a method for detecting the presence of a parvovirus in a sample, comprising detecting one or more nucleic acids or polypeptides derived from the parvovirus, or antibodies against the parvovirus, in the sample. Also provided are vectors and host cells comprising sequences encoded by the parvovirus and related sequences. Also provided are animal models of kidney disease associated with infection by the parvovirus.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: May 17, 2022
    Assignees: Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney
    Inventors: Ben Roediger, Wolfgang Weninger, Shweta Tikoo
  • Publication number: 20220117930
    Abstract: The present disclosure is drawn to methods of treating diseases or disorders, and uses of preparing medicaments. The methods of administering and/or preparation of medicaments can include the use of a compound of Formula (I) disclosed herein, or a geometric isomer, stereoisomer, and/or pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: December 16, 2020
    Publication date: April 21, 2022
    Applicant: The University of Sydney
    Inventors: Colin Charles DUKE, Rujee Kyokajee DUKE, Van Hoan TRAN
  • Publication number: 20220101948
    Abstract: The present invention relates to identification of an abnormal splice site. Provided are methods of identifying an abnormal splice site. Methods of classifying the risk of abnormal splicing of a splice site are also provided. Databases for use in the methods provided herein are also disclosed.
    Type: Application
    Filed: May 13, 2021
    Publication date: March 31, 2022
    Applicants: The University of Sydney, The Sydney Children's Hospitals Network (Randwick and Westmead)
    Inventors: Sandra Cooper, Himanshu Joshi
  • Publication number: 20210401495
    Abstract: A system for monitoring tissue lesion development during a medical ablation process applied to a patient, the system comprising a catheter ablation device having at least one catheter electrode, the device connectable via an electrical feedline to a source of electrical energy and configured to apply ablation energy to ablate tissue in a target region, a plurality of external electrodes for application to the body of the patient, measurement circuitry for determining an electrical characteristic of a current path between the at least one catheter electrode and the external electrodes in the absence of said application of ablation energy, and an electrical controller.
    Type: Application
    Filed: September 7, 2021
    Publication date: December 30, 2021
    Applicants: The University of Sydney, Western Sydney Local Health District
    Inventors: Pierre Qian, Michael Anthony Barry, Alistair McEwan, Duc Minh Nguyen
  • Publication number: 20210388375
    Abstract: An isolated nucleic acid encoding a nucleotide-binding and leucine-rich repeat (NLR) polypeptide including a zinc-finger BED domain, wherein expression of the NLR polypeptide in a plant confers or enhances resistance of the plant to a fungus.
    Type: Application
    Filed: April 9, 2019
    Publication date: December 16, 2021
    Applicants: JOHN INNES CENTRE, COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION, THE UNIVERSITY OF SYDNEY
    Inventors: Cristobal UAUY, Clemence MARCHAL, Evans LAGUDAH, Robert MCINTOSH, Jianping ZHANG, Peng ZHANG
  • Patent number: 11185476
    Abstract: The present application describes fib-reinforced dental composites (FRCs), processes for producing and uses of, the fibre-reinforced dental composites. More particularly, the fibre-reinforced dental 5 composites described herein comprise a polymerisable resin and from about 0.5% to about 25% w/w of fibres having a diameter of from about 3 ?m to about 9 ?m and a length of from about 60 ?m to about 2 mm.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 30, 2021
    Assignees: Newsouth Innovations Pty Limited, The University of Sydney
    Inventors: Bellasanty Gangadhara Prusty, Ginu Rajan, Paul Shouha, Ayman Ellakwa