Abstract: A method of polymerizing monomer to form polymer at the surface of particulate material, said method comprising: providing a dispersion of said particulate material in a continuous liquid phase, said dispersion comprising a RAFT agent as a stabilizer for said particulate material, and said continuous liquid phase comprising one or more ethylenically unsaturated monomers; and polymerizing said one or more ethylenically unsaturated monomers under the control of said RAFT agent to thereby form polymer at the surface of said particulate material.

Abstract: The present invention relates to new omega-3 fatty acid analogues and to their use in cancer therapy, including anti-metastatic therapy.

Abstract: A method of adaptive suppression of over-smoothing in noise/artefact reduction techniques such as total variation minimization or other compressed sensing strategies for Cone Beam Computed Tomography (CBCT) images, the method including the steps of: (a) inputting a CBCT image; (b) identifying the anatomical structures of interest in the CBCT images by exploiting their likely shapes, attenuation coefficients, sizes, positions, or any other similar features that can be used to identify them from an image; (c) extracting intensity, gradient, or other image-related information of the identified anatomical structures from the CBCT image; (d) adaptively suppressing over-smoothing in noise/artefact reduction techniques such as total-variation minimization or other compressed sensing strategies at the anatomical structures of interest using the information of the anatomical structures extracted previously.

Abstract: Methods and systems are described for tracking material through a production chain or operational process chain in which the material is transferred via a plurality of spatially distinct lumped masses of material (12, 14, 16, 18). A dynamic state space (430) is maintained descriptive of the plurality of spatially distinct lumped masses of material, wherein a quantity of entries in the dynamic state space is augmented or diminished dependent on a quantity of spatially distinct lumped masses being tracked. Measurements relating to an observed lumped mass of material are fused into the dynamic state space and a dynamic covariance matrix to provide an updated estimate of material in the plurality of spatially distinct lumped masses of material.

Abstract: Disclosed herein is a notch filter and a method for generating an electrical signal with a suppressed frequency band. The filter generates an optical signal by modulating a modulation optical wave with an electrical signal to generate first and second sidebands. The first sideband or the second sideband has less power than the other. The filter then modifies the optical signal by equalizing the power of light within the first side band at a selected frequency band and light within the second side band at the selected frequency band. The filter then produces an antiphase relationship between the light within the first side band at the selected frequency band and the light within the second side band at the selected frequency band. The filter then detects the modified optical signal to generate a copy of the electrical signal with suppressed frequency components within the selected frequency band.

Abstract: The invention relates generally to the field of bone diseases. More specifically, the invention relates to methods and compositions for the treatment of osteoporosis and related disorders.

Abstract: The present invention generally relates to pharmaceutical compositions containing a protease proenzyme and use thereof for treating cancer. The pharmaceutical compositions are directed to compositions comprising a protease proenzyme and an active agent, the composition being capable of providing a multi-functional approach for treating cancer. The pharmaceutical compositions are also directed to compositions comprising a first and a second protease proenzyme capable of activation at or near a surface of a tumor cell to enhance cell-to-cell adhesion of tumor cells, effect proteolysis of tumor cells, or induce tumor cell apoptosis, differentiation or immunorecognition, wherein the first protease proenzyme is chymotrypsinogen and the second protease proenzyme is trypsinogen. The pharmaceutical compositions are also directed to compositions comprising a first and second active agent each capable of inducing intracellular activity in tumor cells.

Abstract: The present invention relates to a method for detecting cardiovascular oxidative stress in an individual, comprising detecting in a blood sample from the individual modification of a cysteine at position 45 of the ?1-subunit of the human erythrocyte ATP-dependent Na+K+ pump protein or of an equivalent cysteine in a homolog or variant thereof. The invention further relates to a kit for detecting cardiovascular oxidative stress in an individual, the kit comprising at least one agent for detecting the presence of a modification in a cysteine at position 45 of the ?1-subunit of the human erythrocyte ATP-dependent Na+K+ pump protein or of an equivalent cysteine in a homolog or variant thereof, wherein said modification is a result of oxidation.

Abstract: The invention relates to the identification of antigens, including Mycobacterium sulphate assimilation pathway components such as CysD, for preventing and treating Mycobacterium infection, especially but not exclusively Mycobacterium tuberculosis infection; to expression systems including live Mycobacterium for expression of said antigens for prevention and treatment of said infection; and to use of said antigens and expression systems for prevention and treatment of said infection.

Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.

Abstract: The present invention relates to polymers, especially polymers useful as hydrogels, and to use of hydrogels for repair or restoration of tissue. In particular, the polymers and hydrogels of the present invention can be used for the repair or restoration of cartilage, especially articular cartilage. The polymers comprise at least a monomer for binding water, a monomer for imparting mechanical properties and a monomer for binding to an extracellular protein. The hydrogels comprise a polymer comprising at least a monomer for binding water and a monomer for binding to an extracellular protein. Crosslinking polymers by binding of said extra-cellular matrix protein forms hydrogels.

Abstract: Described herein is a method and system for characterizing in-ground rock types from measurement-while-drilling data in a mining environment. The method includes the steps of drilling holes at a plurality of selected locations within a region of interest; collecting measurements while drilling to obtain an array of data samples (162) indicative of rock hardness at various drilling depths in the drill hole locations; obtaining a characteristic measure (163) of the array of data samples; performing Gaussian Process regression (164) on the characteristic measure; and applying boundary detection (166) to the rock hardness output data obtained from the Gaussian process model to identify the distribution (280) of at least one cluster of rock type within the region of interest.

Abstract: A method of optimizing 4D cone beam computed tomography (4DCBCT) imaging is provided that includes using a scanner to generate projections of a target, where the projections are used to form a cone beam computed tomography (CBCT) scan of the target, where the CBCT includes a 3D image of the target, and using an appropriately programmed computer to control rotation speed of a gantry and projection acquisition of the CBCT in real-time according to a measured patient respiratory signal, where the real-time acquisition of the 4CBCT forms an optimized 4DCBCT image set.

Abstract: Novel FXR agonists are disclosed, embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.

Abstract: A process for producing ammonium nitrate is disclosed, which process comprises exposing a gaseous oxidizer feed composed at least substantially of ammonia, steam and an oxidizing gas to conditions whereby the ammonia is oxidized to produce a reaction mixture including nitrogen monoxide and water vapor. The reaction mixture is cooled in a heat exchanger whereby the nitrogen monoxide is oxidized, the water vapor is condensed and the products of the nitrogen monoxide oxidation react with and are absorbed by the condensed water to form a nitric acid stream, with substantially all of the nitrogen monoxide in the reaction mixture being converted to nitric acid. The nitric acid stream is reacted with a stream of ammonia to form the ammonium nitrate.

Abstract: Methods and systems are described for effecting autonomous operations within a defined geographical region (1110). A plurality of localized zones (1102, 1104, 1106, 1108) having operation-defined geographical boundaries are specified within the region. A plurality of control modules are established associated with respective ones of the localized zones and autonomous operations are effected under the supervisory control of the control module associated with the localized zone in which the autonomous operation occurs. The geographical disposition of the boundary of at least one of the localized zones is varied within the defined geographical region.

Abstract: The present disclosure provides a method of characterizing a resource in a block located in an area. The method comprises the step of providing information concerning a property of the resource for a plurality of sample positions in, at or in the environment of the block. The information is obtained from analyzes of samples from the sample positions. The method further comprises modelling a change in the property along a distance at or within the block using the provided information. The method also comprises calculating parameters associated with the modelled change using Bayes' theorem and calculating a property characteristic of the resource for the block using the calculated parameters.

Abstract: The invention relates to methods of controlling orientation of direct covalent binding of a peptide to a polymer substrate surface, to surfaces with peptides directly covalently bound thereto in a manner where the orientation of binding is controlled as well as to devices comprising such substrates. In particular the invention relates to A method of controlling predominant orientation of direct covalent binding of one or more peptides to a polymer substrate surface comprising: (a) exposing the surface to energetic ion treatment to generate a plurality of activated sites comprising reactive radical species; (b) incubating the surface with one or more peptide/s that exhibit or can be induced to exhibit a dipole moment and manipulating the electric field environment and/or charge of said surface and/or of said peptide/s during said incubating; wherein predominant orientation of direct covalent binding of said peptide/s to said surface is thereby controlled.

Abstract: Autonomous operations are conducted within a defined geographical region. In an autonomous system of a management party a plurality of localized zones are established having operation-defined geographical boundaries within the geographical region. Entities having autonomous operating systems to perform specific autonomous operations within respective ones of the localized zones. The autonomous system of the management party is integrated with the autonomous operating systems of the entities.

Abstract: This disclosure relates to controlling an oscillator based on a measurement of a frequency reference. A controller determines a control value to control the oscillator based on multiple error values. Each error value is indicative of a measurement of a frequency difference between the oscillator and a frequency reference over a period of time. The determination of the error value is further based on an application time value indicative of a time of application of the control value to the oscillator. Since the control value is based on the application time the controller can compensate for inaccuracies arising from both evolution of the oscillator between measurements and applying the correction at a later time after the measurement. Further, since the multiple error values represent a frequency difference over different periods of time, the controller can compensate for wide range of statistical effects.