Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: A cell evaluation method includes acquiring a first evaluation index and a first index calculated using the first evaluation index with respect to comparative target cells in a culture process including a cell differentiation-inducing process in which cell differentiation is induced, calculating a second index on the basis of the first evaluation index with respect to evaluation target cells different from the comparative target cells, and evaluating differentiation of the evaluation target cells by comparing the first index with the second index.

Abstract: The present invention provides an induction type oil debris signal monitoring and identification system, which comprises an induction type oil debris sensor, used to detect small electromagnetic changes in the oil and output a monitoring signal after processing through a signal processing circuit; a bubble and debris classification and identification network module, used to analyze whether an abnormal amplitude signal in the monitoring signal contains bubbles or not so as to prevent the bubbles from being c as debris, and a two-level debris signal analysis network module, used to analyze the monitoring signal and determine the size and the quantity of debris.

Abstract: A method for producing hydrogen gas is disclosed. The method includes providing kerogen; providing hydrogen; introducing the kerogen and hydrogen into a reaction chamber wherein the reaction chamber is operated at an operating temperature between about 455° C. and 510° C.; and removing a gas stream comprising hydrogen.

Abstract: Provided herein are methods for selecting a subject with a seizure disorder for treatment, as well as methods of treating the subject, determining the efficacy of the treatment, and adjusting the treatment dosage and frequency. In some aspects, provided herein are methods of treating seizures in a subject by administering to the subject a composition comprising bacteria of the Akkermansia (Akk) and Parabacteroides (Pb) genera.

Abstract: The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ERT) or other therapy involving the administration of a proteinaceous therapeutic agent as well gene replacement therapy with non-viral or viral vectors, or other therapeutic modality or modalities, used alone or in combination, which involve the administration of exogenous substances for potential therapeutic benefit, including, but not limited to DNA vaccines, siRNA, splice-site switching oligomers (SSOs) as well as RNA-based nanoparticles (RNPs) and nanovaccines. The invention further relates to compounds and compositions suitable for use in such methods.

Abstract: Compositions and methods for treating or reducing the severity of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a composition comprising isolated native, bioactive nematicidal crystals formed from a single type of nematicidal crystal protein. The isolated native, bioactive nematicidal crystals are substantially free of any bacterial spores or host bacterial proteins, other than nematicidal crystal protein in the form of a crystal. Methods for making isolated native, bioactive nematicidal crystals are also described. The crystal proteins may be full length, truncated, variant, or sub-variant Cry proteins. Examples of crystal proteins include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A.

Abstract: A method for inter-hospital identity authentication and electronic medical record transfer of patients is provided. Based on a blockchain technology, a patient achieves secure and efficient inter-hospital transfer authentication, and a new hospital accesses an electronic medical record with authorization of the patient, thus achieving reliable electronic medical record access controls. In each hospital, the patient, a medical server, and a doctor achieve efficient tripartite authentication and negotiation of session keys, and communicate based on the session keys. By introducing an elliptic curve to encrypt key parameters in an authentication process, a security of the entire authentication process is improved, and a computational pressure on a wireless device is reduced. In the authentication and the electronic medical record, the patient uses dynamic anonymity policies to protect privacy.

Abstract: An offshore wind turbine with anti-accumulation of aquatic organisms, comprising: a base with an interior space, the base being made of conductive material; a tower incorporated above the base; a nacelle, connected to the tower; a plurality of blades, each interconnected with the nacelle; and a power supply system electrically connected to the base and disposed within the interior space, the power supply system being used to provide electrical energy to the base to energize the surface of the base to form an electric field.

Abstract: A method for identification of characteristic components in a Kai-Xin-San by thin-layer chromatography (TLC) is provided, belonging to the technical field of pharmaceutical raw material detection and traditional Chinese medicine quality control. The method only needs to prepare two test solutions to simultaneously identify six characteristic components in the Kai-Xin-San, namely ginsenoside Rb1, ginsenoside Re, tenuifolin, ?-asarone, dehydrotumulosic acid, and pachymic acid. An automatic TLC spotting instrument can ensure even sampling and flat chromatographic bands and the silica gel G thin-layer plates after spotting are placed in the steam of the optimized developing solvent to allow pre-saturation.

Abstract: A multi-functional reconfigurable intelligence surface (MF-RIS) integrating signal reflection, refraction and amplification and energy harvesting and an application thereof are provided. The MF-RIS can support wireless signal reflection, refraction and amplification and energy harvesting on one surface, to amplify, reflect, or refract a signal through harvested energy, and further enhance effective coverage of wireless signals. When a signal model of the MF-RIS constructed in the present disclosure is applied to a multi-user wireless network, a non-convex optimization problem of jointly designing operation modes and parameters that include BS transmit beamforming, and different components and a deployment position of the MF-RIS is constructed with an objective of maximizing a sum rate (SR) of a plurality of users in an MF-RIS-assisted non-orthogonal multiple access network.

Abstract: The present invention provides certain polymeric materials, precursors thereof as well as the preparation and uses thereof.

Abstract: A power conversion system including a triple active bridge (TAB) is provided. The system includes a power factor correction (PFC) module and a three port converter (TPC) module, with no post-regulation or additional stages required. The TPC module includes an OBC full-bridge and an APM full-bridge, each being inductively coupled to the output of the PFC full-bridge, thereby forming the TAB. The OBC full-bridge is adapted to convert an AC input into a high-voltage DC output for a high-voltage battery, and the APM full-bridge is adapted to convert an AC input into a low-voltage DC output for a low-voltage battery. The power conversion system can accept a single-phase AC input and a three-phase AC input, has a lower current stress as compared to prior art TPCs, and freely transfers power from among any ports.

Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.

Abstract: A detection unit, device, and system for cell capture, spectral analysis, and drug interaction monitoring. The detection unit includes an IR-transparent substrate connected to a plasmonic metasurface with an array of metallic antennas. In a detection device, the detection unit is connected to a microfluidic chamber with a channel such that the channel extends along the metasurface. For the detection system, the detection device is mounted on a microscope. The infrared spectra are collected in reflection, with infrared light impinging on the metasurface from the substrate side and returning back through the substrate in the form of reflected infrared light. The system includes a syringe pump for injecting live cells into the chamber. An AC source is connected to the metasurface for cell capture and its AC voltage creates a dielectrophoretic (DEP) force that causes the live cells to move from the chamber and onto the metasurface for spectral analysis.

Abstract: A semi-powered foot and ankle prosthesis (100) has a foot member (128) coupled to the ankle frame (112) and movable with respect to the ankle frame (112). A linear actuator (144) is coupled to and between the ankle frame (112) and the foot member (128) to move the foot member (128) with respect to the ankle frame (112). The linear actuator (144) has a drive motor (150). A locking mechanism (104) selectively engages the drive motor (150) to selectively lock movement of the drive motor (150) to resist a force on the foot member (128) from backdriving the linear actuator (144).

Abstract: A composition of matter is provided comprising hierarchically ordered crystalline microporous material having well-defined long-range mesoporous ordering of hexagonal symmetry. The composition possesses mesopores having walls of crystalline microporous material and a mass of mesostructure between mesopores of crystalline microporous material. Long-range ordering is defined by presence of secondary peaks in an X-ray diffraction (XRD) pattern and/or hexagonal symmetry observable by microscopy.

Abstract: The present disclosure addresses the problem of UAVs pursuing a swarm of target UAVs. The target UAVs are flying together as a flock that are initially modeled as a circle having a time-varying radius or an arbitrarily-shaped swarm that may change in size. Guidance of the pursuing UAVs is developed based on a collision cone framework, wherein the pursuing UAVs cooperatively steer the velocity vector of any point in their convex hull, to intercept the target. Also, the problem of capturing a swarm of intruder UAVs using a net manipulated by a team of defense UAVs is disclosed. The intruder UAV swarm may be stationary, in motion, and even maneuver. Collision cones in 3-dimensional space are used to determine the strategy used by the net carrying UAVs to maneuver or manipulate the net in space in order to capture the intruders.

Abstract: Disclosed is a method of obfuscating a Controller Area Network (CAN) message performed by a first computing device including a processor, the method including: obtaining a first index from a first input value corresponding to a first time point by using an index output algorithm; determining a first CAN ID of the first computing device corresponding to the first index based on a predetermined CAN ID table; and generating a first normal CAN message including the first CAN ID and first normal data.

Abstract: Embodiments include accessing a set of digital pathology (DP) images having an imaging parameter; applying a low-computational cost histology quality control (HistoQC) pipeline to the DP images, where the low-computational cost HistoQC pipeline computes a first set of image metrics associated with a DP image, and assigns the DP image to a first or a second, different cohort based on the imaging parameter and the first set of image metrics; applying a first, higher-computational-cost HistoQC pipeline to a member of the first cohort; applying a second, different higher-computation-cost HistoQC pipeline to a member of the second cohort; where the first or second, higher-computational-cost HistoQC pipeline determines an artifact-free region of the member of the first or second cohort, respectively, and classifies the member of the first or second cohort, respectively, as suitable or unsuitable for downstream computation or diagnostic analysis based, at least in part, on the artifact free region.