Abstract: A robot arm having a series of rigid links including a first rigid link and a final rigid link, the links being operatively controlled via tendon-driven joints, each tendon-driven joint comprising a motorized spool configured to rotate in either of two directions and operatively coupled, via a cable assembly having an elastic portion, to a pulley configured to move a respective rigid link thereby. A controller adapts robot arm motion in response to position and force sensing signals. A tendon-driven joint may be implemented via one motor controlling the tension of two cables acting in opposing directions and coupled between respective ones of a pair of common-driven spools and a pair of pulleys.

Abstract: The present invention provides a neurite outgrowth promoter for promoting neurite growth on nerve cells of a postnatal mammalian individual for use in a condition in which an effective amount of a glial cell-derived neurotrophic factor (GDNF) is not present, the neurite outgrowth promoter containing at least one protein selected from the group consisting of: GDNF family receptor ?1 (GFR?1): GFR?1 mutants having an amino acid sequence that has at least 90% sequence identity with the amino acid sequence of GFR?1, the GFR?1 mutants having neurite outgrowth activity; fusion proteins that have neurite outgrowth activity and that are obtained by fusing GFR?1 or a GFR?1 mutant with another peptide; and chemically modified proteins that have neurite outgrowth activity and that are obtained by chemically modifying one or a plurality of amino acid residues in GFR?1, a GFR?1 mutant, or a fusion protein. The present invention also provides a pharmaceutical composition for inducing nerve regeneration.

Abstract: A rubber product capable of easily and accurately detecting the presence or absence of leakage and a position of the leakage is provided. A rubber product includes a gas chromic material that changes a color thereof reversibly or changes an electric resistance value thereof, due to oxidation-reduction reaction. The rubber product is a sealing member (sealing product 10) for sealing a gap between two members, wherein the sealing member includes a gas chromic material that changes a color thereof reversibly or changes an electric resistance value thereof, due to oxidation-reduction reaction, and has a ring shape.

Abstract: A method for estimating fault location in an electrical power line system (PLS) is provided. The method includes receiving an observed signal caused by a real fault in the PLS. The observed signal is measured at a real observation point in the PLS. The real fault has occurred at one of two or more real locations in the PLS; accessing a library representing model signals between model guessed fault locations and a model observation point in a network model of the PLS; selecting a model GFL by: (i) calculating metrics for the model signals by processing the model signals with the observed signal, and/or (ii) selecting the model GFL corresponding to a highest calculated metric; estimating a fault location of real locations in the PLS based on a corresponding location of the selected model GFL; and sending the estimated fault location to an external management system.

Abstract: A method of enhancing the presence of alternatively-spliced UMOD protein by inducing exon-skipping of a AS-UMOD m-RNA to protect TAL cells of kidneys in a patient suffering from acute kidney injury or chronic kidney disease.

Abstract: A cell matrix nerve graft for repairing peripheral nerve injury and a preparation method thereof are provided. The cell matrix nerve graft comprises acellular matrix and a scaffold, wherein the acellular matrix is obtained by decellularization after secretion and formation of stem cells, and the acellular matrix is wrapped around the scaffold. The defects of autologous nerve transplantation repair can be overcome and the immunogenicity of allogeneic cell transplantation repair is avoided. The cell matrix nerve graft beneficial to nerve cell proliferation and migration is provided, a microenvironment beneficial to axon growth is established, the purposes of nerve regeneration and function repair are achieved, and a feasible solution is provided for clinical treatment of nerve defects.

Abstract: Parameter optimization method for nonlinear vibration model of complex device, comprising: 1) constructing various structures of complex device into tree structure, to form tree-shaped complex device model subsystem, and carrying out sign convention for dynamic analysis; 2) establishing complex device dynamic model to obtain dynamic relationships among all parts of complex device; 3) according to contact and collision conditions in advancing process of physical complex device, adding constraint relationships among parts in dynamic simulation software; 4) on basis of dynamic simulation software, establishing virtual prototype model of complex device, and determining target parameter and optimization target; 5) simulating vibration characteristics of complex device for different levels of pavement spectrums and different vehicle speeds; 6) adding required input point and output point for virtual prototype model; 7) on basis of optimization algorithm of numerical solution in small sample deep learning, obtaining

Abstract: Disclosed is a method for quantitative detection of a small, aberrant viral nucleic acid. The method includes combining a detection mixture with a sample, and allowing a reaction with the test mixture to begin. The sample includes an RNA sample. The detection mixture includes a Cas13 enzyme, a reporter, a sequence-specific CRISPR RNA (crRNA), and a buffer. The method includes determining a quantitative value representative of the reporter in the test mixture, where the quantitative value is a measure of an amount of target RNA present in the RNA sample.

Abstract: A novel approach for computing efficiently quantum based signal autocorrelations includes example designs associated with quantum circuits for computing the quantum autocorrelation of the signal. Importantly, to compensate for unique challenges associated with quantum signal processing (particularly regarding probabilistic measurements that result from QFT and IQFT operations), normalization and denormalization steps ensure that quantum measurement results are comparable to ranges that would be obtained with classical autocorrelation computation methods. In addition, because probabilistic measurements resulting from QFT and IQFT operations lose important phase information, lost phase information can be restored following measurement using QFT and IQFT.

Abstract: The present invention discloses a method for the preparation and application of modified extracellular vesicles specifically targeted to the kidneys. These modified extracellular vesicles are derived from fibroblastic reticular cells in the mesentery tissue and express anti-inflammatory proteins after being modified with anchor peptides. By combining the extracellular vesicles secreted from fibroblastic reticular cells in the mesentery tissue with anchor peptides, the present invention ensures the effective targeting of the exosomes to the kidneys. Additionally, through genetic engineering of fibroblastic reticular cells, the exosomes secreted by these cells can carry the target molecule, anti-inflammatory protein CD5L, achieving precise targeted therapy for the kidneys. This innovative treatment strategy holds promising potential for the treatment of sepsis-associated acute kidney injury, bringing positive impacts to patients' health.

Abstract: Actuation devices and methods for using same are disclosed. The actuation device includes a first actuation layer including a plurality of first actuators operable within a first frequency range, and a second actuation layer provided on the first actuation layer, the second actuation layer including a plurality of second actuators operable within a second frequency range different from the first frequency range.

Abstract: A first-order differential microphone array (FODMA) system with a steerable beamformer. The system includes a plurality (M) of microphones located on a substantially planar platform, the plurality of microphones comprising a first subset (M_1) of microphones and a second subset (M_2) of microphones, and a processing device, communicatively coupled to the plurality of microphones, configured to construct a first sub-beamformer based on the first sub-set (M_1) of microphones and a target beampattern at a steering angle ?, wherein the first sub-beamformer is characterized according to a first-order cosine (cardioid) first sub-beampattern, construct a second sub-beamformer based on the second sub-set (M_2) of the microphones and the target beampattern at the steering angle ?, wherein the second sub-beamformer is characterized according to a first-order sinusoidal (dipole) second sub-beampattern, and generate the steerable beamformer based on the first sub-beamformer and the second sub-beamformer.

Abstract: A multifunctional suspension device for mechanical engineering, relating to mechanical engineering equipment. The multifunctional suspension device includes a supporting base, wherein guide rods are symmetrically arranged on the left and right sides of the upper surface of the supporting base, the ends, away from the supporting base, of the guide rods are fixedly connected with a top plate, a first screw rod is arranged between the guide rods on the left and right sides, the upper and lower ends of the first screw rod are rotatably connected with the top plate and the supporting base, a first driving motor is arranged in the supporting base, second nuts drive arc-shaped clamps on the two sides to move inwards at the same time through push rods and clamping rods to clamp and fix a tubular part.

Abstract: A composite structural element includes a concrete member and a hollow member covering a part of a length of the concrete member. The concrete member has a first end, a second end, and a first elongated body extending between the first and second ends. The first elongated body has a first length between the first and second ends thereof. The hollow member has a first open end, a second open end, and a second elongated body extending between the first and second open ends. The second elongated body has a second length that is shorter than the first length. The hollow member may include a plurality of studs and a stiffener on its interior, in contact with the concrete member.

Abstract: The multi-turn dialogue system based on retrieval includes the following modules: a representation module, a matching module, an aggregation module and a prediction module; the multi-turn dialogue method based on retrieval includes the following steps: (1) by a representation module, converting each turn of dialogue into a cascade vector of the dialogue, and converting a candidate answer into a cascade vector of the candidate answer; (2) by a matching module, dynamically absorbing context information based on a global attention mechanism, and calculating a matching vector; (3) by aggregation module, obtaining a short-term dependence information sequence and a long-term dependence information sequence; (4) by a prediction module, calculating the matching score of the context and candidate answer involved in the matching; (5) selecting a candidate answer with the highest matching score as a correct answer.

Abstract: The tactile directional guide system provides directional information in the form of vibrations for use during emergency evacuations and the like. The tactile directional guide system includes a vibrational module adapted for mounting on a support surface, such as the floor or wall of a hallway or corridor, as non-limiting examples. The vibrational module includes a plurality of members linearly arrayed along a longitudinal direction and a plurality of vibrators respectively coupled to the plurality of members. A controller is in communication with the plurality of vibrators and is configured to selectively sequentially actuate the plurality of vibrators in either a forward longitudinal direction or a rearward longitudinal direction to provide a tactile directional output.

Abstract: A carrageenan derivative according to the present disclosure can quickly and easily detect and label the presence of inflammation-related macrophages and, particularly, can accurately and easily identify M1-type macrophages highly associated with early inflammation. In addition, the carrageenan derivative has advantages in that it can be produced easily, environmental pollution is minimized because a small amount of organic solvent is used, and initial cost is low.

Abstract: A microfluidic tissue dissociation and filtration device simultaneously filters large tissue fragments and dissociates smaller aggregates into single cells, thereby improving single cell yield and purity. The device includes an inlet coupled to a first microfluidic channel at an upstream location and a first outlet at a downstream location. A first filter membrane is interposed between the first microfluidic channel and a second microfluidic channel, wherein the second microfluidic channel is in fluidic communication with the first microfluidic channel via the first filter membrane. The first filter membrane operates under a tangential flow format. A second outlet is coupled to a downstream location of the second microfluidic channel and includes a second filter membrane interposed between the second outlet and the second microfluidic channel. The dual membrane device increased single cell numbers by at least 3-fold for different tissue types.

Abstract: The present invention provides an antisense oligonucleotide that is formed of 15-22 nucleotides and that is complementary to a nucleic acid including at least 15 consecutive bases in a specific target region of a base sequence of SEQ ID NO: 471 (which encodes atrophin 1; ATN1), or a pharmaceutically acceptable salt thereof, or a hydrate thereof.

Abstract: The present disclosure provides a copper nanowire composition. The copper nanowire composition includes copper nanowire having associated ligands with the structure HNR1R2, where R1 is hydrogen, alkyl group, or arylalkyl group, R2 is alkyl group or arylalkyl group, wherein the associated ligand has an amount of 100 wt % to 10000 wt % versus a weight of the copper nanowire.