Abstract: Provided are embodiments of para-substituted 1,1-dialkyl-4-phenylpiperazin-1-ium iodides advantageous for modulating inflammation that have been synthesized and their electrophysiology activities for ?9, ?9?10, and ?7 nAChRs compared. The para position contained alkyl or aryl amides, or heterocyclic isosteres for the amide, and the alkyl groups were varied at the ammonium piperazine nitrogen to see if compensatory changes in size at this position of the molecule impacted function. The compounds were characterized with two-electrode voltage-clamp measurements on Xenopus oocytes expressing nAChRs. General, the compounds were more potent for ?9-containing receptors than for ?7, and the majority were either full or strong partial agonists for ?9-containing nAChR.

Abstract: Systems and methods are provided for enabling users to work with TimeML annotations and perform advanced temporal analysis, offering a comprehensive suite of features. Systems and methods of embodiments allow users to parse TimeML annotations, construct TimeML graphs, and execute the timeline extraction (TLEX) algorithm to effect complete timeline extraction. An algorithm can be incorporated for increasing connectivity in temporal graphs, which identifies graph disconnectivity and recommends links based on temporal reasoning, thereby enhancing the coherence of the graph representation. Also, a built-in validation algorithm can be included, ensuring compliance with TimeML annotation guidelines.

Abstract: An efficient thermal control system for microcircuits based on liquid metal coolant is provided, including a cooling water system, a liquid metal supply system and a cooling system. The liquid metal supply system is used for supplying liquid metal to the cooling system to achieve heat exchange with a chip through the liquid metal, and the cooling water system is used for cooling the liquid metal. The cooling system includes a cooling capacity distribution unit used for distributing the liquid metal; cabinets provided with chip cooling platforms, which are connected to the cooling capacity distribution unit through a pipe, and are provided with the chip; a temperature measuring component used for measuring temperature of the chips; and a control unit, and cooling capacity distribution unit and the temperature measuring component are electrically connected to the control unit.

Abstract: The present disclosure relates to an ERT/ECT dual-modality combined three-dimensional sensor. A cover box is sheathed with a shielding box, a plurality of small round holes are formed in the top surface and the side surfaces of the cover box, ERT electrodes are arranged in the small round holes, and ECT electrodes are arranged at the outer sides of the ERT electrodes. The ERT electrodes are connected to an ERT data acquisition box via electrode leads, and the ECT electrodes are connected to an ECT data acquisition box via the electrode leads. An integrated cuboid design in line with the concrete structure is employed. Meanwhile, the dimensions, combination modes, placement modes and positions, supporting structures, shielding devices, electrode leads and leading-out modes of two sets of electrode arrays are subjected to comprehensive optimization design to achieve three-dimensional visual nondestructive monitoring of the moisture intrusion process in the concrete structure.

Abstract: Disclosed are a light-driven filtration antibacterial composite membrane and a preparation method and use thereof. The method for preparing the light-driven filtration antibacterial composite membrane includes: mixing dichloromethane and N,N-dimethylformamide to obtain a first solution; adding PCL particles to the first solution, and stirring until being uniform to obtain an electrospinning solution; adding a ZIF-8 powder to the electrospinning solution, and ultrasonically dispersing for at least 1 hour to obtain a PCL/ZIF-8 spinning solution; spraying the PCL/ZIF-8 spinning solution onto a PPCL@PDA/TAEG men-blown membrane to obtain the light-driven filtration antibacterial composite membrane.

Abstract: New methods and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. The method includes administering to a subject in need thereof an effective amount of a small molecule compound inhibitor for EphA4 signaling. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling.

Abstract: Modified integrin polypeptides are provided. Methods of identifying binding agents that bind to a modified integrin polypeptide are also provided.

Abstract: A method of monitoring operation of a reactor system includes causing a chemical reaction to occur within an assembly of the reactor system, and measuring a chemical composition of one or more reactants of the chemical reaction with spatial resolution at a plurality of points along a path within the assembly using a sensor system structured to implement distributed sensing. The sensor system includes an optical fiber sensing member provided at least partially within the assembly, wherein the optical fiber sensing member comprises a functionalized optical fiber based sensor device structured to exhibit a change in one or more optical properties in response to changes in the chemical composition of the one or more reactants.

Abstract: A three-dimensional star-shaped ?-helix polypeptide having a high-efficiency gene delivery capability, and a preparation method and an application thereof. A dendrimer is used as an initiator and dichloromethane is used as a reaction solvent to initiate high-speed ring-opening polymerization of different types of N-carboxylic anhydride monomers, and groups having different electrical properties are introduced at the ends via click chemistry reactions. The abundant amino groups on the surface of the dendrimer provide enough polymerization sites to enable the polypeptide to form a three-dimensional spherical topological structure, and the topological structure provides an opportunity for initial acceleration of the ring-opening polymerization reaction. The higher positive charge density caused by polypeptide side chain modified guanidine/amino groups etc.

Abstract: Provided in the present invention are an imaging device and method for turbid oil abrasive particles based on polarized image enhancement, which belong to the technical field of image processing. The imaging device of the present invention includes a CMOS fixing device, a Stokes polarized CMOS sensor, an optical lens sleeve and an optical magnifying glass, where the Stokes polarized CMOS sensor includes a CMOS sensor and a Stokes analyzer. By using a polarization characteristic difference between scattered light of lubricating oil media and reflected light of abrasive particles, Stokes vector information is measured in real time under turbid lubricating oil scenes, the scattered light of the media is filtered out, image quality of the abrasive particles is improved, coverage duration for monitoring abrasive particle imaging is effectively prolonged.

Abstract: An ethyl 2-[9-(2-hydroxypyridin-3-yl)-3,6-diphenyl-1,8-dioxo-3,4,9,10-tetrahydroacridine-10-yl]-acetate compound, its synthesis, and its use as an antimicrobial agent.

Abstract: A manufacturing method for a composite sheet having excellent rigidity, no shape deformation, and excellent transparency is disclosed. By laminating a film obtained by impregnating a composite resin on a wet cake including cellulose nanofibers and glycerol, rigidity and transparency may be maximized, and a flat and thick composite sheet may be provided.

Abstract: A vehicle body structure capable of modular assembly includes a chassis frame extending from a body frame forming a vehicle body. A corner module is fastened to a side portion of the chassis frame. The corner module includes a knuckle fastened to a wheel, an upper arm positioned between a top end portion of the knuckle and a module bracket mounted on the chassis frame, and an elastic member mounted between the module bracket and a bottom end portion of the knuckle.

Abstract: Disclosed are an offset calibration method and circuit applied to a comparator array. The offset calibration circuit includes a global calibration voltage generation module, integrators, comparators, a global logic control circuit, and local logic control circuits; an entire comparator array shares the single global calibration voltage generation module, and each of the comparators only needs to introduce an integrator circuit, such that a large calibration range and a small calibration step are achieved, a long calibration cycle and a large circuit area are required, and the requirements for a low area are satisfied. The offset calibration method provided by the present disclosure is similar to a binary search algorithm, which is adopted to search for the offset voltage, the calibration step of 1 2 N ? Vref can be realized by only N cycles, and short calibration time is thus realized.

Abstract: A method for data clustering performed in a computing device including one or more processors and a memory that stores one or more programs executed by the one or more processors according to an embodiment includes receiving two or more multivariate discrete time series data as input and generating an embedding vector for each of the multivariate discrete time series data using a first artificial neural network, generating a similarity graph by performing a path-based connectivity test between embedding vectors for each of the two or more multivariate discrete time series data, predicting a label distribution for embedding vectors for each of the two or more multivariate discrete time series data using a second artificial neural network, and clustering the two or more multivariate discrete time series data based on the similarity graph and the label distribution.

Abstract: Disclosed herein is a bio-based copolymer comprising in polymerized form (i) at least one polymerizable bio-based monomer containing one phenolic hydroxyl group which has been derivatized to provide at least one polymerizable functional group which is an ethylenically unsaturated functional group (such as a [meth]acrylate group), where the precursors of the polymerizable bio-based monomers are derived from raw lignin-containing biomass, and (ii) at least one ion-conducting co-monomer other than the bio-based monomer. Also disclosed herein are binders comprising the bio-based copolymer, electrodes comprising the binder, polymer electrolytes comprising the bio-based copolymer and an electrochemical device comprising an electrode in electrical contact with a polymer electrolyte, wherein at least one of the electrode and the polymer electrolyte comprises the bio-based copolymer.

Abstract: The disclosure relates to a device that is configured to be implanted on the native leaflet of a heart valve to increase its length and/or thickness and thereby to improve the valve function and reduce regurgitation. The device may include a leaflet section. The leaflet section may include a central member. The central member may include a first portion, a second portion that opposes the first portion, and a base portion disposed between the first portion and the second portion. The first section may extend from the first portion and the second section may extend from the second portion. The device may include one or more engaging members extending from the central member at an angle with respect to the first section and the second section. The second section may be larger than the first section. The leaflet section may define a three-dimensional region or a bulge.

Abstract: A scale thickness estimating system according an embodiment includes: a fluid temperature acquiring unit that acquires a temperature of a fluid flowing in a pipe; a flow path outer surface-temperature acquiring unit that acquires a temperature of an outer surface of the pipe; a heat flux acquiring unit that acquires a heat flux on the outer surface of the pipe; a flow path wall-thermal conductivity acquiring unit that acquires a flow path wall thermal conductivity of the pipe; a scale thermal conductivity acquiring unit that acquires a scale thermal conductivity of scale depositing on an inner surface of the pipe; and a scale thickness estimating unit that estimates a thickness of the scale based on the temperature of the fluid, the temperature of the outer surface, the heat flux, the flow path wall thermal conductivity, and the scale thermal conductivity.

Abstract: The present disclosure relates to an organ-on-a-chip, and according to the present disclosure, the organ-on-a-chip includes a first layer having a first microfluidic channel to culture a first organ cell, a second layer having a second microfluidic channel, a third layer having a third microfluidic channel to culture a second organ cell, a first membrane to spatially separate the first microfluidic channel from the second microfluidic channel, and a second membrane to spatially separate the second microfluidic channel from the third microfluidic channel, thereby measuring the rate of absorption of a test drug into the first organ cell and the second organ cell at the same time.

Abstract: An insulated heating-unit cover having an opening to permit air to circulate around the heating-source when a vent disposed at the top of the cover is opened, allowing heat into a space. The cover can include a heating-unit temperature sensor disposed within a space covered by the cover and a controller in wireless communication with a space temperature sensor located at a distance away from the heating-unit. The controller can be configured to operate an actuator such that the vent is open when the space temperature sensor indicates that the ambient temperature is below a set point temperature and such that the vent is closed when the ambient temperature is greater than the set point temperature. The controller can communicate with a plurality of other similar controllers and a central server to effect changes in the output of a central heating source coupled to a plurality of individual heating-units.