Abstract: Provided are a hydantoin compound as represented by formula (I) or a pharmaceutically acceptable salt thereof and the medical use thereof. The compound has a strong agonistic action on PPAR? and PPAR?, has a good selectivity to PPAR?, and has good pharmacokinetic properties. The compound or a pharmaceutically acceptable salt, prodrug, deuterated compound or solvate thereof can be used for preparing a PPAR?/? dual agonist, and is used for preparing a drug for preventing or treating diseases mediated by PPAR? and/or PPAR?.

Abstract: Provided is a method of decomposing a crosslinked rubber that can improve monomer yield. The method of decomposing a crosslinked rubber includes: a first decomposition step of pyrolyzing a crosslinked rubber containing a rubber component that includes a diene-based rubber at not lower than 150° C. and not higher than 400° C.; and a second decomposition step of further pyrolyzing a decomposition product obtained through the first decomposition step at not lower than 600° C. and not higher than 950° C. in an inert gas atmosphere and in the absence of a catalyst. The first decomposition step is preferably performed in an inert gas atmosphere.

Abstract: The present invention relates to use of homoharringtonine in manufacturing a drug for treating an acquired immunodeficiency syndrome. A homoharringtonine compound is prepared as a drug for treating the acquired immunodeficiency syndrome and is applied to the treatment of the acquired immunodeficiency syndrome. The homoharringtonine compound can significantly reduce the programmed ribosomal frameshifting (PRF) efficiency of the mRNA of HIV-1 during the translation of a Gag-Pol fusion protein to substantially decrease the translation efficiency of the Pol protein. Therefore, the cell fails to produce protease, integrase, and reverse transcriptase obtained via Pol splicing such that a virus cannot be packaged effectively, which eventually leads to a sharp decline in yield of the virus. Therefore, the compound of the present invention has a good anti-HIV effect.

Abstract: A surface acoustic wave filter includes a support substrate with a first acoustic velocity layer disposed above. The first acoustic velocity layer is silicon dioxide with a piezoelectric layer above. Euler angles of a cut of the piezoelectric layer are (?5° to 5°, 81° to 83°, 85° to 95°), and an interdigital electrode is disposed above the piezoelectric layer. A second acoustic velocity layer included between the first acoustic velocity layer and the support substrate; and a material of the second acoustic velocity layer is aluminum nitride or silicon nitride, where a longitudinal wave acoustic velocity in the first acoustic velocity layer is lower than a longitudinal wave acoustic velocity in the piezoelectric layer, and a longitudinal wave acoustic velocity in the second acoustic velocity layer is higher than the longitudinal wave acoustic velocity in the piezoelectric layer.

Abstract: Methods involving physics-informed deep learning to help solve inverse problems of solid materials/structures related to unknown geometry include (1) identifying and characterizing unknown materials/structures and defects with accuracy and predictive capability and limited non-destructive measurements, and/or (2) designing geometrical features and parameters of solid materials and structures to achieve optimized and/or improved performance.

Abstract: A system for automatically self-labeling a digital dataset includes a first sensor for generating a first data stream, a second sensor for collecting information to generate a second data stream, and a causal model manager (CMM). The CMM is configured to determine a first causal event from a first data segment of the first data stream, and a causal relation between the first causal event and a second data segment selected from the second data stream. The system further includes (a) an interactive time model for determining an interaction time between the first and second data segments, and (b) a self-labeling subsystem configured to derive a label from the second data segment, associate the first data segment with the derived label, form a self-labeled data pair from the associated first data segment and the derived label, and automatically annotate the self-labeled data pair with the interaction time.

Abstract: Improved electrochemical yarn energy harvesters that convert mechanical energy to electrical energy. These harvesters include an ionically conducting electrolyte, and an electronically conducting material, and a material that can undergo charge injection, which can also be the electronically conducting material. At least one device electrode is either twisted, twisted and coiled, or twisted and plied.

Abstract: A dental implant-retained record base device and methods of fabricating thereof are provided, and a method for obtaining an interocclusal record. The method involves inserting an impression post into a dental implant in a partially-dentate patient and capturing a dental impression to obtain a dental cast inclusive of the impression post. A light-curable resin is molded into a cubic shape and subsequently attached to the dental cast at position of the impression post. Upon exposure to visible light, the resin is cured to form a record base device, which is then adjusted to facilitate the positioning of interocclusal record material. The dental implant-retained device constructed from the light-cured resin is configured for attachment to the dental implant for obtaining the interocclusal record for the patient.

Abstract: A method for syngas production includes contacting an electrocatalytic working electrode with a gaseous electrolytic solution including carbon dioxide in a cell with a reference electrode and a counter electrode, applying a potential to the cell during the contacting, and forming a gaseous syngas product by electrocatalytically reducing the carbon dioxide in the gaseous electrolytic solution without forming any liquid syngas product. The electrocatalytic working electrode includes an electrocatalytic material on a conductive carbon paper. The electrocatalytic material includes a zeolitic imidazolate framework-8 (ZIF-8) and silver in an amount of 5 to 10 percent by weight of the electrocatalytic material. The ZIF-8 and silver are in a layer of particles. The particles are in the form of one or more polyhedrons and the one or more polyhedrons have a longest dimension with an average length of 0.1 to 20 ?m.

Abstract: A resist composition includes an alkylated tin-oxo nanocluster and a compound having Lewis basicity. The alkylated tin-oxo nanocluster includes a core structure including tin oxide, and an alkyl group of 1 to 20 carbon atoms, combined with the tin element of the core structure. The compound includes a polymer or an organic single molecule, having a functional group that functions as a Lewis base, and the functional group is a functional group containing lone pair electrons.

Abstract: According to one embodiment of the present invention, a group signature-based federated learning method by a group signature-based federated learning system including at least one client terminal and an administrator terminal provided as a group, and a server distributing a federated learning model to the at least one client terminal may comprise requesting, by the client terminal, a group signature to the administrator terminal; transmitting, by the administrator terminal, a group signature response to the client terminal in response to the request for the group signature; generating, by the client terminal, update information of signed federated learning using the group signature response and transmitting it to the server to request participation in federated learning update; transmitting, when the server receives the request for participation in the federated learning update, a latest group signature request to the administrator terminal and receiving a latest group signature response from the administrato

Abstract: Disclosed is a compound of formula (I), in which R1, R2, R3, R4, R5, X1, X2, X3, X4, and X5 are described herein. The small molecule compounds of formula (I) activate the functional activity of relaxin family peptide receptor 2 (RXFP2), thereby providing therapeutic treatments for a variety of disorders, such as a bone disorder, hypogonadism, cryptorchidism, polycystic ovary syndrome, cancer, infertility, or an ocular wound.

Abstract: The present disclosure relates to an integrated control system for heat pump to optimize energy of solar power generation building, Including a computer comprising a processor and a memory within which a code for execution by the processor is stored, and the computer is configured to collect real-time data measured from at least any one of the heat pump of the solar power generation building, an external environment, a room and a photovoltaic power generation system, where interactions occur in a dynamic behavior of the heat pump; input the real-time data of before pre-set time into multiple dynamic behavior prediction models to derive an indoor air temperature prediction value, heat pump electricity consumption prediction value, and photovoltaic power generation prediction value, of after pre-set time; and search for an optimal control variable of the heat pump using the derived indoor air temperature prediction value, heat pump electricity consumption prediction value, and photovoltaic power generation pred

Abstract: One aspect of the invention provides a method for treatment of a lysosomal storage disorder. The method may include administering to a subject in need of such treatment a composition including a therapeutically effective amount of an agent that mediates upregulation of Transcription Factor EB. In one embodiment, the composition includes a fibrate, such as gemfibrozil or fenofibrate. In another embodiment, the composition also includes all-trans retinoic acid or vitamin A.

Abstract: Disclosed is a molecular diode using the assignment of electrical properties to inactive organic molecules when a self-assembled monolayer (SAM) thin film including an electrically inactive organic molecule is formed without synthesizing a separate organic molecule having electrical activity. The disadvantage of the instability of a conventional SAM can be overcome, a function can be extended, and electrical properties, such as a rectification characteristic in a non-functional molecule, can be induced even without the design and synthesis of organic molecules for introducing a functional molecule. Accordingly, the embodiments of the present disclosure can be usefully used in various technical fields in which an SAM is used, in particular, wide fields such as electronics, an organic display (OLED), solar cells, sensors, non-uniform catalysts, frictional electricity, cell growth surfaces, and a heat transfer control film.

Abstract: A remote computing apparatus communicating with a local computing apparatus is disclosed. The apparatus includes a communication interface, a storage device, a memory in which a driver of the storage device is executed, and a processor that stores data and metadata associated with the data in the storage device. The driver receives input/output commands for the storage device from the local computing apparatus through the communication interface, the processor processes the received input/output commands for the storage device using a plurality of queues, and the driver provides a result of processing the input/output commands to the local computing apparatus through the communication interface. By providing this apparatus, latency of remote memory operations can be reduced.

Abstract: Aspects of the present invention relate to a tray device including a frame having a top surface, a bottom surface, and a thickness, wherein the top surface of the frame has a first recessed region having a sidewall around at least a portion of a perimeter, and a ledge extending laterally from the bottom of the sidewall of the first recessed region, wherein the sidewall defines at least a portion of a first shape, a second recessed region having a sidewall around at least a portion of a perimeter, and a ledge extending laterally from the bottom of the sidewall of the second recessed region, wherein the sidewall defines at least a portion of a second shape, and wherein the depth of the first recessed region is deeper into the thickness of the tray than the depth of the second recessed region.

Abstract: Methods and systems are provided for controlling the level relative to ground of moveable wings in a spray system that includes the moveable wings mounted to a common center frame support structure attached to an associated work vehicle to form a pair of opposed independently moveable wings extending laterally from the associated work vehicle. An initial control signal is determined for moving the moveable wings based on positions of the moveable wings relative to the ground. A compensating signal is determined for compensating the initial control signal, wherein the compensating signal is derived independent from the position of the moveable wings relative to the ground and includes a flexure component dependent upon one or more flexural properties of the associated work vehicle. A level control output signal is generated for controlling the level of the moveable wings based on a combination of the initial control signal and the compensating signal.

Abstract: The disclosed technology relates to methods, transcriptomics systems, and non-transitory computer readable media for enabling natural language transcriptomics analysis. In some examples, genomic data including gene expression profiles for cells is transformed into sequences of genes ordered by expression level for each of the cells. The sequences of genes are annotated with metadata in a natural language format. A large language model (LLM) is then fine-tuned using the annotated sequences. The LLM is pretrained for natural language processing (NLP) tasks. The fine-tuned LLM is applied to generate and output a result in response to a received prompt in the natural language format. Thus, the LLMs of this technology advantageously both generate and interpret transcriptomics data and interact in natural language to generate meaningful text from cells and valid genes, among many other types of results.

Abstract: Disclosed is a method for enhancement of a low-light image based on reinforcement learning and aesthetic evaluation. The method include: generating images of non-normal luminance under different lighting scenes, and constructing a training dataset for a reinforcement learning system based on the images; initializing the training dataset, a policy network, and a value network; updating, based on a no-reference reward score and an aesthetic assessment reward score, the policy network and the value network; completing model training and outputting an enhanced image result. By expanding the action space range defined in reinforcement learning, the enhancement operations for the input low-light image gain a greater dynamic range, offering higher flexibility for real-world scenarios and better meeting low-light image enhancement needs.