Patents Assigned to The University
  • MICROFLUIDIC DEVICES AND FABRICATION
    Publication number: 20170274196
    Abstract: Methods for mass production of new microfluidic devices are described. The microfluidic devices may include an array of micro-needles with open channels in fluid communication with multiple reservoirs located within a substrate that supports the micro-needles. The micro-needles are configured so as to sufficiently penetrate the skin in order to collect or sample bodily fluids and transfer the fluids to the reservoirs. The micro-needles may also deliver medicaments into or below the skin.
    Type: Application
    Filed: September 3, 2015
    Publication date: September 28, 2017
    Applicants: NewSouth Innovations Pty Limited, The University of Birmingham
    Inventors: Robert Ernest Nordon, Graham James Davies, Zahra Faraji Rad, Carl John Anthony, Philip Prewett
  • Methods of Making and Using Bioadhesive Compositions
    Publication number: 20170274115
    Abstract: In one aspect, methods of making a composition are described herein. In some embodiments, a method of making a composition comprises providing a polycarboxylic acid; providing an alcohol; combining the polycarboxylic acid with the alcohol; adding a catechol-containing species to the combination of the polycarboxylic acid and the alcohol; and forming a polymer or oligomer from the polycarboxylic acid, the alcohol, and the catechol-containing species. In some embodiments, the catechol-containing species comprises an amine moiety, a carboxylic acid moiety, or a hydroxyl moiety that is not part of the catechol group.
    Type: Application
    Filed: March 30, 2017
    Publication date: September 28, 2017
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jian Yang, Reza Medizad
  • APTAMER CAPABLE OF BINDING TO HGF RECEPTOR
    Publication number: 20170275630
    Abstract: Provided is an aptamer including a polynucleotide of any of the following (a) to (c) and capable of binding to an HGF receptor to exhibit an activity of inhibiting the binding of HGF to the HGF receptor. (a) A polynucleotide consisting of a base sequence set forth in SEQ ID NO: 1, (b) A polynucleotide consisting of a base sequence having the deletion, substitution, insertion and/or addition of one to several bases in the base sequence set forth in SEQ ID NO: 1, and (c) A polynucleotide consisting of a base sequence having a sequence identity of 80% or more to the base sequence set forth in SEQ ID NO: 1.
    Type: Application
    Filed: September 9, 2015
    Publication date: September 28, 2017
    Applicant: The University of Tokyo
    Inventors: Shinsuke Sando, Ryosuke Ueki
  • Targeting the EGFR-SGLT1 interaction for cancer therapy
    Patent number: 9770482
    Abstract: A compound can destabilize an epidermal growth factor receptor (EGFR) protein and a sodium/glucose co-transporter 1 (SGLT 1) protein. In one embodiment, the compound is a peptide derived from the interacting domain of EGFR. In another embodiment, the peptide is administered to a patient to treat cancer.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: September 26, 2017
    Assignee: The University of Houston System
    Inventor: Zhang Weihua
  • Pyrimidine compounds for the treatment of cancer
    Patent number: 9771330
    Abstract: Compounds of Formula I or II: are described, along with pharmaceutical compositions containing the same and methods of using such compounds for the treatment of cancer.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: September 26, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Xiaodong Wang, Weihe Zhang, Stephen V. Frye, Dmitri Kireev, Andrew Louis McIver, Jing Liu
  • Bimolecular protease-based biosensor
    Patent number: 9772328
    Abstract: A biosensor comprises first and second molecular components and is capable of displaying protease activity in response to a binding event mediated by first and second binding partners of the biosensor. The first and second binding partners may bind each other directly or may both bind a target molecule. At least the first molecular component comprises an autoinhibited protease, whereby the binding event switches the protease frora an autoinhibited inactive state to a protease active state. The second molecular component may activate the protease of the first molecular component by binding a cross-binder which releases the autoinhibitor or by cleaving a linker which releases the autoinhibitor. The first and second molecular components may both have autoinhibited proteases which reciprocally activate each other.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: September 26, 2017
    Assignee: The University of Queensland
    Inventors: Viktor Stein, Kirill Alexandrov
  • Tissue repair scaffold
    Patent number: 9770529
    Abstract: The present invention provides a tissue repair scaffold comprising a secondary fiber bundle, the secondary fiber bundle comprising a plurality of primary fiber bundles, each primary fiber bundle comprising a plurality of fibers, wherein the fibers comprise a biocompatible polymer. In embodiments the biocompatible polymer is polycaprolactone (PCL) (also known as poly-?-caprolactone) and the average diameter of the fibers is less than 1 ?m. The scaffold is particularly adapted for tendon repair. In vivo mouse studies demonstrate that tendon repair can be achieved with normal ambulation returning after 24-48 hours. The scaffolds were easy to handle during surgery, being non-slippery and easy to suture in place.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: September 26, 2017
    Assignee: The University of Manchester
    Inventors: Sandra Downes, Lucy Ann Bosworth
  • Apparatus and method to facilitate singing intended notes
    Patent number: 9773426
    Abstract: A method and apparatus to facilitate tone challenged singers to sing intended notes. In one aspect, the singer determines a note to sing corresponding to an intended frequency fi. The singer utters a note continuously with fundamental frequency fu into a microphone of the natural ear apparatus. The note is processed by the apparatus to produce sound emphasizing the fundamental frequency fu and output through a speaker to the auditory organs of the singer. The singer detects differences between intended frequency fi and uttered fundamental frequency fu. The singer adjusts his vocal organs as he utters the note with the intention of changing fu to reduce difference between fi and fu.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: September 26, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eric A. Freudenthal, Eric M. Hanson, Bryan E. Usevitch
  • Optical device
    Patent number: 9772479
    Abstract: An optical device includes a first sub-assembly having an input lens for collimating illuminating light and having an optical axis. The first sub-assembly also has an output lens for focusing collimated light received from a sample, the output lens having an optical axis which is offset and substantially parallel with the optical axis of the input lens, and further includes a first support piece which houses and supports the input lens and the output lens. The optical device also includes a second sub-assembly having an input filter for filtering the collimated illuminating light, an output filter for filtering the collimated light received from the sample, and a second support piece which houses and supports the input filter and the output filter. The first and second support pieces are joined together by a liquid-tight joint.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: September 26, 2017
    Assignees: The University of Bristol, GLOUCESTERSHIRE HOSPITALS NHS FOUNDATION TRUST
    Inventors: Joanne Hutchings, John Charles Clifford Day, Nicholas Stone
  • ENCODING APPARATUS, DECODING APPARATUS, AND METHOD AND PROGRAM FOR THE SAME
    Publication number: 20170272766
    Abstract: There are provided an encoding or decoding technique capable of performing more efficient encoding or decoding than before. An encoding apparatus for encoding a time-series signal in a frequency domain is provided with: a spectral envelope estimating portion 2A estimating a spectral envelope, regarding absolute values of a frequency domain sample sequence corresponding to the time-series signal raised to the power of ? as a power spectrum, on the assumption that ? is a predetermined positive number other than 2; and an encoding portion 2B performing such encoding that changes bit allocation or that bit allocation substantially changes, for each coefficient of the frequency domain sample sequence corresponding to the time-series signal, based on the estimated spectral envelope.
    Type: Application
    Filed: November 24, 2015
    Publication date: September 21, 2017
    Applicants: NIPPON TELEGRAPH AND TELEPHONE CORPORATION, The University of Tokyo
    Inventors: Takehiro MORIYA, Yutaka KAMAMOTO, Noboru HARADA, Hirokazu KAMEOKA, Ryosuke SUGIURA
  • VOLTAMMETRY IN HIGH-VOLTAGE FIELDS
    Publication number: 20170269035
    Abstract: Herein are described an instrument and a method for using the same. The instrument comprises a fluid channel fluidly connected to at least a first fluid reservoir and a second fluid reservoir; a counter electrode (CE), a reference electrode (RE), and a working electrode (WE); and a potentiostat. The CE, RE, and WE are all disposed within the fluid channel; the potentiostat is isolated from earth ground by at least one isolator and is powered by a floating power supply; and the CE, RE, and WE are each electrically connected to the potentiostat.
    Type: Application
    Filed: March 16, 2017
    Publication date: September 21, 2017
    Applicant: The University of Notre Dame du Lac
    Inventors: Paul Bohn, Lawrence Zaino, III
  • IMPROVED LASER STRUCTURE
    Publication number: 20170271846
    Abstract: A laser structure comprising a first photonic crystal surface emitting laser (PCSEL), a second PCSEL, and a coupling region that extends between the first PCSEL and the second PCSEL along a longitudinal axis and that is electrically controllable so as to be capable of coherently coupling the first PCSEL to the second PCSEL. Each PCSEL include an active layer, a photonic crystal, and a two-dimensional periodic array distributed in an array plane parallel to the longitudinal axis within the photonic crystal where the two-dimensional periodic array is formed of regions having a refractive index that is different to the surrounding photonic crystal.
    Type: Application
    Filed: August 21, 2015
    Publication date: September 21, 2017
    Applicant: The University of Sheffield
    Inventors: Richard James Edward Taylor, David T. D. Childs, Richard Hogg
  • ANTI-OX40 ANTIBODIES AND METHODS OF USING THE SAME
    Publication number: 20170267773
    Abstract: Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.
    Type: Application
    Filed: May 26, 2017
    Publication date: September 21, 2017
    Applicant: Board of Regents, The University of Texas System
    Inventors: Yong-Jun LIU, Kui Shin VOO, Laura BOVER, Naoya TSURUSHITA, J. Yun TSO, Shankar KUMAR
  • Ultrastable silver nanoparticles
    Patent number: 9765094
    Abstract: Ultrastable silver nanoparticles, methods of making the same, and methods of using the same, are disclosed.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 19, 2017
    Assignee: The University of Toledo
    Inventors: Terry Bigioni, Anil Desireddy, Brian Conn
  • Aromatic prenyltransferase from cannabis
    Patent number: 9765308
    Abstract: Nucleic acid molecules from cannabis has been isolated and characterized and encode polypeptides having aromatic prenyltransferase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: September 19, 2017
    Assignees: The University of Saskatchewan, National Research Council of Canada
    Inventors: Jonathan E. Page, Zakia Boubakir
  • Array of micromolded structures for sorting adherent cells
    Patent number: 9765291
    Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: September 19, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah
  • Biological reduction of carbon dioxide pollutants systems and methods
    Patent number: 9764279
    Abstract: Methods and systems to achieve clean fuel processing systems in which carbon dioxide emissions (1) from sources (2) may be processed in at least one processing reactor (4) containing a plurality of chemoautotrophic bacteria (5) which can convert the carbon dioxide emissions into biomass (6) which may then be used for various products (21) such as biofuels, fertilizer, feedstock, or the like. Sulfate reducing bacteria (13) may be used to supply sulfur containing compounds to the chemoautotrophic bacteria (5).
    Type: Grant
    Filed: March 10, 2013
    Date of Patent: September 19, 2017
    Assignee: The University of Wyoming Research Corporation
    Inventors: Song Jin, Paul Fallgren, Jeffrey M. Morris, Alan E. Bland, Patrick Richards, Jesse D. Newcomer, Patricia Colberg
  • Skin stretch feedback devices, systems, and methods
    Patent number: 9767659
    Abstract: Embodiments of the present disclosure relate devices, systems, methods, and for displaying information about the direction and magnitude of position, movement, and/or resistive force experienced for an object. The present disclosure also provides a shear display device that can generate skin shear with one or more tactors. The movement of the tactors can represent to a user various information about an object.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: September 19, 2017
    Assignee: The University of Utah Research Foundation
    Inventors: William R. Provancher, Markus N. Montandon, Andrew J. Doxon, Nathan A. Caswell, Landon T. Gwilliam
  • Systems and methods for designing and fabricating contact-free support structures for overhang geometries of parts in powder-bed metal additive manufacturing
    Patent number: 9767224
    Abstract: Systems and methods are provided for designing and fabricating contact-free support structures for overhang geometries of parts fabricated using electron beam additive manufacturing. One or more layers of un-melted metallic powder are disposed in an elongate gap between an upper horizontal surface of the support structure and a lower surface of the overhang geometry. The powder conducts heat from the overhang geometry to the support structure. The support structure acts as a heat sink to enhance heat transfer and reduce the temperature and severe thermal gradients due to poor thermal conductivity of metallic powders underneath the overhang. Because the support structure is not connected to the part, the support structure can be removed freely without any post-processing step.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: September 19, 2017
    Assignees: The Board of Trustees of The University of Alabama, The United States of America as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Yuag-Shan Chou, Kenneth Cooper
  • STAT6 inhibitors
    Patent number: 9765099
    Abstract: The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some embodiments, the compounds may be used to treat a disease such as, e.g., an allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease, or a cancer.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: September 19, 2017
    Assignees: Board of Regents, The University of Texas System, Baylor College of Medicine
    Inventors: John S. McMurray, Pijus Kumar Mandal, Pietro Morlacchi, Morgan Knight, David B. Corry