Abstract: A temperature insensitive sub-nA current reference is presented with pA-range power overhead. The main concept is to linearly reduce the gate voltage of a sub-threshold-biased MOSFET as temperature increases, in order to compensate for exponential dependence of drain current on temperature. For example, a MOSFET-only, 20 pA, 780 ppm/° C. current reference that consumes 23 pW is disclosed, marking the lowest reported power among current references. The circuit exploits sub-threshold-biased MOSFETs and a complementary-to-absolute temperature (CTAT) gate voltage to compensate for temperature dependency. The design shows high immunity to supply voltage of 0.58%/V and a load sensitivity of 0.25%/V.

Abstract: The present invention includes nanotubes or rods, methods and arrays using plasmonic-magnetic bifunctional nanotubes or rods comprising: one or more silica nanotubes or rods; one or more nanomagnets embedded in a portion of the silica nanotubes or rods; and plasmonic metal nanoparticles uniformly coating in or on at least a portion of the surface of the nanomagnets and the silica nanotubes surface-coated.

Abstract: A database management system (DBMS) generates a query execution plan including information representing one or more database (DB) operations necessary for executing a query, and executes the query in accordance with the query execution plan. In the execution of the query, the DBMS dynamically generates tasks for executing the DB operations and executes the dynamically generated tasks. The query execution plan includes a plurality of query blocks, which are sets of one or more DB operations. When newly generating a task, the DBMS executes determination processing of simultaneous-task-generation number. The determination processing of simultaneous-task-generation number is to calculate, targeting each of the query blocks, the number of simultaneous task generation, which is the number of tasks simultaneously generatable as tasks for executing the query block. The number of the dynamically generated tasks is equal to or smaller than the number of simultaneous task generation.

Abstract: A multiple-input power converter transferring energy from multiple input sources to a load comprises a plurality of voltage inputs. The power converter implements soft-switching techniques thereby reducing the converter switching losses and increasing the converter efficiency while using fewer components than presently designed multiple-input power converters. Such a power converter may include multiple input sources, where serially connected switches are coupled to one of the multiple input sources in an input leg. A voltage blocking capacitor is inserted between these input legs. Furthermore, the power converter includes a transformer for isolating the load from the multiple input sources, where the voltage blocking capacitor is connected to the primary winding of the transformer.

Abstract: Aspects of the disclosure provide a method and system for power amplifier characterization and digital predistortion. The method includes receiving a test signal including K samples with a sampling rate fS, generating a synthetic test signal including the test signal and a sequence of (N-1) delayed versions of the test signal, generating an under-sampled signal including M samples by sampling, at a sampling rate fS/N, an output signal of a device-under-test (DUT) with the synthetic test signal as an input of the DUT, the M samples of the under-sampled signal including N segments each including K/N samples, and generating a reconstructed signal including the M samples of the under-sampled signal.

Abstract: Described herein are compositions and methods useful to treat cancers. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.

Abstract: The present invention provides methods for reducing pain in a subject in need thereof by delivering a volatile anesthetic in a solution or an emulsion that can additionally include an extractive solvent in an amount effective to reduce pain without substantially interfering with motor function. Chronic or acute pain may be treated, or the volatile anesthetic may be delivered as a regional anesthetic to a subject to anesthetize a portion of the subject prior to surgery. Dosing regimes including a one-time administration, continuous and/or periodic administration are contemplated.

Abstract: It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.

Abstract: The present invention provides methods and compositions for the production of vitamin K dependent proteins.

Abstract: Suppository, hot melt and ophthalmic formulations containing amino esters of the formulae (I), (II) and (III), where R1, R2 and R3 are residues of amino acids such as, but not limited to, valine, sarcosine, leucine, glutamine, tryptophan, tyrosine, alanine and 4(4-aminophenyl)butyric acid or combination thereof, and salts thereof.

Abstract: In one embodiment, a system for rearing larvae includes a plurality of culture trays arranged in at least one stack of trays, each stack comprising multiple levels of trays, each tray comprising an open-topped basin adapted to receive larvae and larval food, a feed delivery system adapted to automatically deliver larval feed to individually selected culture trays, and a water delivery system adapted to automatically deliver water to the culture trays.

Abstract: A device including an array of aligned conductive channels. The conductive channels are operable for directional transport of species selected from the group consisting of electrons, ions, phonons, and combinations thereof. The conductive channels are provided for by nanofibers in a form selected from the group consisting of ribbons, sheets, yarns, and combinations thereof.

Abstract: A suspended nanotube film (or films) producing sound by means of the thermoacoustic (TA) effect is encapsulated between two plates, at least one of which vibrates, to enhance sound generation efficiency and protect the film. To avoid the oxidation of carbon nanotubes at elevated temperatures and reduce the thermal inertia of surrounding medium the enclosure is filled with inert gas (preferably with high heat capacity ratio, ?=Cp/Cv, and low heat capacity, Cp). To generate sound directly as the first harmonic of applied audio signal without use of an energy consuming dc biasing, an audio signal modulated carrier frequency at much higher frequency is used to provide power input. Various other inventive means are described to provide enhanced projected sound intensity, increased projector efficiency, and lengthened projector life, like the use of infrared reflecting coatings and particles on the projector plates, non-parallel sheet alignment in sheet stacks, and cooling means on one projector side.

Abstract: The invention provides methods of preventing, treating or ameliorating autoimmune diseases, such as diabetes and celiac disease, by decreasing the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.

Abstract: This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels.

Abstract: Borylated compounds are disclosed, as well as their methods of preparation and their applications. The disclosed borylated compounds are highly stable, and have reduced band gap properties, thereby making them attractive candidates for incorporation into semiconducting materials for use in a variety of electronic, optical or electro-optical devices or components.

Abstract: In a biological simulation apparatus, an operation unit represents a structure domain where tissues of a biological organ exist by a structure mesh model based on a Lagrange description method and a fluid domain where fluid inside the biological organ exists by an ALE fluid mesh model based on an ALE description method. In a fluid-structure interaction simulation, the operation unit deforms the structure mesh model, and then deforms the ALE fluid mesh model so as to form no gap on a first interface between a domain where a site other than a certain site of the biological organ in the structure domain exists and the fluid domain or no overlap with the structure domain. The operation unit captures a position of a second interface between a domain where the certain site exists and the fluid domain by using the ALE fluid mesh model as a reference.

Abstract: The invention concerns compounds of the formula: X—(Y)t wherein: X is Formula (X), each Y is the same or different and is Formula (Y) —O—[CH2—CH(OH)—CH2—O—]m—H; or —C(OR5)3; R1, R2, R3, R6, R7, R8, R9, R10 are each, independently, —(CH2CH2O)m—R4, —[CH2CH(OH)CH2O]nH, OR11, —O(CH2)PR13, or —(CH2)R12; each R4 is independently OR5 or OH; R5, R11 and R12 are each, independently, H or C1-C30 alkyl; R13 is —NH3+Cl? or —NHBoc; t is an integer from 2 to 6; m, n, and p are each, independently, an integer from 1 to 12; and each q, r, and s is 0 or 1 and the sum of q+r+s is at least 2.

Abstract: Antibody-LIGHT fusion products or conjugates stimulate immunity against tumors and eradicate metastases. Tumor-specific antibodies coupled with LIGHT effectively target metastatic tumors and reduces cancer metastases.

Abstract: An apparatus and method for measuring three-dimensional radiation dose distributions with high spatial and temporal resolution using a large-volume scintillator. The scintillator converts the radiation dose distribution into a visible light distribution. The visible light is transported to one or more photo-detectors, which measure the light intensity. The light signals are processed to correct for optical artifacts, and the three-dimensional light distribution is reconstructed. The reconstructed light distribution is post-processed to convert light amplitudes to measured radiation doses. The high temporal resolution of the detector makes it possible to observe the evolution of a dynamic dose distribution as it changes over time. Integral dose distributions can be measured by summing the dose over time.