Abstract: Provided is an enzyme-specific fluorescent compound capable of being retained in cells, which can emit fluorescence specifically in a target cell, particularly a cell capable of expressing a reporter enzyme such as ?-galactosidase, and can covalently bind to a protein in the cell to exhibit an excellent property of being retained in the cell. The fluorescent compound comprises a compound represented by formula (I?) or a salt thereof. In formula (I?), A, X, Y and R1 to R9 are as described in claim 1.
Abstract: Biodegradable, magnesium alloys and composites, articles produced therefrom, methods of making the same, and methods of using the same are described.
Abstract: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.
Type:
Application
Filed:
November 30, 2016
Publication date:
March 16, 2017
Applicants:
Stichting Katholieke Universiteit, more particularly The University Medical Centre Nijmege, The Johns Hopkins University
Inventors:
Marion J.G. Bussemakers, William B. Isaacs
Abstract: Disclosed are various embodiments for measuring a local permeability of a porous material. A probe can be positioned perpendicular to the surface of the material. The probe can be configured to sense a velocity of a fluid flowing over the surface. The probe can be positioned at a distance determined based on an average porosity of the material. The probe can take measurements at various positions at the distance by moving a minimum dimension between each measurement.
Type:
Application
Filed:
September 12, 2016
Publication date:
March 16, 2017
Applicant:
Board of Regents, The University of Texas System
Abstract: Techniques and structures are disclosed in which one or more distortion categories are identified for an image or video, and a quality of the image or video is determined based on the one or more distortion categories. The image or video may be of a natural scene, and may be of unknown provenance. Identifying a distortion category and/or determining a quality may be performed without any corresponding reference (e.g., undistorted) image or video. Identifying a distortion category may be performed using a distortion classifier. Quality may be determined with respect to a plurality of human opinion scores that correspond to a particular distortion category to which an image or video of unknown provenance is identified as belonging. Various statistical methods may be used in performing said identifying and said determining, including use of generalized Gaussian distribution density models and natural scene statistics.
Type:
Grant
Filed:
February 24, 2014
Date of Patent:
March 14, 2017
Assignee:
Board of Regents of The University of Texas System
Abstract: A method of crystallization is disclosed, the method comprises the steps of providing a microfluidic system comprising at least three channels having at least one junction; providing within the at least three channels a continuously flowing water-immiscible carrier-fluid, a continuously flowing first aqueous fluid comprising a crystallization target, and a continuously flowing second aqueous fluid comprising a precipitant; forming at least one plug comprising the first and second aqueous fluids by partitioning the aqueous fluids with the flowing carrier-fluid at the junction of the at least three channels, flowing the at least one plug through an outlet port into a tubing, and stopping the flow of the at least one plug in the tubing, wherein the crystallization target forms a crystal in the tubing.
Type:
Grant
Filed:
October 17, 2014
Date of Patent:
March 14, 2017
Assignee:
The University of Chicago
Inventors:
Rustem F. Ismagilov, Joshua David Tice, Cory John Gerdts, Bo Zheng
Abstract: The subject matter described herein includes a curved VPH grating with tilted fringes and spectrographs, both retroreflective and transmissive, that use such gratings. A VPH grating according to the subject matter described herein includes a first curved surface for receiving light to be diffracted. The grating includes an interior region having tilted fringes to diffract light that passes through the first surface. The grating further includes a second curved surface bounding the interior region on a side opposite the first surface and for passing light diffracted by the fringes.
Type:
Grant
Filed:
July 15, 2013
Date of Patent:
March 14, 2017
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
J. Christopher Clemens, Darragh Evelyn Anthony Adam O'Donoghue
Abstract: The invention relates to an optical absorber comprising a semiconductor micro or nano scale structured array configured for transmission of electromagnetic (EM) radiation when in a passive state and for absorption and/or reflection of electromagnetic (EM) radiation when in an active state. The absorber also includes an activator arranged to inject free carriers into the structured array to activate said array on demand.
Abstract: The present invention relates to a metal organic framework comprising of a metal ion (M) and an organic ligand wherein more than one hydroxy ligand are present about the metal ion. Also provided is a method for synthesizing the metal-organic frameworks and their application in areas including scrubbing exhaust gas streams of acidic gases, scrubbing natural gas of acidic gases by separation or sequestration and separating C2Ha or other VOC gases from other gas mixtures.
Abstract: An integrated vascular delivery system having a frame configured to receive a catheter insertable in a patient to deliver fluid at an insertion site. The frame includes a first hub, a second hub, and a pair of flexible lateral members extending between the hubs and including a tubular lateral member. The system also includes a fluidic channel that fluidically communicates with the catheter, wherein the fluidic channel passes through the tubular lateral member and at least one of the hubs, and includes a fixed turnabout portion in which fluid flows in a direction different from that within the catheter. The first and second hubs provide anchoring points on the patient distributed around the insertion site and on opposite ends of the catheter, thereby anchoring the frame to the patient and stabilizing the catheter. A method is provided for using an integrated vascular delivery system.
Type:
Grant
Filed:
January 22, 2015
Date of Patent:
March 14, 2017
Assignee:
The Regents Of The University Of Michigan
Inventors:
Steven B. White, Adrienne Harris, Merrell Sami, Elyse Kemmerer White
Abstract: The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow.
Type:
Grant
Filed:
March 5, 2013
Date of Patent:
March 14, 2017
Assignee:
Board of Regents, The University of Texas System
Abstract: Amide compounds are defined and are polymerized to create polyesters and polyurethanes having amide units bearing a pendant functional group, where the nitrogen atom of the amide group is part of the polymer backbone. The pendant functional group of the functionalized amide polymer may be modified or added by post polymerization functionalization of the functionalized amide polymer. The pendant functional group of the functionalized amide polymer may include a protecting group that may be removed after polymerization. The pendant functional groups of the functionalized amide polymers may be used to modulate the physical, chemical and biological properties of the polymers.
Abstract: The present invention provides a spectral apparatus for spectrally separating light including a predetermined wavelength, including a slit that the light enters, a first optical system configured to collimate the light from the slit, a transmissive type diffraction element configured to diffract the light from the first optical system, and a second optical system including a first mirror configured to reflect the light diffracted by the transmissive type diffraction element, and a second mirror configured to reflect the light reflected by the first mirror and diffracted by the transmissive type diffraction element, and configured to make the light reciprocally travel between the first mirror and the second mirror via the transmissive type diffraction element.
Type:
Grant
Filed:
June 3, 2014
Date of Patent:
March 14, 2017
Assignees:
CANON KABUSHIKI KAISHA, The University of Tokyo
Abstract: Novel compounds having a formula embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and treating or preventing a metabolic disorder in the subject. Additionally disclosed are embodiments of a method of treating or preventing inflammation in an intestinal region of a subject, comprising administering to the subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or more of the disclosed compounds, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject.
Type:
Application
Filed:
September 12, 2016
Publication date:
March 9, 2017
Applicants:
Salk Institute for Biological Studies, The University of Sydney
Inventors:
Ronald M. Evans, Michael Downes, Annette Atkins, Sungsoon Fang, Jae Myoung Suh, Thomas J. Baiga, Ruth T. Yu, John F.W. Keana, Christopher Liddle
Abstract: The present invention relates to a composition comprising polymer particles and functionalized stimulus responsive polymer; the polymer particles (i) comprising block co-polymer, and (ii) having a core-shell structure, said block co-polymer comprising (a) a non-stimulus responsive polymer block that forms at least part of the core structure, and (b) a stimulus responsive polymer block that forms at least part of the shell structure; wherein the stimulus responsive polymer of both the polymer particles and the functionalized stimulus responsive polymer are responsive to at least one common stimulus.
Type:
Grant
Filed:
June 7, 2013
Date of Patent:
March 7, 2017
Assignee:
The University of Queensland
Inventors:
Peter Gray, Michael John Monteiro, Trent Phillip Munro, Andrew Benjamin James Prowse
Abstract: A forging method according to the present invention includes the steps of placing a work having a first shape which is a rectangular hexahedron in a work space of a forging die which has a rectangular opening, which is formed by rectangular plane wall portions, and which is provided with the work space to hold the work in a placement step and applying a plastic strain to the work by deforming the placed work into a second shape which is a rectangular hexahedron in a working step, with the placement step and the working step being performed at least two times.
Type:
Grant
Filed:
September 2, 2014
Date of Patent:
March 7, 2017
Assignees:
NGK Insulators, Ltd., The University of Electro-Communications
Abstract: A method of preparing an amiphiphilic co-network comprising preparing a molecularly-bimodal crosslinkable amphiphilic graft by polymerizing a dihydrocarbylacrylamide monomer in the presence of a first asymmetric-telechelic polydihydrocarbylsiloxane monomer mixture and a second asymmetric-telechelic polydihydrocarbylsiloxane monomer mixture where the molar mass ratio between average molar mass of the first asymmetric-telechelic monomer mixture polydihydrocarbylsiloxane and average molar mass of the second asymmetric-telechelic monomer mixture polydihydrocarbylsiloxane is between 1:2 and 1:20; and crosslinking the molecularly-bimodal crosslinkable amphiphilic graft with a siloxane compound that includes at least two Si—H bonds.
Type:
Grant
Filed:
June 5, 2014
Date of Patent:
March 7, 2017
Assignee:
The University of Akron
Inventors:
Mukerrem Cakmak, Turgut Nugay, Nihan Nugay, Joseph Kennedy