Patents Assigned to The University
  • Flexible electrode for detecting changes in temperature, humidity, and sodium ion concentration in sweat
    Patent number: 9603560
    Abstract: The present invention includes a flexible sensor suitable for contact with skin comprising: a nanocomposite; and a top layer; where the sensor provides in-situ detection in sweat or other aqueous body fluids at the skin surface of at least one physiological parameter selected from the group consisting of a physiological salt component, temperature, moisture, humidity, or combinations thereof. The present invention further includes a method of fabricating a flexible sensor suitable for contact with skin comprising: electrospinning at least one polyamide-producing monomer to form a non-conductive polyamide substrate; attaching at least one plurality of conductive nanoscale attachments, wherein the nanoscale attachments are selected from nanotubes, nanoparticles, or combinations thereof, to form an intermediate layer; and functionalizing the intermediate layer to form a top layer.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: March 28, 2017
    Assignee: The University of Akron
    Inventors: Chelsea N Monty, Evan K Wujcik, Nathaniel Jacob Blasdel
  • Polymer adhesives comprising a low boiling point biocompatible solvent, high molecular weight multi-arm star cyanoacrylate-telechelic polyisobutylene and 2-octyl cyanoacrylate
    Patent number: 9603868
    Abstract: The present invention is directed to a substantially homogeneous miscible liquid adhesive composition comprising a relatively high number average molecular weight (Mn=6,000-10,000 g/mole) multi-arm star polymer having polyisobutylene chains terminated with cyanoacrylate groups (High-Ø(PIB-CA)3); 2-octyl cyanoacrylate (Oct-CA); and a low boiling point biocompatible solvent having a boiling point of not more than 37° C. When this adhesive composition contacted with living tissue and reacted with a nucleophile, such as water or an initiator, the biocompatible solvent will evaporate and the High-Ø(PIB-CA)3 and Oct-CA will co-polymerize in-situ to form a poly(2-octyl cyanoacrylate)-polyisobutylene co-network suitable for any of a number of biomedical applications, from wound closure and healing of skin tissue, to sealant for surgical cuts.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: March 28, 2017
    Assignee: The University of Akron
    Inventors: Joseph Kennedy, Istvan Szanka, Amalia Szanka
  • MerTK-specific pyrazolopyrimidine compounds
    Patent number: 9603850
    Abstract: The present invention includes pyrazolopyrimidine compounds of Formula I that selectively inhibit Mer tyrosine kinase (MerTK) activity and/or Tyro3 tyrosine kinase activity, and use of these pyrazolopyrimidine compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: March 28, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Xiaodong Wang, Stephen Frye
  • Detecting neurochemical or electrical signals within brain tissue
    Patent number: 9603522
    Abstract: This document relates to methods and materials involved in detecting neurochemical signals, electrophysiological signals, ions, or combinations thereof with brain tissue. For example, methods and materials for using probes to detect neurochemical signals (e.g., neurotransmitter concentrations), electrical signals, or combinations thereof during deep brain stimulation are provided.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: March 28, 2017
    Assignees: Mayo Foundation for Medical Education and Research, The University of Memphis Research Foundation
    Inventors: Kendall H. Lee, Kevin E. Bennet, Charles D. Blaha
  • Shape data generation method and apparatus
    Patent number: 9607423
    Abstract: This shape data generation method include: setting an input shape that has a simple shape that has a same topology as the target shape for a target shape that is a shape of a transformation target identified from image data; identifying first vertices that satisfy a predetermined condition including a first condition that a normal line of a certain vertex of the plural vertices crosses with the target shape, among plural vertices of the input shape; transforming the input shape so that a first vertex is moved in a direction of a normal line of the first vertex by a first distance that is shorter than a distance up to the target shape; and performing the identifying and the transforming a predetermined number of times while changing the input shape after the transforming as the input shape to be processed.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: March 28, 2017
    Assignees: FUJITSU LIMITED, The University of Tokyo
    Inventors: Machiko Nakagawa, Kohei Hatanaka, Toshiaki Hisada, Seiryo Sugiura, Takumi Washio, Jun-ichi Okada
  • Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics
    Patent number: 9604907
    Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: March 28, 2017
    Assignees: The University of North Carolina at Chapel Hill, The Regents of The University of California, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Frank M. Longo, Stephen M. Massa
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 9605262
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: March 28, 2017
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Antioxidant treatment of asphalt binders
    Patent number: 9605104
    Abstract: A combination of antioxidants and method of incorporating the antioxidants into an asphalt binder to make a modified asphalt binder are described. The antioxidants comprise a thioester and an aldehyde. The aldehyde and thioester, in a ratio between about 1:100 and about 100:1 parts by weight, are added to an asphalt binder. An acidic catalyst is also added in a concentration between about 0.1 wt % and about 18 wt % of the asphalt binder. The antioxidants, asphalt binder, and catalyst are mixed at a temperature between about 85° C. and about 135° C. for a time between about 30 minutes and about 6 hours. The antioxidants are capable of improving the performance grade of the asphalt binder. The modified asphalt binder possesses superior resistance to oxidative age hardening compared to other modified asphalt binder compositions that incorporate various antioxidants.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: March 28, 2017
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: Alex K. Apeagyei, William G. Buttlar, Barry J. Dempsey
  • Forward-imaging tunable lens systems and probes
    Patent number: 9606269
    Abstract: Provided herein are forward-imaging tunable lens systems and probes. A lens assembly is disclosed herein and comprises at least one tunable lens.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: March 28, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Karthik Kumar, Jonathan C. Condit, Nathaniel J. Kemp, Thomas E. Milner, Xiaojing Zhang
  • D-Q control system and method for controlling a switched reluctance motor
    Patent number: 9608554
    Abstract: A D-Q or rotating reference frame control system for a switched reluctance motor (SRM) provides a negativity removal module and a non-linear model module. As such, the control system utilizes control inputs fq and fd, which are converted into the ABC domain as electrical current functions f?ix with negative values. The negativity removal module is configured to share the torque portion of the negative values of the electrical current functions f?ix for each of the three phases of the SRM motor to remove the negative values. The non-linear module corrects the non-linearity of the SRM to smooth the torque that is output. The control system also utilizes a phase advancing module, which outputs fd for achieving a wide range of operating speeds.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: March 28, 2017
    Assignee: The University of Akron
    Inventors: Yilmaz Sozer, Tausif Husain, Ali Elrayyah
  • 2,3-Fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals
    Patent number: 9604954
    Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: March 28, 2017
    Assignee: The University of British Columbia
    Inventors: Stephen Withers, Andrew Graham Watts, Jin Hyo Kim, Tom Wennekes
  • Pressure driven microfluidic injection for chemical separations
    Patent number: 9606082
    Abstract: Methods that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods are particularly suitable for use with a mass spectrometer.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: March 28, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: John Scott Mellors, Erin Anne Redman, John Michael Ramsey
  • RADIOOPAQUE, IODINE FUNCTIONALIZED PHENYLALANINE-BASED POLY(ESTER UREA)S
    Publication number: 20170081476
    Abstract: In one or more embodiments, the present invention provides iodine-functionalized phenylalanine-based poly(ester urea)s (PEUs) (and related methods for their synthesis and use) that are metal free, degradable, radiopaque and suitable for use in surgical implants and other medical devices used within a patient. In one or more embodiment of the present invention 4-Iodo-L-phenylalanine and L-phenylalanine are separately reacted with 1,6-hexanediol to produce two monomers, bis-4-I-L-phenylalanine-1,6-hexanediol-diester (1-IPHE-6 monomer) and bis-L-phenylalanine-1,6-hexanediol-diester (1-PHE-6 monomer). It has been found that by varying the feed ratio of the 1-IPHE-6 and 1-PHE-6 monomers, the copolymer composition may be modulated to predictably create phenylalanine-based PEUs having a wide variation in thermal, mechanical and radiopacity properties.
    Type: Application
    Filed: May 7, 2015
    Publication date: March 23, 2017
    Applicant: The University of Akron
    Inventors: Matthew L. BECKER, Shan LI
  • SYSTEMS AND METHODS FOR DETECTING TREMORS
    Publication number: 20170079561
    Abstract: In one embodiment, a system for detecting tremors includes a contactless tremor detector, the detector including an oscillator circuit having a sensing coil, an oscillator configured to generate alternating electromagnetic fields, and a frequency counter configured to sense the resonant frequency of the oscillator circuit as the resonant frequency changes in response to movement of a body part of an individual adjacent to the sensing coil, wherein the system is configured to determine a frequency of movement of the body part from the sensed resonant frequency for the purpose of determining if the individual is experiencing tremors.
    Type: Application
    Filed: September 19, 2016
    Publication date: March 23, 2017
    Applicant: Board of Regents, The University of Texas System
    Inventor: Jung-Chih Chiao
  • Systems And Methods For Containerizing Multilayer Image Segmentation
    Publication number: 20170084040
    Abstract: The present disclosure relates to a cascade thresholding system to find an optimal threshold for binarization of a gray scale image. The cascade system can perform different levels of quantization on an input image. The cascade system can process each quantized image across multiple threshold levels. SSIM scores can be calculated for the quantized images to determine a best image for binarization. A best binary image can be generated.
    Type: Application
    Filed: September 19, 2016
    Publication date: March 23, 2017
    Applicant: Board of Regents, The University of Texas System
    Inventors: Paul Rad, Mohan Muppidi, Sos Agaian, Mo Jamshidi
  • TRANSDUCTION
    Publication number: 20170080101
    Abstract: This invention relates to transduction of cargo molecules into living cells, such as protein transduction, in particular a delivery molecule for transduction of a cargo into a cell comprising: a cargo-binding molecule and/or a cargo; a glycosaminoglycan (GAG) binding element, which is capable of binding to GAG on the surface of the cell; and a protein transduction domain. Methods of transduction, methods of producing or modifying cargo for transduction, delivery molecules for transduction and methods of treatment using transduction, or using transduced cells are also provided.
    Type: Application
    Filed: December 18, 2014
    Publication date: March 23, 2017
    Applicant: The University of Nottingham
    Inventors: James DIXON, Kevin SHAKESHEFF, Chris DENNING
  • Peptide and uses therefor
    Patent number: 9597368
    Abstract: Provided is a method for treatment and/or prophylaxis of a condition associated with T cell mediated chronic inflammatory disease by administration, to a patient, of a peptide comprising N?-SVTEQGAELSNEER-C? (SEQ ID NO: 1) or an analog of the peptide that inhibits T cell migration. Also provided is the peptide or its analog for use in the methods of treatment and/or prophylaxis of the condition.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: March 21, 2017
    Assignee: The University of Birmingham
    Inventors: George Edward Rainger, Parth Narendran, Helen McGettrick, Myriam Chimen
  • Efficient volatile metal removal from low rank coal in gasification, combustion, and processing systems and methods
    Patent number: 9598653
    Abstract: Efficient coal pre-processing systems (69) integrated with gasification, oxy-combustion, and power plant systems include a drying chamber (28), a volatile metal removal chamber (30), recirculated gases, including recycled carbon dioxide (21), nitrogen (6), and gaseous exhaust (60) for increasing the efficiencies and lowering emissions in various coal processing systems.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: March 21, 2017
    Assignee: The University of Wyoming Research Corporation
    Inventors: Alan E. Bland, Kumar Muthusami Sellakumar, Jesse D. Newcomer
  • Methods and devices for generating high-amplitude and high-frequency focused ultrasound with light-absorbing materials
    Patent number: 9601103
    Abstract: A high-frequency light-generated focused ultrasound (LGFU) device is provided. The device has a source of light energy, such as a laser, and an optoacoustic lens comprising a concave composite layer with a plurality of light absorbing particles that absorbs laser energy, e.g., carbon nanotubes, and a polymeric material that rapidly expands upon exposure to heat, e.g., polydimethylsiloxane. The laser energy is directed to the optoacoustic lens and thus can generate high-frequency (e.g., ?10 MHz) and high-amplitude pressure output (e.g., ?10 MPa) focused ultrasound. The disclosure also provides methods of making such new arcuate optoacoustic lenses, as well as methods for generating and using the high-frequency and high-amplitude ultrasound, including for surgery, like lithotripsy and ablation.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: March 21, 2017
    Assignee: The Regents Of The University Of Michigan
    Inventors: Lingjie Jay Guo, Hyoung Won Baac
  • Nanopatterned substrate serving as both a current collector and template for nanostructured electrode growth
    Patent number: 9601747
    Abstract: A process of forming and the resulting nano-pitted metal substrate that serves both as patterns to grow nanostructured materials and as current collectors for the resulting nanostructured material is disclosed herein. The nano-pitted substrate can be fabricated from any suitable conductive material that allows nanostructured electrodes to be grown directly on the substrate.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 21, 2017
    Assignee: The University of Tulsa
    Inventors: Dale Teeters, Matthew Smith