Abstract: A recombinant polypeptide is described including at least one PUF RNA-binding domain capable of specifically binding to a cytosine RNA base. The PUF RNA-binding domain of the polypeptide includes at least one RNA base-binding motif of the general formula X1X2X3X4X5X6X7X8X9X10X11 wherein X1 is selected from a defined group and wherein the RNA base-binding motif is operably capable of specifically binding to a cytosine RNA base.

Abstract: 3-dimensional surface-enhanced Raman scattering (SERS), as well as absorption/fluorescence/luminescence detection is carried out using a platform based on nanoparticle-functionalized flow-through multi-hole capillaries for rapid analyte detection. The configuration provides an increased active area and fluidic channels for efficient sample delivery, and also confines and transmits light for a large signal accumulation. Using a capillary consisting of thousands of micron-sized holes adsorbed with gold nanoparticles, a detection limit better than 100 fM is achieved.

Abstract: The invention provides emissive materials and organic light emitting devices using the emissive materials in an emissive layer disposed between and electrically connected to an anode and a cathode. The emissive materials include compounds with the following structure: wherein at least one of R8 to R14 is phenyl or substituted phenyl, and/or at least two of R8 to R14 that are adjacent are part of a fluorenyl group. The emissive materials have enhanced electroluminescent efficiency and improved lifetime when incorporated into light emitting devices.

Abstract: A remote operation system remotely controls a vehicle. The system may include a RF receiver and a remote interface device. The RF receiver resides in the vehicle and receives RF commands via a RF communication link. The remote interface device may be packaged in a housing and installed in the vehicle. The remote interface device includes a cellular transceiver, a RF transmitter, and a controller. The cellular transceiver may receive a given command via a cellular communication link. The controller may retrieve the given command from the cellular transceiver, and translate the given command to a RF command. The controller may transmit the RF command to the RF receiver by way of the RF transmitter.

Abstract: The resolution of conventional imaging devices is restricted by the diffraction limit. ‘Perfect’ imaging devices which can achieve a resolution beyond the diffraction limit have been considered impossible to implement. However, the present disclosure provides an imaging device which can achieve improved resolution beyond the diffraction limit and which can be implemented in practice. Said imaging device comprises: a. a lens having a refractive index that varies according to a predetermined refractive index profile; b. a source; c. an outlet for decoupling waves from the device; and d. a reflector provided around the lens, the source and the outlet, wherein the reflector and the refractive index profile of the lens are together arranged to direct waves transmitted in any of a plurality of directions from the source to the outlet.

Abstract: Therapeutic agents which target heat shock protein (hsp) 27 in vivo are used to provide treatment to individuals, particularly human individuals, suffering from prostate cancer and other cancers that overexpress hsp27. A therapeutic agent, for example an antisense oligonucleotide or RNAi nucleotide inhibitor with sequence specificity for hsp27 mRNA, for example human hsp27 mRNA, is administered to an individual suffering from prostate cancer or some other cancer expressing elevated levels of hsp 27 in a therapeutically effective amount. The therapeutic agent is suitably formulated into a pharmaceutical composition which includes a pharmaceutically acceptable carrier, and packaged in dosage unit form. A preferred dosage unit form is an injectable dosage unit form.

Abstract: A corrosion detection sensor embedded within a concrete structure. The sensor includes a hermetically sealed resonant circuit that is a resistor-inductor-capacitor (RLC) circuit. The sensor further includes a sacrificial transducer that is inductively or capacitively coupled to the resonant circuit, where the sacrificial transducer is exposed to an environment outside the sensor to monitor corrosion of steel reinforcement in the concrete structure. Additionally, the sensor includes a protective cementitious housing surrounding the resonant circuit and the sacrificial transducer. The sensor further includes a diffusion layer placed over the sacrificial transducer, where the diffusion layer enables a dispersion of a chemical species over the sacrificial transducer. In this manner, a more uniform distribution of the chemical species over the surface of the sacrificial transducer mitigating the localized corrosion is ensured. Furthermore, such a design is less susceptible to false positives.

Abstract: An intracerebral current simulation method including a first step of providing head image data; a second step of forming a three-dimensional brain model including micro-polyhedron units; a third step of providing first information which includes conditions under which a coil is placed on a patient's head, an electric current is applied to the coil, and the patient's reaction to the magnetic stimulation is observed, the conditions including a position and orientation of the coil, an electric current applied to the coil, and a structure relating to a generated magnetic field of the coil; and a fourth step of calculating an eddy current or electric field induced inside each of the micro-polyhedron units on the basis of the first information provided in the third step and second information which includes conductivity assigned to each micro-polyhedron unit. Also disclosed is a transcranial magnetic stimulation device and system.

Abstract: In one embodiment, a hybrid foil bearing includes a bearing sleeve, multiple inner foils provided within the sleeve, the foils having gas outlets from which pressurized gas can be injected into an interior of the bearing, and integrated gas flow paths that radially extend through the bearing sleeve and deliver the gas to the gas outlets.

Abstract: A smart sensor network for power grid health monitoring includes a plurality of spaced sensors that are magnetically coupled to the power transmission line to be monitored. The sensors include a signal injection unit and a signal sensing unit. As such, one of the sensors acts to inject, via its signal injection unit, a high frequency signal through the magnetic coupling into the power transmission line, while sensors on either side of the signal injecting sensor act to block the injected signal, which is then detected by the signal sensing unit of the injecting sensor, and is used to measure the impedance of the power transmission line segment being analyzed. Based on the difference between a pre-measured impedance of the power transmission line being monitored and the actual impedance value of the power transmission line being measured by the sensor, the health of the power line can be obtained.

Abstract: A method for welding together glass workpieces where one of the workpieces has metal nanoparticles positioned at or near the surface to be welded. The method comprises positioning the workpieces in operative contact at an interface where a weld is to be formed, applying a laser beam to be incident upon the interface wherein energy from the laser beam is absorbed by the nanoparticle bearing workpiece and the energy from the laser beam is transferred to the glass surrounding the metal nanoparticles to heat the glass and to weld the workpieces together.

Abstract: An enzymatic method is provided for restructuring an affinity ligand bound heterogenous glycoform antibody sample to a substantially homogenous single desired glycoform antibody sample for therapeutic uses and kits for performing the methods. A method for enzymatically altering the Fc region of an affinity ligand bound antibody from a heterogenous glycoform to a substantially homogenous single glycoform comprises: contacting the affinity ligand bound heterogeneous glycoform antibody with a reaction buffer designed for a particular glycoform modification for a time sufficient and under conditions to modify the glycoform of the Fc region to a substantially homogeneous single form; optionally adding one or more nucleotide sugars and/or cofactors; and releasing the substantially homogeneous single glycoform antibody sample from said affinity ligand.

Abstract: A first capturing image unit mounted on a vehicle body captures an image of surroundings of a work vehicle. A second capturing image unit is disposed above the work implement and captures an image of an area in front of the work implement. A first image generation unit generates, from the image captured by the first capturing image unit, a surroundings composite image, which depicts the surroundings of the work vehicle in a bird's-eye view and is synthesized with a vehicle model depicting the work vehicle. A second image generation unit generates, from the image captured by the second image capturing unit, a work implement composite image, which depicts the area in front of the work implement and is synthesized with the vehicle model and the surroundings composite image. A display unit displays a display image including the vehicle model, the surroundings composite image, and the work implement composite image.

Abstract: A method, system, or computer program product to enhance the performance of multi-hop cellular networks or other wireless networks is provided. A wireless device (e.g., cellular telephone) is able to communicate with a base-station in a cell of the cellular network over a non-cellular interface via another wireless device in the cell through the use of multi-hopping. By enabling wireless devices to communicate with a base station in such a manner, the effective coverage area of the cellular network is expanded and the effective capacity of the cellular network is improved. Distributed routing, device management, adaptive scheduling, and distributed algorithms can be used to enhance the overall performance of multi-hop cellular networks.

Abstract: The present invention provides three-component compositions comprising microparticles, a tumor antigen, a first immune adjuvant, and a second immune adjuvant. Also provided are chemo-immunotherapeutic compositions comprising microparticles, a chemotherapeutic agent, and an immune adjuvant.

Abstract: Disclosed are systems implementing an implicit Feed-Forward Compensated (FFC) op-amp, where the main FFC port is realized by the P-side of the CMOS input structure of the 2nd and 3rd stages of the op-amp, while the main signal path is through the N-side. According to some embodiments, to balance the relative strengths of the main path and feed-forward paths, the 2nd-stage NMOS input pair is split into two pairs, one is used to route the main path while the other is used for auxiliary FFC. The disclosed implicit FCC op-amp is unconditionally stable with adequate phase lead. According to some embodiments, the disclosed op-amp, which may be a wide-band op-amp, can be used in highly linear applications operative at intermediate frequency (IF), such as signal buffers for high-performance data converters or radio-frequency (RF) modulators and demodulators, continuous-time (CT) filters or sigma-delta data converters.

Abstract: A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.

Abstract: A method for producing a high-strength magnesium alloy material includes (a) a step of preparing a magnesium alloy workpiece having a top face and a side face; and (b) a step of applying a compressive load ?p (MPa) from the top face side of the workpiece and performing a uniaxial forging process on the workpiece. Step (b) is performed while suppressing deformation of the workpiece widening outward and under conditions including (i) ?p>?f (where ?f is the compressive breaking stress (MPa) of the workpiece); (ii) a plastic deformation rate is less than or equal to 10%, and (iii) a strain rate is less than or equal to 0.1/sec.

Abstract: An object of the present invention is to provide molecules that bind to a target molecule in a pH dependent manner and a screening method for selecting such molecules. Provided is a screening method for selecting peptides that bind to a target molecule at a first pH and do not bind thereto at a second pH, including a step of preparing a peptide library in which each peptide contains at least one special amino acid that undergoes a pH-dependent change in the charge of the side chain thereof, a step of bringing the peptide library into contact with the target molecule and incubating them under the first pH condition and selecting peptides that bind to the target molecule, and a step of selecting, from the peptides which have bound to the target molecule, peptides that do not bind to the target molecule under the second pH condition.

Abstract: Provided herein are methods and related systems for controlling droplet spreading on a surface, including droplets in which a biological component is suspended. A biological solution is provided as a droplet to a surface. Interference fringes generated by the droplet on the surface are imaged, wherein the imaging is over a time course during which the droplet spreads on the surface. A droplet parameter is determined from the imaging step and a process parameter controlled to obtain an interference fringe pattern corresponding to a desired droplet parameter. In this manner, well-controlled droplet spreading is achieved, which is important in a range of applications, including assays that rely on good metaphase spreading.