Abstract: An apparatus for presuming positions of organs is configured to transform plural organs included in a template that is a model including the plural organs so as to match a predetermined target organ among the plural organs in the template to a corresponding organ in volume data; and perform a first processing and a second processing a predetermined number of times. The first processing includes transforming a first organ selected among the plural organs in the template according to a corresponding first organ in the volume data, and the second processing includes transforming, for each of second organs that are predetermined organs, which are influenced by transformation of the first organ, the second organ according to transformation performed for third organs that are predetermined organs, which influence the second organ in the template.

Abstract: The invention relates to a computer readable medium including software instructions, which when executed by a scaling parameters for processor perform a method. The method includes obtaining a first and a second pre-calculated history, wherein the first and the second pre-calculated history corresponds to a first and a second path of particles through a reference material. The method further includes obtaining a first and a second plurality of phase space points and performing a first and a second set of simulations in parallel on a first and a second GPU. Each simulation uses a distinct one of the first and second plurality of phase space points, the geometry information, and the first and second pre-calculated history. The sets of simulations are performed on the GPU's to obtain a set of simulated histories. The method further includes calculating an absorbed dose of energy in the target using the set of simulated histories.

Abstract: A wireless power transmission system is provided for high power applications. The power transmission system is comprised generally of a charging unit configured to generate an alternating electromagnetic field and a receive unit configured to receive the alternating electromagnetic field from the charging unit. The charging unit includes a power source; an input rectifier; an inverter; and a transmit coil. The transmit coil has a spirangle arrangement segmented into n coil segments with capacitors interconnecting adjacent coil segments. The receive unit includes a receive coil and an output rectifier. The receive coil also has a spirangle arrangement segmented into m coil segments with capacitors interconnecting adjacent coil segments.

Abstract: Methods and compositions are disclosed to target tumor cells with embodiments of the LIGHT proteins linked fused or conjugated to a targeting agent. These compositions bind to both human and mouse receptors with affinity sufficient to conduct preclinical and clinical trials, and with increased affinity as compared to the wild type human LIGHT protein. The targeting of embodiments of LIGHT to tumor cells reduces tumor growth and reduces metastases.

Abstract: The present invention is a tourniquet comprising: a strap; a pelvic pad included in the strap having a pocket defined in the pelvic pad for receiving a semi-rigid stiffening member; base plates slidably attached to the strap allowing the base plates to be positioned along the strap; a threaded shaft received in each of the base plates; a pressure pad removable attached to a distal end of each of the shafts; a handle attached to a proximal end of each of the shafts having openings defined in each end of the handle; and, a rotational arresting strap attached to each base plate having a securing tab that can be received in one of the handle openings thereby preventing the shaft from rotating when the securing tab is received in sand handle opening.

Abstract: An efficient way of predicting the power requirements of electric vehicles is proposed based on a history of vehicle power consumption, speed and acceleration as well as road information. By using this information and the operator's driving pattern, a model extracts the vehicles history of speed and acceleration, which in turn enables the prediction of the vehicle's future power requirements. That is, the power requirement prediction is achieved by combining a real-time power requirement model and the estimation of vehicle's acceleration and speed.

Abstract: Polynucleotides encoding a secreted mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.

Abstract: In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a citrate-presenting composition to the population of bone cells. In some embodiments, the citrate-presenting composition is provided to the bone cells at a first stage of cell development selected to obtain a first cell differentiation or phenotype progression. Additionally, in some cases, a second citrate-presenting composition is further provided to the bone cells at a second stage of cell development selected to obtain a second cell differentiation or phenotype progression.

Abstract: Sensors for target entities having functionalized thereon, at least one aptamer specific to the target entity, and methods of making and using the same are described for use in glycated protein monitoring and/or biomarkers.

Abstract: Provided is: a cell culture membrane, which is free from materials derived from living organisms, can easily be industrially mass-produced, exhibits superior long-term storage properties and chemical resistance, has excellent cell adhesion properties and long-term culture properties and is capable of replicating a cell adhesion morphology that is similar to that of collagen derived from living organisms and being used for conventional cell cultivation. Also provided are a cell culture substrate, and a method for manufacturing the cell culture substrate. In the present invention, as a cell adhesion layer, a polymer membrane represented by formula (I) is formed on the base of a cell culture substrate so as to have a membrane thickness equal to or greater than 0.2 ?m (in the formula, R1 and R2 represent a —(CH2)n—NH2 moiety (n is an integer of 1-10 inclusive.) or H, with at least one of R1 and R2 being a —(CH2)n—NH2 moiety. Moreover, l and m are positive integers expressing polymerization degree).

Abstract: A therapeutic or prophylactic agent for diabetes includes a thiazolidine derivative as a PPAR-? agonist as an effective component which exhibits a reduced side effect of the PPAR-? agonist. The therapeutic or prophylactic agent for diabetes includes a particular IP agonist such as beraprost sodium (BPS), and a thiazolidine derivative such as pioglitazone or a pharmaceutically acceptable salt thereof. Since the therapeutic or prophylactic agent exhibits a sufficiently effective hypoglycemic action without being accompanied by side effects characteristic to PPAR-? agonists, the agent is useful as a highly safe and effective therapeutic or prophylactic agent for diabetes.

Abstract: Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described.

Abstract: The disclosure relates to anti-viral agents that mimic or inhibit packaging singles of RNA viruses that function in viral capsid formation and their use in the control of viral infection.

Abstract: Therapeutic agents which target heat shock protein (hsp) 27 in vivo are used to provide treatment to individuals, particularly human individuals, suffering from prostate cancer and other cancers that overexpress hsp27. A therapeutic agent, for example an antisense oligonucleotide or RNAi nucleotide inhibitor with sequence specificity for hsp27 mRNA, for example human hsp27 mRNA, is administered to an individual suffering from prostate cancer or some other cancer expressing elevated levels of hsp 27 in a therapeutically effective amount. The therapeutic agent is suitably formulated into a pharmaceutical composition which includes a pharmaceutically acceptable carrier, and packaged in dosage unit form. A preferred dosage unit form is an injectable dosage unit form.

Abstract: The present invention relates to an ink formulation comprising two-dimensional inorganic layered particles. The ink formulations of the present invention are for inkjet printing. The present invention also relates to a process for the preparation of these ink formulations, to the use of these ink formulations for the production of printed films and tracks comprising the inorganic material, to the films or tracks produced by the inkjet printing these ink formulations, and to devices that comprise these films or tracks.

Abstract: A brace apparatus for mounting between two structural components of a support infrastructure to absorb vibrational energy imposed on the support infrastructure. The brace apparatus comprises: (i) an elongate piston component having one end engaged with a piston plate and the other end configured for demountable pivotable engagement with a first structural component, (ii) a sleeve component for receiving the piston component therein, said sleeve component having a back cap for receiving the piston component therethrough and a front cap configured for demountable pivotable engagement with a second structural component, and (iii) a plurality of equidistantly spaced-apart tie rods housed within the sleeve component wherein one end of each tie rod is secured to the outer surface of the front cap and the other end is secured to the outer surface of the back cap, the tie rod slidingly inserted through an orifice provided therefore in the piston plate.

Abstract: Described herein is an integrated Faraday modulator and Faraday compensator (IFMC) system. Further described are methods of making an IFMC system, methods of customizing an IFMC system for a specific application, and methods of optimizing an IFMC system for a specific application. Further described is a robust 3D Finite Element Model (FEM) for designing and optimizing an IFMC system. Further described are optical instruments comprising an integrated Faraday modulator and Faraday compensator requiring only one optical crystal.

Abstract: The invention relates to methods for modulating PPAR-? activity using relaxin or agonists thereof. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including small vessel disorders of the brain and those associated with increased blood-brain barrier permeability, cognitive disorders such as Alzheimer's disease, vascular dementia, epilepsy, stroke, CADASIL and migraine.

Abstract: The invention relates to improved cardiac pacemakers and methods of use thereof. In particular the cardiac pacemakers are useful for normalizing heart rates over resting heart rates in order to condition the heart to improve overall cardiac output.

Abstract: Thermal interface materials and methods are disclosed. The thermal interface material can include a matrix and fillers. The filler can include magnetically functionalized graphene flakes that are disposed and aligned within the matrix. The method can include providing or obtaining the magnetically functionalized graphene flakes and aligning the magnetically functionalized graphene flakes from a random orientation to a specific origination while dispersing the thermal interface material onto a substrate.