Abstract: Disclosed is a method comprising the administration of a 3% amino acid and 3% glycerin solution for the use of prevention and disruption of bacterial biofilms. Also disclosed is method comprising the administration of L-cysteine 0.4 g per 100 ml for the prevention and destruction of fungal biofilms.

Abstract: Disclosed herein are ferroelectric perovskites characterized as having a band gap, Egap, of less than 2.5 eV. Also disclosed are compounds comprising a solid solution of KNbO3 and BaNi1/2Nb1/2O3-delta, wherein delta is in the range of from 0 to about 1. The specification also discloses photovoltaic devices comprising one or more solar absorbing layers, wherein at least one of the solar absorbing layers comprises a semiconducting ferroelectric layer. Finally, this patent application provides solar cell, comprising: a heterojunction of n- and p-type semiconductors characterized as comprising an interface layer disposed between the n- and p-type semiconductors, the interface layer comprising a semiconducting ferroelectric absorber layer capable of enhancing light absorption and carrier separation.

Abstract: A cold spray nozzle assembly for applying a coating of particles to a substrate includes a nozzle defining an inner passage with a nozzle exit. The nozzle assembly also includes a particle supply member in communication with the inner passage. The particle supply member supplies the particles to flow and accelerate through the inner passage and out of the nozzle via the nozzle exit toward the substrate to be coated thereon. Furthermore, the nozzle assembly includes a laser that emits a laser beam that is transmitted through the inner passage. The laser heats at least one of the particles and the substrate to promote coating of the substrate with the particles.

Abstract: The present invention is directed to nanofiber yarns, ribbons, and sheets; to methods of making said yarns, ribbons, and sheets; and to applications of said yarns, ribbons, and sheets. In some embodiments, the nanotube yarns, ribbons, and sheets comprise carbon nanotubes. Particularly, such carbon nanotube yarns of the present invention provide unique properties and property combinations such as extreme toughness, resistance to failure at knots, high electrical and thermal conductivities, high absorption of energy that occurs reversibly, up to 13% strain-to-failure compared with the few percent strain-to-failure of other fibers with similar toughness, very high resistance to creep, retention of strength even when heated in air at 450° C. for one hour, and very high radiation and UV resistance, even when irradiated in air. Furthermore these nanotube yarns can be spun as one micron diameter yarns and plied at will to make two-fold, four-fold, and higher fold yarns.

Abstract: This is a new technique of producing high energy X-rays for radiation therapy at a patient's level. The dose delivery system uses a linear accelerator with no flattening filter. The technique improves patient radiation therapy by reducing radiation scattered to surrounding normal tissue and reducing electron contamination. It increases dose rate to shorten treatment time. The flattening filter reduces the efficiency of the beam by reducing the fluence and increasing scattered radiation. This technique involves removal of the flattening filter. It uses inverse planning to shape the dose distribution.

Abstract: The invention provides a method for producing an orexin neuron by culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine and optionally in the presence of at least one inhibitor selected from the group consisting of a Sirtuin 1 inhibitor and an O-linked ?-N-acetylglucosamine transferase inhibitor. The invention also provides a therapeutic agent for narcolepsy or eating disorders, such as anorexia, containing N-acetyl-D-mannosamine, which is based on the induction of orexin neuron in vivo.

Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

Abstract: The invention provides a method of treating anxiety or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.

Abstract: An apparatus for scanning and detecting analytes in real time as they move through a separation conduit is provided. The apparatus may include a detector mounted on a scanner containing a separation conduit positions under the scanner such that the scanner may move back and forth along the conduit, producing time and space data of the column as the analyte moves through and providing information regarding elution of the analyte in real time. A method for real time analysis of analytes as they move through a separation conduit is also provided.

Abstract: A device including an array of aligned conductive channels. The conductive channels are operable for directional transport of species selected from the group consisting of electrons, ions, phonons, and combinations thereof. The conductive channels are provided for by nanofibers in a form selected from the group consisting of ribbons, sheets, yarns, and combinations thereof.

Abstract: Provided herein are systems, methods, and apparatuses for simulating ailments that can be diagnosed by an abdominal palpation exam. Furthermore, provided herein are systems, methods, and apparatuses for analyzing an abdominal palpation exam. An abdominal simulator may include a surface layer, a sensor layer beneath the surface layer, a muscle layer beneath the sensor layer, a tensing layer beneath the muscle layer, an ailment module layer beneath the tensing layer, and a control portion. The abdominal simulator may simulate an ailment that can be diagnosed by an abdominal palpation exam. The abdominal simulator may also detect at least one abdominal palpation that is performed by a user on the abdominal simulator to diagnose the ailment that was simulated by the abdominal simulator. Moreover, the abdominal simulator may determine data for the at least one abdominal palpation that was detected.

Abstract: The invention provides materials and methods to identify and analyze in a genome-wide manner the structural determinants of this organization. Next generation sequencing methods, combined with a novel assay and integrated data analysis, are used to map the long-range interactions in chromatin that are involved in the regulation of transcription.

Abstract: A method for predicting a subject's response to a TUSC2 therapy is provided. In particular, a subject's response is predicted based on the proportion of cancers cells that are apoptotic. Also provided is a method of treating a subject previously predicted to have a favorable response with a TUSC2 therapy. Methods for treating cancer by administration of a TUSC2 therapeutic in conjunction with an EGFR inhibitor and/or a protein kinase inhibitor are also disclosed. Kits and reagents for use in TUSC2 therapy are provided.

Abstract: Methods and systems are described for effecting autonomous operations within a defined geographical region (1110). A plurality of localized zones (1102, 1104, 1106, 1108) having operation-defined geographical boundaries are specified within the region. A plurality of control modules are established associated with respective ones of the localized zones and autonomous operations are effected under the supervisory control of the control module associated with the localized zone in which the autonomous operation occurs. The geographical disposition of the boundary of at least one of the localized zones is varied within the defined geographical region.

Abstract: Methods, articles of manufacture, and devices related to generating six degree of freedom (DOF) haptic feedback are provided. A computing device can receive first depth data about an environment. The computing device can generate a first plurality of points from the first depth data. The computing device can determine a virtual tool, where the virtual tool is specified in terms of a translation component for the virtual tool and a rotation component for the virtual tool. The computing device can determine a first force vector between the virtual tool and the first plurality of points. The computing device can send a first indication of haptic feedback based on the first force vector.

Abstract: An immiscible lipophilic or hydrophilic liquid phase separated respectively from a continuous hydrophilic phase or a lipophilic phase liquid. Fibers having hydrophilic and hydrophobic properties are formed into a filter. The separation mechanism involves capture of small droplets of the immiscible phase, coalescence of the small droplets into larger droplets as the immiscible liquid flows through the fiber filter, and release of the large immiscible droplets from the filter. Regarding separation of a hydrophilic immiscible fluid such as water in a lipophilic continuous fluid such as oil, the hydrophobic fibers cause small water droplets to migrate towards the hydrophilic fibers whereby large droplets form on hydrophilic surface. The large droplets stay on hydrophilic fiber surface for extended periods of time and continue to coalescence until they are so large that they can no longer be maintained by the hydrophilic fibers and are released and drained off of the filter.

Abstract: The present invention provides AAV capsid proteins (VP1, VP2 and/or VP3) comprising a modification in the amino acid sequence in the three-fold axis loop 4 and virus capsids and virus vectors comprising the modified AAV capsid protein. In particular embodiments, the modification comprises a substitution of one or more amino acids at amino acid positions 585 to 590 (inclusive) of the native AAV2 capsid protein sequence or the corresponding positions of other AAV capsid proteins. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.

Abstract: A photovoltaic cell has an active area formed electron donor-fullerene conjugated molecules. The electron donor is formed of a polymer, which is conjugated with an electron acceptor, such as fullerene. By conjugating the fullerene, such as C60, with electron donor moieties, such as that of the polymer, double channels are formed therebetween, whereby one channel provides hole transport and the other channel provides electron transport. As a result, the electronic coupling between the fullerene and the electron donor moiety leads to increased short-circuit current density (Jsc) and increased open-circuit voltage (Voc), resulting in high power conversion efficacy (PCE) in the solar cell.

Abstract: Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.

Abstract: A new and distinct cultivar of Red Bayberry, botanically known as Myrica rubra, and hereinafter referred to by the name ‘N1MR07’ is described. N1MR07 produces fruit having improved sweetness, a good sugar:acid ratio, a palatable low resin taste along with uniform fruit size and colour. N1MR07 has the following traits: mean fruit diameter is 22.3 mm; mean fruit weight is 7.15 g; fruit colour is red; mean fruit flesh total soluble solids (an indicator of sweetness) is 12.4° Brix; mean fruit flesh titratable acidity is 1.08%; and fruit harvest season in the southern hemisphere is mid-late November.