Abstract: The present disclosure relates to uses of TG02, for treating a glioma in a pediatric human subject. In certain embodiments, the glioma can be a pediatric high-grade glioma (PHGG), e.g., a diffuse intrinsic pontine glioma (DIPG), and/or a H3.3-mutated glioma (e.g., a H3K27M-mutated glioma). The present disclosure further provides pharmaceutical compositions and kits that include an ERK5 inhibitor.

Abstract: The presently disclosed subject matter relates to torrefied biomass briquettes and methods for producing the same that make use of a mixture of lightly torrefied material (LTM) and highly torrefied material (HTM) and/or make use of torrefied materials that are subjected to a hydrolysis pretreatment prior to being torrefied.

Abstract: The present invention relates to a graph-computing-oriented heterogeneous in-memory computing apparatus, comprising a memory control unit, a digital signal processing unit, and a plurality of analog signal processing units using the memory control unit.

Abstract: An electroacoustic transducer includes: a diaphragm; a magnetic circuit having a magnetic gap; a frame that holds the diaphragm and the magnetic circuit; a voice coil having one end portion positioned within the magnetic gap and the other end portion coupled to the diaphragm; and a low friction material that is disposed in a sliding portion formed by the voice coil and the magnetic circuit, and includes polymer compounds swollen with liquid.

Abstract: The invention provides a novel microfluidic platform for use in electro-crystallization and electro-crystallography experiments. The manufacturing and use of graphene as X-ray compatible electrodes allows the application of electric fields on-chip, during X-ray analysis. The presence of such electric fields can be used to modulate the structure of protein (or other) molecules in crystalline (for X-ray diffraction) or solution form (for X-ray scattering). Additionally, the presence of an electric field can be used to extend the lifetime of fragile samples by expediting the removal of reactive secondary radiation damage species.

Abstract: The present invention relates to a method of improving fire retardant properties of a substrate, the method comprising providing the substrate with a graphene-based composite, wherein the graphene-based composite comprises graphene-based material intercalated with inorganic metal hydrate.

Abstract: A wearable assembly has a pulse plethysmography (PPG) sensor and a piezoelectric pressure sensor and is attachable to a patient's finger or other area corresponding to a peripheral vascular region, and further includes a signal processor configured to monitor blood flow dependent measurements and pressure measurements over time, comparing these measurements to determine properties of the vascular region, such as vascular resistance of a blood vessel, vascular radius of the blood vessel, vascular stiffness of the vascular region, blood pressure, and/or cardiac vascular power. The signal processor may apply a hysteresis comparison of the sensor outputs, e.g., using an elliptical model, and in some examples may apply an extended Kalman filter for optimizing output of the vascular region properties.

Abstract: A multilayer protective covering can protect a surface from lightning strikes. The covering includes a bottom conductive layer affixed to the surface and having a first opening that is aligned with a grounding connection so that the grounding connection is exposed through first opening and not in contact with the bottom conductive layer. The covering also includes a dielectric layer affixed to the bottom conductive layer and having second opening aligned with the grounding connection so that the grounding connection is exposed through second opening and not in contact with the dielectric layer. The covering additionally includes a top conductive layer affixed to the dielectric layer and covering the grounding connection. The top conductive layer directs electrical current from a lightning strike on the surface to the grounding connection.

Abstract: The nanoparticle assembly includes nanoparticles having an average primary particle size of 60 nm or less, and the nanoparticle assembly has a diameter of more than 500 nm and 5 ?m or less.

Abstract: Provided herein are functionalized phosphonates and methods for making same via phosphite addition to an atom alpha to an electron withdrawing group. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A prosthesis, radiation bolus, pre-surgical model, or burn mask formed using a rapid prototyping device, such as a three-dimensional printer. In some exemplary aspects, the prosthesis includes a scaffolding and a coating at least partially covering the scaffolding. Methods and systems for forming the prosthesis, radiation bolus, pre-surgical model, or burn mask are also provided.

Abstract: A pumping heart simulator is described. The pumping heart simulator can include an inflow pump, an outflow pump, and a control apparatus. The inflow pump can have a first magnetic motor that facilitates flow of fluid from a bottom portion of a fluid reservoir to three inlet valves of a heart via the inflow pump. The outflow pump can have a second magnetic motor that facilitates flow of fluid from two outlet valves of the heart to a top portion of the fluid reservoir via the outflow pump. The control apparatus can alternately activate the first magnetic motor and the second magnetic motor. Related apparatuses, systems, methods, techniques and articles are also described.

Abstract: The present disclosure describes the design, fabrication, and demonstration of a compact spectroscopic analysis system that utilizes a linear variable filter chip attached directly over an image sensor array, and an integrated broadband LED illuminator that supplies light from the edge of the system to provide a low vertical dimension. The instrument is capable of accurately measuring the optical absorption spectra of colored liquids or the scattered spectra from solid objects that are placed in the illumination pathway. Due to the small vertical thickness of the system, the low cost of its components, and the accuracy with which it renders spectra in comparison to conventional spectrometers, we envision potential incorporation of the system into mobile communication devices, such as smartphones and tablets, as a means for providing a dedicated sensor for health diagnostic, environmental monitoring, and general-purpose color sensing applications.

Abstract: Systems and methods in accordance with embodiments of the invention implement all-microwave stabilized microresonator-based optical frequency comb. In one embodiment, an all-microwave stabilized microresonator-based optical frequency comb includes: an optical pump configured to generate pulses of light; a microresonator including an input configured to receive pulses generated by an optical pump and an output configured to generate an optical frequency comb signal characterized by frep and ?; where frep describes spacing of frequency components in the optical frequency comb; where the optical frequency comb includes a primary comb and a plurality of subcombs and ? is a frequency offset between subcombs; and two phase locked loops that phase lock frep and ? to low noise microwave oscillators by modulating output power and pump frequency of the optical pump.

Abstract: Provided herein are drug implants comprising a therapeutically active agent for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and a therapeutically active agent disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may comprise bicalutamide, e.g., for use in the treatment of prostate cancer.

Abstract: A hierarchical porous honeycombed nickel oxide microsphere and a preparation method thereof are disclosed. The method includes mixing nickel sulfate hexahydrate, urea, water and glycerol, to obtain a mixed solution; subjecting the mixed solution to a hydrothermal reaction, to obtain a precursor; and calcining the precursor, to obtain the hierarchical porous honeycombed nickel oxide microspheres.

Abstract: Benzoxazole and indole type KCa3.1 activators as well as the therapeutic uses of such compounds in human or animal subjects and their use in ex vivo preservation of organs or tissues.

Abstract: A transmittable lighting device is provided. The transmittable lighting device includes two substrates, a transmittable layer, two polarizers and a light source. The two substrates are respectively electrically connected to a voltage supply. A switchable electric field is provided between the two substrates, and two alignment directions of the two substrates are orthogonal to each other. The transmittable layer is located between the two substrates and has a plurality of liquid crystal molecules. Each of the plurality of liquid crystal molecule is arranged along the alignment direction of the substrate nearby, and the plurality of liquid crystal molecules is arranged in a 90-degree twisted arrangement. The two polarizers are located at two outer surfaces of the two substrates, respectively. Each polarizer has a polarization direction parallel to the alignment direction of the substrate on the same outer surface. The light source emits a lateral light entering the transmittable layer laterally.

Abstract: In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.

Abstract: An apparatus comprises at least one processing device comprising a processor coupled to a memory. The at least one processing device is configured to obtain a system of nonlinear equations characterizing a physical system, to construct a flexible embedded system from the system of nonlinear equations, wherein the flexible embedded system is configurable with any of a plurality of arbitrary reference states as respective starting points, to utilize the flexible embedded system to generate at least one output providing a solution to the system of nonlinear equations, and to establish one or more operating parameters of the physical system based at least in part on the output generated utilizing the flexible embedded system. The physical system is configured in accordance with the one or more established operating parameters. The physical system in some embodiments illustratively comprises an electric power system, an integrated circuit, or another type of electrical or electronic system or circuit.