Abstract: Provided herein are small-molecules for use in modulating chloride ion channel (CLC) activity, particularly the activity of CLC-2, to elucidate the role of CLC-2 in disorders associated with CLC-2 malfunction, and to identify therapeutic leads for their treatment. Compositions and methods for modulating CLC activity are also provided. In certain aspects, the subject compounds and compositions are useful for imaging or channel pull-down studies.

Abstract: Provided herein is technology relating to polymerization and producing polymers and particularly, but not exclusively, to methods, systems, and compositions for producing articles using three-dimensional printing and for improving control of polymerization using a polymerization photoinhibitor having fast back reaction kinetics such as hexaarylbiimidazole compounds and bridged hexaarylbiimidazole compounds.

Abstract: The invention relates to a composition having polyphenols, protein and a final moisture content of at least about 0.1% by weight and methods of making the same. In some aspects, a composition of the invention includes about 5% to about 40% polyphenols by weight and about 60% to about 90% protein by weight. In other aspects, methods of producing compositions including polyphenols and protein are provided.

Abstract: The invention relates to a method for setting and operating redundant paths in a quantum communication network, wherein a transmitter implements simultaneous transmission of signals on a working path and protection paths. The signal transmitted on the working path is a primary signal, and the signals transmitted on the protection paths are follow-up signals. In a case that the working path is normal, the transmitter forwards the primary signal on the working path level by level, to implement long distance transmission of a quantum signal. In a case that the working path fails, a proxy working path is selected from the remaining protection paths with the highest priority, and the transmission of information is eventually completed on the proxy working path. It can be prevented that unknown quantum information is damaged and becomes unrecoverable during transmission, thereby greatly improving the security, stability, and reliability of information transmission during quantum communication.

Abstract: The present invention provides for compositions and methods for administering one or more UDP compound, alone or in combination with another hematopoietic progenitor cell mobilizing compound (for example, but not limited to G-CSF), to mobilize hematopoietic progenitor cells for transplant or other purposes. The methods of the invention may be particularly advantageous as applied to improve the stem cell yield in so-called “poor mobilizing” patients.

Abstract: The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

Abstract: A computing device can generate predictions for future consumptions for one or more buildings based on a variety of factors. The factors can include a local climate corresponding to each building, a mass and heat transfer for each building, a daily operation for each building, and an occupancy behavior for each building. A power flow can be determined for one or more power generators. The power flow can be determined based on the predictions of future consumption. A control input vector can be determined for the one or more buildings.

Abstract: An optically active structure and a display device are presented. The device utilized an optically active structure comprising liquid crystal material and a plurality of nanorods configured to emit light in one or more predetermined ranges in response to pumping light. Variation in orientation of the liquid crystal varies orientation of the nanorods and modulated light emission therefrom.

Abstract: Embodiments of the present disclosure pertain to adhesive compositions that include a fluorinated molecule and a hydrogen-containing molecule that are non-covalently associated with one another. The molecules may be non-covalently associated with one another through dipole-dipole interactions that create a fluorine-hydrogen electronegativity difference between at least some of the fluorine atoms of the fluorinated molecule and at least some of the hydrogen atoms of the hydrogen-containing molecule. The fluorinated molecule and the hydrogen-containing molecule may be in different phases, such as a liquid phase for one molecule and a solid phase for the other molecule. Additional embodiments pertain to methods of enhancing an adhesiveness of a surface by applying an adhesive composition of the present disclosure to the surface.

Abstract: An object of the present invention is to provide a method for preparing osteoblasts that are applicable, without causing risk of canceration, to bone defect repair or to the treatment of bone resorption, fracture, osteoporosis, or the like. To solve this problem, the present invention provides a method for preparing osteoblasts, the method comprising culturing mammal differentiated somatic cells in a medium in the presence of at least one compound selected from the group consisting of (1) statin compounds, (2) casein kinase 1 inhibitors, (3) cAMP inducers, and (4) histone methyltransferase inhibitors, to convert the somatic cells into osteoblasts.

Abstract: Atomic force microscopy apparatus and method that enable observing charge generation transients with nanometer spatial resolution and nanosecond to picosecond time resolution, the timescale relevant for studying photo-generated charges in the world's highest efficiency photovoltaic films. The AFM apparatus includes an AFM, a light source for illumination of a sample operatively coupled to the AFM, a voltage source operatively coupled to the AFM, and a control circuitry operatively coupled to the light source and the voltage source. The AFM apparatus improves the time resolution and enables rapid acquisition of photocapacitance transients in a wide array of solar-energy-harvesting materials.

Abstract: A transtibial socket for a prosthetic lower limb includes a mesh arranged between rigid struts. The mesh includes a plurality of support members and a plurality of tensile members, optionally in combination with spacer members arranged between different support members. At least one tensioning member coupled with the tensile member extends through of past guides in the struts to an adjustable tensioning apparatus that is configured to allow the mesh to be constricted radially by the amputee-user. The mesh allows for the heat dissipation and volume adjustment, while increasing contact area and force distribution around a residual limb.

Abstract: A low-temperature drift ultra-low-power linear regulator includes eight PMOS transistors, two resistors, two capacitors and three NMOS transistors. The eight PMOS transistors include PMOS transistor PM1 to PMOS transistor PM8. The two resistors include resistor R1 and resistor R2. The two capacitors include capacitor C1 and capacitor C2. The three NMOS transistors include NMOS transistor NM1, NMOS transistor NM2 and NMOS transistor NM3. From right to left, the linear regulator includes a PTAT voltage core starting circuit, a PTAT voltage core circuit, a negative temperature characteristic generating circuit and a driver stage closed-loop control circuit. PM5-PM8 form a feedback circuit. The feedback circuit clamps the current flowing through PM6 to be proportional to PM2 to obtain a temperature-stable output voltage, and can dynamically adjust the gate voltage of PM5 according to the change of load current to output different currents according to the load demand.

Abstract: Compounds of formula (VII), which are useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase, are provided. Also provided are pharmaceutical compositions, kits comprising said compounds, and methods and uses pertaining to said compounds.

Abstract: A sensing device including a transistor, at least one response electrode, and a selective membrane is provided. The transistor includes a gate end, a source end, a drain end, and a semiconductor layer, wherein the source end and the drain end are located on the semiconductor layer, and the gate end is located between the source end and the drain end. The at least one response electrode is disposed opposite to the gate end of the transistor and spaced apart from the transistor. The selective membrane is located on the at least one response electrode or on the transistor.

Abstract: Disclosed herein is a redox flow battery (RFB). The battery generally includes: a positive electrolyte that is a first metal ion, a negative electrolyte that is a second metal ion, an ion exchange membrane positioned between the positive electrolyte and the negative electrolyte. The membrane is configured to restrict and/or prevent the passage of the first metal ion and/or the second metal ion therethrough, and is configured to maintain ionic conductivity between the positive electrolyte and the negative electrolyte.

Abstract: Embodiments of the present disclosure describe burner (10) configurations used in an industrial process to convert methane to olefins, aromatics, and nanoparticles/nanomaterials. Both a vitiated coflow burner and piloted turbulent burner with inhomogeneous inlets are disclosed.

Abstract: As one example, a fluid monitoring apparatus includes a dielectric microsensor that includes a capacitive sensing structure integrated into a microfluidic channel. The microfluidic channel includes a fluid input to receive a sample volume of a sample under test (SUT). A transmitter provides an input radio frequency (RF) signal to an RF input of the microsensor. A receiver receives an output RF signal from the microsensor. A computing device computes dielectric permittivity values of the SUT that vary over a time interval based on the output RF signal. The computing device may determine an indication of platelet count based on the computed dielectric permittivity values over at least a portion of the time interval.

Abstract: An ejecting-clamping-pulling combined seedling fetching device for an automatic transplanter and an operating method therefor. The device comprises: a seedling ejecting mechanism (1), a seedling feeder mechanism (2), a seedling fetching mechanism (3), and a control system. The seedling feeder mechanism (2) is mounted on a stander; the seedling ejecting mechanism (1) is mounted on the seedling feeder mechanism (2) and is located at the rear side of the seedling feeder mechanism (2); the seeding fetching mechanism (3) is mounted at the stander and is located at the front side of the seedling feeder mechanism (2). An upper ejector rod support (1-6) and a lower ejector rod support (1-4) are provided on the seedling ejecting mechanism (1); the seedling ejecting rods on the two supports are disposed in a staggered manner, and the upper ejector rod support (1-6) and the lower ejector rod support (1-4) are configured to alternately eject and loosen seedling trays.

Abstract: A synchrophasor measurement-based disturbance identification method is described considering different penetration levels of renewable energy. A differential Teager-Kaiser energy operator (dTKEO)-based algorithm is first utilized to improve multiple-disturbances detection accuracy. Then, feature extractions via the integrated additive angular margin (AAM) loss and the long short-term memory (LSTM) network is described. This enables one to deal with intra-class similarity and inter-class variance of disturbances when high penetration renewable energy occurs. With the extracted features, a multi-stage weighted summing (MSWS) loss-based criterion is described for adaptive data window determination and fast disturbance pre-classification. Finally, the re-identification model based on feature similarity is established to identify unknown disturbances, a challenge for existing machine learning algorithms.