Patents Assigned to The University
  • MicroRNA induction of pluripotential stem cells and uses thereof
    Patent number: 9115345
    Abstract: Compositions and methods for inducing the formation of an induced pluripotential stem (iPS) cell from a somatic cell are disclosed. The compositions comprise miR 302-367 cluster and valproic acid. Further disclosed are methods for treatment of a disease or condition in a subject through the use of the compositions.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: August 25, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventor: Edward E. Morrisey
  • Surface plasmon-mediated energy transfer of electrically-pumped excitons
    Patent number: 9114981
    Abstract: An electrically pumped light emitting device emits a light when powered by a power source. The light emitting device includes a first electrode, a second electrode including an outer surface, and at least one active organic semiconductor disposed between the first and second electrodes. The device also includes a dye adjacent the outer surface of the second electrode such that the second electrode is disposed between the dye and the active organic semiconductor. A voltage applied by the power source across the first and second electrodes causes energy to couple from decaying dipoles into surface plasmon polariton modes, which then evanescently couple to the dye to cause the light to be emitted.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: August 25, 2015
    Assignee: The Regents of The University of Michigan
    Inventors: Kwang Hyup An, Max Shtein, Kevin P. Pipe
  • Heterocyclic modulators of HIF activity for treatment of disease
    Patent number: 9115120
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: August 25, 2015
    Assignee: Board of Regents, The University of Texas Systems
    Inventors: Philip Jones, Maria Emilia DiFrancesco, Alessia Petrocchi, Joe Marszalek, Gang Liu
  • DEXTRAN-PEPTIDE HYBRID FOR EFFICIENT GENE DELIVERY
    Publication number: 20150231274
    Abstract: One or more embodiments of the present invention provide a novel composition for gene delivery are directed to a group of polysaccharide polymers, having one or more nucleic acid delivery side chains comprising cationic peptides. In some embodiments, these cationic peptides condense and physically bond to one or more nucleic acids to form a polysaccharide-nucleic acid complex that permits delivery to and transfection of the nucleic acid(s) into cells. In some embodiments, the polysaccharide polymers of the present invention may also have one or more zwitterionic side chains and/or reactive side chains.
    Type: Application
    Filed: February 13, 2015
    Publication date: August 20, 2015
    Applicant: The University of Akron
    Inventors: Gang Cheng, Qiong Tang, Bin Cao
  • WEARABLE INDUCTIVE-FORCE SENSOR
    Publication number: 20150233776
    Abstract: A wearable inductive-force sensor, which provides high-sensitivity dynamic measurements of both normal force and shear force, utilizes three spiral planar force sensing coils. These spiral planar coils allow the measurement of shear force in the x and y directions and the measurement of a normal force in the z direction. The force sensor is configured to be mounted in various locations, such as an insole of a shoe, so as to provide real-time force sensing of forces that are applied to a patient's feet as they move. In addition, force-measurement electronics used with the force sensor are configured to use resonance-frequency division signal multiplexing to monitor the response of the force sensing coils, which allows the sensor to have minimal complexity, while still being highly sensitive.
    Type: Application
    Filed: February 20, 2015
    Publication date: August 20, 2015
    Applicant: The University of Akron
    Inventors: Jiang Zhe, Li Du
  • SYSTEMS AND METHODS FOR GAS MIXTURE DELIVERY TO HUMANS INSIDE AN MRI SCANNER
    Publication number: 20150231357
    Abstract: Systems and methods for delivery of gas mixtures to humans inside an MRI scanner, including while monitoring and recording physiological parameters.
    Type: Application
    Filed: February 17, 2015
    Publication date: August 20, 2015
    Applicant: Board of Regents, The University of Texas System
    Inventors: Hanzhang LU, Peiying Liu
  • Methods and compositions for imaging cancer cells
    Patent number: 9107895
    Abstract: Disclosed are compositions comprising nanoparticles and uses thereof. Such nanoparticles include gold nanoparticles conjugated to glucose or a glucose derivative, which are useful as contrast agents in imaging methods such as computed tomography (CT). Nanoparticles disclosed herein are useful in imaging various cells, tissues, and organs, and are particularly useful in imaging tumors and tumor cells in vitro and in vivo.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: August 18, 2015
    Assignees: The University of Chicago, UChicago Argonne, LLC
    Inventors: Bulent Aydogan, Tijana Rajh
  • Method for controlling insect pest by vibration
    Patent number: 9107399
    Abstract: A method for controlling an insect pest with vibrations, including a step of determining a frequency range and an amplitude range of vibrations in a habitat medium of an insect pest that induce or suppress a specific behavior of the insect pest, and a step of controlling the insect pest behavior by applying vibrations in the frequency range and amplitude range once or two or more times in the insect pest habitat medium.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: August 18, 2015
    Assignees: Forestry And Forest Products Research Institute, The University Of Electro-Communications, National University Corporation Hokkaido University
    Inventors: Takuma Takanashi, Wakako Ohmura, Eiji Ohya, Yoshitaka Kubojima, Teruo Mori, Takuji Koike, Hiroshi Nishino
  • Adaptive reading of a resistive memory
    Patent number: 9111613
    Abstract: An adaptive reading and programming method is presented for resistive memory. The core operating principle is to cause a change in the conductance of a resistive memory cell and measure the magnitude of the change. The magnitude of change can be used to determine the logic state of the resistive memory cell. The proposed methods are evaluated in simulation programs with integrated circuit emphasis and a hand analysis model is extracted to help explain the sources of power and energy consumption.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: August 18, 2015
    Assignee: The Regents of The University of Michigan
    Inventors: Pinaki Mazumder, Idongesit Ebong
  • Method for using naturally occurring gas vesicles as ultrasound contrast agent
    Patent number: 9107949
    Abstract: The present invention generally relates to one or more methods of using naturally occurring vesicles as contrasting agents for ultrasound imaging.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: August 18, 2015
    Assignee: The University of Akron
    Inventor: Lu-Kwang Ju
  • Fluid based RC filter for tuning cut-off frequency and for analytical detection
    Patent number: 9112474
    Abstract: An RC filter that is tunable in terms of its cut-off frequency comprising a drop placed on one or more dielectric layers, a conducting layer underneath the dielectric layer, a nonconducting layer underneath the conducting layer, and an external resistor attached to the drop via an electrode, wherein the cut-off frequency of the filter is tuned by changing the shape or composition of the drop and methods of using the filter as a detector.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: August 18, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventors: Daniel W. Armstrong, Yasith S. Nanayakkara, Hyejin Moon
  • Compositions and methods for controlling the stability of ethersulfate surfactants at elevated temperatures
    Patent number: 9109152
    Abstract: The present invention describes the method of making an ether sulfate surfactant solution hydrolytically stable by adding one or more alkalinity generating agents at levels greater than 0.05%. The surfactant solutions of the present invention have half-lives >8 months at 100° C. and find uses in EOR applications, environmental cleanups, detergent industry, and any other surfactant based high temperature applications.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: August 18, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventors: Upali P. Weerasooriya, Gary A. Pope, Quoc P. Nguyen
  • Adhesin-enterotoxin chimera based immunongenic composition against enterotoxigenic
    Patent number: 9107866
    Abstract: The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response.
    Type: Grant
    Filed: January 11, 2007
    Date of Patent: August 18, 2015
    Assignees: The United States of America As Represented by the Secretary of the Navy, The Regents Of The University Of Colorado, A Body Corporate
    Inventors: Stephen J Savarino, Randall K Holmes, Michael G Jobling
  • Pharmacologic method of lowering cholesterol production
    Patent number: 9110051
    Abstract: The present invention provides a screening method for identifying test agents that modulate cell membrane cholesterol activity. The modulating activity of the test agents may be measured using lytic compounds, which cause cell lysis or increases in cell permeability in response to cell membrane cholesterol levels. The invention further provides therapeutic agents that are identified using the screening method. The therapeutic agents either increase or decrease the cell membrane cholesterol activity, cholesterol concentration and/or both in vivo and/or in vitro.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: August 18, 2015
    Assignees: The University of Chicago, Rush University Medical Center
    Inventors: Yvonne Lange, Theodore L. Steck
  • Flexible and scalable sensor arrays for recording and modulating physiologic activity
    Patent number: 9107592
    Abstract: An implantable sensor array incorporates active electronic elements to greatly increase the number of sensors and their density that can be simultaneously recorded and activated. The sensors can be of various configurations and types, for example: optical, chemical, temperature, pressure or other sensors including effectors for applying signals to surrounding tissues. The sensors/effectors are arranged on a flexible and stretchable substrate with incorporated active components that allow the effective size, configuration, number and pattern of sensors/effectors to be dynamically changed, as needed, through a wired or wireless means of communication. Active processing allows many channels to be combined either through analog or digital means such that the number of wires exiting the array can be substantially reduced compared to the number of sensors/effectors on the array.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: August 18, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Brian Litt, Jonathan Viventi
  • Fusing porphyrins with polycyclic aromatic hydrocarbons and heterocycles for optoelectronic applications
    Patent number: 9113535
    Abstract: A compound that can be used as a donor material in organic photovoltaic devices comprising a non-activated porphyrin fused with one or more non-activated polycyclic aromatic rings or one or more non-activated heterocyclic rings can be obtained by a thermal fusion process. The compounds can include structures of Formula I: By heating the reaction mixture of non-activated porphyrins with non-activated polycyclic aromatic rings or heterocyclic rings to a fusion temperature and holding for a predetermined time, fusion of one or more polycyclic rings or heterocyclic rings to the non-activated porphyrin core in meso,? fashion is achieved resulting in hybrid structures containing a distorted porphyrin ring with annulated aromatic rings. The porphyrin core can be olygoporphyrins.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: August 18, 2015
    Assignees: The University of Southern California, The Regents of the University of Michigan
    Inventors: Mark E. Thompson, Viacheslav Diev, Kenneth Hanson, Stephen R. Forrest
  • Pyrophosphate compound and production process thereof
    Patent number: 9112241
    Abstract: To provide a positive electrode active material containing a pyrophosphate compound, ensuring that mixing of impurities is easily prevented to facilitate the synthesis and a high capacity battery is obtained, and a lithium ion battery using the positive electrode material. That is, the present invention relates to a pyrophosphate compound represented by the formula: Li2M1-xFexP2O7 (wherein M represents one or more elements selected from Mn, Zr, Mg, Co, Ni, V and Cu, and 0.3?x?0.9).
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: August 18, 2015
    Assignee: The University of Tokyo
    Inventors: Atsuo Yamada, Shinichi Nishimura, Ryuichi Natsui
  • High resolution large displacement/crack sensor
    Patent number: 9109883
    Abstract: A structural displacement sensor that includes an arched member having two ends, where each end is attached to a fastening member. In an embodiment of the invention, the fastening members are configured to be attached to a structure. Further, a strain gauge is attached to the arched member, and the strain gauge is operatively connected to a signal processing device. In an embodiment, the arched member and strain gauge are configured to measure a displacement of the structure based on the amount of strain detected on the strain gauge.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: August 18, 2015
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: Farhad Ansari, Seyed Asadollah Bassam
  • Immunologically modified carbon nanotubes for cancer treatment
    Patent number: 9107944
    Abstract: A method for constructing a compound of immunologically modified nanotubes and method for using the compound to deliver immunoadjuvants to tumor cells and to produce targeted, synergistic photophysical and immunological reactions for cancer treatment. To prepare the immunologically modified nanotubes, carbon nanotubes are dissolved in a solution of glycated chitosan, an immunostimulant, hence using glycated chitosan as a surfactant for rendering the aqueous solution of nanotubes stable. The compound can be used for treatment of cancer. The method includes steps of intratumorally administering immunologically modified nanotubes and administering laser irradiation of the target tumor. The nanotube serves as a carrier to deliver immunoadjuvants to the tumor cells and serves as a light-absorbing agent in a cell body of a tumor in a host.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: August 18, 2015
    Assignee: The University of Central Oklahoma
    Inventor: Wei R. Chen
  • BLOOD COAGULOMETER AND METHOD
    Publication number: 20150226725
    Abstract: An apparatus for determining blood clotting capacity comprises an actuator to cyclically move a member within a sample of blood received in a well in a tray and one of a deflection sensor and a position sensor to determine the position of the wetted member upon being acted upon by the actuator. The theoretical position of the wetted member, as determined using a known actuator force and wetted member physical data, is compared to the sensed deflection or position of the wetted member, and the resistance to movement of the wetted member caused by the blood is determined and correlated to a clotting capacity.
    Type: Application
    Filed: September 11, 2013
    Publication date: August 13, 2015
    Applicant: Board of Regents The University of Texas System
    Inventors: Brijesh S. Gill, Kevin Aroom, Charles Cox, Jr.