Abstract: A method of treating impaired lymphatic function in a subject is provided. The method includes a step of inducing activation of Piezo1 ion channels in lymphatic tissues of a subject having impaired lymphatic function. Similarly, a method of treating ocular hypertension or glaucoma in a subject includes a step of inducing activation of Piezo1 ion channels in an eye of a subject having an ocular pressure that is greater than 22 mm Hg. Finally, a method of treating ocular hypertension or glaucoma in a subject includes a step of inducing activation of Piezo1 ion channels in an eye of a subject having an ocular pressure that is greater than 22 mm Hg.

Abstract: A dielectric coated plasmonic photoemitter is provided. An aspect of the present photonic apparatus includes a conductive photoemitter including a dielectric material coating or layered on a metallic core. The dielectric material being configured to enhance a local optical field strength and current density of the photoemitter as compared to a bare photoemitter without the dielectric layer. The dielectric layered photoemitter being tunable to transmit photoemissions from corners thereof with different photonic characteristics depending on a laser wavelength pulse received.

Abstract: A method and an apparatus for actively defending against backdoor attacks under an edge computing scenario.

Abstract: A method of carrying out a metathesis reaction includes the combination of at least one alkene or non conjugated diene with a Ruthenium-based catalyst with an cyclic(alkyl)(amino)carbene ligand to form a reaction mixture, heating the reaction mixture to a temperature of 100° C. or greater in the absence of a solvent in bulk conditions, and mechanically stirring the reaction mixture. The reaction can be an ADMET, ROMP, a metathesis ring-closure or an olefin exchange reaction.

Abstract: A solar photovoltaic powered phase change material thermal energy storage system includes a refrigerator unit having a phase change material (PCM) tank and a photovoltaic (PV) panel to provide electrical energy to the PCM tank to melt a PCM stored therein. The PCM tank includes a refrigeration coil immersed in the PCM and configured to circulate refrigerant to between the PCM tank and a condenser. Energy released and absorbed during solidification and melting of the PCM is used to support an air-conditioning (AC) unit and substitute power used by a compressor of the AC unit, to handle demand during peak hours, thereby reducing overall power requirement of a facility. The melting of the PCM is also controlled, so that the AC unit may operate with the aid of the PCM for longer duration during the day.

Abstract: A method and a system of molecular typing and subtyping classifier for immune-related diseases are provided. The method includes: conducting molecular typing via a clustering algorithm in a training set to obtain a plurality of subtypes stably appearing in the training set and a marker gene for each subtype; conducting enrichment analysis on marker genes for the plurality of subtypes, conducting immune cell infiltration evaluation on the plurality of subtypes, and dividing the plurality of subtypes into a plurality of subtype classes according to results of the analysis and the evaluation; comparing treatment response rates of different subtype classes through a comparison set to determine a subtype class to be identified; constructing a support vector machine model with feature genes screened and an optimal parameter combination; and determining whether immune-related disease data to be classified is the subtype class to be identified.

Abstract: The disclosure discloses a magnetic bias active suppression method and system of a hybrid distribution transformer, whether the HDT is closed or not is judged based on the grid-side current, and accordingly smooth switching of the two sets of control strategies is achieved; excitation currents of an HDT main transformer and an isolation transformer are calculated based on a magnetic potential balance principle, and nonlinear feedback is performed, and the excitation currents are superposed after an original control instruction of an HDT converter, so that magnetic bias suppression is realized on the basis of ensuring an HDT grid-side current and load voltage control function. According to the system, a complex and expensive iron core magnetic flux sensor does not need to be additionally arranged, and the DC magnetic bias of the HDT under any working condition can be eliminated while the basic control function of the HDT is not affected.

Abstract: A device receives a real image (e.g., photograph or video frame) that includes a human. The device creates a synthetic image corresponding to the real image. The synthetic image includes a synthetic environment and a humanoid shape that correspond to the human. The device predicts, using a trained viewpoint neural network and based on the synthetic image, a predicted viewpoint heatmap. The device predicts, using a trained pose neural network and based on the synthetic image, a predicted pose heatmap. The device provides, as input to a random synthetic environment, the predicted viewpoint heatmap and the predicted pose heatmap and creates a reconstructed three-dimensional pose based on the predicted viewpoint heatmap, the predicted pose heatmap, and the random synthetic environment. The device classifies the reconstructed three-dimensional pose as a particular type of pose of the human in the real image.

Abstract: Probiotic bacteria are genetically modified to produce and excrete enhanced levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Exemplary probiotic bacteria include Lactococcus lactis (L. lactis). The genetically modified probiotic bacteria can be prepared as an aqueous suspension and/or incorporated into food and nutraceuticals for oral administration to a subject. An oral formulation including the genetically modified probiotic bacteria can be used to treat inflammatory diseases and/or behavioral disorders caused by or associated with GABA-GABA signaling deficiency or by excess of excitatory neurotransmitters (such as glutamate). Inflammatory conditions that can be treated with the genetically modified probiotic bacteria include multiple sclerosis (MS) and irritable bowel disease (IBD).

Abstract: Aspects of the present disclosure are directed to a nanocomposite. The nanocomposite includes graphene oxide and a zeolitic imidazolate framework, wherein the zeolitic imidazolate framework has a phase I, II, or III structure. The nanocomposite of the present disclosure finds use in water filtration and heavy metal ion removal applications.

Abstract: Spirocyclic compounds that are KLHDC2 ligands and methods for inhibiting the enzymatic activity of KLHDC2 using the ligands.

Abstract: A method for detecting internal coating defects in a pipe sample with an electromagnetic acoustic transducer sensor. The method includes recording a plurality of Lamb mode scans of the pipe sample with the EMAT sensor, where each Lamb mode scan is measured along a length of the pipe sample in axial alignment with the pipe sample; and processing the Lamb mode scans by applying a singular spectrum analysis to the Lamb mode scans to generate data from which the internal coating defects in the pipe sample are identified. The Lamb mode scans are at a frequency from dispersion curve of from 0.3 to 2 MHz, at a frequency of from 0.4 MHz to 2 MHz, a group velocity of from 1 mm/?s to 3 mm/?s, a phase velocity of from 5 mm/?s to 25 mm/?s, and a wave count of from 3 to 10.

Abstract: Disclosed are small molecule c-kit inhibitors useful in reducing or eliminating mast cell mediated inflammation. Pharmaceutical formulations containing the c-kit inhibitors are also disclosed. Additionally, methods of treating or preventing a condition, disorder, or disease using the c-kit inhibitors or pharmaceutical formulations thereof are disclosed. The condition, disorder, or disease may be an inflammatory condition, including flares of the inflammatory condition. Exemplary inflammatory conditions relevant to this disclosure include, but are not limited to, mastocytosis, mast cell activation syndrome, hereditary alpha tryptasemia, urticaria, Lyme disease, mast cell leukemia, chronic obstructive pulmonary disease, long COVID, asthma, inflammatory bowel disease, arthritis, allergy, and gout.

Abstract: Hypermethylation near promoter regions prevents expression and is associated with pathogenesis in diseases. Hundreds of methylation barriers contain a 41-bp DNA sequence motif that is common across a variety of genes. The present disclosure provides computational and experimental methods to investigate methylation barriers. More than 500 methylation barriers are identified that shared a common 41-bp sequence motif (MB-41).

Abstract: An electrode includes a transparent substrate, a lead (Pb) layer at least partially covering a surface of the transparent substrate. The Pb layer includes irregular octahedral-shaped Pb particles having an average particle size of from 0.5 to 3 micrometers (?m). The irregular octahedral-shaped Pb particles are uniformly distributed on a surface of the Pb layer. A method of making the electrode is also provided. A method for electrochemical carbon dioxide (CO2) reduction (CO2RR).

Abstract: A method for designing a cylindrical skiving tool without a geometric relief angle is provided. The method includes: designing a teeth number and a crossed shaft angle of a tool; calculating a barrel-shaped conjugate surface conjugated to a tooth surface of a to-be-machined gear; determining an offset of a rake face of the cylindrical skiving tool from a middle section of the barrel-shaped conjugate surface; designing a helix angle of the tool; designing a rake angle of the tool; calculating an edge profile of the rake face; obtaining design parameters and mounting parameters of the skiving tool; manufacturing the tool according to the design parameters of the tool, and performing skiving on a skiving machine according to the mounting parameters of the tool. The present disclosure provides a skiving method under a spatially-offset conjugate condition, to solve the problems of fast accuracy degradation and short service life.

Abstract: Implanted medical devices need a mechanism of immobilization to surrounding tissues, which minimizes tissue damage while providing reliable long-term anchoring. This disclosure relates to techniques for patterning arbitrarily shaped 3D objects and to patterned balloon devices having micro-or nano-patterning on an outer surface of an inflatable balloon. The external pattern can provide enhanced friction and anchoring in an aqueous environment. Examples of these types of patterns are hexagonal arrays inspired by tree frogs, corrugated patterns, and microneedle patterns. The patterned balloon devices can be disposed between an implant and surrounding tissues to facilitate anchoring of the implant.

Abstract: A magnetic field generation module is disclosed. The magnetic field generation module comprises: a main core; at least one auxiliary core located adjacent to the main core; and an auxiliary core driver which moves the auxiliary core along the circumference of the main core by using the center axis of the main core as a shaft.

Abstract: An autonomous landing system includes a vertical landing aircraft, a visual cue coupled to an offshore landing platform and including a visual indicator located that extends vertically across a horizon and is maintained parallel with the horizon, and an autonomous control system configured to control a position of the aircraft with respect to the visual indicator to maneuver the aircraft into a hovering, predefined landing position above the offshore landing platform, and control the position of the aircraft with respect to the visual indicator to cause the aircraft to descend from the landing position and land on the offshore landing platform.