Abstract: A real-time position location system can include one or more location modules configured to be attached to a user or a weapon of the user and to output location data associated with each user and one or more kinematic base station modules configured to receive the location data from each location module. The system can include a position module operatively connected to the one or more kinematic base stations and configured to determine a real-time location of each of the one or more location modules and to output module position data for each of the one or more location modules in real-time.

Abstract: A method of screening a chemical substance as a drug candidate against High-grade serous ovarian carcinoma (HGSOC). Mice with xenograft tumors caused by a cell line comprising HGSOC cells which have been transduced with firefly luciferase gene (Luc), or by a cell line comprising cisplatin-resistant HGSOC cells which have been transduced with Luc are treated with the chemical substance to the mice for a predetermined treatment period. Effects that the chemical substance has on the mice are assessed after the predetermined treatment period. The cell lines may be, for example, OVCAR-8-Luc cells or cisplatin-resistant OVCAR-8-Luc cells.

Abstract: Tetrazine non-canonical amino acids, methods for genetic encoding proteins and polypeptides using the tetrazine amino acids, proteins and polypeptides comprising the tetrazine amino acids, and compositions comprising the proteins and polypeptides having at least one post-translational modification thereof comprising in vivo reaction with the incorporated tetrazine amino acid and a second molecule.

Abstract: A multi-mode magnetic treatment device combining a permanent magnetic field and an electromagnetic field includes a base, a sample stand, an electromagnetic mechanism, a permanent magnetic mechanism, a permanent magnetic mechanism motion drive unit, a sample stand ascent-descent drive unit and a control system. The sample stand, the electromagnetic mechanism and the permanent magnetic mechanism are mounted on the base. The electromagnetic mechanism and the permanent magnetic mechanism are connected to the control system. The permanent magnetic mechanism is mounted on the base through the permanent magnetic mechanism motion drive unit. The sample stand is mounted on the base through the sample stand ascent-descent drive unit. A magnetic field of the electromagnetic mechanism and a magnetic field of the permanent magnetic mechanism respectively act on the sample stand to apply a rotational permanent magnetic force and an alternating electromagnetic force to a sample.

Abstract: Provided is a recombinant adeno-associated virus (rAAV) having an AAV capsid and a vector genome which comprises a nucleic acid sequence encoding a functional CDKL5 (hCDKLK5). Also provided are a production system useful for producing the rAAV, a pharmaceutical composition comprising the rAAV, and a method of treating a subject having CDD, or ameliorating symptoms of CDD, or delaying progression of CDD via administrating an effective amount of the rAAV to a subject in need thereof.

Abstract: Recombinant TGF-?2 monomers engineered to prevent dimerization and block TGF-? signaling are described. The engineered monomers lack the ability to bind and recruit TGF-? type I receptor (TbRI), but retain the capacity to bind the high affinity TGF-? type II receptor (TbRII). The TGF-?2 monomers also include additional modifications that increase their affinity for TbRII, reduce their aggregation and/or improve their folding. Nucleic acid molecules and vectors encoding the recombinant TGF-?2 monomers are also described. Isolated cells, such as T cells, can be re-programmed with a TGF-?2 monomer-encoding nucleic acid or vector to secrete the monomer. Use of the recombinant TGF-?2 monomers and/or cells producing the recombinant TGF-?2 monomers, to inhibit TGF-? signaling, such as to treat disorders associated with aberrant TGF-? signaling, are also described.

Abstract: A rope replacement apparatus includes: a rope conveying mechanism, used for driving a first rope to move along a moving path of a second rope, so as to replace the second rope; a first detection part, used for detecting a first moving speed V1 of the first rope output by the rope conveying mechanism; the first detection part being installed on the rope conveying mechanism; a second detection part, used for detecting a second moving speed V2 of the second rope outside the rope conveying mechanism; the second detection part being installed on the moving path of the second rope; a control part, used for adjusting V1 according to the difference between V1 and V2; the first detection part and the second detection part being both in communication connection with the control part. The rope replacement apparatus improves rope replacement efficiency and slipping can be reduced.

Abstract: An object of the present invention is to provide a method for easily evaluating residual fibrinolytic resistance activity by PAI-1 and ?2AP in blood plasma.

Abstract: A system including at least one processor is configured for executing a mathematical contagion model based on percolation theory to anticipate the loss distribution resulting from a cyberattack on a class of client-server network architectures with K different client types. The system includes a framework that computes the exact mean and variance of the losses depending on key parameters such as probabilities of attack types, the topology of the network of clients, and contagion strength among the clients. This framework can be used by insurance companies to estimate the liability assessments of insuring a given IT network against the damages that may arise from cyberattacks, including the losses of company revenue, and improved decision-making in cybersecurity protection investments of the network. Further, the framework provides insights into better investment strategies for cybersecurity protection on the client-server network.

Abstract: A prodrug of an anticancer drug is used in combination therapy with radiotherapy. In the chemical formula (1), a moiety in which R1 and R2 bond to an N atom is a part of an anticancer drug having an amino group or an imino group with the amino group or the imino group removed, and the anticancer drug is selected from the group consisting of gemcitabine, niraparib, crizotinib, tabrafenib, vemurafenib, entinostat, cobimetinib, and palbociclib, ribociclib. Thereby, the side effects of the treatment, including radiotherapy, for malignant tumors are reduced or the treatment effect is enhanced.

Abstract: A method and apparatus for evaluating soybean quality are disclosed. Automated or semi-automated image processing can be implemented with commercially available machine vision hardware. Post-harvest soybeans are separated, imaged, and analyzed to assess grain quality factors used in official grading. The system may be used prior to sale, purchase, further harvesting, or planting subsequent crops. The system reduces inspection errors, reduces variance in results, increases efficiency, enhances repeatability, and improves the standardization of soybean quality evaluation. Shape analysis, color analysis, and Haralick texture analysis are employed to determine when certain types of damage are present, to distinguish between types of damage, and to classify grains as smooth, cracked, or wrinkled. The system is sufficiently robust to allow successful deployment in rural, remote, and non-standard environments.

Abstract: The present invention relates to a process for preparing an edible foodstuff from food industry waste stream byproducts. This process involves the steps of: (i) combining, in an extruder, an extrusion formulation comprising a first food byproduct and at least one additional ingredient; (ii) introducing supercritical carbon dioxide (SC-CO2) into the extruder to mix with the first food byproduct and the at least one additional ingredient; and (iii) producing an edible foodstuff containing the first food byproduct and the at least one additional ingredient, where the edible foodstuff comprises an extrudate prepared under supercritical fluid extrusion (SCFX) conditions. The present invention also relates to a process for preparing an edible foodstuff from a protein concentrate. The present invention further relates to edible foodstuffs produced by the various processes disclosed herein.

Abstract: Disclosed are a method for processing and recycling an ultrathin lithium foil and a product, which belongs to the field of lithium-ion batteries. According to the disclosure, a liquid-phase thinning agent is adopted to perform a contact reaction with a lithium metal, the fabricated ultrathin lithium foil has a thickness of 20 ?m or less, the surface is flat, the thickness can be randomly regulated, and the uniformity is good. The method of the disclosure can also recycle a lithium-containing byproduct generated in the preparation process. When the ultrathin metal lithium foil prepared by the disclosure is used as a metal lithium negative electrode of a lithium battery, the energy density of the battery can be improved, and the battery manufacturing cost is reduced. The ultrathin metal lithium foil can also be used to supplement lithium for other types of electrode materials, thereby a broad application prospect is achieved.

Abstract: A method of forming a lanthanide or transition metal doped metal halide perovskite material whereby the method includes combining a monovalent metal cation-halide compound, a divalent metal cation-halide compound, and a lanthanide or transition metal halide compound in a solvent; evaporating the solvent to form a powder; and annealing the powder to form the lanthanide or transition metal doped metal halide perovskite material. The resultant materials or devices may be applied to various industrial applications or implemented as a scintillator and applied to various industrial applications.

Abstract: Examples of the present disclosure include a lens. The lens includes a body of a contact lens. The body has a side. The lens includes a plurality of nodes formed onto the side. Each of the plurality of nodes has a parameter value that is based on a reduction of transmission of light through the lens at one or more wavelengths selected to alter a color perception and/or a color discriminability of a wearer of the lens. The parameter value includes a value of: a distance between the node and an adjacent node of the plurality of nodes, a dimension of the node, a configuration of an arrangement in which the plurality of nodes are arranged on the side, a composition of a material coating the node, and/or a material composition of the node.

Abstract: The invention relates to precision measurement technology, specifically a high-sensitivity three-dimensional topography recovery method using dual-channel differentiation. Enhancing a traditional microscopic imaging system, a beam splitter is added between the objective lens and tube lens. This creates an additional light path equipped with a tube lens and camera identical to the original but with a slightly different distance to the camera. During axial scanning of the object, focusing evaluation function curves for each pixel are calculated from images captured by both cameras. The curves from the two cameras show more significant changes near the optimal focusing depth, improving system sensitivity. This method enhances sensitivity by hardware-fixed differentiation of the focusing evaluation function, while maintaining high scanning efficiency and flexible configuration.

Abstract: The present disclosure relates to a novel hydrophobic peptide consisting of short amino acid sequences as repeat units, having a perfectly stabilized ?-helix structure without help from outside. The peptide has no cytotoxicity and has magnetic responsiveness, i.e., its arrangement and orientation are controlled by a magnetic field. In addition, the hydrophobic peptide according to the present disclosure can not only form complexes of various structures with hydrophilic molecules but also provide suitable nanostructures such as nanoribbons and artificial chromosome-like structures through stepwise association with nucleic acid materials.

Abstract: Modified zeolites may include a microporous framework including a plurality of micropores having diameters of less than or equal to 2 nm. The microporous framework may include at least silicon atoms and oxygen atoms. The modified zeolite may include a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm, wherein the plurality of mesopores are ordered with cubic symmetry. The modified zeolite may include a plurality of zirconium hydride moieties each bonded to at least two bridging oxygen atoms, wherein a zirconium atom of the zirconium hydride is bonded to the bridging oxygen atom, and wherein the bridging oxygen atom bridges the zirconium atom of the zirconium hydride moiety and a silicon atom of the microporous framework.

Abstract: A method of generating oxygen including applying a potential of greater than 0 to 2.0 V to an electrochemical cell that is at least partially submerged in an aqueous solution such that on applying the potential the aqueous solution is oxidized thereby forming oxygen. The electrochemical cell includes an electrocatalyst and a counter electrode. The electrocatalyst includes a nickel foam substrate and a layer of particles of manganese oxide having a formula of MnxOy on a surface of the nickel foam substrate, where x is an integer from 1 to 7, and where y is an integer from 1 to 13. The particles of MnO have a spherical shape with an average diameter of 5-15 nanometers (nm) and are aggregated with an average aggregate size of 500-1,000 nm in the shape of a cauliflower.

Abstract: Disclosed herein are methods of treatments with a telomerase-mediated telomere-targeting drug, 6-thio-2?-deoxyguanosine (6-thio-dG), checkpoint inhibitors and/or radiation therapy for treating cancers. eads to tumor regression in innate and adaptive immune-dependent manners in syngeneic and humanized mouse cancer models.