Patents Assigned to The University
  • Patent number: 9134438
    Abstract: Provided is a radiation detecting element, including: a semiconductor layer including a tin oxide crystal; and a detecting unit configured to detect, as an electrical signal, charges generated in the semiconductor layer when the semiconductor layer is irradiated with radiation, in which a resistivity of the semiconductor layer is 107 ?·cm or more.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: September 15, 2015
    Assignees: Canon Kabushiki Kaisha, The University of Tokyo
    Inventors: Tatsuya Iwasaki, Tatsuya Saito, Toru Den, Yoshinobu Nakamura, Hidenori Takagi
  • Patent number: 9133267
    Abstract: Provided is an antibody that selectively binds to an epitope formed by residues 1-11 of A? in an A? oligomer, a method comprising using the antibody to treat a disease characterized by such an A? amyloid deposit in a patient, and kits comprising same.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: September 15, 2015
    Assignee: The Trustees of The University of Pennsylvania
    Inventors: Virginia Man-Yee Lee, Edward Lee, John Q. Trojanowski
  • Patent number: 9132155
    Abstract: The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: September 15, 2015
    Assignee: The University of Vermont and State Agriculture College
    Inventor: Jeffrey Spees
  • Patent number: 9133452
    Abstract: The present invention provides a method of producing a maturated oligonucleotide library, including a step of obtaining a terminal-modified product of a maturation target oligonucleotide library, including adding a tag sequence to the 5? terminus of the maturation target oligonucleotide library and an arrest sequence, which stalls translation elongation on a ribosome, to the 3? terminus of the maturation target oligonucleotide library, a step of transcribing the terminal-modified sequence product to give a transcript, and a step of in vitro translation for translating the transcript in vitro, wherein the maturation target oligonucleotide library is a random oligonucleotide library.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: September 15, 2015
    Assignees: The University of Tokyo, GeneFrontier Corporation
    Inventors: Takuya Ueda, Takashi Kanamori, Kanehisa Kojoh, Shizue Katoh, Akira Miyakoshi
  • Patent number: 9133270
    Abstract: Disclosed herein are recombinant protein scaffolds for use in producing antigen-binding proteins. Related antigen-binding proteins are also provided herein. In addition, nucleic acids encoding such recombinant protein scaffolds and antigen-binding proteins are also described. Vectors and cells useful for expression of the described proteins are also provided, as are methods of use.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: September 15, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Mark I. Greene, Hongtao Zhang
  • Patent number: 9135242
    Abstract: Computerized methods and systems for the analysis of textual data, including: receiving, from one or more memories at one or more processors, textual data; using the processors, formatting the textual data for analysis and applying a probabilistic topic model to the textual data to extract semantically meaningful topics that collectively describe it; using a keyword weighting module, generating a topic cloud view representing the topics as a tagcloud with each being associated with a plurality of keywords; using a topic ordering module, generating a document distribution view representing a distribution of the textual data across multiple topics; using a document entropy calculation module, generating a document scatterplot view representing how many topics are attributable to the textual data; using a temporal topic trend calculation module, generating a temporal view representing changes in the occurrence of topics over time; and displaying one or more of the views to a user.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 15, 2015
    Assignee: The University of North Carolina at Charlotte
    Inventors: Xiaoyu Wang, Wenwen Dou, William Ribarsky
  • Publication number: 20150250864
    Abstract: The present provides tumor-associated antigens and their use as vaccines for treating and limiting cancers in a patient. In specific aspects, HERV type K envelope proteins and peptides are provided. Such proteins and peptides can be used to elicit specific immune responses—both humoral and cellular—that target tumor cells expressing the HERV type K envelope protein.
    Type: Application
    Filed: June 24, 2013
    Publication date: September 10, 2015
    Applicant: Board of Regents, The University of Texas System
    Inventor: Feng Wang-Johanning
  • Publication number: 20150254810
    Abstract: There is provided a computer-implemented method for solving inverse imaging problems to compensate for distortions in an image. The method comprises: minimizing a cost objective function containing a data fitting term and one or more image prior terms to each of the plurality of channels, the one or more image prior terms comprising cross-channel information for a plurality of channels derived from the image.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 10, 2015
    Applicant: The University of British Columbia
    Inventors: Wolfgang Heidrich, Felix Heide, Mushfiqur Rouf, Matthias Hullin
  • Publication number: 20150252355
    Abstract: Methods and systems for using encapsulated microbubbles to process biological samples are disclosed. According to one aspect, a method for using encapsulated microbubbles to process a biological sample includes creating a mixture comprising encapsulated microbubbles mixed with a biological sample and adding activation energy to the mixture to cause at least some of the microbubbles to oscillate or burst and thereby process the sample, including effecting cell lysis, shearing DNA, and/or performing tissue dispersion.
    Type: Application
    Filed: October 4, 2013
    Publication date: September 10, 2015
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: William Perry Janzen, Samantha Gail Pattenden, Chatura Nadisha Jayakody, Jason Eric Streeter, Paul Alexander Dayton, Cameron Champion Wood, Siddharth Kaup Shenoy
  • Patent number: 9127210
    Abstract: Provided herein are, inter alia, compositions including a surfactant and a novel compound useful in enhanced oil recovery. The compositions and methods provided herein may be particularly useful for oil recovery under a broad range of reservoir conditions (e.g. high to low temperatures, high to low salinity, highly viscous oils).
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: September 8, 2015
    Assignees: Board of Regents, The University of Texas System, Taminco US Inc.
    Inventors: Upali P. Weerasooriya, Gary A. Pope, Robin Matton, John Mitchell, Peter Roose
  • Patent number: 9125406
    Abstract: The invention provides in part dialkoxybenzene compounds for controlling infestation by a Trichoplusia ni, and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; except that when R2 is at position 2, R3 if present is at position 3, and when R2 is at position 3, R3 if present is at positions 2 or 4, and when R2 is at position 4, R3 if present is at position 2, and when R2 is at position 4 and R3, if present, has reacted with an OH group at position 1 in a Markovnikov sense, then R3 becomes R4, a dihydrofuran.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: September 8, 2015
    Assignees: Simon Fraser University, The University of British Columbia
    Inventors: Erika Plettner, Murray Bruce Isman
  • Patent number: 9127284
    Abstract: Described herein is a method of treatment of cancer or tumor using a modified bacteria or composition comprising the modified bacteria. In certain embodiments, the method is in combination with other treatment. In certain embodiments, the treatment is chemotherapy, radiation therapy, gene therapy, surgery or a combination thereof. The method makes modified facultative anaerobic bacteria into a conditional obligate anaerobe. The modified bacteria are strictly hypoxia regulated and comprise an essential gene expressing cassette. The vectors of this method comprise the essential gene expressing cassette. Also described herein are therapeutic and prophylactic compositions comprising the modified bacteria. The therapeutic and prophylactic compositions contain a purified form of the modified bacteria, while in certain embodiments, they do not contain other strain of microorganisms. The modified bacteria grow within the solid tumor/cancer, retarding its growth and are rapidly eliminated from normal tissues.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: September 8, 2015
    Assignee: The University of Hong Kong
    Inventors: Jian-dong Huang, Bin Yu, Mei Yang, Lei Shi
  • Patent number: 9128079
    Abstract: Provided herein are cell lines and assays that can be utilized to identify taste receptor modulators.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: September 8, 2015
    Assignees: The Coca-Cola Company, The University of North Carolina
    Inventors: Harish Radhakrishna, Michael D. Brown, David Peter Siderovski, Adam Kimple, Staci Padove Cohen
  • Patent number: 9127040
    Abstract: The present invention relates to the ability of PLUNC proteins, such as SPLUNC1 and SPLUNC2, to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by modulating the binding of PLUNC proteins to sodium channels.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: September 8, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Robert Tarran, Monroe Jack Stutts, Scott Donaldson
  • Patent number: 9129236
    Abstract: Forming a sequence plan for a machine to travel to a series of specified locations is described. An initial cost table (414) and a pattern of locations (412) is inputted to a Sequential Ordering Problem (SOP) solver (402). The resulting sequence (410) is processed by a motion planner (404) to derive by a motion planning procedure a plan of machine motions through the sequence. A cost table update (408) is performed based on the motion plan, which is then used for another iteration of the SOP solver (402).
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: September 8, 2015
    Assignee: The University of Sydney
    Inventors: Pantelis Elinas, Surya P. N. Singh
  • Patent number: 9127076
    Abstract: This invention relates in part to modifying BtBooster (BtB) peptides, in part to increase their stability in insect midgut digestive juices. Some preferred embodiments of BtB have removed proteinase cleavage sites resulting in increased stability of the modified BtB in the insect gut, while retaining the ability to enhance B.t. proteins for improved insect control. In some preferred embodiments, the protease-stable BtB is used in combination with B.t. spores and/or crystals comprising a Cry protein. Also reported herein is the significant and increased enhancement of Bt toxins against relatively Bt-tolerant insects (Helicoverpa zea, Spodoptera exigua and Agrotis ipsilon), when used with BtBs. We also describe increased toxin enhancement with cadherin fragments that are stabilized against over-digestion by insect midgut proteinases. We also report enhancement of Bt Cry1F toxin by cadherin fragments.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: September 8, 2015
    Assignee: The University of Georgia Research Foundation
    Inventors: Mohd Amir-Fursan Abdullah, Michael J. Adang
  • Patent number: 9127293
    Abstract: Compositions and methods for delivering an agent to a cell comprising a prolactin receptor are provided. Also provided is a method of inhibiting a breast, ovarian or prostate cancer cell, where the method includes a step of contacting the cell with a complex comprising a prolactin receptor ligand linked to at least one of an RNAi-inducing agent, a polynucleotide sequence encoding a polypeptide, an miRNA, a cytotoxic moiety, a chemotherapeutic moiety, a radioactive moiety or a nanoparticle. Methods of detecting a cancer cell expressing a prolactin receptor are also provided.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: September 8, 2015
    Assignee: The University of Chicago
    Inventors: Ernst Lengyel, Anthony Kossiakoff, Joseph Piccirilli
  • Patent number: 9129392
    Abstract: A series of rt-3DE images of the mitral valve are quantitatively analyzed so as to enable, for example, prediction of the degree of recurrent ischemic mitral regurgitation (IMR) and comprehensive assessments of leaflet tethering and “tenting” for the entire mitral valve. In accordance with the method, first, the rt-3DE images are registered with symmetric diffeomorphism to obtain information about how the mitral valve deforms over time. Second, the mitral valve is segmented with the level sets or other known segmentation method at each time point in the cardiac cycle with minimal user interaction. Third, the information about mitral valve structure is reduced into a 3D medial model, a compact representation of shape. In other words, a volumetric segmentation of the mitral valve is condensed to a form that is amenable to clinically relevant morphometry.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: September 8, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Robert C. Gorman, Alison Pouch, Joseph H. Gorman, III, Chandra Sehgal, Paul A. Yushkevich, Benjamin Jackson
  • Patent number: 9126165
    Abstract: Disclosed are arrays for monitoring ecosystems, such as bodies of water, and methods and systems for making such arrays. In one embodiment, the array may include a plurality of oligonucleotides immobilized at known locations on a substrate, such that each location on the array is an oligonucleotide having a sequence derived from a single, predetermined operational taxonomic unit (OTU). The sequences immobilized on the array may be from known, or unknown organisms. Also disclosed are methods for identifying and isolating bioindicators diagnostic of specific ecosystems. The arrays and bioindicators of the invention may be used for rapid, and continual monitoring of ecosystems.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: September 8, 2015
    Assignee: The University of North Carolina at Greensboro
    Inventors: Parke A. Rublee, Vincent C. Henrich, III
  • Patent number: 9127285
    Abstract: Ciliate organisms are provided that comprise reduced proteolytic processing in granules. For example, ciliates are provided that lack detectable expression of one or more sortilin (SOR) gene product. Methods for producing such genetically altered ciliates and methods for protein production in a these organisms are also provided.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: September 8, 2015
    Assignee: The University of Chicago
    Inventors: Aaron Turkewitz, Joseph Briguglio