Patents Assigned to The University
  • Use of mutant Herpes Simplex Virus-2 for cancer therapy
    Patent number: 8986672
    Abstract: The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic activity, and comprises a modified/mutated ICP 10 polynucleotide encoding a polypeptide having ribonucleotide reductase activity and lacking protein kinase activity.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: March 24, 2015
    Assignee: The University Of Houston
    Inventors: Xiaoliu Zhang, Fu Xinping
  • Enzyme prodrug cancer therapy selectively targeted to tumor vasculature and methods of production and use thereof
    Patent number: 8986701
    Abstract: Methods of treating cancer by targeting tumor vasculature using an enzyme prodrug cancer therapy treatment are provided.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: March 24, 2015
    Assignee: The Board of Regents of The University of Oklahoma
    Inventor: Roger G. Harrison
  • Automated treatment planning for radiation therapy
    Patent number: 8986186
    Abstract: This patent generally relates to developing treatment plans for use in external beam radiation therapy, and more particularly to a method, a system and a computer readable media that contains programming for the development of external beam radiation therapy treatment plans. Embodiments of the invention include (1) automatically setting beam angles based on a beam angle automation algorithm, (2) judiciously designing planning structures and (3) automatically adjusting the objectives of the objective function based on a parameter automation algorithm.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: March 24, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventors: Xiaodong Zhang, Xiaoning Pan, Yupeng Li, Xiaoqiang Li, Radhe Mohan
  • Device and method for manufacturing a particulate filter with regularly spaced micropores
    Patent number: 8987688
    Abstract: Various embodiments disclose devices and methods for fabricating microporous particulate filters with regularly spaced pores wherein sheet membrane substrates are exposed to energetic particle radiation through a mask and the damaged regions removed in a suitable developer. The required depth of field is achieved by using energetic particles to minimize diffraction and an energetic particle source with suitably small diameter.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: March 24, 2015
    Assignee: The University of Houston
    Inventors: John C. Wolfe, Paul Ruchhoeft
  • Luminescent gold(III) compounds for organic light-emitting devices and their preparation
    Patent number: 8987450
    Abstract: In one embodiment, the present invention provides a class of luminescent gold(III) compounds containing a tridentate ligand with one strong ?-donating group. The present invention also provides methods for synthesizing these compounds, as well as uses of these compounds as electrophosphorescent materials in phosphorescent organic light-emitting devices (OLEDs) to provide electroluminescence (EL).
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 24, 2015
    Assignee: The University of Hong Kong
    Inventors: Vivian Wing-Wah Yam, Vonika Ka-Man Au, Mei-Yee Chan, Keith Man-Chung Wong, King Chin Yim
  • Agent for ameliorating brain hypofunction
    Patent number: 8987232
    Abstract: Provided are effective and highly safe agents, medicaments and the like for ameliorating various disorders caused by brain hypofunction. Also provided is a preventing or ameliorating agent for brain hypofunction containing N-acetyl-D-mannosamine, a pharmaceutical composition for preventing, ameliorating or treating disorders due to brain hypofunction, containing an effective amount of N-acetyl-D-mannosamine and a pharmaceutically acceptable carrier, and a food comprising N-acetyl-D-mannosamine added thereto.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: March 24, 2015
    Assignees: The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
    Inventors: Kunio Shiota, Masayoshi Kuwahara, Takefumi Kikusui, Shintaro Yagi
  • Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold
    Patent number: 8987306
    Abstract: Novel compounds inhibiting the integrin ?2?1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of integrin ?2?1/GPIa-IIa-mediated activity.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: March 24, 2015
    Assignee: The Trustees Of The University of Pennsylvania
    Inventors: William F. DeGrado, Meredith W. Miller, Sandeep Basra, Joel S. Bennett, Sungwook Choi
  • Robust location distinction using temporal link signatures
    Patent number: 8989764
    Abstract: The ability of a receiver to determine when a transmitter has changed location is important for energy conservation in wireless sensor networks, for physical security of radio tagged objects, and for wireless network security in detection of replication attacks. In embodiments of the present invention, a measured temporal link signature is determined to uniquely identify the link between a transmitter and a receiver. The temporal link signature is an impulse response of a transmitted signal from the transmitter over a channel between the transmitter and a receiver over a channel. When the transmitter changes location, or if an attacker at a different location assumes the identity of the transmitter, the proposed link distinction methodology reliably detects the change in the physical channel. This detection can be performed at a single receiver or collaboratively by multiple receivers.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: March 24, 2015
    Assignee: The University of Utah Research Foundation
    Inventors: Neal Patwari, Sneha Kasera
  • Methods for making artificial ligaments and tendons
    Patent number: 8980159
    Abstract: Prosthetic ligaments and tendons comprising ligament- or tendon-mimicking nanofibers and methods of making such nanofibers and prosthetic ligaments and tendons.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: March 17, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventor: Javier Macossay-Torres
  • Golf putter head
    Patent number: 8979667
    Abstract: A golf putter head which includes a putting face having a positive loft angle diverging from vertical to a putter head base. The putting face is formed from a plurality of substantially parallel blades, each of the blades contiguous with each other wherein the blades are arrayed at a downward angle. Each of the blades narrows in width towards the putting face and terminates in a narrow tip. Each of the blades is flexible at its tip in order impart an upward spring force upon impact with a golf ball.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: March 17, 2015
    Assignee: The University of Tulsa
    Inventor: Steven M. Tipton
  • Tertiary -nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same
    Patent number: 8981139
    Abstract: Provided according to embodiments of the invention are novel tertiary alkyl thiol compounds and novel tertiary alkyl nitrosothiol compounds. Further provided according to embodiments of the invention are methods of forming a nitric oxide (NO)-releasing xerogel coating that include (a) co-condensing a sol precursor solution comprising at least one backbone alkoxysilane and at least one tertiary thiol alkoxysilane in a solvent to form a sol; (b) coating a substrate with the sol; (c) optionally, drying the sol to form the xerogel coating; and (d) contacting the xerogel coating with a nitrosating agent. Methods of using xerogel coatings are also included.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: March 17, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark Schoenfisch, Daniel Riccio
  • Pulse height analyzer and nuclear medicine diagnosis apparatus provided with the same
    Patent number: 8981307
    Abstract: With a pulse-height analyzer, a reference-pulse generator generates a reference pulse of a given pulse height for a given period of time when an analog radiation pulse inputted to a comparator is higher than an initial threshold. A capacitor and a resistor receive the reference pulse, and then increase an increment threshold for the given period of time from the initial threshold to the given pulse height. Then the increment threshold is set as a reference voltage of the comparator. A pulse time width of the analog radiation pulse is determined through measuring a period of time from timing where the analog radiation pulse exceeds the initial threshold to timing where the analog radiation pulse being attenuated falls below the increment threshold.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: March 17, 2015
    Assignees: Shimadzu Corporation, The University of Tokyo
    Inventors: Junichi Ohi, Tetsuo Furumiya, Hiroyuki Takahashi, Kenji Shimazoe
  • Na+/K+-ATPase-specific peptide inhibitors/activators of Src and Src family kinases
    Patent number: 8981051
    Abstract: A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogs, and is pathway (Na+/K+-ATPase) specific.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: March 17, 2015
    Assignee: The University of Toledo
    Inventors: Zi-Jian Xie, Joseph I. Shapiro, Jiang Tian, Zhichuan Li
  • BIOMARKERS FOR CANCER CHARACTERIZATION AND TREATMENT
    Publication number: 20150073033
    Abstract: Composition and methods for characterizing cancer cells by determining a marker of PKM2 activity. For example, methods are provided for predicting a patient response to a NF-?B, PKC?, PKM2, MEK/ERK, Pin1 or Src inhibitor therapy. Methods for treating patients with such therapies are likewise provided. Phosphorylation selective ?-catenin, MLC2, histone H3, Bub3, and PKM2-binding antibodies are also provided.
    Type: Application
    Filed: October 31, 2012
    Publication date: March 12, 2015
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zhimin Lu, W.K. Alfred Yung
  • Portable Ultrafine Particle Sizer (PUPS) Apparatus
    Publication number: 20150068282
    Abstract: The Portable Ultrafine Particle Sizer (PUPS) invention is provided. The PUPS is an instrument which can measure particle number concentration for particle sizes under 200 nanometers in-situ. The PUPS is a compact design for quick mounting on vehicles. Size discrimination is accomplished using a compact reverse Differential Mobility Analyzer (rDMA). Particle charging is accomplished using corona ionization. Concentration measurements are completed using a unique flexible printed circuit board electrode which can be removed for cleaning, disposal or chemical analysis of collected particles at the end of its in situ measurement life.
    Type: Application
    Filed: April 20, 2014
    Publication date: March 12, 2015
    Applicant: The University of Vermont and State Agricultural College
    Inventors: Andrew Vize, Matthew Casari, Jeff Frolik, Britt Holmen
  • Optoelectronic devices
    Patent number: 8975644
    Abstract: Optoelectronic devices have a photoactive region containing semiconductor material doped with ions of a rare earth element. Characteristic transitions associated with internal energy states of the rare earth dopant ions are modified by direct interaction of those states with an energy state in the semiconductor band structure. Eu+ and Yb+ doped silicon LEDs and photodetectors are described. The LEDs are emissive of radiation in the wavelength range 1300 nm to 1600 nm, important in optical communications.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: March 10, 2015
    Assignee: The University of Surrey
    Inventors: Kevin Peter Homewood, Russell Mark Gwilliam
  • Binder-free sulfur—carbon nanotube composite cathodes for rechargeable lithium—sulfur batteries and methods of making the same
    Patent number: 8974960
    Abstract: The present disclosure includes a sulfur-carbon nanotube composite comprising a sheet of carbon nanotubes and sulfur nucleated upon the carbon nanotubes, and methods for synthesizing the same. In some embodiments, the sulfur-carbon composite may further be binder-free and include a sheet of carbon nanotubes, rendering a binder and a current collector unnecessary. In other embodiments of the present disclosure, a cathode comprising the sulfur-carbon nanotube composite is disclosed. In additional embodiments of the present disclosure, batteries may include the cathodes described herein. Those batteries may achieve high rate capabilities.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: March 10, 2015
    Assignee: Board of Regents, The University of Texas System
    Inventors: Arumugam Manthiram, Yu-Sheng Su
  • Injectable biomaterials
    Patent number: 8974803
    Abstract: Injectable biomaterial compositions formed from tropoelastin for tissue repair and restoration. The compositions include a coalescence-controlling agent in the form of a polysaccharide or polysaccharide derivative, in an amount effective for providing the substance with the properties of flow, enabling injection.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: March 10, 2015
    Assignee: The University of Sydney
    Inventors: Anthony Steven Weiss, Suzanne Marie Mithieux
  • Deoxynojirimycin and D-arabinitol analogs and methods of using
    Patent number: 8975280
    Abstract: A compound of Formula I are provided: wherein R is: R1 is a substituted or unsubstituted alkyl group; W1-4 are independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups; X1-5 are independently selected from H, NO2, N3, and NH2; Y is absent or is a substituted or unsubstituted C1-alkyl group, other than carbonyl; Z is selected from a bond or NH, provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted C1-alkyl group, other than carbonyl. Also provided are D-arabinitol compounds, methods for preparing such compounds and compositions of such compounds, and methods of using such compounds.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: March 10, 2015
    Assignee: The Chancellor, Masters and Scholars of The University of Oxford
    Inventors: Terry D. Butters, Raymond A. Dwek, George W. J. Fleet
  • Spine replacement system for the treatment of spine instability and degenerative disc disease
    Patent number: 8974528
    Abstract: Apparatuses and methods for single disc arthroplasty and multi-segmental spine replacement recreating the anterior and middle columns of the subaxial spine complete with adjacent motion segments are disclosed. The surgical implant assembly includes a first cage adapted to be rigidly attached to a first vertebra, a second cage adapted to be rigidly attached to a second vertebra, and a spinal disc replacement prosthesis positioned between the first and second cages. The spinal disc replacement prosthesis preferably includes a resilient plastic or elastomeric body having two or more adjustably fluid-filled compartments therein, the fluid-filled compartments each being adjustably fluid filled by a respective port defined in the prosthesis body.
    Type: Grant
    Filed: October 5, 2004
    Date of Patent: March 10, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: David Ming Cheng