Abstract: The present invention relates to a biocompatible ceramic material comprising Baghdadite (Ca3ZrSi2O9), and a method for its preparation. Preferably the Baghdadite is synthetically prepared. The present invention also relates to an implantable medical device comprising biocompatible Baghdadite, and a method for its production. The present invention further relates to a method for improving the long term stability of an implantable medical device and an implantable drug delivery device comprising Baghdadite. Further, the present invention relates to the use of comprising biocompatible Baghdadite in the regeneration or resurfacing of tissue.
Type:
Grant
Filed:
October 24, 2008
Date of Patent:
April 14, 2015
Assignee:
The University of Sydney
Inventors:
Hala Zreiqat, Chengtie Wu, Yogambha Ramaswamy
Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
Type:
Grant
Filed:
October 8, 2012
Date of Patent:
April 14, 2015
Assignees:
The UAB Research Foundation, The State of Oregon Acting By and Through the State Board of Higher Education on Behalf of The University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.
Inventors:
Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
Abstract: Provided herein is a method for quantifying the spatial distribution of cells or sub-cellular structures comprising (a) receiving image data comprising a plurality of biomarkers, N, wherein the data represents a spatial map of the biomarkers; (b) processing the data to obtain a set of coordinates, wherein each coordinate denotes the location of a cell or sub-cellular structure represented by a biomarker or combination of biomarkers; and (c) processing the set of coordinates into a two-dimensional symmetric (2N?1)×(2N?1) or 2N×2N matrix (D). Also provided is the use of this method for assigning subjects one or more clinical characteristics, the use of this method for forming and/or testing scientific hypotheses for one or more interventions, and apparatus comprising at least one processor configured to perform the method.
Abstract: Recommendation systems are widely used in Internet applications. In current recommendation systems, users only play a passive role and have limited control over the recommendation generation process. As a result, there is often considerable mismatch between the recommendations made by these systems and the actual user interests, which are fine-grained and constantly evolving. With a user-powered distributed recommendation architecture, individual users can flexibly define fine-grained communities of interest in a declarative fashion and obtain recommendations accurately tailored to their interests by aggregating opinions of users in such communities. By combining a progressive sampling technique with data perturbation methods, the recommendation system is both scalable and privacy-preserving.
Type:
Application
Filed:
December 11, 2014
Publication date:
April 9, 2015
Applicants:
AT&T Intellectual Property I, L.P., Board of Regents, The University of Texas System
Inventors:
Kadangode K. Ramakrishnan, Divesh Srivastava, Tae Won Cho, Yin Zhang
Abstract: A technique for forming a two-dimensional electronic spectrum of a sample includes illuminating a line within a portion of the sample with four laser pulses; where along the entire line the difference in the arrival times between two of the laser pulses varies as a function of the position and the difference in the arrival times between the other two pulses is constant along the entire line. A spectroscopic analysis may then be performed on the resulting pulsed output signal from the illuminated line to produce a single-shot two dimensional electronic spectroscopy.
Abstract: The present invention relates to the identification of loss-of-function mutations in the filaggrin gene and their use in diagnosing ichthyosis vulgaris and/or susceptibility to other diseases including atopic dermatitis (eczema), asthma, psoriasis and allergies (including food allergy).
Type:
Grant
Filed:
December 15, 2006
Date of Patent:
April 7, 2015
Assignee:
University Court of The University of Dundee
Inventors:
William Henry Irwin McLean, Frances Jane Dorothy Smith
Abstract: An abrasive element comprises a body of crystalline abrasive material. The body has an array of cutting elements formed of crystalline abrasive material which projects from a surface of the body. The shape, size and form of the projections is controlled in the production process. The body may be a natural or synthetic crystal. The body may be a film formed by deposition. The body may be diamond or cubic boron nitride. The body may be monocrystalline or polycrystalline. The projections may be aligned along a crystallographic plane or planes.
Type:
Grant
Filed:
December 18, 2009
Date of Patent:
April 7, 2015
Assignee:
The University of Nottingham
Inventors:
Dragos Axinte, Paul Butler-Smith, Mark Daine
Abstract: The present invention provides nucleic acid aptamers that bind to Plasmodium proteins lactate dehydrogenase and histidine-rich protein II, and uses thereof for the diagnosis of malaria. Aptamers against histidine-rich protein II may be used to detect the presence of Plasmodium species in general, whereas aptamers against lactate dehydrogenase can be used to specifically detect Plasmodium falciparum.
Type:
Grant
Filed:
February 8, 2013
Date of Patent:
April 7, 2015
Assignee:
The University of Hong Kong
Inventors:
Julian A Tanner, Yee Wai Cheung, Masayo Kotaka
Abstract: Transcription of a gene in a mammalian cell is methylase-independently inhibited by contacting the cell with a nucleic acid oligomer of 12-28 bases complementary for a partially single-stranded target genomic sequence of the gene.
Type:
Grant
Filed:
March 14, 2006
Date of Patent:
April 7, 2015
Assignee:
Board of Regents, The University of Texas System
Abstract: A noise processing apparatus measures a first potential difference signal, between a first electrode and a second electrode that is used as a reference electrode, and measures a second potential difference signal, between the second electrode and a third electrode that is arranged on the steering unit in the apparatus. The apparatus calculates the difference between the intensities of the first potential difference signal and the second potential difference signal calculated at the predetermined intervals. The apparatus corrects the first potential difference signal or the second potential difference signal by using the calculated difference such that the intensities of the first potential difference signal and the second potential difference signal are canceled out.
Type:
Grant
Filed:
May 30, 2012
Date of Patent:
April 7, 2015
Assignees:
Fujitsu Limited, The University of Tokyo
Abstract: Fine mesoporous silica particles are provided by which not only the functions of low reflectance (Low-n), low dielectric constant (Low-k) and low thermal conductivity but also improved strength of a molded article are achieved. The fine mesoporous silica particles are manufactured by a process including a surfactant composite fine silica particle preparation step and a mesoporous particle formation step. In the silica fine particle preparation step, a surfactant, water, an alkali and a hydrophobic part-containing additive including a hydrophobic part for increasing the volume of micelles are mixed with a silica source to thereby prepare surfactant composite fine silica particles. In the mesoporous particle formation step, the mixture is mixed with an acid and an organosilicon compound to thereby remove the surfactant and hydrophobic part-containing additive from the surfactant composite fine silica particles and provide the surface of each silica fine particle with an organic functional group.
Type:
Grant
Filed:
May 18, 2010
Date of Patent:
April 7, 2015
Assignees:
Panasonic Corporation, The University of Tokyo
Abstract: The disclosure relates to an endothelin receptor antagonist for use in the prevention or treatment of brain metastases in combination with a cytotoxic chemotherapy agent, radiotherapy or both. The endothelin receptor antagonist may for example be bosentan, macitentan or a mixture of bosentan and macitentan.
Type:
Grant
Filed:
August 9, 2010
Date of Patent:
April 7, 2015
Assignee:
Board of Regents, The University of Texas System
Abstract: Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and A are as defined herein are disclosed. Such compounds have enhanced water solubility and have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Enantioselective methods for preparation of compounds of structure (I), compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluents and methods of SHIP1 modulation by administration of such compounds to an animal in need thereof are also disclosed.
Type:
Grant
Filed:
August 22, 2011
Date of Patent:
April 7, 2015
Assignee:
The University of British Columbia
Inventors:
Xiaoxia Wang, Labros George Meimetis, Matthew Bruce Nodwell, Raymond Andersen
Abstract: A method for fabricating a microarray of plural soft materials includes: vapor-depositing a first layer poly(para-xylylene) resin on a substrate, forming a first micro pattern in the poly(para-xylylene) resin; obtaining a substrate including a first microarray formed by pouring a first soft material solution, freeze-drying the first soft material to obtain a micro-arrayed substrate of the freeze-dried first soft material; vapor-depositing a second layer poly(para-xylylene) resin on the micro-arrayed substrate of the freeze-dried first soft material, forming a second micro pattern placed differently from the first micro pattern by penetrating the poly(para-xylylene) resin of the first and second layers, forming a second microarray on the substrate by pouring a second soft material solution; and forming a microarray of the first and second soft materials on the substrate by peeling off the poly(para-xylylene) resin of the first and second layers.
Type:
Grant
Filed:
March 27, 2012
Date of Patent:
April 7, 2015
Assignees:
NTT DOCOMO, INC., The University of Tokyo
Abstract: A multilayered structure is provided. The multilayered structure may include a silicon substrate and a film of gadolinium oxide disposed on the silicon substrate. The top surface of the silicon substrate may have silicon orientated in the 100 direction (Si(100)) and the gadolinium oxide disposed thereon may have an orientation in the 100 direction (Gd2O3(100)).
Type:
Grant
Filed:
June 25, 2014
Date of Patent:
April 7, 2015
Assignee:
The University of North Carolina at Charlotte
Inventors:
Raphael Tsu, Wattaka Sitapura, John Hudak
Abstract: Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.
Type:
Grant
Filed:
December 11, 2013
Date of Patent:
April 7, 2015
Assignee:
Board of Regents, The University of Texas System
Abstract: A semiconductor substrate that includes a semiconductor layer that exhibits high crystallinity includes a graphite layer formed of a heterocyclic polymer obtained by condensing an aromatic tetracarboxylic acid and an aromatic tetramine, and a semiconductor layer that is grown on the surface of the graphite layer, or includes a substrate that includes a graphite layer formed of a heterocyclic polymer obtained by condensing an aromatic tetracarboxylic acid and an aromatic tetramine on its surface, a buffer layer that is grown on the surface of the graphite layer, and a semiconductor layer that is grown on the surface of the buffer layer.
Type:
Grant
Filed:
September 7, 2010
Date of Patent:
April 7, 2015
Assignees:
The University of Tokyo, Tokai Carbon Co., Ltd., National Institute of Advanced Industrial Science and Technology
Abstract: Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula (I) are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.
Type:
Grant
Filed:
December 10, 2009
Date of Patent:
April 7, 2015
Assignee:
The Trustees Of The University Of Pennsylvania
Inventors:
Robert B. Wilson, Maria Grazia Cotticelli, Phillip A. Benedetti, Amos Smith, Jason E. Melvin, Donna M Huryn
Abstract: Formulations having, as active agents, at least one quaternized polymeric microgel and at least one surfactant, methods of making, and methods of using are described.
Abstract: A device for studying protein conformation transformation can include a macroscopic substrate, and chaperonin proteins bound to the substrate, each chaperonin protein being capable of binding to a protein of interest during or after undergoing protein conformation transformation. The device may also include the proteins of interest bound to the substrate, where the substrate is included in a label-free assay system. A method of studying protein conformation transformation can include: providing a macroscopic substrate bound with the chaperonin protein and immersing the chaperonin protein in a study composition having the protein of interest, or include providing a macroscopic substrate bound with the protein of interest; and immersing the protein in a study composition having the chaperonin. Such a method can be done with and without a potential stabilizer in order to determine whether the potential stabilizer stabilizes the protein of interest.