Abstract: Embodiments of the present systems and methods may provide improved capability to predict the risk of recurrence of ductal carcinoma in situ (DCIS) conditions using whole slide image analysis based on machine learning techniques. For example, in an embodiment, a computer-implemented method for determining treatment of a patient may comprise receiving an image of living tissue of a patient, annotating the entire image into tissue structures, extracting texture features from the annotated image, determining a distribution of the extracted texture features relative to tissue conditions, classifying the patient into a risk group based on the distribution, and treating the patient accordingly based on the risk group.
Type:
Grant
Filed:
December 16, 2019
Date of Patent:
December 24, 2024
Assignee:
Georgia State University Research Foundation, Inc.
Inventors:
Sergey Klimov, Yi Jiang, Arkadiusz Gertych
Abstract: Provided herein, inter alia, are splice modulator compounds. The compounds include optically pure, stereospecific analogs of FD-895. The methods provided herein allow, for example, for scalable preparation of said compounds, and further allow, for example, use of said compounds for inhibiting spliceosome activity.
Type:
Grant
Filed:
January 12, 2022
Date of Patent:
December 24, 2024
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors:
Michael D. Burkart, Warren C. Chan, James J. La Clair, Kelsey A. Trieger, Catriona Jamieson
Abstract: The present invention is directed to kits for identifying the presence of one or more target nucleotide sequences in a sample that involve a ligation and/or polymerase reaction. In some embodiments, the ligation products formed in the ligation process of the present invention are subsequently amplified using a polymerase chain reaction. The ligated product sequences or extension products thereof are detected, and the presence of one or more target nucleotide sequences in the sample is identified based on the detection.
Type:
Grant
Filed:
December 16, 2021
Date of Patent:
December 24, 2024
Assignee:
CORNELL UNIVERSITY
Inventors:
Francis Barany, Eugene Spier, Alain Mir
Abstract: Provided herein is technology relating to polymerization and producing polymers and particularly, but not exclusively, to methods, systems, and compositions for producing articles using three-dimensional printing and for improving control of polymerization using a polymerization photoinhibitor having fast back reaction kinetics such as hexaarylbiimidazole compounds and bridged hexaarylbiimidazole compounds.
Type:
Grant
Filed:
November 13, 2023
Date of Patent:
December 24, 2024
Assignee:
The Regents of the University of Michigan
Inventors:
Timothy F. Scott, Harry van der Laan, Megan A. Cole, Mark A. Burns, Martin P. De Beer, Zachary D. Pritchard, Avi Bregman
Abstract: The disclosure discloses a system for controlling a multi-point synchronous braking of a monorail hoist and a utilization method thereof. The system comprises a contact detection unit, a common end roller unit, a hydraulic unit, a synchronous control unit and connection cables. The contact detection unit is installed on a brake shoe of a monorail hoist. The common end roller unit is installed on a travelling track and connected with a frame of the monorail hoist. The contact detection unit includes a tube in connection with the brake shoe. A metal probe corresponding to the travelling track is arranged inside the tube. A circular boss is formed on the metal probe. A limiting bolt corresponding to the circular boss is formed on an inner side wall of the tube. The metal probe is contactable with the travelling track or the limiting bolt when the brake shoe brakes.
Type:
Grant
Filed:
September 19, 2022
Date of Patent:
December 24, 2024
Assignee:
China University of Mining and Technology
Abstract: The present invention relates to an image encoding and decoding technique, and more particularly, to an image encoder and decoder using unidirectional prediction. The image encoder includes a dividing unit to divide a macro block into a plurality of sub-blocks, a unidirectional application determining unit to determine whether an identical prediction mode is applied to each of the plurality of sub-blocks, and a prediction mode determining unit to determine a prediction mode with respect to each of the plurality of sub-blocks based on a determined result of the unidirectional application determining unit.
Type:
Grant
Filed:
May 3, 2023
Date of Patent:
December 24, 2024
Assignees:
Electronics and Telecommunications Research Institute, Kwangwoon University Industry-Academic Collaboration Foundation, University-Industry Cooperation Group of Kyung Hee University
Inventors:
Hae Chul Choi, Se Yoon Jeong, Sung-Chang Lim, Jin Soo Choi, Jin Woo Hong, Dong Gyu Sim, Seoung-Jun Oh, Chang-Beom Ahn, Gwang Hoon Park, Seung Ryong Kook, Sea-Nae Park, Kwang-Su Jeong
Abstract: A BMOFs nanosheet based on a ZIF/MIL topology, and a preparation method and an application thereof are provided. The preparation method includes dispersing a MOF material of a ZIFs series in an organic phase, then adding an aqueous phase to obtain a mixture; and adding a MOF material of a MILs series into the mixture, sealing, standing for 1-5 days, filtering, performing centrifugal washing, drying, and performing acetone ultrasonic exfoliation to obtain the BMOFs nanosheet based on the ZIF/MIL topology. The preparation method is simple to operate and moderate in conditions, and the prepared ZIF/MIL BMOFs nanosheet has good electrocatalytic activity and stability in an OER.
Type:
Grant
Filed:
May 3, 2024
Date of Patent:
December 24, 2024
Assignees:
Zhejiang University of Technology, Zhejiang Marine Fisheries Research Institute
Inventors:
Lei Qin, Xiaoyan Mao, Tiejun Li, Yingyu Tan, Wenjie Liu, Lei Jin
Abstract: An identification device includes an acquirer for acquiring a captured image obtained by imaging a predetermined target, a specifier for specifying a linear region extending in a plurality of mutually different directions, from a region of the captured image acquired by the acquirer, the region including the predetermined target, and an extractor for extracting a feature quantity based on the pixel value, from the linear region specified by the specifier.
Abstract: A method of producing a degradable material comprising steps of hydrogenating 2-ethylidene-6-hepten-5-olide (EVL) by introducing hydrogen to the EVL in order to obtain modified EVL; combining the modified EVL with a catalyst to form a reaction mixture; and subjecting the reaction mixture to reaction conditions that will allow the modified EVL to react by ring-opening polymerization in the presence of the catalyst to form a product composition including polymeric-EVL, wherein the polymeric-EVL is hydrolytically degradable, wherein the reaction conditions include a reaction temperature of from ?40° C. to 70° C.
Type:
Grant
Filed:
September 8, 2021
Date of Patent:
December 24, 2024
Assignee:
THE UNIVERSITY OF AKRON
Inventors:
James M. Eagan, Luis D. Garcia Espinosa
Abstract: Provided are an essential oil composition and a preparation method thereof. The essential oil composition includes a eutectic composition and an essential oil; the eutectic composition includes a hydrogen-bond donor and a hydrogen-bond acceptor; the hydrogen-bond donor is geranic acid or derivatives of the geranic acid; the hydrogen-bond acceptor is choline or derivatives or hydrates of the choline; a mass ratio of the hydrogen-bond donor to the hydrogen-bond acceptor is 1-10:1-10.
Type:
Grant
Filed:
March 13, 2024
Date of Patent:
December 24, 2024
Assignee:
Jiangxi University of Chinese Medicine
Inventors:
Zhenfeng Wu, Wei He, Di Wang, Ming Yang, Na Wan
Abstract: The present application is directed to a compound having the Formula (I): wherein R1, R2, and R3 are as described herein. The present application is also directed to a wax composition comprising a wax and a compound of Formula (I). Processes of making a wax composition and for coating a plant or plant part with the compound of Formula (I) are also described.
Type:
Grant
Filed:
October 19, 2023
Date of Patent:
December 24, 2024
Assignees:
IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC., UNIVERSITY OF TENNESSE RESEARCH FOUNDATION
Inventors:
Tong Wang, Tao Fei, Francisco Miquel Ang Leyva Gutierrez
Abstract: The present disclosure provides a carbide blade cutter head filling device and method, and relates to the field of alloy blade processing. The carbide blade cutter head filling device includes a feeding unit, a storage unit, a loading unit and a discharging unit which are arranged successively. The output end of the feeding unit is matched with the input end of the storage unit through the guide mechanism. The output end of the storage unit faces a conveying tray of the loading unit. The conveying tray is provided with a plurality of group of transition holes for accommodating blades. A receiving mechanism for accommodating a cutter head is arranged below the falling pull plate of the discharging unit. The falling pull plate adjusts the communication and isolation between the transition hole and the cutter head in the receiving mechanism by changing the relative position of the falling pull plate and the transition hole.
Type:
Grant
Filed:
June 7, 2021
Date of Patent:
December 24, 2024
Assignees:
QINGDAO UNIVERSITY OF TECHNOLOGY NINGBO SANHAN ALLOY MATERIAL CO., LTD., NINGBO SANHAN ALLOY MATERIAL CO., LTD.
Abstract: Described herein are composite materials composed of ceramic particles coated with a surfactant incorporated within a polymer matrix, methods of making same, filaments composed of the same, and articles printed using the filaments. The composite materials and articles described herein have desirable electronic and thermal properties for use in radio frequency (RF) and millimeter wave devices and demonstrate reliable performance at elevated humidity levels.
Abstract: Using nucleotide architectures to very closely and precisely placed chromophores that produce quantum coherent excitons, biexcitons, and triexcitons upon excitement to create excitonic quantum wires, switching, and gates that would then form the basis of quantum computation. Creating the various excitons and controlling the timing of the excitons would be performed using light of the corresponding wavelength and polarization to stimulate the corresponding chromophores.
Abstract: A composite interface transport material-based perovskite photovoltaic, light emission and light detection multi-functional device and a preparation method therefor. The multi-functional device comprises a transparent conductive glass, a composite electron transport layer, a perovskite active layer, a composite hole transport layer and a metal electrode layer which are sequentially arranged in a stacked manner from bottom to top. The work functions of the interface transport layers are adjusted by means of the multi-element interface transport materials, so that the work functions of the electron transport layer and the hole transport layer are respectively levelled with conduction band and valence band positions of the perovskite active layer. According to experiment result comparisons, the photoelectric conversion efficiency and the luminous efficiency of the perovskite multi-functional device, after energy band regulation, are significantly increased.
Abstract: Disclosed is a multi-angle image semantic segmentation method for cadmium zinc telluride chips, belonging to the field of image quality augmentation. Firstly, construction of an n+1 dataset is performed by using acquire CZT images, and then pixel-level and latent-level knowledge representation is performed through a Pixel Aggregation Network PAN and a Latent Aggregation Network LAN in a Progressive Complementary Knowledge Aggregation network PCKA, which ultimately improves the quality and speed of CZT image segmentation. The method is suitable for applications that require multi-angle image acquisition and semantic segmentation, such as semiconductor material segmentation.
Type:
Grant
Filed:
August 27, 2024
Date of Patent:
December 24, 2024
Assignees:
Beijing Jiaotong University, Taiyuan University of Science and Technology, Shanxi Zhishi Haotai Technology Co., LTD
Abstract: An internal peeping detection-while-drilling system includes an intelligent probing rod, cable drill pipes, a signal relay sub, a ground control terminal, a data interpretation and goaf reconstruction imaging software system, and a remote data transmission system, where the intelligent probing rod includes an up-down separated protective transmission mechanism and an instrument cabin; the intelligent probing rod includes a lower end connected to a drilling bit, and an upper end connected to each of the cable drill pipes; the instrument cabin is provided in the up-down separated protective transmission mechanism, and provided with a sonar-lidar-audio/video sensor assembly; the cable drill pipes are connected to each other to form a cable and data transmission channel; the signal relay sub is provided between the cable drill pipes at intervals; and an uppermost end of the cable drill pipe is connected to the ground control terminal.
Type:
Grant
Filed:
December 29, 2023
Date of Patent:
December 24, 2024
Assignees:
CHINA UNIVERSITY OF GEOSCIENCES (WUHAN), Institute of Rock and Soil Mechanics, Chinese Academy of Sciences
Abstract: The present invention provides a composition for delivering a polynucleotide into cells via a polyplex. The polyplex comprises the polynucleotide and a polymer. The composition comprises the polyplex, a collagen-mimetic peptide (CMP) and collagen fragments. The CMP is bound to the polyplex and the collagen fragments. Also provided are the uses of the composition in methods of delivering a polynucleotide into cells as well as methods of improving wound healing in a subject, enhancing cell proliferation in a subject, enhancing production of extracellular matrix by cells in a subject and/or enhancing cell migration by cells in a subject.
Type:
Grant
Filed:
July 18, 2017
Date of Patent:
December 24, 2024
Assignee:
UNIVERSITY OF DELAWARE
Inventors:
Kristi Kiick, Millicent Sullivan, Morgan Urello
Abstract: A method for making an improved fuel cell using a porosity gradient design for gas diffusion layers in a hydrogen fuel cell, a gas diffusion layer made by the method and a fuel cell containing the gas diffusion layer.
Type:
Grant
Filed:
March 18, 2024
Date of Patent:
December 24, 2024
Assignee:
KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
Abstract: Disclosed are a Type-II Autonomous Emergency Braking System (AEBS) test and evaluation device and method based on a BeiDou space-time reference, where the device includes three parts: a roadside-end information acquisition module, a vehicle-end information acquisition module, and an integrated information processing module. The roadside-end information acquisition module can acquire accurate message sending time by means of a BeiDou time service unit: the vehicle-end information acquisition module can acquire accurate time of receiving a roadside-end message, information acquired by a combined inertial navigation unit, and audio/vibration information acquired by a Single Chip Microcomputer (SCM) embedded unit; and the integrated information processing module can implement accurate, quantitative test and evaluation of indexes such as a vehicle-road communication delay and warning signal sending time.