Abstract: Described herein is a beads-free bioprocessor as an automated and cost-effective T cell processing and manufacturing platform. T cells are a core component in CAR T cell therapies for cancer treatment, but are difficult to manufacture to scale in clinically relevant quantities. The 3D bioprocessor provides an alternative device that is scalable, beads-free, easy-to-use, and cost-effective for using CAR T cell therapy in cancer immunotherapy. Besides CAR T cell application, this platform technology has potential for many other applications such as cancer cell isolation.

Abstract: Provided herein is a novel composition for oral administration and delivery of Noble gas, such as xenon or argon. Methods of treating and preventing neuronal or cardiovascular damage with such compositions are also provided.

Abstract: A control system according to an embodiment includes a motor configured to drive a link, a first sensor configured to detect information about the driving by the motor or information about a relation between the driving means and the load member as first sensor information, a second sensor configured to detect information about a displacement of the link as second sensor information, and a control unit configured to perform feedback control of the driving means so as to follow a command value in a two-inertial system model including an inertial system on a load side and an inertial system on a driving side. The control unit includes a disturbance observer configured to estimate a disturbance, and a filter configured to convert an estimated value of the disturbance into a driving force of the motor.

Abstract: The disclosed embodiments relate to the design of a preconcentrator system for preconcentrating air samples. This preconcentrator system includes a plurality of preconcentrators that preconcentrate the air samples prior to chemical analysis, and a delivery structure comprising a manifold that selectively routes a sample airflow to the plurality of concentrators so that the plurality of preconcentrators receive a sample airflow concurrently or individually.

Abstract: Nanoparticles coated with extracellular matrix (ECM) are provided, in some aspects, for the delivery of a therapeutic protein, nucleic acid, or drug. In some embodiments, the nanoparticles are delivered to a subject via inhalation or aerosol delivery. Also provided, in some aspects, are methods for treating acute lung injury comprising administering ?-Klotho (?Klotho) protein or DNA to a subject.

Abstract: Provided are antibodies, and antigen-binding fragments thereof, which specifically bind to an extracellular poor loop of an alpha 1a subunit of L-type voltage gated calcium channel, and related compositions, kits, and methods of use thereof, for instance, administration to a subject in need thereof to modify an immune response, for example, in the treatment of cancer.

Abstract: The present invention relates to a bio-based polyol comprising a thiol-epoxy reaction product of an epoxidized nut or seed oil derivative, and a thiol-containing reactant. The bio-based polyol of the present invention can then be combined with a diisocyanate or a polymeric isocyanate to create a polyurethane material.

Abstract: When a DBMS receives a suspend instruction in which a suspend completion time of query processing is a future time and between receipt of the suspend instruction and the suspend completion time, if there is a target object (at least a processing object whose execution is in progress upon receipt of the suspend instruction) whose predicted completion time is at or precedes the suspend completion time, the DBMS changes the state of the target object to a state signifying a snapshot suspend. If there is a processing object whose state signifies a snapshot suspend, the DBMS executes the processing object at or before the suspend completion time.

Abstract: This invention relates to SARS-CoV-2 viruses adapted with nanoluciferase reporter molecules and mouse-adapted SARS-CoV-2 viruses, compositions including the same and methods of use thereof.

Abstract: A tunable optical electrowetting element having a liquid-liquid interface shape controlled by an applied voltage. Circuitry for applying a voltage to the electrowetting element is configured to apply a shaped voltage signal comprising a first fast-rising signal combined with a second fast-rising signal. The second signal is selected to damp oscillations in the liquid-liquid interface caused by the first signal.

Abstract: A medium for fast, selective oil-water separation and/or oil absorption includes steel wool modified with a polymer a polymer or a polymer mixture. The polymer or the polymer mixture is adapted such that the medium is a superwetting material that is superhydrophobic and superoleophilic under water. The polymer or the polymer mixture includes polydimethylsiloxane, polytetrafluoroethylene, polyvinylpyrrolidone, or a combination thereof. The solution immersion method used to synthesize the medium requires only a single, simple step and affordable materials and, as a result, is easy to scale up.

Abstract: Polypeptides that fold into biologies are stabilized by diselenide bonds between selenocysteine amino acids. Methods to produce such polypeptides in genomically recoded organisms (GRO) can be scaled up for industrial production. Since diselenides have the same geometric bond angles and torsions as disulfides, as well as very similar bond lengths, they can be substituted into polypeptides without disrupting the three dimensional structure of the polypeptides. Diselenides render the polypeptides resistant to reduction when they are exposed to blood serum or to reducing components of blood serum or to reducing components components within cells.

Abstract: [Object] To provide a fusion protein of an antibody that recognizes cancer cells and a mutant streptavidin, which is for use in the treatment or diagnosis of cancer. [Means for Solution] A fusion protein comprising a protein-recognizing substance and the amino acid sequence as set forth in SEQ ID NO: 19 that is fused with the protein-recognizing substance.

Abstract: Compositions and methods of transplanting cells by grafting strategies into solid organs (especially internal organs) are provided. These methods and compositions can be used to repair diseased organs or to establish models of disease states in experimental hosts. The method involves attachment onto the surface of a tissue or organ, a patch graft, a “bandaid-like” covering, containing epithelial cells with supporting early lineage stage mesenchymal cells. The cells are incorporated into soft gel-forming biomaterials prepared under serum-free, defined conditions comprised of nutrients, lipids, vitamins, and regulatory signals that collectively support stemness of the donor cells. The graft is covered with a biodegradable, biocompatible, bioresorbable backing used to affix the graft to the target site. The cells in the graft migrate into and throughout the tissue such that within a couple of weeks they are uniformly dispersed within the recipient (host) tissue.

Abstract: A heliostat includes a reflecting surface; an elastically deformable frame on which the reflecting surface is mounted; a truss structure behind the elastically deformable frame that includes at least four bracing struts with first ends attached to the elastically deformable frame and second ends attached to at least one node located centrally behind the frame; at least one actuator connected to at least one of the at least four struts at the at least one node; an electronic control system configured to communicate with the least one actuator; and a dual-axis mount to support and orient the above assembly. The actuation of the at least one actuator in response to the electronic control system causes compression or tension of at least one of the at least four bracing struts to thereby control a shape of the reflecting surface and the elastically deformable frame in at least low order bending modes.

Abstract: Automated devices for detecting and removing dental biofilms are described herein. In some embodiments, the disclosed subject matter includes a device for administering a suspension comprising iron oxide nanoparticles to teeth to chemically treat and mechanically remove dental biofilms. In some embodiments, disclosed subject matter includes a device for administering a suspension comprising iron oxide nanoparticles and hydrogen peroxide to teeth to kill bacteria within a biofilm matrix and degrade the biofilm matrix and assembling the iron oxide nanoparticles into autonomous magnetic bristles or antimicrobial robots to mechanically remove biofilm. Devices and methods for real-time detection of dental plaque and monitoring of removal of dental plaque are also disclosed herein.

Abstract: A method of removing a substrate, comprising: forming a growth restrict mask with a plurality of striped opening areas directly or indirectly upon a GaN-based substrate; and growing a plurality of semiconductor layers upon the GaN-based substrate using the growth restrict mask, such that the growth extends in a direction parallel to the striped opening areas of the growth restrict mask, and growth is stopped before the semiconductor layers coalesce, thereby resulting in island-like semiconductor layers. A device is processed for each of the island-like semiconductor layers. Etching is performed until at least a part of the growth restrict mask is exposed. The devices are then bonded to a support substrate. The GaN-based substrate is removed from the devices by a wet etching technique that at least partially dissolves the growth restrict mask. The GaN substrate that is removed then can be recycled.

Abstract: The present invention provides in certain embodiments compositions comprising at least one CD200 inhibitor, and methods of reversing or modulating immune suppression in a patient having a disease or disorder arising from abnormal cell growth, function or behavior, which method comprises administering to a patient in need thereof a CD200 inhibitor composition.

Abstract: A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary component for stability. Such attachment may include actuatable interlocking members.

Abstract: Certain embodiments are directed to novel heterotrimeric fusions in which the ectodomain of the TGF-? type II receptor (T?P?II) is coupled to the N- and C-terminal ends of the endoglin-domain of the TGF-? type III receptor (TpRIIIE). Certain embodiments are directed to novel heterotrimeric polypeptides in which the ectodomain of the TGF-? type II receptor (TI3RII) is coupled to the N- and C-terminal ends of the endoglin-domain (E domain) of the TGF-? type III receptor (TI3RIII). This trimeric receptor, known as RER, can bind all three TGF-? isoforms with sub-nanomolar affinity and is effective at neutralizing signaling induced by all three TGF-? isoforms, but not other ligands of the TGF-? superfamily, such as activins, growth and differentiation factors (GDFs), and bone morphonogenetic proteins (BMPs).