Abstract: A design and a fabrication method for an intravascular imaging and therapeutic catheters for combined ultrasound, photoacoustic, and elasticity imaging and for optical and/or acoustic therapy of hollow organs and diseased blood vessels and tissues are disclosed in the present invention. The invention comprises both a device—optical fiber-based intravascular catheter designs for combined IVUS/IVPA, and elasticity imaging and for acoustic and/or optical therapy—and a method of combined ultrasound, photoacoustic, and elasticity imaging and optical and/or acoustic therapy. The designs of the catheters are based on single-element catheter-based ultrasound transducers or on ultrasound array-based units coupled with optical fiber, fiber bundles or a combination thereof with specially designed light delivery systems. One approach uses the side fire fiber, similar to the one utilized for biomedical optical spectroscopy.
Type:
Grant
Filed:
November 1, 2010
Date of Patent:
January 13, 2015
Assignee:
Board of Regents, The University of Texas System
Inventors:
Stanislav Emelianov, Andrei Karpiouk, Bo Wang
Abstract: Compositions comprising NKT cell agonist compounds and a physiologically acceptable vehicle are provided. Methods of stimulating an NKT cell and enhancing an immune response are also disclosed. Further provided are vaccine preparations comprising NKT cell agonist compounds.
Type:
Grant
Filed:
August 4, 2010
Date of Patent:
January 13, 2015
Assignees:
The Scripps Research Institute, The University of Chicago, Brigham Young University
Inventors:
Luc Teyton, Albert Bendelac, Paul B. Savage
Abstract: A metallic magnetic powder where a primary particle of each metallic magnetic particle is a powder without forming an aggregate, and a method of making the same that includes manufacturing a metallic magnetic powder constituted of metallic magnetic particles, containing a metallic magnetic phase, with Fe, or Fe and Co as main components, rare earth elements, or yttrium and one or more non-magnetic components removing the non-magnetic component from the metallic magnetic with a reducing agent, while making a complexing agent exist for forming a complex with the non-magnetic component in water; oxidizing the metallic magnetic particle with the non-magnetic component removed; substituting water adhered to the oxidized metallic magnetic particle with an organic solvent; and coating the surface of the metallic magnetic particle with an organic matter different from the organic solvent, while maintaining a wet condition of the metallic magnetic particle with the organic solvent adhered thereto.
Type:
Grant
Filed:
May 9, 2011
Date of Patent:
January 13, 2015
Assignees:
The Arizona Board of Regents on Behalf of The University of Arizona, Materials Co., Ltd.
Inventors:
Dong Chul Pyun, Heemin Yoo, Hirohisa Omoto, Takayuki Yoshida
Abstract: A beam forming antenna device emitting a predetermined free space energy pattern, the device including: an optical signal source having predetermined wavelength characteristics; an optical modulator for modulating predetermined wavelengths of the optical signal source to produce a modulated signal source including frequency sideband components; a dispersion element for spreading and projecting the modulated signal source in a wavelength dependant manner onto a relative phase manipulation element; a relative phase manipulation element manipulating the relative phase of the modulated signal source in a predetermined manner, said phase manipulation element further amplitude modulating predetermined wavelengths of said modulated signal source and outputting a predetermined groupings of wavelengths on a series of output ports; optical to electrical conversion means converting the amplitude of the optical signal on said output ports to a corresponding electrical signal; and a series of irradiating antenna elements
Type:
Grant
Filed:
March 2, 2011
Date of Patent:
January 13, 2015
Assignee:
The University of Sydney
Inventors:
Xiaoke Yi, Thomas Huang, Robert Minasian
Abstract: Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
Type:
Grant
Filed:
June 16, 2009
Date of Patent:
January 13, 2015
Assignee:
The Board of Regents, The University of Texas System
Inventors:
Michael Kilgard, Larry Cauller, Navzer Engineer, Christa McIntyre, Will Rosellini
Abstract: The present invention provides for organometallic and organic dopants suitable for use in organic carrier transporting materials. Also provided are organic light emitting devices containing doped organic carrier transporting materials.
Abstract: A first device is provided. The device includes a print head. The print head further includes a first nozzle hermetically sealed to a first source of gas. The first nozzle has an aperture having a smallest dimension of 0.5 to 500 microns in a direction perpendicular to a flow direction of the first nozzle. At a distance from the aperture into the first nozzle that is 5 times the smallest dimension of the aperture of the first nozzle, the smallest dimension perpendicular to the flow direction is at least twice the smallest dimension of the aperture of the first nozzle.
Type:
Grant
Filed:
March 23, 2010
Date of Patent:
January 13, 2015
Assignee:
The Regents of The University of Michigan
Abstract: A first aspect of the invention is a compound (sometimes also referred to herein as an “active agent” or “active compound”) of Formula I or Ia: or a pharmaceutically acceptable salt or prodrug thereof. Compositions thereof and methods of using the same (e.g. for the treatment of a neurological disease) are also described.
Type:
Grant
Filed:
September 17, 2010
Date of Patent:
January 13, 2015
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
Harold L. Kohn, Christophe Salomé, Ki Duk Park, Elise Salomé-Grosjean
Abstract: Methods are directed to the treatment of subjects with prostate cancer, in particular those with castration resistant prostate cancer, with glucocorticoid receptor antagonists. The prostate cancer may be one that has become resistant to androgen deprivation therapy, for example, by increase in glucocorticoid receptor expression and/or activity.
Type:
Application
Filed:
February 21, 2013
Publication date:
January 8, 2015
Applicant:
The University of Chicago
Inventors:
Russell Z. Szmulewitz, Suzanne D. Conzen
Abstract: This invention relates to an improved structure for an interspinous stabilization device that more evenly distributes loads throughout the adjacent vertebrae than known interspinous stabilization devices, and further readily compensates for graft settling so as to maintain continued axial loading of the graft. More specifically, this invention relates to a medical device that helps in performing a spinal fusion procedure by holding the bone graft in place and stabilizing the facet screw by a plate that is attached to it. The invention also performs a dynamic function that compensates for settling of the bone graft over time. This dynamic function may, if desired, be enhanced by a movement-limiting mechanism that allows extension but not flexion such that the bone graft fusion remains in contact and fusion takes place.
Type:
Application
Filed:
February 19, 2013
Publication date:
January 8, 2015
Applicant:
The University of Toledo
Inventors:
Anand K. Agarwal, Vijay K. Goel, Aakash Agarwal
Abstract: This invention relates to therapeutic compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in mammals. The methods are particularly effective for protecting mammals from herpes simplex virus.
Type:
Application
Filed:
September 12, 2014
Publication date:
January 8, 2015
Applicants:
Vical Incorporated, The University of Washington
Inventors:
Adrian VILALTA, Michal Margalith, Lichun Dong, David M. Koelle
Abstract: A Raman spectrometer system provides a tool for discriminating between different tissue pathologies. The tool may provide discrimination indicators for a plurality of different pairs of tissue pathologies. Improved sensitivity and specificity are achieved by basing discriminations on appropriate ranges within a Raman spectrum.
Type:
Application
Filed:
November 7, 2012
Publication date:
January 8, 2015
Applicant:
The University of British Columbia
Inventors:
Harvey Lui, Haishan Zeng, David I. McLean, Jianhua Zhao, Michael Schulzer
Abstract: This invention relates to therapeutic polynucleotide compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in mammals. The polynucleotide compositions are particularly effective for protecting mammals from herpes simplex virus (HSV), such as HSV gD2, VP11/12, and VP13/14 polypeptides.
Type:
Application
Filed:
September 17, 2014
Publication date:
January 8, 2015
Applicants:
Vical Incorporated, The University Of Washington
Inventors:
Adrian VILALTA, Michal Margalith, Lichun Dong, David M. Koelle
Abstract: A body motion detection section (2) for continuously detecting the frequency of a user's activity as an activity level is provided. The activity level detected by the body motion detection section (2) is outputted to a fatigue detection section (3) for estimating a user's fatigue level on the basis of the activity level.
Type:
Grant
Filed:
May 22, 2007
Date of Patent:
January 6, 2015
Assignees:
Sharp Kabushiki Kaisha, The University of Tokyo
Abstract: The present invention is directed to methods of making nanofiber yarns. In some embodiments, the nanotube yarns comprise carbon nanotubes. Particularly, such carbon nanotube yarns of the present invention provide unique properties and property combinations such as extreme toughness, resistance to failure at knots, high electrical and thermal conductivities, high absorption of energy that occurs reversibly, up to 13% strain-to-failure compared with the few percent strain-to-failure of other fibers with similar toughness, very high resistance to creep, retention of strength even when heated in air at 450° C. for one hour, and very high radiation and UV resistance, even when irradiated in air.
Type:
Grant
Filed:
November 9, 2005
Date of Patent:
January 6, 2015
Assignee:
The Board of Regents of The University of Texas System
Inventors:
Mei Zhang, Ray H. Baughman, Kenneth Ross Atkinson
Abstract: The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing such HSV particles are provided. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention are useful for targeting cells that express the selected receptor, which itself may be a product of genetic engineering. The ability to selectively target cells render the HSV particles. particularly useful in selectively diagnosing, treating, and imaging cells bearing the selected binding pair member, such as a receptor. The invention also provides for polynucleotide-based therapy to cells bearing the selected binding pair member such as a receptor.
Abstract: An apparatus for determining cardiac performance in the patient. The apparatus includes a conductance catheter for measuring conductance and blood volume in a heart chamber of the patient. The apparatus includes a processor for determining instantaneous volume of the ventricle by applying a non-linear relationship between the measured conductance and the volume of blood in the heart chamber to identify mechanical strength of the chamber. The processor is in communication with the conductance catheter. Methods for determining cardiac performance in a patient. Apparatuses for determining cardiac performance in a patient.
Type:
Grant
Filed:
April 8, 2011
Date of Patent:
January 6, 2015
Assignee:
Board of Regents, The University of Texas System
Inventors:
Marc D. Feldman, Jonathan W. Valvano, John A. Pearce, Chia-Ling Wei
Abstract: The present invention is an adaptive secure wireless communications system and method. Generally, the present invention may be operable to address challenges and threats to a secure communication session. The secure wireless communication system of the present invention may operate one or more of the following: multiple physical-layer attributes monitoring; multiple parameter confidence testing related to transceiver (Tx-Rx) specific environment and transmitter receiver hardware characteristics; continuous and interleaved authentication; and security enhancement using dynamic adaptation of the transmission system parameters based concurrent and/or conjugated transmission of data-carrying signal and security control information. The real-time physical-layer related monitoring and interaction between transmitter and receiver, using Tx-Rx related physical environment, of the present invention may effectively reduce many wireless security threats including interception and spoofing.
Abstract: Anchoring devices and systems are disclosed for use with elongated reinforcement members such as FRP, SRP, metallic bars, or cables. Such devices and systems impart a compressive stress into a static structure having the elongated reinforcement member running there through or there along. An anchoring system can include an anchor block that includes a front end surface for contacting the static structure, an axial bore for receiving the elongated reinforcement member, and clamping members that work with fasteners to provide a clamping force. The bore may be tapered and the fasteners optionally provide different clamping levels to reduce the stress on the elongated reinforcement member near the front end surface. The disclosed systems also include pre-stressing devices that can be used with the disclosed anchor systems, and that can place a tensile force on the elongated reinforcement members to also impart a compressive force on the static structure.
Type:
Grant
Filed:
June 12, 2009
Date of Patent:
January 6, 2015
Assignee:
The University of Utah Research Foundation
Inventors:
Chris P. Pantelides, Lawrence D. Reaveley, Clayton A. Burningham